Pharmacology - Phillips Lab

Research Output 1987 2019

Filter
Article
2019

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex

Uchikawa, E., Choi, E., Shang, G., Yu, H. & Bai, X. C., Aug 22 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Insulin Receptor
Insulins
Chemical activation
Ligands
Dimers
3 Citations (Scopus)

Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

Choi, E., Kikuchi, S., Gao, H., Brodzik, K., Nassour, I., Yopp, A. C., Singal, A., Zhu, H. & Yu, H., Dec 1 2019, In : Nature communications. 10, 1, 1473.

Research output: Contribution to journalArticle

Open Access
Dual Specificity Phosphatase 1
insulin
phosphatases
regulators
Insulin Receptor

Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment

Yang, H., Zhang, F., Huang, C. J., Liao, J., Han, Y., Hao, P., Chu, Y., Lu, X., Li, W., Yu, H. & Kang, J., Jan 1 2019, In : Molecular Biology of the Cell. 30, 9, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

Kinetochores
Microtubules
Chromosomes
M Phase Cell Cycle Checkpoints
Anaphase
6 Citations (Scopus)

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Kopp, F., Elguindy, M. M., Yalvac, M. E., Zhang, H., Chen, B., Gillett, F. A., Lee, S., Sivakumar, S., Yu, H., Xie, Y., Mishra, P., Sahenk, Z. & Mendell, J. T., Feb 8 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Premature Aging
Aging of materials
Physiology
Phenotype

Structural basis of the activation of type 1 insulin-like growth factor receptor

Li, J., Choi, E., Yu, H. & Bai, X. C., Dec 1 2019, In : Nature communications. 10, 1, 4567.

Research output: Contribution to journalArticle

Open Access
IGF Type 1 Receptor
insulin
Protein Subunits
Receptor Protein-Tyrosine Kinases
Dimerization
1 Citation (Scopus)

Structural basis of tubulin detyrosination by vasohibins

Li, F., Hu, Y., Qi, S., Luo, X. & Yu, H., Jul 1 2019, In : Nature Structural and Molecular Biology. 26, 7, p. 583-591 9 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
Carrier Proteins
Post Translational Protein Processing
Biological Products
2018
1 Citation (Scopus)
Adenosylmethionine Decarboxylase
Trypanosoma brucei brucei
S-Adenosylmethionine
Polyamines
Enzymes
16 Citations (Scopus)

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

Llanos-Cuentas, A., Casapia, M., Chuquiyauri, R., Hinojosa, J. C., Kerr, N., Rosario, M., Toovey, S., Arch, R. H., Phillips, M. A., Rozenberg, F. D., Bath, J., Ng, C. L., Cowell, A. N., Winzeler, E. A., Fidock, D. A., Baker, M., Möhrle, J. J., Hooft van Huijsduijnen, R., Gobeau, N., Araeipour, N. & 3 others, Andenmatten, N., Rückle, T. & Duparc, S., Jan 1 2018, (Accepted/In press) In : The Lancet Infectious Diseases.

Research output: Contribution to journalArticle

Vivax Malaria
Plasmodium
Antimalarials
Plasmodium falciparum
Infection
6 Citations (Scopus)

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo

Flannery, E. L., Foquet, L., Chuenchob, V., Fishbaugher, M., Billman, Z., Navarro, M. J., Betz, W., Olsen, T. M., Lee, J., Camargo, N., Nguyen, T., Schafer, C., Sack, B. K., Wilson, E. M., Saunders, J., Bial, J., Campo, B., Charman, S. A., Murphy, S. C., Phillips, M. A. & 2 others, Kappe, S. H. & Mikolajczak, S. A., Jan 11 2018, In : JCI insight. 3, 1

Research output: Contribution to journalArticle

Open Access
Plasmodium falciparum
Liver
Pharmaceutical Preparations
Antimalarials
Parasites
2 Citations (Scopus)

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

White, J., Dhingra, S. K., Deng, X., El Mazouni, F., Lee, M. C. S., Afanador, G. A., Lawong, A., Tomchick, D. R., Ng, C. L., Bath, J., Rathod, P. K., Fidock, D. A. & Phillips, M. A., Jan 1 2018, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Plasmodium falciparum
Point Mutation
Parasites
Malaria
Mutation
3 Citations (Scopus)

Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion

Cortone, G., Zheng, G., Pensieri, P., Chiappetta, V., Tatè, R., Malacaria, E., Pichierri, P., Yu, H. & Pisani, F. M., Oct 1 2018, In : PLoS Genetics. 14, 10, p. e1007622

Research output: Contribution to journalArticle

DNA helicases
DNA Helicases
Chromatids
chromatids
breakage
5 Citations (Scopus)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

Kokkonda, S., El Mazouni, F., White, K. L., White, J., Shackleford, D. M., Lafuente-Monasterio, M. J., Rowland, P., Manjalanagara, K., Joseph, J. T., Garcia-Pérez, A., Fernandez, J., Gamo, F. J., Waterson, D., Burrows, J. N., Palmer, M. J., Charman, S. A., Rathod, P. K. & Phillips, M. A., Aug 31 2018, In : ACS Omega. 3, 8, p. 9227-9240 14 p.

Research output: Contribution to journalArticle

Antimalarials
Pharmacokinetics
Pharmaceutical Preparations
Lead
dihydroorotate dehydrogenase
14 Citations (Scopus)

MCM2–7-dependent cohesin loading during s phase promotes sister-chromatid cohesion

Zheng, G., Kanchwala, M., Xing, C. & Yu, H., Apr 3 2018, In : eLife. 7, e33920.

Research output: Contribution to journalArticle

Chromatids
Chemical activation
Loaders
Nucleosomes
Interphase
3 Citations (Scopus)

Partner switching for Ran during the mitosis dance

Yang, Y. & Yu, H., Feb 1 2018, In : Journal of molecular cell biology. 10, 1, p. 89-90 2 p.

Research output: Contribution to journalArticle

Open Access
Mitosis
17 Citations (Scopus)

Scc2 Is a Potent Activator of Cohesin's ATPase that Promotes Loading by Binding Scc1 without Pds5

Petela, N. J., Gligoris, T. G., Metson, J., Lee, B. G., Voulgaris, M., Hu, B., Kikuchi, S., Chapard, C., Chen, W., Rajendra, E., Srinivisan, M., Yu, H., Löwe, J. & Nasmyth, K. A., Jun 21 2018, In : Molecular Cell. 70, 6, p. 1134-1148.e7

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Adenosine Triphosphate
Chromatids
Chromosomes
Mutation
4 Citations (Scopus)

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase

Volkov, O. A., Brockway, A. J., Wring, S. A., Peel, M., Chen, Z., Phillips, M. A. & De Brabander, J. K., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1182-1203 22 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Trypanosoma brucei brucei
African Trypanosomiasis
Parasites
Enzymes
7 Citations (Scopus)

Sumoylation promotes optimal apc/c activation and timely anaphase

Lee, C. C., Li, B., Yu, H. & Matunis, M. J., Mar 8 2018, In : eLife. 7, e29539.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
Sumoylation
Anaphase
Chemical activation
Mitosis
7 Citations (Scopus)

The BUB3-BUB1 Complex Promotes Telomere DNA Replication

Li, F., Kim, H., Ji, Z., Zhang, T., Chen, B., Ge, Y., Hu, Y., Feng, X., Han, X., Xu, H., Zhang, Y., Yu, H., Liu, D., Ma, W. & Songyang, Z., Jan 1 2018, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

Telomere
DNA Replication
S Phase
Telomere-Binding Proteins
Nucleoproteins
2 Citations (Scopus)

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation

Lee, H. S., Lin, Z., Chae, S., Yoo, Y. S., Kim, B. G., Lee, Y., Johnson, J. L., Kim, Y. S., Cantley, L. C., Lee, C. W., Yu, H. & Cho, H., Sep 21 2018, In : Nature Communications. 9, 1, 1 p.

Research output: Contribution to journalArticle

Histone Code
acetylation
Acetylation
Chromosome Segregation
phosphorylation
2 Citations (Scopus)

Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs

Afanador, G. A., Tomchick, D. R. & Phillips, M. A., Nov 6 2018, In : Structure. 26, 11, p. 1499-1512.e5

Research output: Contribution to journalArticle

Catalytic Domain
Trypanosoma brucei brucei
X-Rays
Neglected Diseases
Eukaryotic Initiation Factors
2017
41 Citations (Scopus)

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

Ji, Z., Gao, H., Jia, L., Li, B. & Yu, H., Jan 10 2017, In : eLife. 6, e22513.

Research output: Contribution to journalArticle

Kinetochores
Phosphorylation
Anaphase-Promoting Complex-Cyclosome
M Phase Cell Cycle Checkpoints
Chromosomes
12 Citations (Scopus)

Familial stag2 germline mutation defines a new human cohesinopathy

Soardi, F. C., Machado-Silva, A., Linhares, N. D., Zheng, G., Qu, Q., Pena, H. B., Martins, T. M. M., Vieira, H. G. S., Pereira, N. B., Melo-Minardi, R. C., Gomes, C. C., Gomez, R. S., Gomes, D. A., Pires, D. E. V., Ascher, D. B., Yu, H. & Pena, S. D. J., Dec 1 2017, In : npj Genomic Medicine. 2, 1, 7.

Research output: Contribution to journalArticle

Germ-Line Mutation
Phenotype
cdc Genes
Chromatids
Intellectual Disability
6 Citations (Scopus)

Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay

Volkov, O. A., Cosner, C. C., Brockway, A. J., Kramer, M., Booker, M., Zhong, S., Ketcherside, A., Wei, S., Longgood, J., McCoy, M., Richardson, T. E., Wring, S. A., Peel, M., Klinger, J. D., Posner, B. A., De Brabander, J. K. & Phillips, M. A., Jul 14 2017, In : ACS Infectious Diseases. 3, 7, p. 512-526 15 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Trypanosoma brucei brucei
African Trypanosomiasis
Mass Spectrometry
Parasites
80 Citations (Scopus)

Malaria

Phillips, M. A., Burrows, J. N., Manyando, C., Van Huijsduijnen, R. H., Van Voorhis, W. C. & Wells, T. N. C., Aug 3 2017, In : Nature Reviews Disease Primers. 3, 17050.

Research output: Contribution to journalArticle

Malaria
Insecticides
Parasites
Insecticide-Treated Bednets
Pharmaceutical Preparations
6 Citations (Scopus)

Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

Brulotte, M. L., Jeong, B. C., Li, F., Li, B., Yu, E. B., Wu, Q., Brautigam, C. A., Yu, H. & Luo, X., Dec 1 2017, In : Nature Communications. 8, 1, 1956.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
M Phase Cell Cycle Checkpoints
spindles
Mad2 Proteins
proteins
34 Citations (Scopus)

Mitotic transcription and waves of gene reactivation during mitotic exit

Palozola, K. C., Donahue, G., Liu, H., Grant, G. R., Becker, J. S., Cote, A., Yu, H., Raj, A. & Zaret, K. S., Oct 6 2017, In : Science. 358, 6359, p. 119-122 4 p.

Research output: Contribution to journalArticle

Mitosis
Genes
Interphase
Fluorescein
Fluorescence In Situ Hybridization
10 Citations (Scopus)

Releasing the cohesin ring: A rigid scaffold model for opening the DNA exit gate by Pds5 and Wapl

Ouyang, Z. & Yu, H., 2017, (Accepted/In press) In : BioEssays.

Research output: Contribution to journalArticle

Scaffolds
Adenosine Triphosphatases
DNA
Adenosine Triphosphate
Acetylation
38 Citations (Scopus)

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

McCarthy, J. S., Lotharius, J., Rückle, T., Chalon, S., Phillips, M. A., Elliott, S., Sekuloski, S., Griffin, P., Ng, C. L., Fidock, D. A., Marquart, L., Williams, N. S., Gobeau, N., Bebrevska, L., Rosario, M., Marsh, K. & Möhrle, J. J., Jun 1 2017, In : The Lancet Infectious Diseases. 17, 6, p. 626-635 10 p.

Research output: Contribution to journalArticle

Antimalarials
Pharmacokinetics
Safety
Mefloquine
Half-Life
17 Citations (Scopus)

Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression

Zhang, Q., Sivakumar, S., Chen, Y., Gao, H., Yang, L., Yuan, Z., Yu, H. & Liu, H., May 22 2017, In : Current Biology. 27, 10, p. 1477-1484.e4

Research output: Contribution to journalArticle

Protein Phosphatase 1
Kinetochores
kinetochores
Phosphorylation
Chromosomes
2 Citations (Scopus)

Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity

Brockway, A. J., Volkov, O. A., Cosner, C. C., MacMillan, K. S., Wring, S. A., Richardson, T. E., Peel, M., Phillips, M. A. & De Brabander, J. K., 2017, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
African Trypanosomiasis
Lead compounds
Antiparasitic Agents
Trypanosoma brucei brucei
2016
30 Citations (Scopus)

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

Phillips, M. A., White, K. L., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Shackleford, D. M., Chiu, F. C. K., Campbell, M., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 16 others, Martinez, M. S., Lafuente-Monasterio, M., Kaminsky, W., Silue, K., Zeeman, A. M., Kocken, C., Leroy, D., Blasco, B., Rossignol, E., Rueckle, T., Matthews, D., Burrows, J. N., Waterson, D., Palmer, M. J., Rathod, P. K. & Charman, S. A., Dec 9 2016, In : ACS Infectious Diseases. 2, 12, p. 945-957 13 p.

Research output: Contribution to journalArticle

Malaria
Pharmaceutical Preparations
Vivax Malaria
SCID Mice
Plasmodium
21 Citations (Scopus)

Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation

Craney, A., Kelly, A., Jia, L., Fedrigo, I., Yu, H. & Rape, M., Feb 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 6, p. 1540-1545 6 p.

Research output: Contribution to journalArticle

Ubiquitin C
Phosphorylation
Anaphase-Promoting Complex-Cyclosome
Kinetochores
Ubiquitin-Protein Ligases
26 Citations (Scopus)
Chromatids
Chaetomium
Adenosine Triphosphatases
Chromosomes
cohesins
2 Citations (Scopus)

Evaluation of antigens for development of a serological test for human african trypanosomiasis

Biéler, S., Waltenberger, H., Barrett, M. P., McCulloch, R., Mottram, J. C., Carrington, M., Schwaeble, W., McKerrowa, J., Phillips, M. A., Michels, P. A., Büscher, P., Sanchez, J. C., Bishop, R., Robinson, D. R., Bangsb, J., Ferguson, M., Nerima, B., Albertini, A., Michel, G., Radwandskac, M. & 1 others, Ndung'U, J. M., Dec 1 2016, In : PLoS One. 11, 12, e0168074.

Research output: Contribution to journalArticle

African trypanosomiasis
African Trypanosomiasis
Serologic Tests
immunologic techniques
antigens
33 Citations (Scopus)

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening

Pavadai, E., El Mazouni, F., Wittlin, S., De Kock, C., Phillips, M. A. & Chibale, K., Mar 28 2016, In : Journal of Chemical Information and Modeling. 56, 3, p. 548-562 15 p.

Research output: Contribution to journalArticle

Screening
Values
mechanic
cancer
drug
2 Citations (Scopus)

Improved Synthesis of MDL 73811 - A Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound

Brockway, A. J., Cosner, C. C., Volkov, O. A., Phillips, M. A. & De Brabander, J. K., Jul 1 2016, In : Synthesis (Germany). 48, 13, p. 2065-2068 4 p., ss-2016-m0105-op.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Chemical activation
MDL 73811
5 Citations (Scopus)

Magic Acts with the Cohesin Ring

Yu, H., Feb 18 2016, In : Molecular Cell. 61, 4, p. 489-491 3 p.

Research output: Contribution to journalArticle

Magic
Hydrolysis
Chromosomes
Adenosine Triphosphate
cohesins
24 Citations (Scopus)

Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis

Choi, E., Zhang, X., Xing, C. & Yu, H., Jul 28 2016, In : Cell. 166, 3, p. 567-581 15 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Insulin Receptor
Homeostasis
Insulin
Chromosomes
205 Citations (Scopus)

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

Lee, S., Kopp, F., Chang, T. C., Sataluri, A., Chen, B., Sivakumar, S., Yu, H., Xie, Y. & Mendell, J. T., Jan 14 2016, In : Cell. 164, 1-2, p. 69-80 12 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Untranslated RNA
Genomic Instability
DNA Damage
DNA
5 Citations (Scopus)

Opposing functions of the N-terminal acetyltransferases Naa50 and NatA in sister-chromatid cohesion

Rong, Z., Ouyang, Z., Magin, R. S., Marmorstein, R. & Yu, H., Sep 2 2016, In : Journal of Biological Chemistry. 291, 36, p. 19079-19091 13 p.

Research output: Contribution to journalArticle

N-Terminal Acetyltransferase A
N-Terminal Acetyltransferases
Chromatids
Acetylation
Defects
9 Citations (Scopus)

Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei

Leija, C., Rijo-Ferreira, F., Kinch, L. N., Grishin, N. V., Nischan, N., Kohler, J. J., Hu, Z. & Phillips, M. A., Nov 1 2016, In : PLoS Pathogens. 12, 11, e1006010.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Thymidine Kinase
Nucleotides
Enzymes
Nucleosides
11 Citations (Scopus)

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

Volkov, O. A., Kinch, L., Ariagno, C., Deng, X., Zhong, S., Grishin, N., Tomchick, D. R., Chen, Z. & Phillips, M. A., Dec 15 2016, In : eLife. 5, DECEMBER2016, e20198.

Research output: Contribution to journalArticle

Enzyme Activation
Chemical activation
Switches
Enzymes
Adenosylmethionine Decarboxylase
24 Citations (Scopus)

Structural basis of cohesin cleavage by separase

Lin, Z., Luo, X. & Yu, H., Apr 7 2016, In : Nature. 532, 7597, p. 131-134 4 p.

Research output: Contribution to journalArticle

Separase
Securin
Chromosome Segregation
Chromosomes
Chaetomium
30 Citations (Scopus)

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Kokkonda, S., Deng, X., White, K. L., Coteron, J. M., Marco, M., De Las Heras, L., White, J., El Mazouni, F., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Chen, G., Morizzi, J., Ryan, E., Kaminsky, W., Leroy, D., Martínez-Martínez, M. S., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 6 others, Waterson, D., Burrows, J. N., Matthews, D., Charman, S. A., Phillips, M. A. & Rathod, P. K., Jun 9 2016, In : Journal of Medicinal Chemistry. 59, 11, p. 5416-5431 16 p.

Research output: Contribution to journalArticle

Antimalarials
Plasmodium falciparum
Malaria
Halogens
SCID Mice
39 Citations (Scopus)

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation

Jia, L., Li, B. & Yu, H., Feb 25 2016, In : Nature Communications. 7, 10818.

Research output: Contribution to journalArticle

Anaphase-Promoting Complex-Cyclosome
M Phase Cell Cycle Checkpoints
phosphorylation
Phosphorylation
spindles
31 Citations (Scopus)

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

Sivakumar, S., Janczyk, P., Qu, Q., Brautigam, C. A., Stukenberg, P. T., Yu, H. & Gorbsky, G. J., Mar 16 2016, In : eLife. 5, MARCH2016, e12902.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Kinetochores
Anaphase
Metaphase
Cell Cycle
2015
109 Citations (Scopus)

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Phillips, M. A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K. L., Njoroge, J. W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D. R., Deng, X., Laird, T., Bhatia, S. N., March, S., Ng, C. L., Fidock, D. A., Wittlin, S., Lafuente-Monasterio, M., Benito, F. J. G. & 33 others, Alonso, L. M. S., Martinez, M. S., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I., Haselden, J. N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A. M., Kocken, C., Sauerwein, R., Dechering, K., Avery, V. M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K. S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D., Rogers, M. J., Rathod, P. K., Burrows, J. N. & Charman, S. A., Jul 15 2015, In : Science Translational Medicine. 7, 296, aaa6645.

Research output: Contribution to journalArticle

Malaria
Parasites
Drug Combinations
Therapeutics
Liver
8 Citations (Scopus)

A teach-discover-treat application of ZincPharmer: An online interactive pharmacophore modeling and virtual screening tool

Koes, D. R., Pabon, N. A., Deng, X., Phillips, M. A. & Camacho, C. J., Aug 10 2015, In : PLoS One. 10, 8, e0134697.

Research output: Contribution to journalArticle

Screening
screening
antimalarials
crystals
Antimalarials
7 Citations (Scopus)

Atovaquone tolerance in plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor

Guler, J. L., White, J., Phillips, M. A. & Rathoda, P. K., Jan 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 1, p. 686-689 4 p.

Research output: Contribution to journalArticle

Atovaquone
Antimalarials
Plasmodium falciparum
Respiration
Parasites
33 Citations (Scopus)

Cancer: The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling

Nyati, S., Schinske-Sebolt, K., Pitchiaya, S., Chekhovskiy, K., Chator, A., Chaudhry, N., Dosch, J., Van Dort, M. E., Varambally, S., Kumar-Sinha, C., Nyati, M. K., Ray, D., Walter, N. G., Yu, H., Ross, B. D. & Rehemtulla, A., Jan 6 2015, In : Science Signaling. 8, 358, ra1.

Research output: Contribution to journalArticle

Benzimidazoles
Transforming Growth Factors
Phosphotransferases
Neoplasms
Bearings (structural)