Pharmacology - Michael Lab

Research Output 1996 2019

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2019

A polyamine-independent role for S-adenosylmethionine decarboxylase

Li, B., Kurihara, S., Kim, S. H., Liang, J. & Michael, A. J., Sep 20 2019, In : The Biochemical journal. 476, 18, p. 2579-2594 16 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Adenosylmethionine Decarboxylase
Polyamines
Genes
Fusion reactions
2018
6 Citations (Scopus)

Homospermidine biosynthesis in the cyanobacterium Anabaena requires a deoxyhypusine synthase homologue and is essential for normal diazotrophic growth

Burnat, M., Li, B., Kim, S. H., Michael, A. J. & Flores, E., Jan 1 2018, (Accepted/In press) In : Molecular Microbiology.

Research output: Contribution to journalArticle

Anabaena
Polyamines
Cyanobacteria
Growth
Glycolipids
1 Citation (Scopus)

Polyamine-independent growth and biofilm formation, and functional spermidine/spermine N-acetyltransferases in Staphylococcus aureus and Enterococcus faecalis

Li, B., Maezato, Y., Kim, S. H., Kurihara, S., Liang, J. & Michael, A. J., Jan 1 2018, (Accepted/In press) In : Molecular Microbiology.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Enterococcus faecalis
Polyamines
2017
13 Citations (Scopus)

Metabolomics of tomato xylem sap during bacterial wilt reveals Ralstonia solanacearum produces abundant putrescine, a metabolite that accelerates wilt disease

Lowe-Power, T. M., Hendrich, C. G., von Roepenack-Lahaye, E., Li, B., Wu, D., Mitra, R., Dalsing, B. L., Ricca, P., Naidoo, J., Cook, D., Jancewicz, A., Masson, P., Thomma, B., Lahaye, T., Michael, A. J. & Allen, C., Jan 1 2017, (Accepted/In press) In : Environmental Microbiology.

Research output: Contribution to journalArticle

Ralstonia solanacearum
Xylem
bacterial wilt
wilt
Putrescine
12 Citations (Scopus)

Spermidine promotes Bacillus subtilis biofilm formation by activating expression of the matrix regulator slrR

Hobley, L., Li, B., Wood, J. L., Kim, S. H., Naidoo, J., Ferreira, A. S., Khomutov, M., Khomutov, A., Stanley-Wall, N. R. & Michael, A. J., 2017, In : Journal of Biological Chemistry. 292, 29, p. 12041-12053 13 p.

Research output: Contribution to journalArticle

Spermidine
Biofilms
Bacilli
Bacillus subtilis
Methionine
2016
10 Citations (Scopus)

Functional Identification of Putrescine C- and N-Hydroxylases

Li, B., Lowe-Power, T., Kurihara, S., Gonzales, S., Naidoo, J., Macmillan, J. B., Allen, C. & Michael, A. J., Oct 21 2016, In : ACS Chemical Biology. 11, 10, p. 2782-2789 8 p.

Research output: Contribution to journalArticle

Putrescine
Mixed Function Oxygenases
Polyamines
Biosynthesis
Siderophores
11 Citations (Scopus)

Spermidine inversely influences surface interactions and planktonic growth in Agrobacterium tumefaciens

Wang, Y., Kim, S. H., Natarajan, R., Heindl, J. E., Bruger, E. L., Waters, C. M., Michael, A. J. & Fuqua, C., 2016, In : Journal of Bacteriology. 198, 19, p. 2682-2691 10 p.

Research output: Contribution to journalArticle

Agrobacterium tumefaciens
Spermidine
Biofilms
Ornithine Decarboxylase
Carboxy-Lyases
14 Citations (Scopus)

The Essential Role of Spermidine in Growth of Agrobacterium tumefaciens Is Determined by the 1,3-Diaminopropane Moiety

Kim, S. H., Wang, Y., Khomutov, M., Khomutov, A., Fuqua, C. & Michael, A. J., Feb 19 2016, In : ACS Chemical Biology. 11, 2, p. 491-499 9 p.

Research output: Contribution to journalArticle

Agrobacterium tumefaciens
Spermidine
Growth
Spermine
Polyamines
2015
7 Citations (Scopus)

Different polyamine pathways from bacteria have replaced eukaryotic spermidine biosynthesis in ciliates Tetrahymena thermophila and Paramecium tetaurelia

Li, B., Kim, S. H., Zhang, Y., Hanfrey, C. C., Elliott, K. A., Ealick, S. E. & Michael, A. J., Sep 1 2015, In : Molecular Microbiology. 97, 5, p. 791-807 17 p.

Research output: Contribution to journalArticle

Tetrahymena thermophila
Paramecium
Spermidine
Polyamines
Bacteria
2014
261 Citations (Scopus)

Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids

Nakabayashi, R., Yonekura-Sakakibara, K., Urano, K., Suzuki, M., Yamada, Y., Nishizawa, T., Matsuda, F., Kojima, M., Sakakibara, H., Shinozaki, K., Michael, A. J., Tohge, T., Yamazaki, M. & Saito, K., Feb 2014, In : Plant Journal. 77, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

Droughts
Arabidopsis
Flavonoids
drought tolerance
flavonoids
31 Citations (Scopus)

Norspermidine is not a self-produced trigger for biofilm disassembly

Hobley, L., Kim, S. H., Maezato, Y., Wyllie, S., Fairlamb, A. H., Stanley-Wall, N. R. & Michael, A. J., Feb 13 2014, In : Cell. 156, 4, p. 844-854 11 p.

Research output: Contribution to journalArticle

Biofilms
Bacillus subtilis
Vibrio cholerae
Biosynthetic Pathways
Polyamines
43 Citations (Scopus)

Polyamine oxidase5 regulates arabidopsis growth through thermospermine oxidase activity

Kim, D. W., Watanabe, K., Murayama, C., Izawa, S., Niitsu, M., Michael, A. J., Berberich, T. & Kusano, T., 2014, In : Plant Physiology. 165, 4, p. 1575-1590 16 p.

Research output: Contribution to journalArticle

Polyamines
polyamines
Arabidopsis
Oxidoreductases
mutants
2013
16 Citations (Scopus)

A wider role for polyamines in biofilm formation

Karatan, E. & Michael, A. J., Nov 2013, In : Biotechnology Letters. 35, 11, p. 1715-1717 3 p.

Research output: Contribution to journalArticle

Polyamines
Biofilms
Biosynthetic Pathways
Gram-Positive Bacteria
Bacteria
2012
25 Citations (Scopus)

Enhanced biofilm formation and/or cell viability by polyamines through stimulation of response regulators UvrY and CpxR in the two-component signal transducing systems, and ribosome recycling factor

Sakamoto, A., Terui, Y., Yamamoto, T., Kasahara, T., Nakamura, M., Tomitori, H., Yamamoto, K., Ishihama, A., Michael, A. J., Igarashi, K. & Kashiwagi, K., Nov 2012, In : International Journal of Biochemistry and Cell Biology. 44, 11, p. 1877-1886 10 p.

Research output: Contribution to journalArticle

Signal systems
Polyamines
Biofilms
Cell Survival
Cells
20 Citations (Scopus)

Evolution of a novel lysine decarboxylase in siderophore biosynthesis

Burrell, M., Hanfrey, C. C., Kinch, L. N., Elliott, K. A. & Michael, A. J., Oct 2012, In : Molecular Microbiology. 86, 2, p. 485-499 15 p.

Research output: Contribution to journalArticle

lysine decarboxylase
Siderophores
Carboxy-Lyases
Cadaverine
Open Reading Frames
3 Citations (Scopus)

Expression of a bacterial, phenylpropanoid-metabolizing enzyme in tobacco reveals essential roles of phenolic precursors in normal leaf development and growth

Merali, Z., Mayer, M. J., Parker, M. L., Michael, A. J., Smith, A. C. & Waldron, K. W., Jun 2012, In : Physiologia Plantarum. 145, 2, p. 260-274 15 p.

Research output: Contribution to journalArticle

Hydro-Lyases
Lyases
Lignin
lyases
phenylpropanoids
8 Citations (Scopus)
Ornithine Decarboxylase
Polyamines
Feedback
Peptides
Yeast
2011
43 Citations (Scopus)

Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota

Hanfrey, C. C., Pearson, B. M., Hazeldine, S., Lee, J., Gaskin, D. J., Woster, P. M., Phillips, M. A. & Michael, A. J., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43301-43312 12 p.

Research output: Contribution to journalArticle

Campylobacter jejuni
Spermidine
Polyamines
Hydrothermal Vents
Growth
3 Citations (Scopus)
Polyamines
Genomics
Diamines
Horizontal Gene Transfer
Gene Duplication
16 Citations (Scopus)

Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation

Green, R., Hanfrey, C. C., Elliott, K. A., Mccloskey, D. E., Wang, X., Kanugula, S., Pegg, A. E. & Michael, A. J., Aug 2011, In : Molecular Microbiology. 81, 4, p. 1109-1124 16 p.

Research output: Contribution to journalArticle

Proteobacteria
Diamines
Gene Fusion
Polyamines
Spermidine Synthase
21 Citations (Scopus)
Diatoms
Gene Fusion
Polyamines
Fusion reactions
Genes
2010
34 Citations (Scopus)

Evolution and multifarious horizontal transfer of an alternative biosynthetic pathway for the alternative polyamine sym-homospermidine

Shaw, F. L., Elliott, K. A., Kinch, L. N., Fuell, C., Phillips, M. A. & Michael, A. J., May 7 2010, In : Journal of Biological Chemistry. 285, 19, p. 14711-14723 13 p.

Research output: Contribution to journalArticle

Biosynthetic Pathways
Polyamines
Spermidine
Proteobacteria
Bacteria
55 Citations (Scopus)

Evolution and multiplicity of arginine decarboxylases in polyamine biosynthesis and essential role in Bacillus subtilis biofilm formation

Burrell, M., Hanfrey, C. C., Murray, E. J., Stanley-Wall, N. R. & Michael, A. J., Dec 10 2010, In : Journal of Biological Chemistry. 285, 50, p. 39224-39238 15 p.

Research output: Contribution to journalArticle

Biosynthesis
Alanine Racemase
Polyamines
Biofilms
Bacilli
16 Citations (Scopus)
Basic Amino Acids
Carboxy-Lyases
Substrate Specificity
Arginine
X-Rays
105 Citations (Scopus)

Polyamine biosynthetic diversity in plants and algae

Fuell, C., Elliott, K. A., Hanfrey, C. C., Franceschetti, M. & Michael, A. J., Jul 2010, In : Plant Physiology and Biochemistry. 48, 7, p. 513-520 8 p.

Research output: Contribution to journalArticle

algae
Polyamines
polyamines
arginine
Arginine
73 Citations (Scopus)

Spermine synthase

Pegg, A. E. & Michael, A. J., Jan 2010, In : Cellular and Molecular Life Sciences. 67, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

Spermine Synthase
Spermine
Catalytic Domain
Spermidine Synthase
Adenosylmethionine Decarboxylase
2009
96 Citations (Scopus)

An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae

Lee, J., Sperandio, V., Frantz, D. E., Longgood, J., Camilli, A., Phillips, M. A. & Michael, A. J., Apr 10 2009, In : Journal of Biological Chemistry. 284, 15, p. 9899-9907 9 p.

Research output: Contribution to journalArticle

Vibrio cholerae
Spermidine
Biosynthetic Pathways
Polyamines
Biofilms
84 Citations (Scopus)

A novel polyamine acyltransferase responsible for the accumulation of spermidine conjugates in Arabidopsis seed

Luo, J., Fuell, C., Parr, A., Hill, L., Bailey, P., Elliott, K., Fairhurst, S. A., Martin, C. & Michael, A. J., Jan 2009, In : Plant Cell. 21, 1, p. 318-333 16 p.

Research output: Contribution to journalArticle

Acyltransferases
acyltransferases
Spermidine
Polyamines
spermidine
52 Citations (Scopus)

A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

Ivanov, I. P., Atkins, J. F. & Michael, A. J., Nov 17 2009, In : Nucleic Acids Research. 38, 2, p. 353-359 7 p., gkp1037.

Research output: Contribution to journalArticle

Polyamines
Open Reading Frames
Messenger RNA
Biosynthetic Pathways
Proteome
2008
67 Citations (Scopus)

Crystal structure of human spermine synthase: Implications of substrate binding and catalytic mechanism

Wu, H., Min, J., Zeng, H., McCloskey, D. E., Ikeguchi, Y., Loppnau, P., Michael, A. J., Pegg, A. E. & Plotnikov, A. N., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 16135-16146 12 p.

Research output: Contribution to journalArticle

Spermine Synthase
Spermidine Synthase
Crystal structure
Spermine
Dimerization
23 Citations (Scopus)

Transcript-specific translational regulation in the unfolded protein response of Saccharomyces cerevisiae

Payne, T., Hanfrey, C., Bishop, A. L., Michael, A. J., Avery, S. V. & Archer, D. B., Feb 20 2008, In : FEBS Letters. 582, 4, p. 503-509 7 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Yeast
Saccharomyces cerevisiae
Proteins
Endoplasmic Reticulum-Associated Degradation
2007
192 Citations (Scopus)

A protective role for the polyamine spermine against drought stress in Arabidopsis

Yamaguchi, K., Takahashi, Y., Berberich, T., Imai, A., Takahashi, T., Michael, A. J. & Kusano, T., Jan 12 2007, In : Biochemical and Biophysical Research Communications. 352, 2, p. 486-490 5 p.

Research output: Contribution to journalArticle

Spermine
Drought
Droughts
Polyamines
Arabidopsis
118 Citations (Scopus)

Convergent evolution in the BAHD family of acyl transferases: Identification and characterization of anthocyanin acyl transferases from Arabidopsis thaliana

Luo, J., Nishiyama, Y., Fuell, C., Taguchi, G., Elliott, K., Hill, L., Tanaka, Y., Kitayama, M., Yamazaki, M., Bailey, P., Parr, A., Michael, A. J., Saito, K. & Martin, C., May 2007, In : Plant Journal. 50, 4, p. 678-695 18 p.

Research output: Contribution to journalArticle

Anthocyanins
convergent evolution
Transferases
transferases
Arabidopsis
21 Citations (Scopus)

Metabolic diversion of the phenylpropanoid pathway causes cell wall and morphological changes in transgenic tobacco stems

Merali, Z., Mayer, M. J., Parker, M. L., Michael, A. J., Smith, A. C. & Waldron, K. W., Apr 2007, In : Planta. 225, 5, p. 1165-1178 14 p.

Research output: Contribution to journalArticle

lyases
Hydro-Lyases
phenylpropanoids
Coenzyme A
Lyases
36 Citations (Scopus)
Basic Amino Acids
Ornithine Decarboxylase
Carboxy-Lyases
Substrate Specificity
Ornithine
2006
11 Citations (Scopus)

Shall I compare thee to a GM potato?

Colquhoun, I. J., Le Gall, G., Elliott, K. A., Mellon, F. A. & Michael, A. J., Oct 2006, In : Trends in Genetics. 22, 10, p. 525-528 4 p.

Research output: Contribution to journalArticle

Solanum tuberosum
Safety
148 Citations (Scopus)

The polyamine spermine protects against high salt stress in Arabidopsis thaliana

Yamaguchi, K., Takahashi, Y., Berberich, T., Imai, A., Miyazaki, A., Takahashi, T., Michael, A. & Kusano, T., Dec 22 2006, In : FEBS Letters. 580, 30, p. 6783-6788 6 p.

Research output: Contribution to journalArticle

Spermine
Polyamines
Arabidopsis
Salts
Hypersensitivity
2005
95 Citations (Scopus)

A dual upstream open reading frame-based autoregulatory circuit controlling polyamine-responsive translation

Hanfrey, C., Elliott, K. A., Franceschetti, M., Mayer, M. J., Illingworth, C. & Michael, A. J., Nov 25 2005, In : Journal of Biological Chemistry. 280, 47, p. 39229-39237 9 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Polyamines
Open Reading Frames
Networks (circuits)
Messenger RNA
139 Citations (Scopus)

Jasmonates and Na-orthovanadate promote resveratrol production in Vitis vinifera cv. Barbera cell cultures

Tassoni, A., Fornalè, S., Franceschetti, M., Musiani, F., Michael, A. J., Perry, B. & Bagni, N., Jun 2005, In : New Phytologist. 166, 3, p. 895-905 11 p.

Research output: Contribution to journalArticle

Vanadates
resveratrol
Vitis
jasmonic acid
Cell culture
38 Citations (Scopus)

Molecular analysis of alkaloid metabolism in AABB v. aabb genotype Nicotiana tabacum in response to wounding of aerial tissues and methyl jasmonate treatment of cultured roots

Cane, K. A., Mayer, M., Lidgett, A. J., Michael, A. J. & Hamill, J. D., 2005, In : Functional Plant Biology. 32, 4, p. 305-320 16 p.

Research output: Contribution to journalArticle

methyl jasmonate
Nicotiana tabacum
alkaloids
metabolism
genotype
2004
430 Citations (Scopus)

Engineering plants with increased levels of the antioxidant chlorogenic acid

Niggeweg, R., Michael, A. J. & Martin, C., Jun 2004, In : Nature Biotechnology. 22, 6, p. 746-754 9 p.

Research output: Contribution to journalArticle

Chlorogenic Acid
Antioxidants
Acids
Lycopersicon esculentum
Food
9 Citations (Scopus)

Expression proteomics identifies biochemical adaptations and defense responses in transgenic plants with perturbed polyamine metabolism

Franceschetti, M., Perry, B., Thompson, B., Hanfrey, C. & Michael, A. J., Oct 22 2004, In : FEBS Letters. 576, 3, p. 477-480 4 p.

Research output: Contribution to journalArticle

Genetically Modified Plants
Polyamines
Metabolism
Proteomics
Chloroplasts
2003
27 Citations (Scopus)

Polyamine Homeostasis in Transgenic Plants Overexpressing Ornithine Decarboxylase Includes Ornithine Limitation

Mayer, M. J. & Michael, A. J., Nov 2003, In : Journal of Biochemistry. 134, 5, p. 765-772 8 p.

Research output: Contribution to journalArticle

Ornithine
Ornithine Decarboxylase
Genetically Modified Plants
Polyamines
Homeostasis
49 Citations (Scopus)

The diverse bacterial origins of the Arabidopsis polyamine biosynthetic pathway

Illingworth, C., Mayer, M. J., Elliott, K., Hanfrey, C., Walton, N. J. & Michael, A. J., Aug 14 2003, In : FEBS Letters. 549, 1-3, p. 26-30 5 p.

Research output: Contribution to journalArticle

agmatine deiminase
Biosynthetic Pathways
Polyamines
Arabidopsis
Spermidine Synthase
23 Citations (Scopus)

Translational regulation of the plant S-adenosylmethionine decarboxylase

Hanfrey, C., Franceschetti, M., Mayer, M. J., Illingworth, C., Elliott, K., Collier, M., Thompson, B., Perry, B. & Michael, A. J., Apr 2003, In : Biochemical Society Transactions. 31, 2, p. 424-427 4 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Polyamines
Open Reading Frames
Biosynthesis
Protein Biosynthesis
2002
42 Citations (Scopus)

4-Hydroxycinnamoyl-CoA hydratase/lyase, an enzyme of phenylpropanoid cleavage from Pseudomonas, causes formation of C6-C1 acid and alcohol glucose conjugates when expressed in hairy roots of Datura stramonium L.

Mitra, A., Mayer, M. J., Mellon, F. A., Michael, A. J., Narbad, A., Parr, A. J., Waldron, K. W. & Walton, N. J., 2002, In : Planta. 215, 1, p. 79-89 11 p.

Research output: Contribution to journalArticle

Datura stramonium
lyases
Glucosides
phenylpropanoids
Pseudomonas
93 Citations (Scopus)

Abrogation of upstream open reading frame-mediated translational control of a plant S-adenosylmethionine decarboxylase results in polyamine disruption and growth perturbations

Hanfrey, C., Franceschetti, M., Mayer, M. J., Illingworth, C. & Michael, A. J., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 44131-44139 9 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Polyamines
Open Reading Frames
Growth
S-Adenosylmethionine
84 Citations (Scopus)

Characterization of the spermidine synthase-related gene family in Arabidopsis thaliana

Hanzawa, Y., Imai, A., Michael, A. J., Komeda, Y. & Takahashi, T., Sep 11 2002, In : FEBS Letters. 527, 1-3, p. 176-180 5 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Spermine Synthase
Arabidopsis
Genes
Plant Growth Regulators
2001
179 Citations (Scopus)

Arabidopsis polyamine biosynthesis: Absence of ornithine decarboxylase and the mechanism of arginine decarboxylase activity

Hanfrey, C., Sommer, S., Mayer, M. J., Burtin, D. & Michael, A. J., 2001, In : Plant Journal. 27, 6, p. 551-560 10 p.

Research output: Contribution to journalArticle

arginine decarboxylase
ornithine decarboxylase
Ornithine Decarboxylase
Polyamines
polyamines
79 Citations (Scopus)

Characterization of monocot and dicot plant S-adenosyl-L-methionine decarboxylase gene families including identification in the mRNA of a highly conserved pair of upstream overlapping open reading frames

Franceschetti, M., Hanfrey, C., Scaramagli, S., Torrigiani, P., Bagni, N., Burtin, D. & Michael, A. J., Jan 15 2001, In : Biochemical Journal. 353, 2, p. 403-409 7 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Introns
Open Reading Frames
Gene encoding
Genes