Pharmacology - Mangelsdorf Lab

Research Output

2020

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation

Ayoade, K. O., Carranza, F. R., Cho, W. H., Wang, Z., Kliewer, S. A., Mangelsdorf, D. J. & Stoltzfus, J. D. C., Apr 1 2020, In : Parasites and Vectors. 13, 1, 162.

Research output: Contribution to journalArticle

Open Access

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

Hernandez, G., Luo, T., Javed, T. A., Wen, L., Kalwat, M. A., Vale, K., Ammouri, F., Husain, S. Z., Kliewer, S. A. & Mangelsdorf, D. J., Jan 8 2020, In : Science translational medicine. 12, 525, eaay5186.

Research output: Contribution to journalArticle

2 Scopus citations
2019

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Kliewer, S. A. & Mangelsdorf, D. J., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 246-253 8 p.

Research output: Contribution to journalReview article

21 Scopus citations

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang, D., Fang, B., Russell, J., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 others, Moresco, E. Y. & Beutler, B., Jan 1 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

3 Scopus citations

Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40

Zhang, D., Yue, T., Choi, J. H., Nair-Gill, E., Zhong, X., Wang, K. W., Zhan, X., Li, X., Choi, M., Tang, M., Quan, J., Hildebrand, S., Moresco, E. M. Y. & Beutler, B., Jan 1 2019, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

2 Scopus citations

The orphan nuclear receptor SHP regulates er stress response by inhibiting XBP1s degradation

Sun, S., Kelekar, S., Kliewer, S. A. & Mangelsdorf, D. J., Aug 1 2019, In : Genes and Development. 33, 15-16, p. 1083-1094 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

Patton, J. B., Bonne-Année, S., Deckman, J., Hess, J. A., Torigian, A., Nolan, T. J., Wang, Z., Kliewer, S. A., Durham, A. C., Lee, J. J., Eberhard, M. L., Mangelsdorf, D. J., Lok, J. B. & Abraham, D., Jan 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 1, p. 204-209 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice

Katafuchi, T., Holland, W. L., Kollipara, R. K., Kittler, R., Mangelsdorf, D. J. & Kliewer, S. A., Nov 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 48, p. 12102-12111 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol

Song, P., Zechner, C. P. G., Hernandez, G., Cánovas, J., Xie, Y., Sondhi, V., Wagner, M., Stadlbauer, V., Horvath, A., Leber, B., Hu, M. C., Moe, O. W., Mangelsdorf, D. J. & Kliewer, S. A., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

15 Scopus citations
2017

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A. & Mangelsdorf, D. J., 2017, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

54 Scopus citations

FGF21 Is an Exocrine Pancreas Secretagogue

Coate, K. C., Hernandez, G., Thorne, C. A., Sun, S., Le, T. D. V., Vale, K., Kliewer, S. A. & Mangelsdorf, D. J., Feb 7 2017, In : Cell Metabolism. 25, 2, p. 472-480 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Nuclear receptors: Emerging drug targets for parasitic diseases

Wang, Z., Schaffer, N. E., Kliewer, S. A. & Mangelsdorf, D. J., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1165-1171 7 p.

Research output: Contribution to journalReview article

6 Scopus citations
2016

FGF21 regulates sweet and alcohol preference

Talukdar, S., Owen, B. M., Song, P., Hernandez, G., Zhang, Y., Zhou, Y., Scott, W. T., Paratala, B., Turner, T., Smith, A., Bernardo, B., Müller, C. P., Tang, H., Mangelsdorf, D. J., Goodwin, B. & Kliewer, S. A., Feb 9 2016, In : Cell Metabolism. 23, 2, p. 344-349 6 p.

Research output: Contribution to journalArticle

100 Scopus citations

Impaired 17,20-lyase activity in male mice lacking cytochrome b5 in leydig cells

Sondhi, V., Owen, B. M., Liu, J., Chomic, R., Kliewer, S. A., Hughes, B. A., Arlt, W., Mangelsdorf, D. J. & Auchus, R. J., Apr 2016, In : Molecular Endocrinology. 30, 4, p. 469-478 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O'Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S., Lepe, M. S., Akira, S., Barbieri, C., Baumeister, S., Cauchi, S., Clarke, T. K., Enroth, S., Fischer, K., Hällfors, J., Harris, S. E. & 107 others, Hieber, S., Hofer, E., Hottenga, J. J., Johansson, Å., Joshi, P. K., Kaartinen, N., Laitinen, J., Lemaitre, R., Loukola, A., Luan, J., Lyytikäinen, L. P., Mangino, M., Manichaikul, A., Mbarek, H., Milaneschi, Y., Moayyeri, A., Mukamal, K., Nelson, C., Nettleton, J., Partinen, E., Rawal, R., Robino, A., Rose, L., Sala, C., Satoh, T., Schmidt, R., Schraut, K., Scott, R., Smith, A. V., Starr, J. M., Teumer, A., Trompet, S., Uitterlinden, A. G., Venturini, C., Vergnaud, A. C., Verweij, N., Vitart, V., Vuckovic, D., Wedenoja, J., Yengo, L., Yu, B., Zhang, W., Zhao, J. H., Boomsma, D. I., Chambers, J., Chasman, D. I., Daniela, T., De Geus, E., Deary, I., Eriksson, J. G., Esko, T., Eulenburg, V., Franco, O. H., Froguel, P., Gieger, C., Grabe, H. J., Gudnason, V., Gyllensten, U., Harris, T. B., Hartikainen, A. L., Heath, A. C., Hocking, L., Hofman, A., Huth, C., Jarvelin, M. R., Jukema, J. W., Kaprio, J., Kooner, J. S., Kutalik, Z., Lahti, J., Langenberg, C., Lehtimäki, T., Liu, Y., Madden, P. A. F., Martin, N., Morrison, A., Penninx, B., Pirastu, N., Psaty, B., Raitakari, O., Ridker, P., Rose, R., Rotter, J. I., Samani, N. J., Schmidt, H., Spector, T. D., Stott, D., Strachan, D., Tzoulaki, I., Van Der Harst, P., Van Duijn, C. M., Marques-Vidal, P., Vollenweider, P., Wareham, N. J., Whitfield, J. B., Wilson, J., Wolffenbuttel, B., Bakalkin, G., Evangelou, E., Liu, Y., Rice, K. M., Desrivières, S., Kliewer, S. A., Mangelsdorf, D. J., Müller, C. P., Levy, D. & Elliott, P., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14372-14377 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

Youm, Y. H., Horvath, T. L., Mangelsdorf, D. J., Kliewer, S. A. & Dixit, V. D., Jan 26 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 4, p. 1026-1031 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid

Albarqi, M. M. Y., Stoltzfus, J. D., Pilgrim, A. A., Nolan, T. J., Wang, Z., Kliewer, S. A., Mangelsdorf, D. J. & Lok, J. B., 2016, In : PLoS Pathogens. 12, 1, e1005358.

Research output: Contribution to journalArticle

28 Scopus citations
2015

Bile acids as hormones: The FXR-FGF15/19 pathway

Kliewer, S. A. & Mangelsdorf, D. J., Jun 9 2015, In : Digestive Diseases. 33, 3, p. 327-331 5 p.

Research output: Contribution to journalArticle

103 Scopus citations

Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry

Katafuchi, T., Esterházy, D., Lemoff, A., Ding, X., Sondhi, V., Kliewer, S. A., Mirzaei, H. & Mangelsdorf, D. J., Jun 2 2015, In : Cell Metabolism. 21, 6, p. 898-904 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop

Patel, R., Bookout, A. L., Magomedova, L., Owen, B. M., Consiglio, G. P., Shimizu, M., Zhang, Y., Mangelsdorf, D. J., Kliewer, S. A. & Cummins, C. L., Jan 1 2015, In : Molecular Endocrinology. 29, 2, p. 213-223 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Mansuy-Aubert, V., Gautron, L., Lee, S., Bookout, A. L., Kusminski, C. M., Sun, K., Zhang, Y., Scherer, P. E., Mangelsdorf, D. J. & Elmquist, J. K., Jun 15 2015, In : eLife. 4, JUNE, e06667.

Research output: Contribution to journalArticle

12 Scopus citations

Reflections on the field of metabolism

Moller, D. E., Cuervo, A. M. A., Gordon, J., Froguel, P. & Mangelsdorf, D. J., Apr 7 2015, In : Cell Metabolism. 21, 4, p. 505-506 2 p.

Research output: Contribution to journalArticle

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

Wang, Z., Stoltzfus, J., You, Y. J., Ranjit, N., Tang, H., Xie, Y., Lok, J. B., Mangelsdorf, D. J. & Kliewer, S. A., Mar 16 2015, In : PLoS genetics. 11, 3, e1005027.

Research output: Contribution to journalArticle

21 Scopus citations

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

Owen, B. M., Mangelsdorf, D. J. & Kliewer, S. A., Jan 1 2015, In : Trends in Endocrinology and Metabolism. 26, 1, p. 22-29 8 p.

Research output: Contribution to journalReview article

135 Scopus citations
2014

Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding

Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M. & Potthoff, M. J., Dec 1 2014, In : Diabetes. 63, 12, p. 4057-4063 7 p.

Research output: Contribution to journalArticle

223 Scopus citations

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A. & Mangelsdorf, D. J., Oct 7 2014, In : Cell Metabolism. 20, 4, p. 670-677 8 p.

Research output: Contribution to journalArticle

220 Scopus citations

Nuclear receptors, RXR, and the big bang

Evans, R. M. & Mangelsdorf, D. J., Mar 27 2014, In : Cell. 157, 1, p. 255-266 12 p.

Research output: Contribution to journalReview article

438 Scopus citations

PPARγ in vagal neurons regulates high-fat diet induced thermogenesis

Liu, C., Bookout, A. L., Lee, S., Sun, K., Jia, L., Lee, C., Udit, S., Deng, Y., Scherer, P. E., Mangelsdorf, D. J., Gautron, L. & Elmquist, J. K., Apr 1 2014, In : Cell Metabolism. 19, 4, p. 722-730 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

SnapShot: Hormones of the gastrointestinal tract

Coate, K. C., Kliewer, S. A. & Mangelsdorf, D. J., Dec 4 2014, In : Cell. 159, 6, p. 1478-1478.e1

Research output: Contribution to journalShort survey

6 Scopus citations

SnapShot: Hormones of the gastrointestinal tract

Coate, K. C., Kliewer, S. A. & Mangelsdorf, D. J., Dec 4 2014, In : Cell. 159, 6, p. 1478-1478.e1

Research output: Contribution to journalArticle

Structural insights into gene repression by the orphan nuclear receptor SHP

Zhi, X., Zhou, X. E., He, Y., Zechner, C., Suino-Powell, K. M., Kliewer, S. A., Melcher, K., Mangelsdorf, D. J. & Xu, H. E., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 2, p. 839-844 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

Potthoff, M. J., Potts, A., He, T., Duarte, J. A. G., Taussig, R., Mangelsdorf, D. J., Kliewer, S. A. & Burgess, S. C., Feb 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 4, p. G371-G380

Research output: Contribution to journalArticle

93 Scopus citations

Enhanced transcription of pancreatic peptide YY by 1α-hydroxyvitamin D3 administration in streptozotocin-induced diabetic mice

Ozeki, J., Choi, M., Endo-Umeda, K., Sakurai, K., Amano, S. & Makishima, M., Oct 1 2013, In : Neuropeptides. 47, 5, p. 329-332 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

FGF21 contributes to neuroendocrine control of female reproduction

Owen, B. M., Bookout, A. L., Ding, X., Lin, V. Y., Atkin, S. D., Gautron, L., Kliewer, S. A. & Mangelsdorf, D. J., Sep 1 2013, In : Nature medicine. 19, 9, p. 1153-1156 4 p.

Research output: Contribution to journalArticle

116 Scopus citations

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., De Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J. & Kliewer, S. A., Sep 1 2013, In : Nature medicine. 19, 9, p. 1147-1152 6 p.

Research output: Contribution to journalArticle

238 Scopus citations

Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus

Atkin, S. D., Owen, B. M., Bookout, A. L., Cravo, R. M., Lee, C., Elias, C. F., Elmquist, J. K., Kliewer, S. A. & Mangelsdorf, D. J., Apr 1 2013, In : Molecular Endocrinology. 27, 4, p. 598-605 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

Endocrine fibroblast growth factors 15/19 and 21: From feast to famine

Potthoff, M. J., Kliewer, S. A. & Mangelsdorf, D. J., Feb 15 2012, In : Genes and Development. 26, 4, p. 312-324 13 p.

Research output: Contribution to journalReview article

256 Scopus citations

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., Mangelsdorf, D. J., Kliewer, S. A. & Wan, Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3143-3148 6 p.

Research output: Contribution to journalArticle

233 Scopus citations

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J. & Kliewer, S. A., Feb 3 2012, In : Cell. 148, 3, p. 556-567 12 p.

Research output: Contribution to journalArticle

340 Scopus citations

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

Zhang, Y., Breevoort, S. R., Angdisen, J., Fu, M., Schmidt, D. R., Holmstrom, S. R., Kliewer, S. A., Mangelsdorf, D. J. & Schulman, I. G., May 1 2012, In : Journal of Clinical Investigation. 122, 5, p. 1688-1699 12 p.

Research output: Contribution to journalArticle

106 Scopus citations

Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo

Kir, S., Zhang, Y., Gerard, R. D., Kliewer, S. A. & Mangelsdorf, D. J., Nov 30 2012, In : Journal of Biological Chemistry. 287, 49, p. 41334-41341 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer

Jeong, Y., Xie, Y., Lee, W., Bookout, A. L., Girard, L., Raso, G., Behrens, C., Wistuba, I. I., Gadzar, A. F., Minna, J. D. & Mangelsdorf, D. J., Aug 1 2012, In : Molecular Endocrinology. 26, 8, p. 1443-1454 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE

Lee, S., Wang, P. Y., Jeong, Y., Mangelsdorf, D. J., Anderson, R. G. W. & Michaely, P., Oct 1 2012, In : Experimental Cell Research. 318, 16, p. 2128-2142 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes

Zhi, X., Zhou, X. E., Melcher, K., Motola, D. L., Gelmedin, V., Hawdon, J., Kliewer, S. A., Mangelsdorf, D. J. & Xu, H. E., Feb 10 2012, In : Journal of Biological Chemistry. 287, 7, p. 4894-4903 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Colbert Coate, K., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., Yu, R. T., Evans, R. M., Kliewer, S. A. & Mangelsdorf, D. J., Oct 15 2012, In : eLife. 2012, 1, e00065.

Research output: Contribution to journalArticle

177 Scopus citations

Vitamin D receptor activation induces peptide YY transcription in pancreatic islets

Choi, M., Ozeki, J., Hashizume, M., Kato, S., Ishihara, H. & Makishima, M., Nov 1 2012, In : Endocrinology. 153, 11, p. 5188-5199 12 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

βKslotho is required for fibroblast growth factor 21 effects on growth and metabolism

Ding, X., Boney-Montoya, J., Owen, B. M., Bookout, A. L., Coate, K. C., Mangelsdorf, D. J. & Kliewer, S. A., Sep 5 2012, In : Cell Metabolism. 16, 3, p. 387-393 7 p.

Research output: Contribution to journalArticle

205 Scopus citations
2011

AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids

Schmidt, D. R., Schmidt, S., Holmstrom, S. R., Makishima, M., Yu, R. T., Cummins, C. L., Mangelsdorf, D. J. & Kliewer, S. A., Jan 28 2011, In : Journal of Biological Chemistry. 286, 4, p. 2425-2432 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice

Ozeki, J., Uno, S., Ogura, M., Choi, M., Maeda, T., Sakurai, K., Matsuo, S., Amano, S., Nebert, D. W. & Makishima, M., Feb 4 2011, In : Toxicology. 280, 1-2, p. 10-17 8 p.

Research output: Contribution to journalArticle

19 Scopus citations