Pharmacology - Luo Lab – Research output — University of Texas Southwestern Medical Center

2022

Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode

Hu, L., Sun, Y., Liu, S., Erb, H., Singh, A., Mao, J., Luo, X. & Wu, X., Nov 2022, In: eLife. 11, e80210.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Cryo-EM structure of the Hippo signaling integrator human STRIPAK

Jeong, B. C., Bae, S. J., Ni, L., Zhang, X., Bai, X. C. & Luo, X., Mar 2021, In: Nature Structural and Molecular Biology. 28, 3, p. 290-299 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2020

Cryo-em structure of vash1-svbp bound to microtubules

Li, F., Li, Y., Ye, X., Gao, H., Shi, Z., Luo, X., Rice, L. M. & Yu, H., Aug 2020, In: eLife. 9, p. 1-19 19 p., e58157.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

Li, Q., Sun, Y., Jarugumilli, G. K., Liu, S., Dang, K., Cotton, J. L., Xiol, J., Chan, P. Y., DeRan, M., Ma, L., Li, R., Zhu, L. J., Li, J. H., Leiter, A. B., Ip, Y. T., Camargo, F. D., Luo, X., Johnson, R. L., Wu, X. & Mao, J., May 7 2020, In: Cell Stem Cell. 26, 5, p. 675-692.e8

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

STK25 suppresses hippo signaling by regulating SAV1-STRIPAK antagonism

Bae, S. J., Ni, L. & Luo, X., Apr 2020, In: eLife. 9, e54863.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2019

Structural and Biochemical Analyses of the Core Components of the Hippo Pathway

Ni, L. & Luo, X., 2019, Methods in Molecular Biology. Humana Press Inc., p. 239-256 18 p. (Methods in Molecular Biology; vol. 1893).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Structural basis of tubulin detyrosination by vasohibins

Li, F., Hu, Y., Qi, S., Luo, X. & Yu, H., Jul 1 2019, In: Nature Structural and Molecular Biology. 26, 7, p. 583-591 9 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

2018

Activation mechanisms of the Hippo kinase signaling cascade

Bae, S. J. & Luo, X., Aug 29 2018, In: Bioscience reports. 38, 4, BSR20171469.

Research output: Contribution to journal › Review article › peer-review

Open Access

50 Scopus citations

2017

Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

Brulotte, M. L., Jeong, B. C., Li, F., Li, B., Yu, E. B., Wu, Q., Brautigam, C. A., Yu, H. & Luo, X., Dec 1 2017, In: Nature communications. 8, 1, 1956.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

Bae, S. J., Ni, L., Osinski, A., Tomchick, D. R., Brautigam, C. A. & Luo, X., Oct 24 2017, In: eLife. 6, e30278.

Research output: Contribution to journal › Article › peer-review

Open Access

89 Scopus citations

2016

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Chan, P., Han, X., Zheng, B., Deran, M., Yu, J., Jarugumilli, G. K., Deng, H., Pan, D., Luo, X. & Wu, X., Apr 1 2016, In: Nature chemical biology. 12, 4, p. 282-289 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

176 Scopus citations

Structural Basis and IP₆ Requirement for Pds5-Dependent Cohesin Dynamics

Ouyang, Z., Zheng, G., Tomchick, D. R., Luo, X. & Yu, H., Apr 21 2016, In: Molecular cell. 62, 2, p. 248-259 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Structural basis of cohesin cleavage by separase

Lin, Z., Luo, X. & Yu, H., Apr 7 2016, In: Nature. 532, 7597, p. 131-134 4 p.

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

2015

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

Ni, L., Zheng, Y., Hara, M., Pan, D. & Luo, X., Jul 1 2015, In: Genes and Development. 29, 13, p. 1416-1431 16 p.

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Structure of an intermediate conformer of the spindle checkpoint protein Mad2

Hara, M., Özkan, E., Sun, H., Yu, H. & Luo, X., Sep 8 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 36, p. 11252-11257 6 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy

Pobbati, A. V., Han, X., Hung, A. W., Weiguang, S., Huda, N., Chen, G. Y., Kang, C., Chia, C. S. B., Luo, X., Hong, W. & Poulsen, A., Nov 3 2015, In: Structure. 23, 11, p. 2076-2086 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

135 Scopus citations

The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis

Diaz-Martinez, L. A., Tian, W., Li, B., Warrington, R., Jia, L., Brautigam, C. A., Luo, X. & Yu, H., Jan 23 2015, In: Journal of Biological Chemistry. 290, 4, p. 2431-2443 13 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

2014

Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting

Lin, Z., Jia, L., Tomchick, D. R., Luo, X. & Yu, H., Nov 4 2014, In: Structure. 22, 11, p. 1616-1627 12 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

Sackton, K. L., Dimova, N., Zeng, X., Tian, W., Zhang, M., Sackton, T. B., Meaders, J., Pfaff, K. L., Sigoillot, F., Yu, H., Luo, X. & King, R. W., Aug 14 2014, In: Nature. 514, 7524, p. 646-649 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

193 Scopus citations

2013

Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5

Ni, L., Li, S., Yu, J., Min, J., Brautigam, C. A., Tomchick, D. R., Pan, D. & Luo, X., Oct 8 2013, In: Structure. 21, 10, p. 1757-1768 12 p.

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

2012

In support of the BMRB.

Markley, J. L., Akutsu, H., Asakura, T., Baldus, M., Boelens, R., Bonvin, A., Kaptein, R., Bax, A., Bezsonova, I., Gryk, M. R., Hoch, J. C., Korzhnev, D. M., Maciejewski, M. W., Case, D., Chazin, W. J., Cross, T. A., Dames, S., Kessler, H., Lange, O., Madl, T., & 71 othersReif, B., Sattler, M., Eliezer, D., Fersht, A., Forman-Kay, J., Kay, L. E., Fraser, J., Gross, J., Kortemme, T., Sali, A., Fujiwara, T., Gardner, K. H., Luo, X., Rizo-Rey, J., Rosen, M. K., Gil, R. R., Ho, C., Rule, G., Gronenborn, A. M., Ishima, R., Klein-Seetharaman, J., Tang, P., van der Wel, P., Xu, Y., Grzesiek, S., Hiller, S., Seelig, J., Laue, E. D., Mott, H., Nietlispach, D., Barsukov, I., Lian, L. Y., Middleton, D., Blumenschein, T., Moore, G., Campbell, I., Schnell, J., Vakonakis, I. J., Watts, A., Conte, M. R., Mason, J., Pfuhl, M., Sanderson, M. R., Craven, J., Williamson, M., Dominguez, C., Roberts, G., Günther, U., Overduin, M., Werner, J., Williamson, P., Blindauer, C., Crump, M., Driscoll, P., Frenkiel, T., Golovanov, A., Matthews, S., Parkinson, J., Uhrin, D., Williams, M., Neuhaus, D., Oschkinat, H., Ramos, A., Shaw, D. E., Steinbeck, C., Vendruscolo, M., Vuister, G. W., Walters, K. J., Weinstein, H., Wüthrich, K. & Yokoyama, S., 2012, In: Nature structural & molecular biology. 19, 9, p. 854-860 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Mitosis: Short-circuiting spindle checkpoint signaling

Luo, X. & Yu, H., Feb 21 2012, In: Current Biology. 22, 4, p. R128-R130

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

Tian, W., Li, B., Warrington, R., Tomchick, D. R., Yu, H. & Luo, X., Nov 6 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18419-18424 6 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting

Kim, S., Sun, H., Tomchick, D. R., Yu, H. & Luo, X., Apr 24 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6549-6554 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

2010

Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition

Kim, S., Sun, H., Ball, H. L., Wassmann, K., Luo, X. & Yu, H., Nov 16 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 46, p. 19772-19777 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Snapshots of a hybrid transcription factor in the Hippo pathway

Luo, X., Sep 2010, In: Protein and Cell. 1, 9, p. 811-819 9 p.

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Structural and functional analysis of the YAP-binding domain of human TEAD2

Tian, W., Yu, J., Tomchick, D. R., Pan, D. & Luo, X., Apr 20 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 16, p. 7293-7298 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

128 Scopus citations

2008

Insights into Mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric Mad2 dimer

Yang, M., Li, B., Liu, C. J., Tomchick, D. R., Machius, M., Rizo-Rey, J., Yu, H. & Luo, X., Mar 2008, In: PLoS biology. 6, 3, p. 643-655 13 p., e50.

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Protein Metamorphosis: The Two-State Behavior of Mad2

Luo, X. & Yu, H., Nov 12 2008, In: Structure. 16, 11, p. 1616-1625 10 p.

Research output: Contribution to journal › Review article › peer-review

123 Scopus citations

2007

p31^comet Blocks Mad2 Activation through Structural Mimicry

Yang, M., Li, B., Tomchick, D. R., Machius, M., Rizo-Rey, J., Yu, H. & Luo, X., Nov 16 2007, In: Cell. 131, 4, p. 744-755 12 p.

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

2006

Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase

Yang, M., Gocke, C. B., Luo, X., Borek, D., Tomchick, D. R., Machius, M., Otwinowski, Z. & Yu, H., Aug 4 2006, In: Molecular cell. 23, 3, p. 377-387 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

259 Scopus citations

2005

Purification and assay of Mad2: A two-state inhibitor of anaphase-promoting complex/cyclosome

Luo, X. & Yu, H., 2005, In: Methods in Enzymology. 398, p. 246-255 10 p.

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

2004

Conformation-specific binding of p31^comet antagonizes the function of Mad2 in the spindle checkpoint

Xia, G., Luo, X., Habu, T., Rizo-Rey, J., Matsumoto, T. & Yu, H., Aug 4 2004, In: EMBO Journal. 23, 15, p. 3133-3143 11 p.

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

T antigen origin-binding domain of simian virus 40: Determinants of specific DNA binding

Bradshaw, E. M., Sanford, D. G., Luo, X., Sudmeier, J. L., Gurard-Levin, Z. A., Bullock, P. A. & Bachovchin, W. W., Jun 8 2004, In: Biochemistry. 43, 22, p. 6928-6936 9 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

The Mad2 spindle checkpoint protein has two distinct natively folded states

Luo, X., Tang, Z., Xia, G., Wassmann, K., Matsumoto, T., Rizo-Rey, J. & Yu, H., Apr 2004, In: Nature Structural and Molecular Biology. 11, 4, p. 338-345 8 p.

Research output: Contribution to journal › Article › peer-review

243 Scopus citations

2002

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

Luo, X., Tang, Z., Rizo-Rey, J. & Yu, H., 2002, In: Molecular cell. 9, 1, p. 59-71 13 p.

Research output: Contribution to journal › Article › peer-review

266 Scopus citations

1997

Purification of the simian virus 40 (SV40) T antigen DNA-binding domain and characterization of its interactions with the SV40 origin

Joo, W. S., Luo, X., Denis, D., Kim, H. Y., Rainey, G. J., Jones, C., Sreekumar, K. R. & Bullock, P. A., May 1997, In: Journal of virology. 71, 5, p. 3972-3985 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

1996

HCN, a triple-resonance NMR technique for selective observation of histidine and tryptophan side chains in ¹³C/¹⁵N-labeled proteins

Sudmeier, J. L., Ash, E. L., Günther, U. L., Luo, X., Bullock, P. A. & Bachovchin, W. W., 1996, In: Journal of Magnetic Resonance - Series B. 113, 3, p. 236-247 12 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Solution structure of the origin DNA-binding domain of SV40 T-antigen

Luo, X., Sanford, D. G., Bullock, P. A. & Bachovchin, W. W., 1996, In: Nature Structural Biology. 3, 12, p. 1034-1039 6 p.

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Pharmacology - Luo Lab

Research output

Search results