Pharmacology - Luo Lab

Research Output

2020

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

Li, Q., Sun, Y., Jarugumilli, G. K., Liu, S., Dang, K., Cotton, J. L., Xiol, J., Chan, P. Y., DeRan, M., Ma, L., Li, R., Zhu, L. J., Li, J. H., Leiter, A. B., Ip, Y. T., Camargo, F. D., Luo, X., Johnson, R. L., Wu, X. & Mao, J., May 7 2020, In : Cell Stem Cell. 26, 5, p. 675-692.e8

Research output: Contribution to journalArticle

STK25 suppresses hippo signaling by regulating SAV1-STRIPAK antagonism

Bae, S. J., Ni, L. & Luo, X., Apr 2020, In : eLife. 9, e54863.

Research output: Contribution to journalArticle

Open Access
2019

Structural and Biochemical Analyses of the Core Components of the Hippo Pathway

Ni, L. & Luo, X., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 239-256 18 p. (Methods in Molecular Biology; vol. 1893).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Structural basis of tubulin detyrosination by vasohibins

Li, F., Hu, Y., Qi, S., Luo, X. & Yu, H., Jul 1 2019, In : Nature Structural and Molecular Biology. 26, 7, p. 583-591 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Activation mechanisms of the Hippo kinase signaling cascade

Bae, S. J. & Luo, X., Aug 29 2018, In : Bioscience Reports. 38, 4, BSR20171469.

Research output: Contribution to journalReview article

9 Scopus citations
2017

Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

Brulotte, M. L., Jeong, B. C., Li, F., Li, B., Yu, E. B., Wu, Q., Brautigam, C. A., Yu, H. & Luo, X., Dec 1 2017, In : Nature communications. 8, 1, 1956.

Research output: Contribution to journalArticle

10 Scopus citations

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

Bae, S. J., Ni, L., Osinski, A., Tomchick, D. R., Brautigam, C. A. & Luo, X., Oct 24 2017, In : eLife. 6, e30278.

Research output: Contribution to journalArticle

26 Scopus citations
2016

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Chan, P., Han, X., Zheng, B., Deran, M., Yu, J., Jarugumilli, G. K., Deng, H., Pan, D., Luo, X. & Wu, X., Apr 1 2016, In : Nature Chemical Biology. 12, 4, p. 282-289 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Structural basis of cohesin cleavage by separase

Lin, Z., Luo, X. & Yu, H., Apr 7 2016, In : Nature. 532, 7597, p. 131-134 4 p.

Research output: Contribution to journalArticle

30 Scopus citations
2015

Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics

Ouyang, Z., Zheng, G., Tomchick, D. R., Luo, X. & Yu, H., Nov 16 2015, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

54 Scopus citations

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

Ni, L., Zheng, Y., Hara, M., Pan, D. & Luo, X., Jul 1 2015, In : Genes and Development. 29, 13, p. 1416-1431 16 p.

Research output: Contribution to journalArticle

61 Scopus citations

Structure of an intermediate conformer of the spindle checkpoint protein Mad2

Hara, M., Özkan, E., Sun, H., Yu, H. & Luo, X., Sep 8 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 36, p. 11252-11257 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy

Pobbati, A. V., Han, X., Hung, A. W., Weiguang, S., Huda, N., Chen, G. Y., Kang, C., Chia, C. S. B., Luo, X., Hong, W. & Poulsen, A., Nov 3 2015, In : Structure. 23, 11, p. 2076-2086 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis

Diaz-Martinez, L. A., Tian, W., Li, B., Warrington, R., Jia, L., Brautigam, C. A., Luo, X. & Yu, H., Jan 23 2015, In : Journal of Biological Chemistry. 290, 4, p. 2431-2443 13 p.

Research output: Contribution to journalArticle

32 Scopus citations
2014

Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting

Lin, Z., Jia, L., Tomchick, D. R., Luo, X. & Yu, H., Nov 4 2014, In : Structure. 22, 11, p. 1616-1627 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

Sackton, K. L., Dimova, N., Zeng, X., Tian, W., Zhang, M., Sackton, T. B., Meaders, J., Pfaff, K. L., Sigoillot, F., Yu, H., Luo, X. & King, R. W., Aug 14 2014, In : Nature. 514, 7524, p. 646-649 4 p.

Research output: Contribution to journalArticle

100 Scopus citations
2013

Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5

Ni, L., Li, S., Yu, J., Min, J., Brautigam, C. A., Tomchick, D. R., Pan, D. & Luo, X., Oct 8 2013, In : Structure. 21, 10, p. 1757-1768 12 p.

Research output: Contribution to journalArticle

50 Scopus citations
2012

In support of the BMRB.

Markley, J. L., Akutsu, H., Asakura, T., Baldus, M., Boelens, R., Bonvin, A., Kaptein, R., Bax, A., Bezsonova, I., Gryk, M. R., Hoch, J. C., Korzhnev, D. M., Maciejewski, M. W., Case, D., Chazin, W. J., Cross, T. A., Dames, S., Kessler, H., Lange, O., Madl, T. & 71 others, Reif, B., Sattler, M., Eliezer, D., Fersht, A., Forman-Kay, J., Kay, L. E., Fraser, J., Gross, J., Kortemme, T., Sali, A., Fujiwara, T., Gardner, K. H., Luo, X., Rizo-Rey, J., Rosen, M. K., Gil, R. R., Ho, C., Rule, G., Gronenborn, A. M., Ishima, R., Klein-Seetharaman, J., Tang, P., van der Wel, P., Xu, Y., Grzesiek, S., Hiller, S., Seelig, J., Laue, E. D., Mott, H., Nietlispach, D., Barsukov, I., Lian, L. Y., Middleton, D., Blumenschein, T., Moore, G., Campbell, I., Schnell, J., Vakonakis, I. J., Watts, A., Conte, M. R., Mason, J., Pfuhl, M., Sanderson, M. R., Craven, J., Williamson, M., Dominguez, C., Roberts, G., Günther, U., Overduin, M., Werner, J., Williamson, P., Blindauer, C., Crump, M., Driscoll, P., Frenkiel, T., Golovanov, A., Matthews, S., Parkinson, J., Uhrin, D., Williams, M., Neuhaus, D., Oschkinat, H., Ramos, A., Shaw, D. E., Steinbeck, C., Vendruscolo, M., Vuister, G. W., Walters, K. J., Weinstein, H., Wüthrich, K. & Yokoyama, S., Sep 2012, In : Nature structural & molecular biology. 19, 9, p. 854-860 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mitosis: Short-circuiting spindle checkpoint signaling

Luo, X. & Yu, H., Feb 21 2012, In : Current Biology. 22, 4, p. R128-R130

Research output: Contribution to journalShort survey

4 Scopus citations

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

Tian, W., Li, B., Warrington, R., Tomchick, D. R., Yu, H. & Luo, X., Nov 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18419-18424 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
68 Scopus citations
2010

Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition

Kim, S., Sun, H., Ball, H. L., Wassmann, K., Luo, X. & Yu, H., Nov 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 46, p. 19772-19777 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Snapshots of a hybrid transcription factor in the Hippo pathway

Luo, X., Sep 2010, In : Protein and Cell. 1, 9, p. 811-819 9 p.

Research output: Contribution to journalReview article

8 Scopus citations
83 Scopus citations
2008

Insights into Mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric Mad2 dimer

Yang, M., Li, B., Liu, C. J., Tomchick, D. R., Machius, M., Rizo-Rey, J., Yu, H. & Luo, X., Mar 1 2008, In : PLoS biology. 6, 3, p. 643-655 13 p., e50.

Research output: Contribution to journalArticle

63 Scopus citations

Protein Metamorphosis: The Two-State Behavior of Mad2

Luo, X. & Yu, H., Nov 12 2008, In : Structure. 16, 11, p. 1616-1625 10 p.

Research output: Contribution to journalReview article

91 Scopus citations
2007

p31comet Blocks Mad2 Activation through Structural Mimicry

Yang, M., Li, B., Tomchick, D. R., Machius, M., Rizo-Rey, J., Yu, H. & Luo, X., Nov 16 2007, In : Cell. 131, 4, p. 744-755 12 p.

Research output: Contribution to journalArticle

131 Scopus citations
2006

Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase

Yang, M., Gocke, C. B., Luo, X., Borek, D., Tomchick, D. R., Machius, M., Otwinowski, Z. & Yu, H., Aug 4 2006, In : Molecular cell. 23, 3, p. 377-387 11 p.

Research output: Contribution to journalArticle

206 Scopus citations
2005

Purification and assay of Mad2: A two-state inhibitor of anaphase-promoting complex/cyclosome

Luo, X. & Yu, H., Jan 1 2005, In : Methods in Enzymology. 398, p. 246-255 10 p.

Research output: Contribution to journalReview article

2004

Conformation-specific binding of p31comet antagonizes the function of Mad2 in the spindle checkpoint

Xia, G., Luo, X., Habu, T., Rizo-Rey, J., Matsumoto, T. & Yu, H., Aug 4 2004, In : EMBO Journal. 23, 15, p. 3133-3143 11 p.

Research output: Contribution to journalArticle

147 Scopus citations

T antigen origin-binding domain of simian virus 40: Determinants of specific DNA binding

Bradshaw, E. M., Sanford, D. G., Luo, X., Sudmeier, J. L., Gurard-Levin, Z. A., Bullock, P. A. & Bachovchin, W. W., Jun 8 2004, In : Biochemistry. 43, 22, p. 6928-6936 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The Mad2 spindle checkpoint protein has two distinct natively folded states

Luo, X., Tang, Z., Xia, G., Wassmann, K., Matsumoto, T., Rizo-Rey, J. & Yu, H., Apr 1 2004, In : Nature Structural and Molecular Biology. 11, 4, p. 338-345 8 p.

Research output: Contribution to journalArticle

197 Scopus citations
2002

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

Luo, X., Tang, Z., Rizo-Rey, J. & Yu, H., Jan 1 2002, In : Molecular cell. 9, 1, p. 59-71 13 p.

Research output: Contribution to journalArticle

231 Scopus citations
1997

Purification of the simian virus 40 (SV40) T antigen DNA-binding domain and characterization of its interactions with the SV40 origin

Joo, W. S., Luo, X., Denis, D., Kim, H. Y., Rainey, G. J., Jones, C., Sreekumar, K. R. & Bullock, P. A., May 1997, In : Journal of virology. 71, 5, p. 3972-3985 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
1996

HCN, a triple-resonance NMR technique for selective observation of histidine and tryptophan side chains in 13C/15N-labeled proteins

Sudmeier, J. L., Ash, E. L., Günther, U. L., Luo, X., Bullock, P. A. & Bachovchin, W. W., Jan 1 1996, In : Journal of Magnetic Resonance - Series B. 113, 3, p. 236-247 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Solution structure of the origin DNA-binding domain of SV40 T-antigen

Luo, X., Sanford, D. G., Bullock, P. A. & Bachovchin, W. W., Dec 1 1996, In : Nature Structural Biology. 3, 12, p. 1034-1039 6 p.

Research output: Contribution to journalArticle

95 Scopus citations