Pharmacology - Ross Lab

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Activation Biosensor for G Protein-Coupled Receptors: A FRET-Based m1 Muscarinic Activation Sensor That Regulates Gq

Chang, S. & Ross, E. M., Sep 20 2012, In : PloS one. 7, 9, e45651.

Research output: Contribution to journalArticle

11 Scopus citations

Activation of the inhibitory GTP-binding protein of adenylate cyclase, G(i), by β-adrenergic receptors in reconstituted phospholipid vesicles

Asano, T., Katada, T., Gilman, A. G. & Ross, E. M., Jan 1 1984, In : Journal of Biological Chemistry. 259, 15, p. 9351-9354 4 p.

Research output: Contribution to journalArticle

92 Scopus citations

Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells

Haga, T., Ross, E. M., Anderson, H. J. & Gilman, A. G., Jan 1 1977, In : Proceedings of the National Academy of Sciences of the United States of America. 74, 5, p. 2016-2020 5 p.

Research output: Contribution to journalArticle

92 Scopus citations

A G(s)-selective analog of the receptor-mimetic peptide mastoparan binds to G(s)α in a kinked helical conformation

Sukumar, M., Ross, E. M. & Higashijima, T., Mar 25 1997, In : Biochemistry. 36, 12, p. 3632-3639 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

A GTPase-activating protein for the G protein Gα(z). Identification, purification, and mechanism of action

Wang, J., Tu, Y., Woodson, J., Song, X. & Ross, E. M., Feb 28 1997, In : Journal of Biological Chemistry. 272, 9, p. 5732-5740 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Alteration in the protein components of catecholamine-sensitive adenylate cyclase during maturation of rat reticulocytes.

Larner, A. C. & Ross, E. M., Sep 25 1981, In : Journal of Biological Chemistry. 256, 18, p. 9551-9557 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Amino acids regulate mTORC1 by an obligate two-step mechanism

Dyachok, J., Earnest, S., Iturraran, E. N., Cobb, M. H. & Ross, E. M., Oct 21 2016, In : Journal of Biological Chemistry. 291, 43, p. 22414-22426 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Assay of protein in the presence of high concentrations of sulfhydryl compounds

Ross, E. & Schatz, G., Jul 1973, In : Analytical Biochemistry. 54, 1, p. 304-306 3 p.

Research output: Contribution to journalArticle

262 Scopus citations

ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii

Zhang, Y., Ross, E. M. & Snell, W. J., Dec 1 1991, In : Journal of Biological Chemistry. 266, 34, p. 22954-22959 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

A truncation mutation in the avian β-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors

Hertel, C., Nunnally, M. H., Wong, S. K. F., Murphy, E. A., Ross, E. M. & Perkins, J. P., Nov 12 1990, In : Journal of Biological Chemistry. 265, 29, p. 17988-17994 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

beta-Adrenergic receptors and regulatory GTP-binding proteins: reconstitution of coupling in phospholipid vesicles.

Asano, T., Brandt, D. R., Pedersen, S. E. & Ross, E. M., Jan 1 1985, In : Advances in cyclic nucleotide and protein phosphorylation research. 19, p. 47-56 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
51 Scopus citations

Carboxyl-terminal domains in the avian β1-adrenergic receptor that regulate agonist-promoted endocytosis

Parker, E. M., Swigart, P., Nunnally, M. H., Perkins, J. P. & Ross, E. M., Jan 1 1995, In : Journal of Biological Chemistry. 270, 12, p. 6482-6487 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Carboxyl-terminal fragments of phospholipase C-β1 with intrinsic G(q) GTPase-activating protein (GAP) activity

Paulssen, R. H., Woodson, J., Liu, Z. & Ross, E. M., Nov 6 1996, In : Journal of Biological Chemistry. 271, 43, p. 26622-26629 8 p.

Research output: Contribution to journalArticle

58 Scopus citations
142 Scopus citations
29 Scopus citations

Chimeric muscarinic cholinergic:β-adrenergic receptors that activate G(s) in response to muscarinic agonists

Wong, S. K. F., Parker, E. M. & Ross, E. M., May 16 1990, In : Journal of Biological Chemistry. 265, 11, p. 6219-6224 6 p.

Research output: Contribution to journalArticle

176 Scopus citations

Chimeric muscarinic cholinergic:β-adrenergic receptors that are functionally promiscuous among G proteins

Wong, S. K. F. & Ross, E. M., Jul 22 1994, In : Journal of Biological Chemistry. 269, 29, p. 18968-18976 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997)

Taylor, P., Ross, E. M., Sternweis, P. C., Neubig, R. R. & McCammon, J. A., Jan 1 1997, In : Molecular Pharmacology. 52, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAP

Turcotte, M., Tang, W. & Ross, E. M., Aug 2008, In : PLoS Computational Biology. 4, 8, e1000148.

Research output: Contribution to journalArticle

35 Scopus citations

Cytochrome c1 of baker's yeast. I. Isolation and properties

Ross, E. & Schatz, G., Jan 1 1976, In : Journal of Biological Chemistry. 251, 7, p. 1991-1996 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
37 Scopus citations

DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi

Marivin, A., Maziarz, M., Zhao, J., DiGiacomo, V., Calvo, I. O., Mann, E. A., Ear, J., Blanco-Canosa, J. B., Ross, E. M., Ghosh, P. & Garcia-Marcos, M., Feb 21 2020, In : Journal of Biological Chemistry. 295, 8, p. 2270-2284 15 p.

Research output: Contribution to journalArticle

Differential regulation of ERK1/2 and mTORC1 through T1R1/T1R3 in MIN6 cells

Wauson, E. M., Guerra, M. L., Dyachok, J., McGlynn, K., Giles, J., Ross, E. M. & Cobb, M. H., Jul 31 2015, In : Molecular Endocrinology. 29, 8, p. 1114-1122 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity

Ingi, T., Krumins, A. M., Chidiac, P., Brothers, G. M., Chung, S., Snow, B. E., Barnes, C. A., Lanahan, A. A., Siderovski, D. P., Ross, E. M., Gilman, A. G. & Worley, P. F., Sep 15 1998, In : Journal of Neuroscience. 18, 18, p. 7178-7188 11 p.

Research output: Contribution to journalArticle

Open Access
250 Scopus citations

Effect of Al3+ plus F- on the Catecholamine-Stimulated GTPase Activity of Purified and Reconstituted Gs

Brandt, D. R. & Ross, E. M., Nov 1986, In : Biochemistry. 25, 22, p. 7036-7041 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Expression of human muscarinic cholinergic receptors in tobacco

Mu, J. H., Chua, N. H. & Ross, E. M., May 1 1997, In : Plant Molecular Biology. 34, 2, p. 357-362 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Functional activation of β-adrenergic receptors by thiols in the presence or absence of agonists

Pedersen, S. E. & Ross, E. M., Dec 1 1985, In : Journal of Biological Chemistry. 260, 26, p. 14150-14157 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Functional domains in the β-adrenergic receptor

Ross, E. M., Wong, S. K. F., Rubenstein, R. C. & Higashijima, T., 1988, In : Cold Spring Harbor symposia on quantitative biology. 53, 1, p. 499-506 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Functional importance of the amino terminus of G

Hepler, J. R., Biddlecome, G. H., Kleuss, C., Camp, L. A., Hofmann, S. L., Ross, E. M. & Gilman, A. G., Jan 5 1996, In : Journal of Biological Chemistry. 271, 1, p. 496-504 9 p.

Research output: Contribution to journalArticle

Open Access
95 Scopus citations
Open Access
57 Scopus citations

G(s) regulation of endosome fusion suggests a role for signal transduction pathways in endocytosis

Colombo, M. I., Mayorga, L. S., Nishimoto, I., Ross, E. M. & Stahl, P. D., 1994, In : Journal of Biological Chemistry. 269, 21, p. 14919-14923 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes

Strittmatter, S. M., Cannon, S. C., Ross, E. M., Higashijima, T. & Fishman, M. C., Jan 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 11, p. 5327-5331 5 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

G Protein-Coupled Receptors: Structure and Function of Signal-Transducing Proteins

Parker, E. M. & Ross, E. M., Jan 1 1990, In : Current Topics in Membranes and Transport. 36, C, p. 131-144 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
42 Scopus citations
91 Scopus citations

Guanosine Triphosphatase-Activating Proteins for Heterotrimeric G-Proteins

Ross, E. M., Wang, J., Tu, Y. & Biddlecome, G. H., 1997, In : Advances in Pharmacology. 42, C, p. 458-461 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Gβγinhibits Gα GTPase-activating proteins by inhibition of Gα-GTP binding during stimulation by receptor

Tang, W., Tu, Y., Nayak, S. K., Woodson, J., Jehl, M. & Ross, E. M., Feb 24 2006, In : Journal of Biological Chemistry. 281, 8, p. 4746-4753 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Shin, D. M., Dehoff, M., Luo, X., Kang, S. H., Tu, J., Nayak, S. K., Ross, E. M., Worley, P. E. & Muallem, S., Jul 21 2003, In : Journal of Cell Biology. 162, 2, p. 293-303 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Hormone receptors uncoupled from adenylate cyclase (AC) in a variant S49 lymphoma cell clone

Ross, E. M., Raga, T. & Gilman, A. G., Jan 1 1977, In : Federation Proceedings. 36, 3, p. no.259

Research output: Contribution to journalArticle

Hormone-sensitive adenylate cyclase: resolution and reconstitution of some components necessary for regulation of the enzyme.

Ross, E. M., Haga, T., Howlett, A. C., Schwarzmeier, J., Schleifer, L. S. & Gilman, A. G., Jan 1 1978, In : Advances in cyclic nucleotide research. 9, p. 53-68 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hormone-Sensitive Adenylate Cyclase: Identity, Function, and Regulation of the Protein Components

Ross, E. M., Pedersen, S. E. & Florio, V. A., Jan 1 1983, In : Current Topics in Membranes and Transport. 18, C, p. 109-142 34 p.

Research output: Contribution to journalArticle

12 Scopus citations

Immunologic mapping of the amino- and carboxy-termini of the turkey erythrocyte β-adrenergic receptor; Selective proteolysis of both domains

Luxembourg, A., Hekman, M. & Ross, E. M., May 20 1991, In : FEBS Letters. 283, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of brain G(z) GAP and other RGS proteins by palmitoylation of G protein α subunits

Tu, Y., Wang, J. & Ross, E. M., Nov 7 1997, In : Science. 278, 5340, p. 1132-1135 4 p.

Research output: Contribution to journalArticle

127 Scopus citations

Intrinsic Pleckstrin Homology (PH) domain motion in phospholipase C-β exposes a Gβγ protein binding site

Kadamur, G. & Ross, E. M., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11394-11406 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Kinetic control of guanine nucleotide binding to soluble Gα(q)

Markin, V. S. & Ross, E. M., Jul 1 1999, In : Biochemical Pharmacology. 58, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Mapping of the mastoparan-binding site on G proteins: Cross-linking of [125I-Tyr3,Cys11]mastoparan to G(o)

Higashijima, T. & Ross, E. M., Sep 23 1991, In : Journal of Biological Chemistry. 266, 19, p. 12655-12661 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins)

Higashijima, T., Uzu, S., Nakajima, T. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 14, p. 6491-6494 4 p.

Research output: Contribution to journalArticle

561 Scopus citations