Research output per year
Research output per year
- 1 - 50 out of 284 results
Search results
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2022
Development of a biomarker to monitor target engagement after treatment with dihydroorotate dehydrogenase inhibitors
Pontikos, M. A., Leija, C., Zhao, Z., Wang, X., Kilgore, J., Tornesi, B., Adenmatten, N., Phillips, M. A. & Williams, N. S., Oct 2022, In: Biochemical Pharmacology. 204, 115237.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin
Li, B., Deng, X., Kim, S. H., Buhrow, L., Tomchick, D. R., Phillips, M. A. & Michael, A. J., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100146.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Discovery of ancestral L-ornithine and L-lysine decarboxylases reveals parallel, pseudoconvergent evolution of polyamine biosynthesis
Li, B., Liang, J., Hanfrey, C. C., Phillips, M. A. & Michael, A. J., Oct 1 2021, In: Journal of Biological Chemistry. 279, 4, 101219.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum
Lawong, A., Gahalawat, S., Okombo, J., Striepen, J., Yeo, T., Mok, S., Deni, I., Bridgford, J. L., Niederstrasser, H., Zhou, A., Posner, B., Wittlin, S., Gamo, F. J., Crespo, B., Churchyard, A., Baum, J., Mittal, N., Winzeler, E., Laleu, B., Palmer, M. J., & 4 others, Mar 11 2021, In: Journal of Medicinal Chemistry. 64, 5, p. 2739-2761 23 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
Palmer, M. J., Deng, X., Watts, S., Krilov, G., Gerasyuto, A., Kokkonda, S., El Mazouni, F., White, J., White, K. L., Striepen, J., Bath, J., Schindler, K. A., Yeo, T., Shackleford, D. M., Mok, S., Deni, I., Lawong, A., Huang, A., Chen, G., Wang, W., & 24 others, May 13 2021, In: Journal of Medicinal Chemistry. 64, 9, p. 6085-6136 52 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity
Zhang, Z., Ray, S., Imlay, L., Callaghan, L. T., Niederstrasser, H., Mallipeddi, P. L., Posner, B. A., Wetzel, D. M., Phillips, M. A. & Smith, M. W., Aug 14 2021, In: Chemical Science. 12, 30, p. 10388-10394 7 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2020
Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of malaria
Kokkonda, S., Deng, X., White, K. L., El Mazouni, F., White, J., Shackleford, D. M., Katneni, K., Chiu, F. C. K., Barker, H., Mclaren, J., Crighton, E., Chen, G., Angulo-Barturen, I., Jimenez-Diaz, M. B., Ferrer, S., Huertas-Valentin, L., Martinez-Martinez, M. S., Lafuente-Monasterio, M. J., Chittimalla, R., Shahi, S. P., & 9 others, May 14 2020, In: Journal of Medicinal Chemistry. 63, 9, p. 4929-4956 28 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2019
Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex
Uchikawa, E., Choi, E., Shang, G., Yu, H. & Xiao-Chen, B., Aug 2019, In: eLife. 8, e48630.Research output: Contribution to journal › Article › peer-review
Open Access101 Scopus citations -
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265
White, J., Dhingra, S. K., Deng, X., El Mazouni, F., Lee, M. C. S., Afanador, G. A., Lawong, A., Tomchick, D. R., Ng, C. L., Bath, J., Rathod, P. K., Fidock, D. A. & Phillips, M. A., Nov 1 2019, In: ACS infectious diseases. 5, 1, p. 90-101 12 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment
Yang, H., Zhang, F., Huang, C. J., Liao, J., Han, Y., Hao, P., Chu, Y., Lu, X., Li, W., Yu, H. & Kang, J., 2019, In: Molecular biology of the cell. 30, 9, p. 1060-1068 9 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
PUMILIO hyperactivity drives premature aging of norad-deficient mice
Kopp, F., Elguindy, M. M., Yalvac, M. E., Zhang, H., Chen, B., Gillett, F. A., Lee, S., Sivakumar, S., Yu, H., Xie, Y., Mishra, P., Sahenk, Z. & Mendell, J. T., Feb 2019, In: eLife. 8, e42650.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
Racial profiling harms science
Lu, S., Han, Z., Hung, M. C., Xu, J., Xu, Y., Zheng, P., Zheng, Z. M., Zou, L., Li, Z., Zheng, L., Kang, Y., Yang, Y., He, L., Liao, X. C., Yu, H., Yue, Z., Liu, S. L. & Zheng, H., Mar 22 2019, In: Science. 363, 6433, p. 1290-1292 3 p.Research output: Contribution to journal › Letter › peer-review
2 Scopus citations -
Structural basis of tubulin detyrosination by vasohibins
Li, F., Hu, Y., Qi, S., Luo, X. & Yu, H., Jul 1 2019, In: Nature Structural and Molecular Biology. 26, 7, p. 583-591 9 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan
Li, F., Raczynska, J. E., Chen, Z. & Yu, H., Mar 19 2019, In: Cell Reports. 26, 12, p. 3336-3346.e4Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
2018
A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei
Patel, M. M., Volkov, O. A., Leija, C., Lemoff, A. & Phillips, M. A., Oct 2018, In: PLoS pathogens. 14, 10, e1007404.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study
Llanos-Cuentas, A., Casapia, M., Chuquiyauri, R., Hinojosa, J. C., Kerr, N., Rosario, M., Toovey, S., Arch, R. H., Phillips, M. A., Rozenberg, F. D., Bath, J., Ng, C. L., Cowell, A. N., Winzeler, E. A., Fidock, D. A., Baker, M., Möhrle, J. J., Hooft van Huijsduijnen, R., Gobeau, N., Araeipour, N., & 3 others, Aug 2018, In: The Lancet Infectious Diseases. 18, 8, p. 874-883 10 p.Research output: Contribution to journal › Article › peer-review
Open Access95 Scopus citations -
Assessing drug efficacy against Plasmodium falciparum liver stages in vivo
Flannery, E. L., Foquet, L., Chuenchob, V., Fishbaugher, M., Billman, Z., Navarro, M. J., Betz, W., Olsen, T. M., Lee, J., Camargo, N., Nguyen, T., Schafer, C., Sack, B. K., Wilson, E. M., Saunders, J., Bial, J., Campo, B., Charman, S. A., Murphy, S. C., Phillips, M. A., & 2 others, Jan 11 2018, In: JCI Insight. 3, 1Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
CENP-T bears the load in mitosis
Yang, Y. & Yu, H., Dec 1 2018, In: Nature cell biology. 20, 12, p. 1335-1337 3 p.Research output: Contribution to journal › Comment/debate › peer-review
1 Scopus citations -
Cyclin A Turns on Bora to Light the Path to Mitosis
Zheng, G. & Yu, H., Jun 4 2018, In: Developmental cell. 45, 5, p. 542-543 2 p.Research output: Contribution to journal › Short survey › peer-review
4 Scopus citations -
Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion
Cortone, G., Zheng, G., Pensieri, P., Chiappetta, V., Tatè, R., Malacaria, E., Pichierri, P., Yu, H. & Pisani, F. M., Oct 2018, In: PLoS genetics. 14, 10, e1007622.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
Kokkonda, S., El Mazouni, F., White, K. L., White, J., Shackleford, D. M., Lafuente-Monasterio, M. J., Rowland, P., Manjalanagara, K., Joseph, J. T., Garcia-Pérez, A., Fernandez, J., Gamo, F. J., Waterson, D., Burrows, J. N., Palmer, M. J., Charman, S. A., Rathod, P. K. & Phillips, M. A., Aug 31 2018, In: ACS Omega. 3, 8, p. 9227-9240 14 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
MCM2–7-dependent cohesin loading during s phase promotes sister-chromatid cohesion
Zheng, G., Kanchwala, M., Xing, C. & Yu, H., Apr 3 2018, In: eLife. 7, e33920.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Partner switching for Ran during the mitosis dance
Yang, Y. & Yu, H., Feb 1 2018, In: Journal of molecular cell biology. 10, 1, p. 89-90 2 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Polyamines in protozoan pathogens
Phillips, M. A., Nov 30 2018, In: Journal of Biological Chemistry. 293, 48, p. 18746-18756 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access33 Scopus citations -
Scc2 Is a Potent Activator of Cohesin's ATPase that Promotes Loading by Binding Scc1 without Pds5
Petela, N. J., Gligoris, T. G., Metson, J., Lee, B. G., Voulgaris, M., Hu, B., Kikuchi, S., Chapard, C., Chen, W., Rajendra, E., Srinivisan, M., Yu, H., Löwe, J. & Nasmyth, K. A., Jun 21 2018, In: Molecular cell. 70, 6, p. 1134-1148.e7Research output: Contribution to journal › Article › peer-review
Open Access94 Scopus citations -
Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase
Volkov, O. A., Brockway, A. J., Wring, S. A., Peel, M., Chen, Z., Phillips, M. A. & De Brabander, J. K., Feb 8 2018, In: Journal of Medicinal Chemistry. 61, 3, p. 1182-1203 22 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Sumoylation promotes optimal apc/c activation and timely anaphase
Lee, C. C., Li, B., Yu, H. & Matunis, M. J., Mar 8 2018, In: eLife. 7, e29539.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
The BUB3-BUB1 Complex Promotes Telomere DNA Replication
Li, F., Kim, H., Ji, Z., Zhang, T., Chen, B., Ge, Y., Hu, Y., Feng, X., Han, X., Xu, H., Zhang, Y., Yu, H., Liu, D., Ma, W. & Songyang, Z., May 3 2018, In: Molecular cell. 70, 3, p. 395-407.e4Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation
Lee, H. S., Lin, Z., Chae, S., Yoo, Y. S., Kim, B. G., Lee, Y., Johnson, J. L., Kim, Y. S., Cantley, L. C., Lee, C. W., Yu, H. & Cho, H., Dec 1 2018, In: Nature communications. 9, 1, 3848.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Toward a chemical vaccine for malaria A high-throughput screen puts us on the road to protecting populations against malaria
Phillips, M. A. & Goldberg, D. E., Dec 7 2018, In: Science. 362, 6419, p. 1112-1113 2 p.Research output: Contribution to journal › Short survey › peer-review
5 Scopus citations -
Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs
Afanador, G. A., Tomchick, D. R. & Phillips, M. A., Nov 6 2018, In: Structure. 26, 11, p. 1499-1512.e5Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2017
A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling
Ji, Z., Gao, H., Jia, L., Li, B. & Yu, H., Jan 10 2017, In: eLife. 6, e22513.Research output: Contribution to journal › Article › peer-review
Open Access108 Scopus citations -
Biochemical and functional assays of human cohesin-releasing factor Wapl
Zheng, G., Ouyang, Z. & Yu, H., 2017, Methods in Molecular Biology. Humana Press Inc., p. 37-53 17 p. (Methods in Molecular Biology; vol. 1515).Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
Familial stag2 germline mutation defines a new human cohesinopathy
Soardi, F. C., Machado-Silva, A., Linhares, N. D., Zheng, G., Qu, Q., Pena, H. B., Martins, T. M. M., Vieira, H. G. S., Pereira, N. B., Melo-Minardi, R. C., Gomes, C. C., Gomez, R. S., Gomes, D. A., Pires, D. E. V., Ascher, D. B., Yu, H. & Pena, S. D. J., Dec 1 2017, In: npj Genomic Medicine. 2, 1, 7.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay
Volkov, O. A., Cosner, C. C., Brockway, A. J., Kramer, M., Booker, M., Zhong, S., Ketcherside, A., Wei, S., Longgood, J., McCoy, M., Richardson, T. E., Wring, S. A., Peel, M., Klinger, J. D., Posner, B. A., De Brabander, J. K. & Phillips, M. A., Jul 14 2017, In: ACS infectious diseases. 3, 7, p. 512-526 15 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Malaria
Phillips, M. A., Burrows, J. N., Manyando, C., Van Huijsduijnen, R. H., Van Voorhis, W. C. & Wells, T. N. C., Aug 3 2017, In: Nature Reviews Disease Primers. 3, 17050.Research output: Contribution to journal › Article › peer-review
Open Access409 Scopus citations -
Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
Brulotte, M. L., Jeong, B. C., Li, F., Li, B., Yu, E. B., Wu, Q., Brautigam, C. A., Yu, H. & Luo, X., Dec 1 2017, In: Nature communications. 8, 1, 1956.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Medicinal Chemistry Case History: Discovery of the Dihydroorate Dehydrogenase Inhibitor DSM265 as an Antimalarial Drug Candidate
Phillips, M. A., Rathod, P. K., Rueckle, T., Matthews, D., Burrows, J. N. & Charman, S. A., Jun 3 2017, Case Histories in Recent Drug Discovery. Elsevier Inc., Vol. 8-8. p. 544-557 14 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
4 Scopus citations -
Mitotic transcription and waves of gene reactivation during mitotic exit
Palozola, K. C., Donahue, G., Liu, H., Grant, G. R., Becker, J. S., Cote, A., Yu, H., Raj, A. & Zaret, K. S., Oct 6 2017, In: Science. 358, 6359, p. 119-122 4 p.Research output: Contribution to journal › Article › peer-review
Open Access143 Scopus citations -
Releasing the cohesin ring: A rigid scaffold model for opening the DNA exit gate by Pds5 and Wapl
Ouyang, Z. & Yu, H., Apr 1 2017, In: BioEssays. 39, 4, 1600207.Research output: Contribution to journal › Review article › peer-review
22 Scopus citations -
Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study
McCarthy, J. S., Lotharius, J., Rückle, T., Chalon, S., Phillips, M. A., Elliott, S., Sekuloski, S., Griffin, P., Ng, C. L., Fidock, D. A., Marquart, L., Williams, N. S., Gobeau, N., Bebrevska, L., Rosario, M., Marsh, K. & Möhrle, J. J., Jun 2017, In: The Lancet Infectious Diseases. 17, 6, p. 626-635 10 p.Research output: Contribution to journal › Article › peer-review
Open Access96 Scopus citations -
Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression
Zhang, Q., Sivakumar, S., Chen, Y., Gao, H., Yang, L., Yuan, Z., Yu, H. & Liu, H., May 22 2017, In: Current Biology. 27, 10, p. 1477-1484.e4Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
Synthesis and evaluation of analogs of 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (MDL 73811, or AbeAdo) – An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity
Brockway, A. J., Volkov, O. A., Cosner, C. C., MacMillan, K. S., Wring, S. A., Richardson, T. E., Peel, M., Phillips, M. A. & De Brabander, J. K., 2017, In: Bioorganic and Medicinal Chemistry. 25, 20, p. 5433-5440 8 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2016
A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria
Phillips, M. A., White, K. L., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Shackleford, D. M., Chiu, F. C. K., Campbell, M., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I., & 16 others, Dec 9 2016, In: ACS infectious diseases. 2, 12, p. 945-957 13 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Scopus citations -
Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation
Craney, A., Kelly, A., Jia, L., Fedrigo, I., Yu, H. & Rape, M., Feb 9 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 6, p. 1540-1545 6 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy
Kikuchi, S., Borek, D. M., Otwinowski, Z., Tomchick, D. R. & Yu, H., Nov 1 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 44, p. 12444-12449 6 p.Research output: Contribution to journal › Article › peer-review
Open Access78 Scopus citations -
Evaluation of antigens for development of a serological test for human african trypanosomiasis
Biéler, S., Waltenberger, H., Barrett, M. P., McCulloch, R., Mottram, J. C., Carrington, M., Schwaeble, W., McKerrowa, J., Phillips, M. A., Michels, P. A., Büscher, P., Sanchez, J. C., Bishop, R., Robinson, D. R., Bangsb, J., Ferguson, M., Nerima, B., Albertini, A., Michel, G., Radwandskac, M., & 1 others, Dec 2016, In: PloS one. 11, 12, e0168074.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening
Pavadai, E., El Mazouni, F., Wittlin, S., De Kock, C., Phillips, M. A. & Chibale, K., Mar 28 2016, In: Journal of Chemical Information and Modeling. 56, 3, p. 548-562 15 p.Research output: Contribution to journal › Article › peer-review
57 Scopus citations -
Improved Synthesis of MDL 73811 - A Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound
Brockway, A. J., Cosner, C. C., Volkov, O. A., Phillips, M. A. & De Brabander, J. K., Jul 1 2016, In: Synthesis (Germany). 48, 13, p. 2065-2068 4 p., ss-2016-m0105-op.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Magic Acts with the Cohesin Ring
Yu, H., Feb 18 2016, In: Molecular cell. 61, 4, p. 489-491 3 p.Research output: Contribution to journal › Short survey › peer-review
Open Access6 Scopus citations