Pharmacology - Ross Lab

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1991

Mapping of the mastoparan-binding site on G proteins: Cross-linking of [125I-Tyr3,Cys11]mastoparan to G(o)

Higashijima, T. & Ross, E. M., 1991, In : Journal of Biological Chemistry. 266, 19, p. 12655-12661 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Reconstitution of Receptors and G Proteins in Phospholipid Vesicles

Cerione, R. A. & Ross, E. M., Jan 1991, In : Methods in Enzymology. 195, C, p. 329-342 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells

Parker, E. M., Kameyama, K., Higashijima, T. & Ross, E. M., 1991, In : Journal of Biological Chemistry. 266, 1, p. 519-527 9 p.

Research output: Contribution to journalArticle

260 Scopus citations

Selectivity of the β-Adrenergic Receptor among Gs, Gi’s, and Go: Assay Using Recombinant α Subunits in Reconstituted Phospholipid Vesicles

Rubenstein, R. C., Linder, M. E. & Ross, E. M., Nov 1 1991, In : Biochemistry. 30, 44, p. 10769-10777 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
48 Scopus citations
1992

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

Berstein, G., Blank, J. L., Jhon, D. Y., Exton, J. H., Rhee, S. G. & Ross, E. M., Aug 7 1992, In : Cell. 70, 3, p. 411-418 8 p.

Research output: Contribution to journalArticle

337 Scopus citations

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, G(q/11), and phospholipase C-β1

Berstein, G., Blank, J. L., Smrcka, A. V., Higashijima, T., Sternweis, P. C., Exton, J. H. & Ross, E. M., 1992, In : Journal of Biological Chemistry. 267, 12, p. 8081-8088 8 p.

Research output: Contribution to journalArticle

272 Scopus citations

Twists and turns on G-protein signalling pathways

Ross, E. M., Oct 1992, In : Current Biology. 2, 10, p. 517-519 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
1993

GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes

Strittmatter, S. M., Cannon, S. C., Ross, E. M., Higashijima, T. & Fishman, M. C., Jan 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 11, p. 5327-5331 5 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Regulation of the M1 muscarinic receptor-Gg-phospholipase C-β pathway by nucleotide exchange and GTP hydrolysis

Ross, E. M. & Berstein, G., 1993, In : Life Sciences. 52, 5-6, p. 413-419 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
1994

Chimeric muscarinic cholinergic:β-adrenergic receptors that are functionally promiscuous among G proteins

Wong, S. K. F. & Ross, E. M., Jul 22 1994, In : Journal of Biological Chemistry. 269, 29, p. 18968-18976 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

G(s) regulation of endosome fusion suggests a role for signal transduction pathways in endocytosis

Colombo, M. I., Mayorga, L. S., Nishimoto, I., Ross, E. M. & Stahl, P. D., 1994, In : Journal of Biological Chemistry. 269, 21, p. 14919-14923 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

Regulation of G-protein activation by mastoparans and other cationic peptides

Ross, E. M. & Higashijima, T., Jan 1 1994, In : Methods in Enzymology. 237, C, p. 26-37 12 p.

Research output: Contribution to journalArticle

96 Scopus citations
1995

Carboxyl-terminal domains in the avian β1-adrenergic receptor that regulate agonist-promoted endocytosis

Parker, E. M., Swigart, P., Nunnally, M. H., Perkins, J. P. & Ross, E. M., 1995, In : Journal of Biological Chemistry. 270, 12, p. 6482-6487 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
42 Scopus citations

Protein Modification: Palmitoylation in G-protein signaling pathways

Ross, E. M., Feb 1995, In : Current Biology. 5, 2, p. 107-109 3 p.

Research output: Contribution to journalArticle

68 Scopus citations
15 Scopus citations
1996

Carboxyl-terminal fragments of phospholipase C-β1 with intrinsic G(q) GTPase-activating protein (GAP) activity

Paulssen, R. H., Woodson, J., Liu, Z. & Ross, E. M., 1996, In : Journal of Biological Chemistry. 271, 43, p. 26622-26629 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Functional importance of the amino terminus of G

Hepler, J. R., Biddlecome, G. H., Kleuss, C., Camp, L. A., Hofmann, S. L., Ross, E. M. & Gilman, A. G., Jan 5 1996, In : Journal of Biological Chemistry. 271, 1, p. 496-504 9 p.

Research output: Contribution to journalArticle

Open Access
95 Scopus citations

Purification and characterization of phospholipase C-β1 mutants expressed in E. coli

Meij, J. T. A. & Ross, E. M., Aug 23 1996, In : Biochemical and Biophysical Research Communications. 225, 3, p. 705-711 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
Open Access
205 Scopus citations
1997

A G(s)-selective analog of the receptor-mimetic peptide mastoparan binds to G(s)α in a kinked helical conformation

Sukumar, M., Ross, E. M. & Higashijima, T., Mar 25 1997, In : Biochemistry. 36, 12, p. 3632-3639 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

A GTPase-activating protein for the G protein Gα(z). Identification, purification, and mechanism of action

Wang, J., Tu, Y., Woodson, J., Song, X. & Ross, E. M., Feb 28 1997, In : Journal of Biological Chemistry. 272, 9, p. 5732-5740 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997)

Taylor, P., Ross, E. M., Sternweis, P. C., Neubig, R. R. & McCammon, J. A., Jan 1 1997, In : Molecular Pharmacology. 52, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Expression of human muscarinic cholinergic receptors in tobacco

Mu, J. H., Chua, N. H. & Ross, E. M., May 1 1997, In : Plant Molecular Biology. 34, 2, p. 357-362 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Guanosine Triphosphatase-Activating Proteins for Heterotrimeric G-Proteins

Ross, E. M., Wang, J., Tu, Y. & Biddlecome, G. H., 1997, In : Advances in Pharmacology. 42, C, p. 458-461 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibition of brain G(z) GAP and other RGS proteins by palmitoylation of G protein α subunits

Tu, Y., Wang, J. & Ross, E. M., Nov 7 1997, In : Science. 278, 5340, p. 1132-1135 4 p.

Research output: Contribution to journalArticle

128 Scopus citations
1998

Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity

Ingi, T., Krumins, A. M., Chidiac, P., Brothers, G. M., Chung, S., Snow, B. E., Barnes, C. A., Lanahan, A. A., Siderovski, D. P., Ross, E. M., Gilman, A. G. & Worley, P. F., Sep 15 1998, In : Journal of Neuroscience. 18, 18, p. 7178-7188 11 p.

Research output: Contribution to journalArticle

Open Access
250 Scopus citations

RGSZ1, a G(z)-selective rgs protein in brain: Structure, membrane association, regulation by Gα(z) phosphorylation, and relationship to a G(z) gtpase-activating protein subfamily

Wang, J., Ducret, A., Tu, Y., Kozasa, T., Aebersold, R. & Ross, E. M., Oct 2 1998, In : Journal of Biological Chemistry. 273, 40, p. 26014-26025 12 p.

Research output: Contribution to journalArticle

127 Scopus citations

The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

Zeng, W., Xu, X., Popov, S., Mukhopadhyay, S., Chidiac, P., Swistok, J., Danho, W., Yagaloff, K. A., Fisher, S. L., Ross, E. M., Muallem, S. & Wilkie, T. M., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 34687-34690 4 p.

Research output: Contribution to journalArticle

218 Scopus citations
1999

Kinetic control of guanine nucleotide binding to soluble Gα(q)

Markin, V. S. & Ross, E. M., Jul 1 1999, In : Biochemical Pharmacology. 58, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Modulation of the affinity and selectivity of RGS protein interaction with Gα subunits by a conserved asparagine/serine residue

Posner, B. A., Mukhopadhyay, S., Tesmer, J. J., Gilman, A. G. & Ross, E. M., Jun 15 1999, In : Biochemistry. 38, 24, p. 7773-7779 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10

Tu, Y., Popov, S., Slaughter, C. & Ross, E. M., Dec 31 1999, In : Journal of Biological Chemistry. 274, 53, p. 38260-38267 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Phospholipase C-β1 directly accelerates GTP hydrolysis by Gα(q) and acceleration is inhibited by Gβγ subunits

Chidiac, P. & Ross, E. M., Jul 9 1999, In : Journal of Biological Chemistry. 274, 28, p. 19639-19643 5 p.

Research output: Contribution to journalArticle

80 Scopus citations
146 Scopus citations

Reciprocal signaling between heterotrimeric G proteins and the p21- stimulated protein kinase

Wang, J., Frost, J. A., Cobb, M. H. & Ross, E. M., Oct 29 1999, In : Journal of Biological Chemistry. 274, 44, p. 31641-31647 7 p.

Research output: Contribution to journalArticle

49 Scopus citations
2001
52 Scopus citations

Quantitative assays for GTPase-activating proteins

Ross, E. M., 2001, In : Methods in Enzymology. 344, p. 601-617 17 p.

Research output: Contribution to journalArticle

25 Scopus citations

Quench-flow kinetic measurement of individual reactions of G-protein-catalyzed GTPase cycle

Mukhopadhyay, S. & Ross, E. M., 2001, In : Methods in Enzymology. 344, p. 350-369 20 p.

Research output: Contribution to journalArticle

11 Scopus citations

RGSZ1 and Ret RGS: Two of several splice variants from the gene RGS20

Barker, S. A., Wang, J., Sierra, D. A. & Ross, E. M., Dec 2001, In : Genomics. 78, 3, p. 223-229 7 p.

Research output: Contribution to journalArticle

28 Scopus citations
2002

Mutations in the carboxyl-terminal domain of phospholipase C-β1 delineate the dimer interface and a potential Gαq interaction site

Ilkaeva, O., Kinch, L. N., Paulssen, R. H. & Ross, E. M., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4294-4300 7 p.

Research output: Contribution to journalArticle

50 Scopus citations
2003

Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Shin, D. M., Dehoff, M., Luo, X., Kang, S. H., Tu, J., Nayak, S. K., Ross, E. M., Worley, P. E. & Muallem, S., Jul 21 2003, In : Journal of Cell Biology. 162, 2, p. 293-303 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

Phosphorylation-regulated Inhibition of the Gz GTPase-activating Protein Activity of RGS Proteins by Synapsin I

Tu, Y., Nayak, S. K., Woodson, J. & Ross, E. M., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52273-52281 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2004

Uncoupling conformational change from GTP hydrolysis in a heterotrimetric G protein α-subunit

Thomas, C. J., Du, X., Li, P., Wang, Y., Ross, E. M. & Sprang, S. R., May 18 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 20, p. 7560-7565 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
2005

Q & A. Elliott Ross.

Ross, E., Dec 6 2005, In : Current biology : CB. 15, 23, p. R942-943

Research output: Contribution to journalArticle

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors

Wang, X., Zeng, W., Syombo, A. A., Tang, W., Ross, E. M., Barnes, A. P., Milgram, S. L., Penninger, J. M., Allen, P. B., Greengard, P. & Muallem, S., Apr 1 2005, In : Nature Cell Biology. 7, 4, p. 405-411 7 p.

Research output: Contribution to journalArticle

122 Scopus citations
2006

Gβγinhibits Gα GTPase-activating proteins by inhibition of Gα-GTP binding during stimulation by receptor

Tang, W., Tu, Y., Nayak, S. K., Woodson, J., Jehl, M. & Ross, E. M., Feb 24 2006, In : Journal of Biological Chemistry. 281, 8, p. 4746-4753 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Structural determinants for phosphatidic acid regulation of phospholipase C-β1

Ross, E. M., Mateu, D., Gomes, A. V., Arana, C., Tran, T. & Litosch, I., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33087-33094 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2007

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

Jiang, L. I., Collins, J., Davis, R., Lin, K. M., DeCamp, D., Roach, T., Hsueh, R., Rebres, R. A., Ross, E. M., Taussig, R., Fraser, I. & Sternweis, P. C., Apr 6 2007, In : Journal of Biological Chemistry. 282, 14, p. 10576-10584 9 p.

Research output: Contribution to journalArticle

177 Scopus citations
2008

Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAP

Turcotte, M., Tang, W. & Ross, E. M., Aug 2008, In : PLoS Computational Biology. 4, 8, e1000148.

Research output: Contribution to journalArticle

36 Scopus citations