Pharmacology - Reese Lab

Research Output

2020

Loss of a conserved MAPK causes catastrophic failure in assembly of a specialized cilium-like structure in Toxoplasma gondii

O'Shaughnessy, W. J., Hu, X., Beraki, T., McDougal, M. & Reese, M. L., Apr 15 2020, In : Molecular biology of the cell. 31, 9, p. 881-888 8 p.

Research output: Contribution to journalArticle

2019
Open Access

Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole

Beraki, T., Hu, X., Broncel, M., Young, J. C., O'Shaughnessy, W. J., Borek, D., Treeck, M. & Reese, M. L., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6361-6370 10 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals

Park, B. C., Reese, M. & Tagliabracci, V. S., Jun 2019, In : IUBMB life. 71, 6, p. 749-759 11 p.

Research output: Contribution to journalReview article

2018

The assembly of lipid droplets and their roles in challenged cells

Henne, W. M., Reese, M. L. & Goodman, J. M., Jun 15 2018, In : EMBO Journal. 37, 12, e98947.

Research output: Contribution to journalReview article

35 Scopus citations
2017

The coccidian parasites Toxoplasma and Neospora dysregulate mammalian lipid droplet biogenesis

Hu, X., Binns, D. & Reese, M. L., Jun 30 2017, In : Journal of Biological Chemistry. 292, 26, p. 11009-11020 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Toxoplasma DJ-1 regulates organelle secretion by a direct interaction with calcium-dependent protein kinase 1

Child, M. A., Garland, M., Foe, I., Madzelan, P., Treeck, M., Van Der Linden, W. A., Bender, K. O., Weerapana, E., Wilson, M. A., Boothroyd, J. C., Reese, M. L. & Bogyo, M., Jan 1 2017, In : mBio. 8, 1, e02189-16.

Research output: Contribution to journalArticle

6 Scopus citations
2014

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Murphy, J. M., Zhang, Q., Young, S. N., Reese, M. L., Bailey, F. P., Eyers, P. A., Ungureanu, D., Hammaren, H., Silvennoinen, O., Varghese, L. N., Chen, K., Tripaydonis, A., Jura, N., Fukuda, K., Qin, J., Nimchuk, Z., Mudgett, M. B., Elowe, S., Gee, C. L., Liu, L. & 4 others, Daly, R. J., Manning, G., Babon, J. J. & Lucet, I. S., Jan 15 2014, In : Biochemical Journal. 457, 2, p. 323-334 12 p.

Research output: Contribution to journalArticle

131 Scopus citations

Expression of the essential kinase PFCDPK1 from plasmodium falciparum in toxoplasma gondii facilitates the discovery of novel antimalarial drugs

Gaji, R. Y., Checkley, L., Reese, M. L., Ferdig, M. T. & Arrizabalaga, G., May 2014, In : Antimicrobial agents and chemotherapy. 58, 5, p. 2598-2607 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Impact of regulated secretion on antiparasitic CD8 T cell responses

Grover, H., Chu, H. H., Kelly, F., Yang, S., Reese, M., Blanchard, N., Gonzalez, F., Chan, S., Boothroyd, J., Shastri, N. & Robey, E., Jun 12 2014, In : Cell Reports. 7, 5, p. 1716-1728 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

The toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases

Reese, M. L., Shah & Boothroyd, J. C., Oct 3 2014, In : Journal of Biological Chemistry. 289, 40, p. 27849-27858 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2013

Immune to defeat

Reese, M. L., Oct 29 2013, In : eLife. 2013, 2, e01599.

Research output: Contribution to journalArticle

Interactions Between Toxoplasma Effectors and Host Immune Responses

Butcher, B. A., Reese, M. L., Boothroyd, J. C. & Denkers, E. Y., Sep 1 2013, Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition. Elsevier Ltd, p. 505-519 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2012

A toxoplasma gondii pseudokinase inhibits host irg resistance proteins

Fleckenstein, M. C., Reese, M. L., Könen-Waisman, S., Boothroyd, J. C., Howard, J. C. & Steinfeldt, T., Jul 1 2012, In : PLoS biology. 10, 7, 1 p., e1001358.

Research output: Contribution to journalArticle

91 Scopus citations

Virulence without catalysis: How can a pseudokinase affect host cell signaling?

Reese, M. L. & Boyle, J. P., Feb 1 2012, In : Trends in Parasitology. 28, 2, p. 53-57 5 p.

Research output: Contribution to journalReview article

18 Scopus citations
2011

A conserved non-canonical motif in the pseudoactive site of the ROP5 pseudokinase domain mediates its effect on toxoplasma virulence

Reese, M. L. & Boothroyd, J. C., Aug 19 2011, In : Journal of Biological Chemistry. 286, 33, p. 29366-29375 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

Hall, C. I., Reese, M. L., Weerapana, E., Child, M. A., Bowyer, P. W., Albrow, V. E., Haraldsen, J. D., Phillips, M. R., Sandoval, E. D., Ward, G. E., Cravatt, B. F., Boothroyd, J. C. & Bogyo, M., Jun 28 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 26, p. 10568-10573 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

Reese, M. L., Zeiner, G. M., Saeij, J. P. J., Boothroyd, J. C. & Boyle, J. P., Jun 7 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 23, p. 9625-9630 6 p.

Research output: Contribution to journalArticle

158 Scopus citations

Rapid identification of protein-protein interfaces for the construction of a complex model based on multiple unassigned signals by using time-sharing NMR measurements

Kodama, Y., Reese, M. L., Shimba, N., Ono, K., Kanamori, E., Dötsch, V., Noguchi, S., Fukunishi, Y., Suzuki, E. I., Shimada, I. & Takahashi, H., Jun 1 2011, In : Journal of Structural Biology. 174, 3, p. 434-442 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2010

Toxoplasma Rhoptry Protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6

Ong, Y. C., Reese, M. L. & Boothroyd, J. C., Sep 10 2010, In : Journal of Biological Chemistry. 285, 37, p. 28731-28740 10 p.

Research output: Contribution to journalArticle

137 Scopus citations
2009

A helical membrane-binding domain targets the Toxoplasma ROP2 family to the parasitophorous vacuole

Reese, M. L. & Boothroyd, J. C., Oct 1 2009, In : Traffic. 10, 10, p. 1458-1470 13 p.

Research output: Contribution to journalArticle

56 Scopus citations
2007

The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a

Reese, M. L., Dakoji, S., Bredt, D. S. & Dötsch, V., Feb 1 2007, In : Nature Structural and Molecular Biology. 14, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
2003

Fast Mapping of Protein-Protein Interfaces by NMR Spectroscopy

Reese, M. L. & Dötsch, V., Nov 26 2003, In : Journal of the American Chemical Society. 125, 47, p. 14250-14251 2 p.

Research output: Contribution to journalArticle

25 Scopus citations
2002

Clathrin light and heavy chain interface: α-helix binding superhelix loops via critical tryptophans

Chen, C. Y., Reese, M. L., Hwang, P. K., Ota, N., Agard, D. & Brodsky, F. M., Nov 15 2002, In : EMBO Journal. 21, 22, p. 6072-6082 11 p.

Research output: Contribution to journalArticle

38 Scopus citations