Pharmacology - Michael Lab

Research Output

2019

A Plant Pathogen Type III Effector Protein Subverts Translational Regulation to Boost Host Polyamine Levels

Wu, D., von Roepenack-Lahaye, E., Buntru, M., de Lange, O., Schandry, N., Pérez-Quintero, A. L., Weinberg, Z., Lowe-Power, T. M., Szurek, B., Michael, A. J., Allen, C., Schillberg, S. & Lahaye, T., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 638-649.e5

Research output: Contribution to journalArticle

3 Scopus citations

A polyamine-independent role for S-adenosylmethionine decarboxylase

Li, B., Kurihara, S., Kim, S. H., Liang, J. & Michael, A. J., Sep 20 2019, In : The Biochemical journal. 476, 18, p. 2579-2594 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Polyamine-independent growth and biofilm formation, and functional spermidine/spermine N-acetyltransferases in Staphylococcus aureus and Enterococcus faecalis

Li, B., Maezato, Y., Kim, S. H., Kurihara, S., Liang, J. & Michael, A. J., Jan 2019, In : Molecular Microbiology. 111, 1, p. 159-175 17 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Homospermidine biosynthesis in the cyanobacterium Anabaena requires a deoxyhypusine synthase homologue and is essential for normal diazotrophic growth

Burnat, M., Li, B., Kim, S. H., Michael, A. J. & Flores, E., Jan 1 2018, (Accepted/In press) In : Molecular Microbiology.

Research output: Contribution to journalArticle

8 Scopus citations

Metabolomics of tomato xylem sap during bacterial wilt reveals Ralstonia solanacearum produces abundant putrescine, a metabolite that accelerates wilt disease

Lowe-Power, T. M., Hendrich, C. G., von Roepenack-Lahaye, E., Li, B., Wu, D., Mitra, R., Dalsing, B. L., Ricca, P., Naidoo, J., Cook, D., Jancewicz, A., Masson, P., Thomma, B., Lahaye, T., Michael, A. J. & Allen, C., Apr 2018, In : Environmental Microbiology. 20, 4, p. 1330-1349 20 p.

Research output: Contribution to journalArticle

23 Scopus citations

Polyamine function in archaea and bacteria

Michael, A. J., Nov 30 2018, In : Journal of Biological Chemistry. 293, 48, p. 18693-18701 9 p.

Research output: Contribution to journalReview article

23 Scopus citations
2017

Evolution of biosynthetic diversity

Michael, A. J., Jul 15 2017, In : Biochemical Journal. 474, 14, p. 2277-2299 23 p.

Research output: Contribution to journalReview article

16 Scopus citations

Spermidine promotes Bacillus subtilis biofilm formation by activating expression of the matrix regulator slrR

Hobley, L., Li, B., Wood, J. L., Kim, S. H., Naidoo, J., Ferreira, A. S., Khomutov, M., Khomutov, A., Stanley-Wall, N. R. & Michael, A. J., Jul 21 2017, In : Journal of Biological Chemistry. 292, 29, p. 12041-12053 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

Biosynthesis of polyamines and polyamine-containing molecules

Michael, A. J., 2016, In : Biochemical Journal. 473, 15, p. 2315-2329 15 p.

Research output: Contribution to journalReview article

51 Scopus citations

Functional Identification of Putrescine C- and N-Hydroxylases

Li, B., Lowe-Power, T., Kurihara, S., Gonzales, S., Naidoo, J., Macmillan, J. B., Allen, C. & Michael, A. J., Oct 21 2016, In : ACS Chemical Biology. 11, 10, p. 2782-2789 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Polyamines in eukaryotes, bacteria, and archaea

Michael, A. J., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 14896-14903 8 p.

Research output: Contribution to journalReview article

78 Scopus citations

Spermidine inversely influences surface interactions and planktonic growth in Agrobacterium tumefaciens

Wang, Y., Kim, S. H., Natarajan, R., Heindl, J. E., Bruger, E. L., Waters, C. M., Michael, A. J. & Fuqua, C., 2016, In : Journal of Bacteriology. 198, 19, p. 2682-2691 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

The Essential Role of Spermidine in Growth of Agrobacterium tumefaciens Is Determined by the 1,3-Diaminopropane Moiety

Kim, S. H., Wang, Y., Khomutov, M., Khomutov, A., Fuqua, C. & Michael, A. J., Feb 19 2016, In : ACS Chemical Biology. 11, 2, p. 491-499 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Biosynthesis of polyamines in eukaryotes, Archaea, and bacteria

Michael, A. J., Jan 1 2015, Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer Japan, p. 3-14 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Different polyamine pathways from bacteria have replaced eukaryotic spermidine biosynthesis in ciliates Tetrahymena thermophila and Paramecium tetaurelia

Li, B., Kim, S. H., Zhang, Y., Hanfrey, C. C., Elliott, K. A., Ealick, S. E. & Michael, A. J., Sep 1 2015, In : Molecular Microbiology. 97, 5, p. 791-807 17 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids

Nakabayashi, R., Yonekura-Sakakibara, K., Urano, K., Suzuki, M., Yamada, Y., Nishizawa, T., Matsuda, F., Kojima, M., Sakakibara, H., Shinozaki, K., Michael, A. J., Tohge, T., Yamazaki, M. & Saito, K., Feb 1 2014, In : Plant Journal. 77, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

329 Scopus citations

Norspermidine is not a self-produced trigger for biofilm disassembly

Hobley, L., Kim, S. H., Maezato, Y., Wyllie, S., Fairlamb, A. H., Stanley-Wall, N. R. & Michael, A. J., Feb 13 2014, In : Cell. 156, 4, p. 844-854 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Polyamine oxidase5 regulates arabidopsis growth through thermospermine oxidase activity

Kim, D. W., Watanabe, K., Murayama, C., Izawa, S., Niitsu, M., Michael, A. J., Berberich, T. & Kusano, T., Aug 2014, In : Plant Physiology. 165, 4, p. 1575-1590 16 p.

Research output: Contribution to journalArticle

47 Scopus citations
2013

A wider role for polyamines in biofilm formation

Karatan, E. & Michael, A. J., Nov 1 2013, In : Biotechnology Letters. 35, 11, p. 1715-1717 3 p.

Research output: Contribution to journalEditorial

17 Scopus citations
2012

Enhanced biofilm formation and/or cell viability by polyamines through stimulation of response regulators UvrY and CpxR in the two-component signal transducing systems, and ribosome recycling factor

Sakamoto, A., Terui, Y., Yamamoto, T., Kasahara, T., Nakamura, M., Tomitori, H., Yamamoto, K., Ishihama, A., Michael, A. J., Igarashi, K. & Kashiwagi, K., Nov 1 2012, In : International Journal of Biochemistry and Cell Biology. 44, 11, p. 1877-1886 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Evolution of a novel lysine decarboxylase in siderophore biosynthesis

Burrell, M., Hanfrey, C. C., Kinch, L. N., Elliott, K. A. & Michael, A. J., Oct 1 2012, In : Molecular Microbiology. 86, 2, p. 485-499 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Expression of a bacterial, phenylpropanoid-metabolizing enzyme in tobacco reveals essential roles of phenolic precursors in normal leaf development and growth

Merali, Z., Mayer, M. J., Parker, M. L., Michael, A. J., Smith, A. C. & Waldron, K. W., Jun 1 2012, In : Physiologia Plantarum. 145, 2, p. 260-274 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
8 Scopus citations
2011

Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota

Hanfrey, C. C., Pearson, B. M., Hazeldine, S., Lee, J., Gaskin, D. J., Woster, P. M., Phillips, M. A. & Michael, A. J., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43301-43312 12 p.

Research output: Contribution to journalArticle

49 Scopus citations
3 Scopus citations

Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation

Green, R., Hanfrey, C. C., Elliott, K. A., Mccloskey, D. E., Wang, X., Kanugula, S., Pegg, A. E. & Michael, A. J., Aug 1 2011, In : Molecular Microbiology. 81, 4, p. 1109-1124 16 p.

Research output: Contribution to journalArticle

16 Scopus citations
22 Scopus citations
2010

Evolution and multifarious horizontal transfer of an alternative biosynthetic pathway for the alternative polyamine sym-homospermidine

Shaw, F. L., Elliott, K. A., Kinch, L. N., Fuell, C., Phillips, M. A. & Michael, A. J., May 7 2010, In : Journal of Biological Chemistry. 285, 19, p. 14711-14723 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Evolution and multiplicity of arginine decarboxylases in polyamine biosynthesis and essential role in Bacillus subtilis biofilm formation

Burrell, M., Hanfrey, C. C., Murray, E. J., Stanley-Wall, N. R. & Michael, A. J., Dec 10 2010, In : Journal of Biological Chemistry. 285, 50, p. 39224-39238 15 p.

Research output: Contribution to journalArticle

62 Scopus citations
17 Scopus citations

Polyamine biosynthetic diversity in plants and algae

Fuell, C., Elliott, K. A., Hanfrey, C. C., Franceschetti, M. & Michael, A. J., Jul 1 2010, In : Plant Physiology and Biochemistry. 48, 7, p. 513-520 8 p.

Research output: Contribution to journalArticle

110 Scopus citations

Spermine synthase

Pegg, A. E. & Michael, A. J., Jan 1 2010, In : Cellular and Molecular Life Sciences. 67, 1, p. 113-121 9 p.

Research output: Contribution to journalReview article

78 Scopus citations
2009

An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae

Lee, J., Sperandio, V., Frantz, D. E., Longgood, J., Camilli, A., Phillips, M. A. & Michael, A. J., Apr 10 2009, In : Journal of Biological Chemistry. 284, 15, p. 9899-9907 9 p.

Research output: Contribution to journalArticle

102 Scopus citations

A novel polyamine acyltransferase responsible for the accumulation of spermidine conjugates in Arabidopsis seed

Luo, J., Fuell, C., Parr, A., Hill, L., Bailey, P., Elliott, K., Fairhurst, S. A., Martin, C. & Michael, A. J., Jan 1 2009, In : Plant Cell. 21, 1, p. 318-333 16 p.

Research output: Contribution to journalArticle

87 Scopus citations

A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

Ivanov, I. P., Atkins, J. F. & Michael, A. J., Nov 17 2009, In : Nucleic acids research. 38, 2, p. 353-359 7 p., gkp1037.

Research output: Contribution to journalArticle

56 Scopus citations
2008

Crystal structure of human spermine synthase: Implications of substrate binding and catalytic mechanism

Wu, H., Min, J., Zeng, H., McCloskey, D. E., Ikeguchi, Y., Loppnau, P., Michael, A. J., Pegg, A. E. & Plotnikov, A. N., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 16135-16146 12 p.

Research output: Contribution to journalArticle

68 Scopus citations

Transcript-specific translational regulation in the unfolded protein response of Saccharomyces cerevisiae

Payne, T., Hanfrey, C., Bishop, A. L., Michael, A. J., Avery, S. V. & Archer, D. B., Feb 20 2008, In : FEBS Letters. 582, 4, p. 503-509 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2007

A protective role for the polyamine spermine against drought stress in Arabidopsis

Yamaguchi, K., Takahashi, Y., Berberich, T., Imai, A., Takahashi, T., Michael, A. J. & Kusano, T., Jan 12 2007, In : Biochemical and Biophysical Research Communications. 352, 2, p. 486-490 5 p.

Research output: Contribution to journalArticle

195 Scopus citations

Convergent evolution in the BAHD family of acyl transferases: Identification and characterization of anthocyanin acyl transferases from Arabidopsis thaliana

Luo, J., Nishiyama, Y., Fuell, C., Taguchi, G., Elliott, K., Hill, L., Tanaka, Y., Kitayama, M., Yamazaki, M., Bailey, P., Parr, A., Michael, A. J., Saito, K. & Martin, C., May 1 2007, In : Plant Journal. 50, 4, p. 678-695 18 p.

Research output: Contribution to journalArticle

128 Scopus citations

Metabolic diversion of the phenylpropanoid pathway causes cell wall and morphological changes in transgenic tobacco stems

Merali, Z., Mayer, M. J., Parker, M. L., Michael, A. J., Smith, A. C. & Waldron, K. W., Apr 1 2007, In : Planta. 225, 5, p. 1165-1178 14 p.

Research output: Contribution to journalArticle

22 Scopus citations
37 Scopus citations
2006

Shall I compare thee to a GM potato?

Colquhoun, I. J., Le Gall, G., Elliott, K. A., Mellon, F. A. & Michael, A. J., Oct 1 2006, In : Trends in Genetics. 22, 10, p. 525-528 4 p.

Research output: Contribution to journalShort survey

11 Scopus citations

The polyamine spermine protects against high salt stress in Arabidopsis thaliana

Yamaguchi, K., Takahashi, Y., Berberich, T., Imai, A., Miyazaki, A., Takahashi, T., Michael, A. & Kusano, T., Dec 22 2006, In : FEBS Letters. 580, 30, p. 6783-6788 6 p.

Research output: Contribution to journalArticle

156 Scopus citations
2005

A dual upstream open reading frame-based autoregulatory circuit controlling polyamine-responsive translation

Hanfrey, C., Elliott, K. A., Franceschetti, M., Mayer, M. J., Illingworth, C. & Michael, A. J., Nov 25 2005, In : Journal of Biological Chemistry. 280, 47, p. 39229-39237 9 p.

Research output: Contribution to journalArticle

101 Scopus citations

Jasmonates and Na-orthovanadate promote resveratrol production in Vitis vinifera cv. Barbera cell cultures

Tassoni, A., Fornalè, S., Franceschetti, M., Musiani, F., Michael, A. J., Perry, B. & Bagni, N., Jun 1 2005, In : New Phytologist. 166, 3, p. 895-905 11 p.

Research output: Contribution to journalArticle

146 Scopus citations

Molecular analysis of alkaloid metabolism in AABB v. aabb genotype Nicotiana tabacum in response to wounding of aerial tissues and methyl jasmonate treatment of cultured roots

Cane, K. A., Mayer, M., Lidgett, A. J., Michael, A. J. & Hamill, J. D., Jun 8 2005, In : Functional Plant Biology. 32, 4, p. 305-320 16 p.

Research output: Contribution to journalArticle

39 Scopus citations
2004

Engineering plants with increased levels of the antioxidant chlorogenic acid

Niggeweg, R., Michael, A. J. & Martin, C., Jun 1 2004, In : Nature biotechnology. 22, 6, p. 746-754 9 p.

Research output: Contribution to journalArticle

458 Scopus citations

Expression proteomics identifies biochemical adaptations and defense responses in transgenic plants with perturbed polyamine metabolism

Franceschetti, M., Perry, B., Thompson, B., Hanfrey, C. & Michael, A. J., Oct 22 2004, In : FEBS Letters. 576, 3, p. 477-480 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2003

Polyamine Homeostasis in Transgenic Plants Overexpressing Ornithine Decarboxylase Includes Ornithine Limitation

Mayer, M. J. & Michael, A. J., Nov 1 2003, In : Journal of Biochemistry. 134, 5, p. 765-772 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

The diverse bacterial origins of the Arabidopsis polyamine biosynthetic pathway

Illingworth, C., Mayer, M. J., Elliott, K., Hanfrey, C., Walton, N. J. & Michael, A. J., Aug 14 2003, In : FEBS Letters. 549, 1-3, p. 26-30 5 p.

Research output: Contribution to journalArticle

51 Scopus citations