Pharmacology - Ross Lab

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β-Adrenergic receptors display intramolecular disulfide bridges in situ: Analysis by immunoblotting and functional reconstitution

Moxham, C. P., Ross, E. M., George, S. T. & Malbon, C. C., 1988, In : Molecular Pharmacology. 33, 5, p. 486-492 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

WNK1 promotes PIP2 synthesis to coordinate growth factor and GPCR-Gq signaling

An, S. W., Cha, S. K., Yoon, J., Chang, S., Ross, E. M. & Huang, C. L., Dec 6 2011, In : Current Biology. 21, 23, p. 1979-1987 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

Jiang, L. I., Collins, J., Davis, R., Lin, K. M., DeCamp, D., Roach, T., Hsueh, R., Rebres, R. A., Ross, E. M., Taussig, R., Fraser, I. & Sternweis, P. C., Apr 6 2007, In : Journal of Biological Chemistry. 282, 14, p. 10576-10584 9 p.

Research output: Contribution to journalArticle

177 Scopus citations

Uncoupling conformational change from GTP hydrolysis in a heterotrimetric G protein α-subunit

Thomas, C. J., Du, X., Li, P., Wang, Y., Ross, E. M. & Sprang, S. R., May 18 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 20, p. 7560-7565 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Twists and turns on G-protein signalling pathways

Ross, E. M., Oct 1992, In : Current Biology. 2, 10, p. 517-519 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
48 Scopus citations

The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

Zeng, W., Xu, X., Popov, S., Mukhopadhyay, S., Chidiac, P., Swistok, J., Danho, W., Yagaloff, K. A., Fisher, S. L., Ross, E. M., Muallem, S. & Wilkie, T. M., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 34687-34690 4 p.

Research output: Contribution to journalArticle

218 Scopus citations

The hydrophobic tryptic core of the β-adrenergic receptor retains G(s) regulatory activity in response to agonists and thiols

Rubenstein, R. C., Wong, S. K. F. & Ross, E. M., 1987, In : Journal of Biological Chemistry. 262, 34, p. 16655-16662 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins

Higashijima, T., Ferguson, K. M., Sternweis, P. C., Ross, E. M., Smigel, M. D. & Gilman, A. G., 1987, In : Journal of Biological Chemistry. 262, 2, p. 752-756 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

The catecholamine binding site of the β-adrenergic receptor is formed by juxtaposed membrane-spanning domains

Wong, S. K. F., Slaughter, C., Ruoho, A. E. & Ross, E. M., 1988, In : Journal of Biological Chemistry. 263, 17, p. 7925-7928 4 p.

Research output: Contribution to journalArticle

85 Scopus citations
15 Scopus citations

The binding of activated Gq to phospholipase C- exhibits anomalous affinity

Navaratnarajah, P., Gershenson, A. & Ross, E. M., Oct 6 2017, In : Journal of Biological Chemistry. 292, 40, p. 16787-16801 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synergistic Ca2+ responses by Gαi- and Gαq-coupled G-protein-coupled receptors require a single PLCβ isoform that is sensitive to both Gβγ and Gαq

Rebres, R. A., Roach, T. I. A., Fraser, I. D. C., Philip, F., Moon, C., Lin, K. M., Liu, J., Santat, L., Cheadle, L., Ross, E. M., Simon, M. I. & Seaman, W. E., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 942-951 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Synergistic activation of phospholipase C-β3 by Gαq and Gβγ describes a simple two-state coincidence detector

Philip, F., Kadamur, G., Silos, R. G., Woodson, J. & Ross, E. M., Aug 10 2010, In : Current Biology. 20, 15, p. 1327-1335 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway

Gaspari, S., Purushothaman, I., Cogliani, V., Sakloth, F., Neve, R. L., Howland, D., Ring, R. H., Ross, E. M., Shen, L. & Zachariou, V., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. E2085-E2094

Research output: Contribution to journalArticle

8 Scopus citations

Structural determinants for phosphatidic acid regulation of phospholipase C-β1

Ross, E. M., Mateu, D., Gomes, A. V., Arana, C., Tran, T. & Litosch, I., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33087-33094 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors

Wang, X., Zeng, W., Syombo, A. A., Tang, W., Ross, E. M., Barnes, A. P., Milgram, S. L., Penninger, J. M., Allen, P. B., Greengard, P. & Muallem, S., Apr 1 2005, In : Nature Cell Biology. 7, 4, p. 405-411 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

Selectivity of the β-Adrenergic Receptor among Gs, Gi’s, and Go: Assay Using Recombinant α Subunits in Reconstituted Phospholipid Vesicles

Rubenstein, R. C., Linder, M. E. & Ross, E. M., Nov 1 1991, In : Biochemistry. 30, 44, p. 10769-10777 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

RGSZ1 and Ret RGS: Two of several splice variants from the gene RGS20

Barker, S. A., Wang, J., Sierra, D. A. & Ross, E. M., Dec 2001, In : Genomics. 78, 3, p. 223-229 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

RGSZ1, a G(z)-selective rgs protein in brain: Structure, membrane association, regulation by Gα(z) phosphorylation, and relationship to a G(z) gtpase-activating protein subfamily

Wang, J., Ducret, A., Tu, Y., Kozasa, T., Aebersold, R. & Ross, E. M., Oct 2 1998, In : Journal of Biological Chemistry. 273, 40, p. 26014-26025 12 p.

Research output: Contribution to journalArticle

127 Scopus citations

Resolution of some components of adenylate cyclase necessary for catalytic activity

Ross, E. M. & Gilman, A. G., Dec 1 1977, In : Journal of Biological Chemistry. 252, 20, p. 6966-6969 4 p.

Research output: Contribution to journalArticle

130 Scopus citations

Relationship between the β adrenergic receptor and adenylate cyclase. Studies of ligand binding and enzyme activity in purified membranes of S49 lymphoma cells

Ross, E. M., Maguire, M. E., Sturgill, T. W., Biltonen, R. L. & Gilman, A. G., Dec 14 1977, In : Journal of Biological Chemistry. 252, 16, p. 5761-5775 15 p.

Research output: Contribution to journalArticle

280 Scopus citations

Regulatory activities of reconstituted β-adrenergic receptors

Ross, E. M., Asano, T., Pedersen, S. E. & Brandt, D. R., Jan 1 1984, In : Federation Proceedings. 43, 6, p. no. 462

Research output: Contribution to journalArticle

Regulation of the M1 muscarinic receptor-Gg-phospholipase C-β pathway by nucleotide exchange and GTP hydrolysis

Ross, E. M. & Berstein, G., 1993, In : Life Sciences. 52, 5-6, p. 413-419 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
69 Scopus citations

Regulation of rat placental phosphorylase

Ross, E. & Walsh, D., May 16 1972, In : BBA - General Subjects. 264, 3, p. 490-496 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
205 Scopus citations

Regulation of G-protein activation by mastoparans and other cationic peptides

Ross, E. M. & Higashijima, T., Jan 1 1994, In : Methods in Enzymology. 237, C, p. 26-37 12 p.

Research output: Contribution to journalArticle

96 Scopus citations

Regulation of G(i) and G(o) by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity

Higashijima, T., Burnier, J. & Ross, E. M., 1990, In : Journal of Biological Chemistry. 265, 24, p. 14176-14186 11 p.

Research output: Contribution to journalArticle

519 Scopus citations

Regulating G protein-coupled receptors by topological inversion

Denard, B., Han, S., Kim, J. Y., Ross, E. M. & Ye, J., Mar 2019, In : eLife. 8, e40234.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells

Parker, E. M., Kameyama, K., Higashijima, T. & Ross, E. M., 1991, In : Journal of Biological Chemistry. 266, 1, p. 519-527 9 p.

Research output: Contribution to journalArticle

260 Scopus citations

Reconstitution of Receptors and G Proteins in Phospholipid Vesicles

Cerione, R. A. & Ross, E. M., Jan 1991, In : Methods in Enzymology. 195, C, p. 329-342 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme

Ross, E. M., Howlett, A. C., Ferguson, K. M. & Gilman, A. G., Dec 1 1978, In : Journal of Biological Chemistry. 253, 18, p. 6401-6412 12 p.

Research output: Contribution to journalArticle

257 Scopus citations

Reconstitution of Catecholamine-Stimulated Guanosinetriphosphatase Activity

Brandt, D. R., Asano, T., Pedersen, S. E. & Ross, E. M., 1983, In : Biochemistry. 22, 19, p. 4357-4362 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

Reconstitution of Catecholamine-Stimulated Binding of Guanosine 5’ -O-(3-Thiotnphosphate) to the Stimulatory GTP-Binding Protein of Adenylate Cyclase

Asano, T., Pedersen, S. E., Scott, C. W. & Ross, E. M., Nov 1984, In : Biochemistry. 23, 23, p. 5460-5467 8 p.

Research output: Contribution to journalArticle

88 Scopus citations

Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins

May, D. C., Ross, E. M., Gilman, A. G. & Smigel, M. D., 1985, In : Journal of Biological Chemistry. 260, 29, p. 15829-15833 5 p.

Research output: Contribution to journalArticle

105 Scopus citations
Open Access
101 Scopus citations
16 Scopus citations

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, G(q/11), and phospholipase C-β1

Berstein, G., Blank, J. L., Smrcka, A. V., Higashijima, T., Sternweis, P. C., Exton, J. H. & Ross, E. M., 1992, In : Journal of Biological Chemistry. 267, 12, p. 8081-8088 8 p.

Research output: Contribution to journalArticle

272 Scopus citations

Reciprocal signaling between heterotrimeric G proteins and the p21- stimulated protein kinase

Wang, J., Frost, J. A., Cobb, M. H. & Ross, E. M., Oct 29 1999, In : Journal of Biological Chemistry. 274, 44, p. 31641-31647 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Receptor-G protein-effector: The design of a biochemical switchboard

Ross, E. M., Dec 1 1988, In : Journal Of Chemical Education. 65, 11, p. 937-942 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
146 Scopus citations
17 Scopus citations

Radioimmunoassay of digitonin

Brooker, G., Fleming, J. W. & Ross, E. M., Feb 8 1982, In : BBA - Biomembranes. 685, 1, p. 39-43 5 p.

Research output: Contribution to journalArticle

Quench-flow kinetic measurement of individual reactions of G-protein-catalyzed GTPase cycle

Mukhopadhyay, S. & Ross, E. M., 2001, In : Methods in Enzymology. 344, p. 350-369 20 p.

Research output: Contribution to journalArticle

11 Scopus citations

Quantitative assays for GTPase-activating proteins

Ross, E. M., 2001, In : Methods in Enzymology. 344, p. 601-617 17 p.

Research output: Contribution to journalArticle

25 Scopus citations

Q & A. Elliott Ross.

Ross, E., Dec 6 2005, In : Current biology : CB. 15, 23, p. R942-943

Research output: Contribution to journalArticle

Purification of the regulatory component of adenylate cyclase

Northup, J. K., Sternweis, P. C., Smigel, M. D., Schleifer, L. S., Ross, E. M. & Gilman, A. G., 1980, In : Proceedings of the National Academy of Sciences of the United States of America. 77, 11 I, p. 6516-6520 5 p.

Research output: Contribution to journalArticle

310 Scopus citations

Purification and subunit composition of cytochrome c1 from baker's yeast Saccharomyces cerevisiae

Ross, E. M. & Schatz, G., Jan 1 1978, In : Methods in Enzymology. 53, C, p. 222-229 8 p.

Research output: Contribution to journalArticle

7 Scopus citations