Pharmacology - Mangelsdorf Lab

Research Output 1983 2019

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2019

The orphan nuclear receptor SHP regulates er stress response by inhibiting XBP1s degradation

Sun, S., Kelekar, S., Kliewer, S. A. & Mangelsdorf, D. J., Aug 1 2019, In : Genes and Development. 33, 15-16, p. 1083-1094 12 p.

Research output: Contribution to journalArticle

Open Access
Orphan Nuclear Receptors
Endoplasmic Reticulum Stress
Proteolysis
Ceruletide
Co-Repressor Proteins
2018
14 Citations (Scopus)

Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

Patton, J. B., Bonne-Année, S., Deckman, J., Hess, J. A., Torigian, A., Nolan, T. J., Wang, Z., Kliewer, S. A., Durham, A. C., Lee, J. J., Eberhard, M. L., Mangelsdorf, D. J., Lok, J. B. & Abraham, D., Jan 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 1, p. 204-209 6 p.

Research output: Contribution to journalArticle

Strongyloides stercoralis
Larva
Glucocorticoids
methylprednisolone acetate
dafachronic acid
2 Citations (Scopus)

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice

Katafuchi, T., Holland, W. L., Kollipara, R. K., Kittler, R., Mangelsdorf, D. J. & Kliewer, S. A., Nov 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 48, p. 12102-12111 10 p.

Research output: Contribution to journalArticle

Sumoylation
Peroxisome Proliferator-Activated Receptors
Adiposity
Insulin Resistance
White Adipose Tissue
13 Citations (Scopus)

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol

Song, P., Zechner, C. P. G., Hernandez, G., Cánovas, J., Xie, Y., Sondhi, V., Wagner, M., Stadlbauer, V., Horvath, A., Leber, B., Hu, M. C., Moe, O. W., Mangelsdorf, D. J. & Kliewer, S. A., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Ketogenic Diet
Drinking Water
Alcohols
Hormones
Drinking
2017
44 Citations (Scopus)

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A. & Mangelsdorf, D. J., 2017, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Nervous System
Body Weight
Antibodies
Weight Loss
Neurons
22 Citations (Scopus)

FGF21 Is an Exocrine Pancreas Secretagogue

Coate, K. C., Hernandez, G., Thorne, C. A., Sun, S., Le, T. D. V., Vale, K., Kliewer, S. A. & Mangelsdorf, D. J., Feb 7 2017, In : Cell Metabolism. 25, 2, p. 472-480 9 p.

Research output: Contribution to journalArticle

Exocrine Pancreas
Acinar Cells
Cholecystokinin
Secretory Vesicles
Fibroblast Growth Factor Receptors
2016
92 Citations (Scopus)

FGF21 regulates sweet and alcohol preference

Talukdar, S., Owen, B. M., Song, P., Hernandez, G., Zhang, Y., Zhou, Y., Scott, W. T., Paratala, B., Turner, T., Smith, A., Bernardo, B., Müller, C. P., Tang, H., Mangelsdorf, D. J., Goodwin, B. & Kliewer, S. A., Feb 9 2016, In : Cell Metabolism. 23, 2, p. 344-349 6 p.

Research output: Contribution to journalArticle

Alcohols
Carbohydrates
Physiological Stress
Macaca fascicularis
Nucleus Accumbens
8 Citations (Scopus)

Impaired 17,20-lyase activity in male mice lacking cytochrome b5 in leydig cells

Sondhi, V., Owen, B. M., Liu, J., Chomic, R., Kliewer, S. A., Hughes, B. A., Arlt, W., Mangelsdorf, D. J. & Auchus, R. J., Apr 1 2016, In : Molecular Endocrinology. 30, 4, p. 469-478 10 p.

Research output: Contribution to journalArticle

Steroid 17-alpha-Hydroxylase
Cytochromes b5
Leydig Cells
17-alpha-Hydroxyprogesterone
Testis
70 Citations (Scopus)

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O'Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S., Lepe, M. S., Akira, S., Barbieri, C., Baumeister, S., Cauchi, S., Clarke, T. K., Enroth, S., Fischer, K., Hällfors, J., Harris, S. E. & 107 others, Hieber, S., Hofer, E., Hottenga, J. J., Johansson, Å., Joshi, P. K., Kaartinen, N., Laitinen, J., Lemaitre, R., Loukola, A., Luan, J., Lyytikäinen, L. P., Mangino, M., Manichaikul, A., Mbarek, H., Milaneschi, Y., Moayyeri, A., Mukamal, K., Nelson, C., Nettleton, J., Partinen, E., Rawal, R., Robino, A., Rose, L., Sala, C., Satoh, T., Schmidt, R., Schraut, K., Scott, R., Smith, A. V., Starr, J. M., Teumer, A., Trompet, S., Uitterlinden, A. G., Venturini, C., Vergnaud, A. C., Verweij, N., Vitart, V., Vuckovic, D., Wedenoja, J., Yengo, L., Yu, B., Zhang, W., Zhao, J. H., Boomsma, D. I., Chambers, J., Chasman, D. I., Daniela, T., De Geus, E., Deary, I., Eriksson, J. G., Esko, T., Eulenburg, V., Franco, O. H., Froguel, P., Gieger, C., Grabe, H. J., Gudnason, V., Gyllensten, U., Harris, T. B., Hartikainen, A. L., Heath, A. C., Hocking, L., Hofman, A., Huth, C., Jarvelin, M. R., Jukema, J. W., Kaprio, J., Kooner, J. S., Kutalik, Z., Lahti, J., Langenberg, C., Lehtimäki, T., Liu, Y., Madden, P. A. F., Martin, N., Morrison, A., Penninx, B., Pirastu, N., Psaty, B., Raitakari, O., Ridker, P., Rose, R., Rotter, J. I., Samani, N. J., Schmidt, H., Spector, T. D., Stott, D., Strachan, D., Tzoulaki, I., Van Der Harst, P., Van Duijn, C. M., Marques-Vidal, P., Vollenweider, P., Wareham, N. J., Whitfield, J. B., Wilson, J., Wolffenbuttel, B., Bakalkin, G., Evangelou, E., Liu, Y., Rice, K. M., Desrivières, S., Kliewer, S. A., Mangelsdorf, D. J., Müller, C. P., Levy, D. & Elliott, P., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14372-14377 6 p.

Research output: Contribution to journalArticle

Alcohol Drinking
Alcohols
Genes
Brain
Drinking Behavior
37 Citations (Scopus)

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

Youm, Y. H., Horvath, T. L., Mangelsdorf, D. J., Kliewer, S. A. & Dixit, V. D., Jan 26 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 4, p. 1026-1031 6 p.

Research output: Contribution to journalArticle

Hormones
T-Lymphocytes
Caloric Restriction
Hematopoietic Stem Cell Transplantation
Epithelial Cells
24 Citations (Scopus)

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid

Albarqi, M. M. Y., Stoltzfus, J. D., Pilgrim, A. A., Nolan, T. J., Wang, Z., Kliewer, S. A., Mangelsdorf, D. J. & Lok, J. B., 2016, In : PLoS Pathogens. 12, 1, e1005358.

Research output: Contribution to journalArticle

Strongyloides stercoralis
Life Cycle Stages
Larva
Ketoconazole
Cytochrome P-450 Enzyme System
2015
83 Citations (Scopus)

Bile acids as hormones: The FXR-FGF15/19 pathway

Kliewer, S. A. & Mangelsdorf, D. J., Jun 9 2015, In : Digestive Diseases. 33, 3, p. 327-331 5 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Hormones
Fibroblast Growth Factors
Gluconeogenesis
Biliary Liver Cirrhosis
35 Citations (Scopus)

Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry

Katafuchi, T., Esterházy, D., Lemoff, A., Ding, X., Sondhi, V., Kliewer, S. A., Mirzaei, H. & Mangelsdorf, D. J., Jun 2 2015, In : Cell Metabolism. 21, 6, p. 898-904 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Isotopes
Anti-Idiotypic Antibodies
Mass Spectrometry
Peptides
32 Citations (Scopus)

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop

Patel, R., Bookout, A. L., Magomedova, L., Owen, B. M., Consiglio, G. P., Shimizu, M., Zhang, Y., Mangelsdorf, D. J., Kliewer, S. A. & Cummins, C. L., 2015, In : Molecular Endocrinology. 29, 2, p. 213-223 11 p.

Research output: Contribution to journalArticle

Glucocorticoids
Hormones
Peroxisome Proliferator-Activated Receptors
Corticosterone
Starvation
10 Citations (Scopus)

Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Mansuy-Aubert, V., Gautron, L., Lee, S., Bookout, A. L., Kusminski, C. M., Sun, K., Zhang, Y., Scherer, P. E., Mangelsdorf, D. J. & Elmquist, J. K., Jun 15 2015, In : eLife. 4, JUNE, e06667.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Liver
Energy Metabolism
Neurons
Nodose Ganglion

Reflections on the field of metabolism

Moller, D. E., Cuervo, A. M. A., Gordon, J., Froguel, P. & Mangelsdorf, D. J., Apr 7 2015, In : Cell Metabolism. 21, 4, p. 505-506 2 p.

Research output: Contribution to journalArticle

Biochemistry
19 Citations (Scopus)

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

Wang, Z., Stoltzfus, J., You, Y. J., Ranjit, N., Tang, H., Xie, Y., Lok, J. B., Mangelsdorf, D. J. & Kliewer, S. A., Mar 16 2015, In : PLoS Genetics. 11, 3, e1005027.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
nematode
metabolism
Strongyloides stercoralis
Nematoda
126 Citations (Scopus)

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

Owen, B. M., Mangelsdorf, D. J. & Kliewer, S. A., Jan 1 2015, In : Trends in Endocrinology and Metabolism. 26, 1, p. 22-29 8 p.

Research output: Contribution to journalArticle

Hormones
Metabolic Diseases
Fibroblast Growth Factor Receptors
Fibroblast Growth Factors
Cell Surface Receptors
2014
207 Citations (Scopus)

Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding

Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M. & Potthoff, M. J., Dec 1 2014, In : Diabetes. 63, 12, p. 4057-4063 7 p.

Research output: Contribution to journalArticle

Glucose
Liver
Insulin Resistance
Vascular Resistance
Fasting
199 Citations (Scopus)

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A. & Mangelsdorf, D. J., Oct 7 2014, In : Cell Metabolism. 20, 4, p. 670-677 8 p.

Research output: Contribution to journalArticle

Energy Metabolism
Weight Loss
Obese Mice
Brown Adipose Tissue
Corticotropin-Releasing Hormone
390 Citations (Scopus)

Nuclear receptors, RXR, and the big bang

Evans, R. M. & Mangelsdorf, D. J., Mar 27 2014, In : Cell. 157, 1, p. 255-266 12 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Cytoplasmic and Nuclear Receptors
Gene encoding
Endocrinology
Functional analysis
33 Citations (Scopus)

PPARγ in vagal neurons regulates high-fat diet induced thermogenesis

Liu, C., Bookout, A. L., Lee, S., Sun, K., Jia, L., Lee, C., Udit, S., Deng, Y., Scherer, P. E., Mangelsdorf, D. J., Gautron, L. & Elmquist, J. K., Apr 1 2014, In : Cell Metabolism. 19, 4, p. 722-730 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Thermogenesis
High Fat Diet
Nodose Ganglion
Neurons

SnapShot: Hormones of the gastrointestinal tract

Coate, K. C., Kliewer, S. A. & Mangelsdorf, D. J., Dec 4 2014, In : Cell. 159, 6, p. 1478-1478.e1

Research output: Contribution to journalArticle

Gastrointestinal Hormones
Endocrine Cells
Gastrointestinal Tract
Cells
Hormones
5 Citations (Scopus)

SnapShot: Hormones of the gastrointestinal tract

Coate, K. C., Kliewer, S. A. & Mangelsdorf, D. J., Dec 4 2014, In : Cell. 159, 6, p. 1478.e1

Research output: Contribution to journalArticle

Gastrointestinal Hormones
Endocrine Cells
Gastrointestinal Tract
Cells
Hormones
15 Citations (Scopus)

Structural insights into gene repression by the orphan nuclear receptor SHP

Zhi, X., Zhou, X. E., He, Y., Zechner, C., Suino-Powell, K. M., Kliewer, S. A., Melcher, K., Mangelsdorf, D. J. & Xu, H. E., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 2, p. 839-844 6 p.

Research output: Contribution to journalArticle

Orphan Nuclear Receptors
Binding Sites
Genes
Bile Acids and Salts
Homeostasis
2013
90 Citations (Scopus)
Glycogenolysis
Glucagon-Like Peptide 1
Bile Acids and Salts
Liver
Cholesterol
106 Citations (Scopus)

FGF21 contributes to neuroendocrine control of female reproduction

Owen, B. M., Bookout, A. L., Ding, X., Lin, V. Y., Atkin, S. D., Gautron, L., Kliewer, S. A. & Mangelsdorf, D. J., Sep 2013, In : Nature Medicine. 19, 9, p. 1153-1156 4 p.

Research output: Contribution to journalArticle

Reproduction
Suprachiasmatic Nucleus
Starvation
Fertility
Kisspeptins
219 Citations (Scopus)

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., De Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J. & Kliewer, S. A., Sep 2013, In : Nature Medicine. 19, 9, p. 1147-1152 6 p.

Research output: Contribution to journalArticle

Neurology
Metabolism
Nervous System
Starvation
Receptor, Fibroblast Growth Factor, Type 2
16 Citations (Scopus)

Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus

Atkin, S. D., Owen, B. M., Bookout, A. L., Cravo, R. M., Lee, C., Elias, C. F., Elmquist, J. K., Kliewer, S. A. & Mangelsdorf, D. J., Apr 1 2013, In : Molecular Endocrinology. 27, 4, p. 598-605 8 p.

Research output: Contribution to journalArticle

Kisspeptins
Cytoplasmic and Nuclear Receptors
Neuropeptides
Hypothalamus
Liver
2012
244 Citations (Scopus)

Endocrine fibroblast growth factors 15/19 and 21: From feast to famine

Potthoff, M. J., Kliewer, S. A. & Mangelsdorf, D. J., Feb 15 2012, In : Genes and Development. 26, 4, p. 312-324 13 p.

Research output: Contribution to journalArticle

Starvation
Pharmacology
Fibroblast Growth Factors
Metabolic Diseases
Carbohydrate Metabolism
222 Citations (Scopus)

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., Mangelsdorf, D. J., Kliewer, S. A. & Wan, Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3143-3148 6 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Bone and Bones
rosiglitazone
Adipogenesis
fibroblast growth factor 21
323 Citations (Scopus)

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J. & Kliewer, S. A., Feb 3 2012, In : Cell. 148, 3, p. 556-567 12 p.

Research output: Contribution to journalArticle

Thiazolidinediones
Peroxisome Proliferator-Activated Receptors
Hypoglycemic Agents
Knockout Mice
Sumoylation
100 Citations (Scopus)

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

Zhang, Y., Breevoort, S. R., Angdisen, J., Fu, M., Schmidt, D. R., Holmstrom, S. R., Kliewer, S. A., Mangelsdorf, D. J. & Schulman, I. G., May 1 2012, In : Journal of Clinical Investigation. 122, 5, p. 1688-1699 12 p.

Research output: Contribution to journalArticle

Homeostasis
Cholesterol
Liver
Cardiovascular Diseases
Atherosclerosis
65 Citations (Scopus)

Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo

Kir, S., Zhang, Y., Gerard, R. D., Kliewer, S. A. & Mangelsdorf, D. J., Nov 30 2012, In : Journal of Biological Chemistry. 287, 49, p. 41334-41341 8 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Cytoplasmic and Nuclear Receptors
Bile Acids and Salts
Transcription
Histone Code
26 Citations (Scopus)

Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer

Jeong, Y., Xie, Y., Lee, W., Bookout, A. L., Girard, L., Raso, G., Behrens, C., Wistuba, I. I., Gadzar, A. F., Minna, J. D. & Mangelsdorf, D. J., Aug 1 2012, In : Molecular Endocrinology. 26, 8, p. 1443-1454 12 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Lung Neoplasms
Research
Peroxisome Proliferator-Activated Receptors
Therapeutics
10 Citations (Scopus)

Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE

Lee, S., Wang, P. Y., Jeong, Y., Mangelsdorf, D. J., Anderson, R. G. W. & Michaely, P., Oct 1 2012, In : Experimental Cell Research. 318, 16, p. 2128-2142 15 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Apolipoproteins E
Sterols
Proteins
Response Elements
19 Citations (Scopus)

Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes

Zhi, X., Zhou, X. E., Melcher, K., Motola, D. L., Gelmedin, V., Hawdon, J., Kliewer, S. A., Mangelsdorf, D. J. & Xu, H. E., Feb 10 2012, In : Journal of Biological Chemistry. 287, 7, p. 4894-4903 10 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Conservation
Ligands
Ancylostomatoidea
Parasites
167 Citations (Scopus)

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Colbert Coate, K., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., Yu, R. T., Evans, R. M., Kliewer, S. A. & Mangelsdorf, D. J., Oct 15 2012, In : eLife. 2012, 1, e00065.

Research output: Contribution to journalArticle

Starvation
Hormones
Liver
Adenylate Kinase
Bone Development
196 Citations (Scopus)

βKslotho is required for fibroblast growth factor 21 effects on growth and metabolism

Ding, X., Boney-Montoya, J., Owen, B. M., Bookout, A. L., Coate, K. C., Mangelsdorf, D. J. & Kliewer, S. A., Sep 5 2012, In : Cell Metabolism. 16, 3, p. 387-393 7 p.

Research output: Contribution to journalArticle

Growth
Adipose Tissue
Knockout Mice
fibroblast growth factor 21
Insulin Resistance
2011
25 Citations (Scopus)

AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids

Schmidt, D. R., Schmidt, S., Holmstrom, S. R., Makishima, M., Yu, R. T., Cummins, C. L., Mangelsdorf, D. J. & Kliewer, S. A., Jan 28 2011, In : Journal of Biological Chemistry. 286, 4, p. 2425-2432 8 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Liver
Tissue
Hydroxy Acids
Poisons
173 Citations (Scopus)

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway

Potthoff, M. J., Boney-Montoya, J., Choi, M., He, T., Sunny, N. E., Satapati, S., Suino-Powell, K., Xu, H. E., Gerard, R. D., Finck, B. N., Burgess, S. C., Mangelsdorf, D. J. & Kliewer, S. A., Jun 8 2011, In : Cell Metabolism. 13, 6, p. 729-738 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Carrier Proteins
Glucose
Liver
Gluconeogenesis
293 Citations (Scopus)

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis

Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A. & Mangelsdorf, D. J., Mar 25 2011, In : Science. 331, 6024, p. 1621-1624 4 p.

Research output: Contribution to journalArticle

Liver Glycogen
Insulin
Glycogen Synthase
Lipogenesis
Proteins

Interview: Interview with David Mangelsdorf for personalized medicine

Mangelsdorf, D., Sep 2011, In : Personalized Medicine. 8, 5, p. 513-516 4 p.

Research output: Contribution to journalArticle

Precision Medicine
Cytoplasmic and Nuclear Receptors
Interviews
Nuclear Proteins
Non-Small Cell Lung Carcinoma
60 Citations (Scopus)

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function

Holmstrom, S. R., Deering, T., Swift, G. H., Poelwijk, F. J., Mangelsdorf, D. J., Kliewer, S. A. & Macdonald, R. J., Aug 15 2011, In : Genes and Development. 25, 16, p. 1674-1679 6 p.

Research output: Contribution to journalArticle

Exocrine Pancreas
Gene Regulatory Networks
Pancreas
Transcription Factors
Liver
75 Citations (Scopus)

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice

Patel, R., Patel, M., Tsai, R., Lin, V., Bookout, A. L., Zhang, Y., Magomedova, L., Li, T., Chan, J. F., Budd, C., Mangelsdorf, D. J. & Cummins, C. L., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 431-441 11 p.

Research output: Contribution to journalArticle

Hyperglycemia
Glucocorticoids
Liver
Dexamethasone
Phosphoenolpyruvate
61 Citations (Scopus)

Roles of FGF19 in liver metabolism

Kir, S., Kliewer, S. A. & Mangelsdorf, D. J., 2011, In : Cold Spring Harbor Symposia on Quantitative Biology. 76, p. 139-144 6 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Metabolism
Liver
Bile Acids and Salts
Insulin
125 Citations (Scopus)

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling

Li, T., Holmstrom, S. R., Kir, S., Umetani, M., Schmidt, D. R., Kliewer, S. A. & Mangelsdorf, D. J., Jun 2011, In : Molecular Endocrinology. 25, 6, p. 1066-1071 6 p.

Research output: Contribution to journalArticle

Gallbladder
Bile Acids and Salts
GTP-Binding Proteins
Metabolic Diseases
Lithocholic Acid
35 Citations (Scopus)

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity

Wollam, J., Magomedova, L., Magner, D. B., Shen, Y., Rottiers, V., Motola, D. L., Mangelsdorf, D. J., Cummins, C. L. & Antebi, A., Oct 2011, In : Aging Cell. 10, 5, p. 879-884 6 p.

Research output: Contribution to journalArticle

Oxygenases
Cholesterol
Cytoplasmic and Nuclear Receptors
Bile Acids and Salts
Sterols
10 Citations (Scopus)

Transgenic C. elegans dauer larvae expressing hookworm phospho null DAF-16/FoxO exit dauer

Gelmedin, V., Brodigan, T., Gao, X., Krause, M., Wang, Z. & Hawdon, J. M., Oct 7 2011, In : PLoS One. 6, 10, e25996.

Research output: Contribution to journalArticle

Ancylostomatoidea
hookworms
Phosphorylation
nematode larvae
Larva