Pharmacology - Mangelsdorf Lab

Research Output

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Review article
2019

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Kliewer, S. A. & Mangelsdorf, D. J., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 246-253 8 p.

Research output: Contribution to journalReview article

21 Scopus citations
2017

Nuclear receptors: Emerging drug targets for parasitic diseases

Wang, Z., Schaffer, N. E., Kliewer, S. A. & Mangelsdorf, D. J., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1165-1171 7 p.

Research output: Contribution to journalReview article

6 Scopus citations
2015

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

Owen, B. M., Mangelsdorf, D. J. & Kliewer, S. A., Jan 1 2015, In : Trends in Endocrinology and Metabolism. 26, 1, p. 22-29 8 p.

Research output: Contribution to journalReview article

135 Scopus citations
2014

Nuclear receptors, RXR, and the big bang

Evans, R. M. & Mangelsdorf, D. J., Mar 27 2014, In : Cell. 157, 1, p. 255-266 12 p.

Research output: Contribution to journalReview article

438 Scopus citations
2012

Endocrine fibroblast growth factors 15/19 and 21: From feast to famine

Potthoff, M. J., Kliewer, S. A. & Mangelsdorf, D. J., Feb 15 2012, In : Genes and Development. 26, 4, p. 312-324 13 p.

Research output: Contribution to journalReview article

256 Scopus citations
2011

Interview: Interview with David Mangelsdorf for personalized medicine

Mangelsdorf, D., Sep 1 2011, In : Personalized Medicine. 8, 5, p. 513-516 4 p.

Research output: Contribution to journalReview article

2009

Nuclear receptor regulation of stemness and stem cell differentiation

Jeong, Y. & Mangelsdorf, D. J., Aug 31 2009, In : Experimental and Molecular Medicine. 41, 8, p. 525-537 13 p.

Research output: Contribution to journalReview article

47 Scopus citations

Therapeutic applications for novel non-hypercalcemic vitamin D receptor ligands

Choi, M. & Makishima, M., May 1 2009, In : Expert Opinion on Therapeutic Patents. 19, 5, p. 593-606 14 p.

Research output: Contribution to journalReview article

32 Scopus citations
2006

International union of pharmacology. LX. Retinoic acid receptors

Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J. & Gronemeyer, H., Dec 1 2006, In : Pharmacological Reviews. 58, 4, p. 712-725 14 p.

Research output: Contribution to journalReview article

295 Scopus citations
139 Scopus citations

International union of pharmacology. LXIII. Retinoid X receptors

Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J. & Gronemeyer, H., Dec 1 2006, In : Pharmacological Reviews. 58, 4, p. 760-772 13 p.

Research output: Contribution to journalReview article

365 Scopus citations

LXRs and FXR: The Yin and Yang of cholesterol and fat metabolism

Kalaany, N. Y. & Mangelsdorf, D. J., May 1 2006, In : Annual Review of Physiology. 68, p. 159-191 33 p.

Research output: Contribution to journalReview article

414 Scopus citations
2005

Retinoid X receptor heterodimers in the metabolic syndrome

Shulman, A. I. & Mangelsdorf, D. J., Aug 11 2005, In : New England Journal of Medicine. 353, 6, p. 604-615 12 p.

Research output: Contribution to journalReview article

310 Scopus citations
2002

LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing.

Zhang, Y. & Mangelsdorf, D. J., Apr 2002, In : Molecular interventions. 2, 2, p. 78-87 10 p.

Research output: Contribution to journalReview article

50 Scopus citations

The liver X receptor gene team: Potential new players in atherosclerosis

Repa, J. J. & Mangelsdorf, D. J., Nov 1 2002, In : Nature medicine. 8, 11, p. 1243-1248 6 p.

Research output: Contribution to journalReview article

316 Scopus citations
2001

Nuclear receptors and lipid physiology: Opening the x-files

Chawta, A., Repa, J. J., Evans, R. M. & Mangelsdorf, D. J., Nov 30 2001, In : Science. 294, 5548, p. 1866-1870 5 p.

Research output: Contribution to journalReview article

1536 Scopus citations

Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs)

Sporn, M. B., Suh, N. & Mangelsdorf, D. J., Sep 17 2001, In : Trends in Molecular Medicine. 7, 9, p. 395-400 6 p.

Research output: Contribution to journalReview article

140 Scopus citations

Régulation du métabolisme des lipides par les récepteurs nucléaires orphelins

Translated title of the contribution: Regulation of lipid metabolism by the orphan nuclear receptorsLobaccaro, J. M. A., Repa, J. J., Lu, T. T., Caira, F., Henry-Berger, J., Volle, D. H. & Mangelsdorf, D. J., Jul 26 2001, In : Annales d'Endocrinologie. 62, 3, p. 239-247 9 p.

Research output: Contribution to journalReview article

18 Scopus citations
2000

Modifying ligand specificity of gene regulatory proteins

Doyle, D. F., Mangelsdorf, D. J. & Corey, D. R., Feb 1 2000, In : Current Opinion in Chemical Biology. 4, 1, p. 60-64 5 p.

Research output: Contribution to journalReview article

10 Scopus citations

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

Repa, J. J., Turley, S. D., Lobaccaro, J. M. A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R. A., Dietschy, J. M. & Mangelsdorf, D. J., Sep 1 2000, In : Science. 289, 5484, p. 1524-1529 6 p.

Research output: Contribution to journalReview article

1073 Scopus citations

Sterols and gene expression: Control of affluence

Schoonjans, K., Brendel, C., Mangelsdorf, D. & Auwerx, J., Dec 15 2000, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1529, 1-3, p. 114-125 12 p.

Research output: Contribution to journalReview article

37 Scopus citations
537 Scopus citations
1999

Nuclear receptor regulation of cholesterol and bile acid metabolism

Repa, J. J. & Mangelsdorf, D. J., Dec 1 1999, In : Current Opinion in Biotechnology. 10, 6, p. 557-563 7 p.

Research output: Contribution to journalReview article

157 Scopus citations

Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research

Alberts, D. S., Colvin, O. M., Conney, A. H., Ernster, V. L., Garber, J. E., Greenwald, P., Gudas, L. J., Waun Ki Hong, K. H., Kelloff, G. J., Kramer, R. A., Lerman, C. E., Mangelsdorf, D. J., Matter, A., Minna, J. D., Nelson V, W. G., Pezzuto, J. M., Prendergast, F., Rusch, V. W., Sporn, M. B., Wattenberg, L. W. & 1 others, Weinstein, I. B., Oct 1 1999, In : Cancer research. 59, 19, p. 4743-4758 16 p.

Research output: Contribution to journalReview article

162 Scopus citations
1995

The RXR heterodimers and orphan receptors

Mangelsdorf, D. J. & Evans, R. M., Dec 15 1995, In : Cell. 83, 6, p. 841-850 10 p.

Research output: Contribution to journalReview article

2690 Scopus citations
1988

Molecular biology of the vitamin D hormone.

Haussler, M. R., Mangelsdorf, D. J., Komm, B. S., Terpening, C. M., Yamaoka, K., Allegretto, E. A., Baker, A. R., Shine, J., McDonnell, D. P. & Hughes, M., Dec 1 1988, In : Recent progress in hormone research. 44, p. 263-305 43 p.

Research output: Contribution to journalReview article

151 Scopus citations
1986

1,25-Dihydroxyvitamin D3 receptors: altered functional domains are associated with cellular resistance to vitamin D3.

Pike, J. W., Allegretto, E. A., Kelly, M. A., Donaldson, C. A., Marion, S. L., Mangelsdorf, D. J. & Haussler, M. R., 1986, In : Advances in experimental medicine and biology. 196, p. 377-390 14 p.

Research output: Contribution to journalReview article