Pharmacology - Ross Lab

Research Output

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Article
1972

Regulation of rat placental phosphorylase

Ross, E. & Walsh, D., May 16 1972, In : BBA - General Subjects. 264, 3, p. 490-496 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
1973

Assay of protein in the presence of high concentrations of sulfhydryl compounds

Ross, E. & Schatz, G., Jul 1973, In : Analytical Biochemistry. 54, 1, p. 304-306 3 p.

Research output: Contribution to journalArticle

262 Scopus citations
1976

Cytochrome c1 of baker's yeast. I. Isolation and properties

Ross, E. & Schatz, G., Jan 1 1976, In : Journal of Biological Chemistry. 251, 7, p. 1991-1996 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
37 Scopus citations
1977

Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells

Haga, T., Ross, E. M., Anderson, H. J. & Gilman, A. G., Jan 1 1977, In : Proceedings of the National Academy of Sciences of the United States of America. 74, 5, p. 2016-2020 5 p.

Research output: Contribution to journalArticle

92 Scopus citations

Hormone receptors uncoupled from adenylate cyclase (AC) in a variant S49 lymphoma cell clone

Ross, E. M., Raga, T. & Gilman, A. G., Jan 1 1977, In : Federation Proceedings. 36, 3, p. no.259

Research output: Contribution to journalArticle

Open Access
101 Scopus citations

Relationship between the β adrenergic receptor and adenylate cyclase. Studies of ligand binding and enzyme activity in purified membranes of S49 lymphoma cells

Ross, E. M., Maguire, M. E., Sturgill, T. W., Biltonen, R. L. & Gilman, A. G., Dec 14 1977, In : Journal of Biological Chemistry. 252, 16, p. 5761-5775 15 p.

Research output: Contribution to journalArticle

280 Scopus citations

Resolution of some components of adenylate cyclase necessary for catalytic activity

Ross, E. M. & Gilman, A. G., Dec 1 1977, In : Journal of Biological Chemistry. 252, 20, p. 6966-6969 4 p.

Research output: Contribution to journalArticle

130 Scopus citations
1978

Hormone-sensitive adenylate cyclase: resolution and reconstitution of some components necessary for regulation of the enzyme.

Ross, E. M., Haga, T., Howlett, A. C., Schwarzmeier, J., Schleifer, L. S. & Gilman, A. G., Jan 1 1978, In : Advances in cyclic nucleotide research. 9, p. 53-68 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Purification and subunit composition of cytochrome c1 from baker's yeast Saccharomyces cerevisiae

Ross, E. M. & Schatz, G., Jan 1 1978, In : Methods in Enzymology. 53, C, p. 222-229 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme

Ross, E. M., Howlett, A. C., Ferguson, K. M. & Gilman, A. G., Dec 1 1978, In : Journal of Biological Chemistry. 253, 18, p. 6401-6412 12 p.

Research output: Contribution to journalArticle

257 Scopus citations
1980

Purification of the regulatory component of adenylate cyclase

Northup, J. K., Sternweis, P. C., Smigel, M. D., Schleifer, L. S., Ross, E. M. & Gilman, A. G., 1980, In : Proceedings of the National Academy of Sciences of the United States of America. 77, 11 I, p. 6516-6520 5 p.

Research output: Contribution to journalArticle

310 Scopus citations
16 Scopus citations
1981

Alteration in the protein components of catecholamine-sensitive adenylate cyclase during maturation of rat reticulocytes.

Larner, A. C. & Ross, E. M., Sep 25 1981, In : Journal of Biological Chemistry. 256, 18, p. 9551-9557 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Modulation of the protein components of β-adrenergic adenylate cyclase (AC) during maturation of rat reticulocytes

Larner, A. C. & Ross, E. M., Jan 1 1981, In : Federation Proceedings. 40, 3 I, p. No. 2421

Research output: Contribution to journalArticle

Physical separation of the catalytic and regulatory proteins of hepatic adenylate cyclase

Ross, E. M., Jan 1 1981, In : Journal of Biological Chemistry. 256, 4, p. 1949-1953 5 p.

Research output: Contribution to journalArticle

30 Scopus citations
Open Access
57 Scopus citations

Phosphatidylcholine-promoted interaction of the catalytic and regulatory proteins of adenylate cyclase

Ross, E. M., Dec 1 1982, In : Journal of Biological Chemistry. 257, 18, p. 10751-10758 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Radioimmunoassay of digitonin

Brooker, G., Fleming, J. W. & Ross, E. M., Feb 8 1982, In : BBA - Biomembranes. 685, 1, p. 39-43 5 p.

Research output: Contribution to journalArticle

1983

Hormone-Sensitive Adenylate Cyclase: Identity, Function, and Regulation of the Protein Components

Ross, E. M., Pedersen, S. E. & Florio, V. A., Jan 1 1983, In : Current Topics in Membranes and Transport. 18, C, p. 109-142 34 p.

Research output: Contribution to journalArticle

12 Scopus citations

Reconstitution of Catecholamine-Stimulated Guanosinetriphosphatase Activity

Brandt, D. R., Asano, T., Pedersen, S. E. & Ross, E. M., Jan 1 1983, In : Biochemistry. 22, 19, p. 4357-4362 6 p.

Research output: Contribution to journalArticle

107 Scopus citations
69 Scopus citations
1984

Activation of the inhibitory GTP-binding protein of adenylate cyclase, G(i), by β-adrenergic receptors in reconstituted phospholipid vesicles

Asano, T., Katada, T., Gilman, A. G. & Ross, E. M., Jan 1 1984, In : Journal of Biological Chemistry. 259, 15, p. 9351-9354 4 p.

Research output: Contribution to journalArticle

92 Scopus citations
29 Scopus citations

Reconstitution of Catecholamine-Stimulated Binding of Guanosine 5’ -O-(3-Thiotnphosphate) to the Stimulatory GTP-Binding Protein of Adenylate Cyclase

Asano, T., Pedersen, S. E., Scott, C. W. & Ross, E. M., Nov 1984, In : Biochemistry. 23, 23, p. 5460-5467 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

Regulatory activities of reconstituted β-adrenergic receptors

Ross, E. M., Asano, T., Pedersen, S. E. & Brandt, D. R., Jan 1 1984, In : Federation Proceedings. 43, 6, p. no. 462

Research output: Contribution to journalArticle

1985

beta-Adrenergic receptors and regulatory GTP-binding proteins: reconstitution of coupling in phospholipid vesicles.

Asano, T., Brandt, D. R., Pedersen, S. E. & Ross, E. M., Jan 1 1985, In : Advances in cyclic nucleotide and protein phosphorylation research. 19, p. 47-56 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Functional activation of β-adrenergic receptors by thiols in the presence or absence of agonists

Pedersen, S. E. & Ross, E. M., Dec 1 1985, In : Journal of Biological Chemistry. 260, 26, p. 14150-14157 8 p.

Research output: Contribution to journalArticle

63 Scopus citations
91 Scopus citations

Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins

May, D. C., Ross, E. M., Gilman, A. G. & Smigel, M. D., Dec 1 1985, In : Journal of Biological Chemistry. 260, 29, p. 15829-15833 5 p.

Research output: Contribution to journalArticle

105 Scopus citations
1986
142 Scopus citations

Effect of Al3+ plus F- on the Catecholamine-Stimulated GTPase Activity of Purified and Reconstituted Gs

Brandt, D. R. & Ross, E. M., Nov 1986, In : Biochemistry. 25, 22, p. 7036-7041 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
1987

The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins

Higashijima, T., Ferguson, K. M., Sternweis, P. C., Ross, E. M., Smigel, M. D. & Gilman, A. G., Mar 26 1987, In : Journal of Biological Chemistry. 262, 2, p. 752-756 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

The hydrophobic tryptic core of the β-adrenergic receptor retains G(s) regulatory activity in response to agonists and thiols

Rubenstein, R. C., Wong, S. K. F. & Ross, E. M., Dec 1 1987, In : Journal of Biological Chemistry. 262, 34, p. 16655-16662 8 p.

Research output: Contribution to journalArticle

50 Scopus citations
1988

Functional domains in the β-adrenergic receptor

Ross, E. M., Wong, S. K. F., Rubenstein, R. C. & Higashijima, T., 1988, In : Cold Spring Harbor symposia on quantitative biology. 53, 1, p. 499-506 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins)

Higashijima, T., Uzu, S., Nakajima, T. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 14, p. 6491-6494 4 p.

Research output: Contribution to journalArticle

561 Scopus citations
17 Scopus citations

Receptor-G protein-effector: The design of a biochemical switchboard

Ross, E. M., Dec 1 1988, In : Journal Of Chemical Education. 65, 11, p. 937-942 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

The catecholamine binding site of the β-adrenergic receptor is formed by juxtaposed membrane-spanning domains

Wong, S. K. F., Slaughter, C., Ruoho, A. E. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 17, p. 7925-7928 4 p.

Research output: Contribution to journalArticle

85 Scopus citations

β-Adrenergic receptors display intramolecular disulfide bridges in situ: Analysis by immunoblotting and functional reconstitution

Moxham, C. P., Ross, E. M., George, S. T. & Malbon, C. C., Jan 1 1988, In : Molecular Pharmacology. 33, 5, p. 486-492 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
1990

A truncation mutation in the avian β-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors

Hertel, C., Nunnally, M. H., Wong, S. K. F., Murphy, E. A., Ross, E. M. & Perkins, J. P., Nov 12 1990, In : Journal of Biological Chemistry. 265, 29, p. 17988-17994 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Chimeric muscarinic cholinergic:β-adrenergic receptors that activate G(s) in response to muscarinic agonists

Wong, S. K. F., Parker, E. M. & Ross, E. M., May 16 1990, In : Journal of Biological Chemistry. 265, 11, p. 6219-6224 6 p.

Research output: Contribution to journalArticle

176 Scopus citations

G Protein-Coupled Receptors: Structure and Function of Signal-Transducing Proteins

Parker, E. M. & Ross, E. M., Jan 1 1990, In : Current Topics in Membranes and Transport. 36, C, p. 131-144 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Regulation of G(i) and G(o) by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity

Higashijima, T., Burnier, J. & Ross, E. M., Sep 10 1990, In : Journal of Biological Chemistry. 265, 24, p. 14176-14186 11 p.

Research output: Contribution to journalArticle

519 Scopus citations
1991

ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii

Zhang, Y., Ross, E. M. & Snell, W. J., Dec 1 1991, In : Journal of Biological Chemistry. 266, 34, p. 22954-22959 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Immunologic mapping of the amino- and carboxy-termini of the turkey erythrocyte β-adrenergic receptor; Selective proteolysis of both domains

Luxembourg, A., Hekman, M. & Ross, E. M., May 20 1991, In : FEBS Letters. 283, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

10 Scopus citations