Pharmacology - Lehrman Lab – Research output — University of Texas Southwestern Medical Center

2018

Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis

Lu, H., Fermaintt, C. S., Cherepanova, N. A., Reid, G., Yan, N. & Lehrman, M. A., Sep 18 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9557-9562 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2016

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

Lopez-Sambrooks, C., Shrimal, S., Khodier, C., Flaherty, D. P., Rinis, N., Charest, J. C., Gao, N., Zhao, P., Wells, L., Lewis, T. A., Lehrman, M. A., Gilmore, R., Golden, J. E. & Contessa, J. N., Dec 1 2016, In: Nature chemical biology. 12, 12, p. 1023-1030 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

72 Scopus citations

Trappc11 is required for protein glycosylation in zebrafish and humans

DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imriea, D., Nayar, S., Baryshnikova, A., Milev, M. P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H. H., Lehrman, M. A., Sacher, M. & Sadler, K. C., Apr 15 2016, In: Molecular biology of the cell. 27, 8, p. 1220-1234 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

2015

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

Hasan, M., Fermaintt, C. S., Gao, N., Sakai, T., Miyazaki, T., Jiang, S., Li, Q. Z., Atkinson, J. P., Morse, H. C., Lehrman, M. A. & Yan, N., Sep 15 2015, In: Immunity. 43, 3, p. 463-474 12 p., 3143.

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

Flipping a Lipid-Linked Oligosaccharide? You Must Whip It

Lehrman, M. A., 2015, In: Trends in biochemical sciences. 40, 12, p. 715-717 3 p.

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

Leclerc, G. J., DeSalvo, J., Du, J., Gao, N., Leclerc, G. M., Lehrman, M. A., Lampidis, T. J. & Barredo, J. C., May 13 2015, In: Leukemia Research. 39, 11, p. 1246-1254 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2014

Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose

Philips, K. B., Kurtoglu, M., Leung, H. J., Liu, H., Gao, N., Lehrman, M. A., Murray, T. G. & Lampidis, T. J., Feb 2014, In: Cancer Chemotherapy and Pharmacology. 73, 2, p. 349-361 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway

Wang, Z., Deng, Y., Gao, N., Pedrozo, Z., Li, D. L., Morales, C. R., Criollo, A., Luo, X., Tan, W., Jiang, N., Lehrman, M. A., Rothermel, B. A., Lee, A. H., Lavandero, S., Mammen, P. P., Ferdous, A., Gillette, T. G., Scherer, P. E. & Hill, J. A., Mar 13 2014, In: Cell. 156, 6, p. 1179-1192 14 p.

Research output: Contribution to journal › Article › peer-review

299 Scopus citations

2013

A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation

Chu, J., Mir, A., Gao, N., Rosa, S., Monson, C., Sharma, V., Steet, R., Freeze, H. H., Lehrman, M. A. & Sadler, K. C., Jan 2013, In: DMM Disease Models and Mechanisms. 6, 1, p. 95-105 11 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1

Jelk, J., Gao, N., Serricchio, M., Signorell, A., Schmidt, R. S., Bangs, J. D., Acosta-Serrano, A., Lehrman, M. A., Bütikofer, P. & Menon, A. K., Jul 12 2013, In: Journal of Biological Chemistry. 288, 28, p. 20616-20623 8 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Glycoproteins, N-Linked

Lehrman, M. A., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 457-464 8 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

High-throughput screening identifies aclacinomycin as a radiosensitizer of EGFR-mutant non-small cell lung cancer

Bennett, D. C., Charest, J., Sebolt, K., Lehrman, M., Rehemtulla, A. & Contessa, J. N., 2013, In: Translational Oncology. 6, 3, p. 382-391 10 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Letter to the glycoforum: Improved protocols for preparing lipid-linked and related saccharides for fluorophore-assisted carbohydrate electrophoresis (FACE)

Gao, N., Holmes, J. & Lehrman, M. A., Oct 2013, In: Glycobiology. 23, 10, p. 1111 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

7 Scopus citations

Mannose-6-phosphate: A regulator of LLO destruction

Gao, N. & Lehrman, M. A., 2013, Glycosyltransferases: Methods and Protocols. Humana Press Inc., p. 277-282 6 p. (Methods in Molecular Biology; vol. 1022).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

Deng, Y., Wang, Z., Tao, C., Gao, N., Holland, W. L., Ferdous, A., Repa, J., Liang, G., Ye, J., Lehrman, M. A., Hill, J. A., Horton, J. D. & Scherer, P. E., Jan 2 2013, In: Journal of Clinical Investigation. 123, 1, p. 455-468 14 p.

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

2012

5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation

Zandberg, W. F., Gao, N., Kumarasamy, J., Lehrman, M. A., Seidah, N. G. & Pinto, B. M., Feb 13 2012, In: ChemBioChem. 13, 3, p. 392-401 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency

Cline, A., Gao, N., Flanagan-Steet, H., Sharma, V., Rosa, S., Sonon, R., Azadi, P., Sadler, K. C., Freeze, H. H., Lehrman, M. A. & Steet, R., Nov 1 2012, In: Molecular biology of the cell. 23, 21, p. 4175-4187 13 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

2011

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides

Gao, N., Shang, J., Huynh, D., Manthati, V. L., Arias, C., Harding, H. P., Kaufman, R. J., Mohr, I., Ron, D., Falck, J. R. & Lehrman, M. A., Sep 1 2011, In: Molecular biology of the cell. 22, 17, p. 2994-3009 16 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation

Harrison, K. D., Park, E. J., Gao, N., Kuo, A., Rush, J. S., Waechter, C. J., Lehrman, M. A. & Sessa, W. C., May 2011, In: EMBO Journal. 30, 12, p. 2490-2500 11 p.

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

2010

Antiangiogenic activity of 2-deoxy-D-glucose

Merchan, J. R., Kovács, K., Railsback, J. W., Kurtoglu, M., Jing, Y., Piña, Y., Gao, N., Murray, T. G., Lehrman, M. A. & Lampidis, T. J., 2010, In: PloS one. 5, 10, e13699.

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

2009

Suppression of Rft1 expression does not impair the transbilayer movement of Man₅GlcNAc₂-P-P-dolichol in sealed microsomes from yeast

Rush, J. S., Gao, N., Lehrman, M. A., Matveev, S. & Waechter, C. J., Jul 24 2009, In: Journal of Biological Chemistry. 284, 30, p. 19835-19842 8 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

2008

Recycling of dolichyl monophosphate to the cytoplasmic leaflet of the endoplasmic reticulum after the cleavage of dolichyl pyrophosphate on the lumenal monolayer

Rush, J. S., Gao, N., Lehrman, M. A. & Waechter, C. J., Feb 15 2008, In: Journal of Biological Chemistry. 283, 7, p. 4087-4093 7 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Unexpected basis for impaired Glc₃Man₉ GlcNAc₂-P-P-dolichol biosynthesis by elevated expression of GlcNAc-1-P transferase

Gao, N., Shang, J. & Lehrman, M. A., Jan 2008, In: Glycobiology. 18, 1, p. 125-134 10 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2007

Teaching dolichol-linked oligosaccharides more tricks with alternatives to metabolic radiolabeling

Lehrman, M. A., Aug 2007, In: Glycobiology. 17, 8, p. 75R-85R

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux

Shang, J., Gao, N., Kaufman, R. J., Ron, D., Harding, H. P. & Lehrman, M. A., Feb 26 2007, In: Journal of Cell Biology. 176, 5, p. 605-616 12 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

Kurtoglu, M., Gao, N., Shang, J., Maher, J. C., Lehrman, M. A., Wangpaichitr, M., Savaraj, N., Lane, A. N. & Lampidis, T. J., Nov 1 2007, In: Molecular Cancer Therapeutics. 6, 11, p. 3049-3058 10 p.

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

2006

Erratum: Stimulation of N-linked glycosylation and lipid-linked oligosaccharide synthesis by stress responses in metazoan cells (Critical Reviews in Biochemistry and Molecular Biology (2006) 41,2)

Lehrman, M. A., Jun 1 2006, In: Critical reviews in biochemistry and molecular biology. 41, 3, p. 209 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Non-Radioactive Analysis of Lipid-Linked Oligosaccharide Compositions by Fluorophore-Assisted Carbohydrate Electrophoresis

Gao, N. & Lehrman, M. A., 2006, In: Methods in Enzymology. 415, p. 3-20 18 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Stimulation of N-linked glycosylation and lipid-linked oligosaccharide synthesis by stress responses in metazoan cells

Lehrman, M. A., May 1 2006, In: Critical reviews in biochemistry and molecular biology. 41, 2, p. 51-75 25 p.

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

2005

Analysis of glycosylation in CDG-Ia fibroblasts by fluorophore-assisted carbohydrate electrophoresis: Implications for extracellular glucose and intracellular mannose 6-phosphate

Gao, N., Shang, J. & Lehrman, M. A., May 6 2005, In: Journal of Biological Chemistry. 280, 18, p. 17901-17909 9 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease

Cho, S. K., Gao, N., Pearce, D. A., Lehrman, M. A. & Hofmann, S. L., 2005, In: Glycobiology. 15, 6, p. 637-648 12 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Erratum: Overview: A sugary view of endoplasmic reticulum function (Methods (2005) 35 (315) DOI: 10.1016/j.ymeth.2004.10.001)

Lehrman, M. A., Aug 2005, In: Methods. 36, 4, p. 404 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Overview: A sugary view of endoplasmic reticulum function

Lehrman, M. A., Apr 2005, In: Methods. 35, 4, 1 p.

Research output: Contribution to journal › Editorial › peer-review

2004

Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR): Assessment of glycogen as a precursor of mannosyl residues in glycoconjugates

Shang, J. & Lehrman, M. A., Mar 26 2004, In: Journal of Biological Chemistry. 279, 13, p. 12076-12080 5 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts

Shang, J. & Lehrman, M. A., Apr 30 2004, In: Biochemical and Biophysical Research Communications. 317, 2, p. 390-396 7 p.

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Inhibition of mammalian RNA synthesis by the cytoplasmic Ca²⁺ buffer BAPTA. Analyses of [³H]uridine incorporation and stress-dependent transcription

Shang, J. & Lehrman, M. A., Jul 27 2004, In: Biochemistry. 43, 29, p. 9576-9582 7 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Metformin-stimulated Mannose Transport in Dermal Fibroblasts

Shang, J. & Lehrman, M. A., Mar 12 2004, In: Journal of Biological Chemistry. 279, 11, p. 9703-9712 10 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2003

Alternative and sources of reagents and supplies of fluorophore-assisted carbohydrate electrophoresis(FACE).

Lehrman, M. A. & Gao, N., Jan 2003, In: Glycobiology. 13, 1, p. 1G-3G

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Letter to the Glyco-Forum. Alternative sources of reagents and supplies for fluorophore-assisted carbohydrate electrophoresis (FACE)

Gao, N. & Lehrman, M. A., Jan 1 2003, In: Glycobiology. 13, 1, p. 1G-3G

Research output: Contribution to journal › Letter › peer-review

17 Scopus citations

2002

Analyses of dolichol pyrophosphate-linked oligosaccharides in cell cultures and tissues by fluorophore-assisted carbohydrate electrophoresis

Gao, N. & Lehrman, M. A., 2002, In: Glycobiology. 12, 5, p. 353-360 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Coupling of the dolichol-P-P-oligosaccharide pathway to translation by perturbation-sensitive regulation of the initiating enzyme, GlcNAc-1-P transferase

Gao, N. & Lehrman, M. A., Oct 18 2002, In: Journal of Biological Chemistry. 277, 42, p. 39425-39435 11 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Extension of lipid-linked oligosaccharides is a high-priority aspect of the unfolded protein response: Endoplasmic reticulum stress in Type I congenital disorder of glycosylation fibroblasts

Shang, J., Körner, C., Freeze, H. & Lehrman, M. A., 2002, In: Glycobiology. 12, 5, p. 307-317 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

Rapid activation of glycogen phosphorylase by the endoplasmic reticulum unfolded protein response

Gill, A., Gao, N. & Lehrman, M. A., Nov 22 2002, In: Journal of Biological Chemistry. 277, 47, p. 44747-44753 7 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2001

A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If)

Kranz, C., Denecke, J., Lehrman, M. A., Ray, S., Kienz, P., Kreissel, G., Sagi, D., Peter-Katalinic, J., Freeze, H. H., Schmid, T., Jackowski-Dohrmann, S., Harms, E. & Marquardt, T., 2001, In: Journal of Clinical Investigation. 108, 11, p. 1613-1619 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

112 Scopus citations

Oligosaccharide-based Information in Endoplasmic Reticulum Quality Control and Other Biological Systems

Lehrman, M. A., Mar 23 2001, In: Journal of Biological Chemistry. 276, 12, p. 8623-8626 4 p.

Research output: Contribution to journal › Short survey › peer-review

60 Scopus citations

Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals

Anand, M., Rush, J. S., Ray, S., Doucey, M. A., Weik, J., Ware, F. E., Hofsteenge, J., Waechter, C. J. & Lehrman, M. A., 2001, In: Molecular biology of the cell. 12, 2, p. 487-501 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access