Pharmacology - Ross Lab

Research Output

Filter
Article
2010

Synergistic activation of phospholipase C-β3 by Gαq and Gβγ describes a simple two-state coincidence detector

Philip, F., Kadamur, G., Silos, R. G., Woodson, J. & Ross, E. M., Aug 10 2010, In : Current Biology. 20, 15, p. 1327-1335 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2011

Synergistic Ca2+ responses by Gαi- and Gαq-coupled G-protein-coupled receptors require a single PLCβ isoform that is sensitive to both Gβγ and Gαq

Rebres, R. A., Roach, T. I. A., Fraser, I. D. C., Philip, F., Moon, C., Lin, K. M., Liu, J., Santat, L., Cheadle, L., Ross, E. M., Simon, M. I. & Seaman, W. E., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 942-951 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

WNK1 promotes PIP2 synthesis to coordinate growth factor and GPCR-Gq signaling

An, S. W., Cha, S. K., Yoon, J., Chang, S., Ross, E. M. & Huang, C. L., Dec 6 2011, In : Current Biology. 21, 23, p. 1979-1987 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

Activation Biosensor for G Protein-Coupled Receptors: A FRET-Based m1 Muscarinic Activation Sensor That Regulates Gq

Chang, S. & Ross, E. M., Sep 20 2012, In : PloS one. 7, 9, e45651.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Differential regulation of ERK1/2 and mTORC1 through T1R1/T1R3 in MIN6 cells

Wauson, E. M., Guerra, M. L., Dyachok, J., McGlynn, K., Giles, J., Ross, E. M. & Cobb, M. H., Jul 31 2015, In : Molecular Endocrinology. 29, 8, p. 1114-1122 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Amino acids regulate mTORC1 by an obligate two-step mechanism

Dyachok, J., Earnest, S., Iturraran, E. N., Cobb, M. H. & Ross, E. M., Oct 21 2016, In : Journal of Biological Chemistry. 291, 43, p. 22414-22426 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Intrinsic Pleckstrin Homology (PH) domain motion in phospholipase C-β exposes a Gβγ protein binding site

Kadamur, G. & Ross, E. M., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11394-11406 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

The binding of activated Gq to phospholipase C- exhibits anomalous affinity

Navaratnarajah, P., Gershenson, A. & Ross, E. M., Oct 6 2017, In : Journal of Biological Chemistry. 292, 40, p. 16787-16801 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway

Gaspari, S., Purushothaman, I., Cogliani, V., Sakloth, F., Neve, R. L., Howland, D., Ring, R. H., Ross, E. M., Shen, L. & Zachariou, V., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. E2085-E2094

Research output: Contribution to journalArticle

8 Scopus citations
2019

Regulating G protein-coupled receptors by topological inversion

Denard, B., Han, S., Kim, J. Y., Ross, E. M. & Ye, J., Mar 2019, In : eLife. 8, e40234.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2020

DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi

Marivin, A., Maziarz, M., Zhao, J., DiGiacomo, V., Calvo, I. O., Mann, E. A., Ear, J., Blanco-Canosa, J. B., Ross, E. M., Ghosh, P. & Garcia-Marcos, M., Feb 21 2020, In : Journal of Biological Chemistry. 295, 8, p. 2270-2284 15 p.

Research output: Contribution to journalArticle