Pharmacology - Ross Lab

Research Output

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1994

Regulation of G-protein activation by mastoparans and other cationic peptides

Ross, E. M. & Higashijima, T., Jan 1 1994, In : Methods in Enzymology. 237, C, p. 26-37 12 p.

Research output: Contribution to journalArticle

96 Scopus citations
1993

GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes

Strittmatter, S. M., Cannon, S. C., Ross, E. M., Higashijima, T. & Fishman, M. C., Jan 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 11, p. 5327-5331 5 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Regulation of the M1 muscarinic receptor-Gg-phospholipase C-β pathway by nucleotide exchange and GTP hydrolysis

Ross, E. M. & Berstein, G., 1993, In : Life Sciences. 52, 5-6, p. 413-419 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
1992

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

Berstein, G., Blank, J. L., Jhon, D. Y., Exton, J. H., Rhee, S. G. & Ross, E. M., Aug 7 1992, In : Cell. 70, 3, p. 411-418 8 p.

Research output: Contribution to journalArticle

335 Scopus citations

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, G(q/11), and phospholipase C-β1

Berstein, G., Blank, J. L., Smrcka, A. V., Higashijima, T., Sternweis, P. C., Exton, J. H. & Ross, E. M., Jan 1 1992, In : Journal of Biological Chemistry. 267, 12, p. 8081-8088 8 p.

Research output: Contribution to journalArticle

272 Scopus citations

Twists and turns on G-protein signalling pathways

Ross, E. M., Oct 1992, In : Current Biology. 2, 10, p. 517-519 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
1991

ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii

Zhang, Y., Ross, E. M. & Snell, W. J., Dec 1 1991, In : Journal of Biological Chemistry. 266, 34, p. 22954-22959 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Immunologic mapping of the amino- and carboxy-termini of the turkey erythrocyte β-adrenergic receptor; Selective proteolysis of both domains

Luxembourg, A., Hekman, M. & Ross, E. M., May 20 1991, In : FEBS Letters. 283, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mapping of the mastoparan-binding site on G proteins: Cross-linking of [125I-Tyr3,Cys11]mastoparan to G(o)

Higashijima, T. & Ross, E. M., Sep 23 1991, In : Journal of Biological Chemistry. 266, 19, p. 12655-12661 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Reconstitution of Receptors and G Proteins in Phospholipid Vesicles

Cerione, R. A. & Ross, E. M., Jan 1991, In : Methods in Enzymology. 195, C, p. 329-342 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells

Parker, E. M., Kameyama, K., Higashijima, T. & Ross, E. M., 1991, In : Journal of Biological Chemistry. 266, 1, p. 519-527 9 p.

Research output: Contribution to journalArticle

260 Scopus citations

Selectivity of the β-Adrenergic Receptor among Gs, Gi’s, and Go: Assay Using Recombinant α Subunits in Reconstituted Phospholipid Vesicles

Rubenstein, R. C., Linder, M. E. & Ross, E. M., Nov 1 1991, In : Biochemistry. 30, 44, p. 10769-10777 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
48 Scopus citations
1990

A truncation mutation in the avian β-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors

Hertel, C., Nunnally, M. H., Wong, S. K. F., Murphy, E. A., Ross, E. M. & Perkins, J. P., Nov 12 1990, In : Journal of Biological Chemistry. 265, 29, p. 17988-17994 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Chimeric muscarinic cholinergic:β-adrenergic receptors that activate G(s) in response to muscarinic agonists

Wong, S. K. F., Parker, E. M. & Ross, E. M., May 16 1990, In : Journal of Biological Chemistry. 265, 11, p. 6219-6224 6 p.

Research output: Contribution to journalArticle

176 Scopus citations

G Protein-Coupled Receptors: Structure and Function of Signal-Transducing Proteins

Parker, E. M. & Ross, E. M., Jan 1 1990, In : Current Topics in Membranes and Transport. 36, C, p. 131-144 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Regulation of G(i) and G(o) by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity

Higashijima, T., Burnier, J. & Ross, E. M., Sep 10 1990, In : Journal of Biological Chemistry. 265, 24, p. 14176-14186 11 p.

Research output: Contribution to journalArticle

519 Scopus citations
1988

Functional domains in the β-adrenergic receptor

Ross, E. M., Wong, S. K. F., Rubenstein, R. C. & Higashijima, T., 1988, In : Cold Spring Harbor symposia on quantitative biology. 53, 1, p. 499-506 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins)

Higashijima, T., Uzu, S., Nakajima, T. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 14, p. 6491-6494 4 p.

Research output: Contribution to journalArticle

561 Scopus citations
17 Scopus citations

Receptor-G protein-effector: The design of a biochemical switchboard

Ross, E. M., Dec 1 1988, In : Journal Of Chemical Education. 65, 11, p. 937-942 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

The catecholamine binding site of the β-adrenergic receptor is formed by juxtaposed membrane-spanning domains

Wong, S. K. F., Slaughter, C., Ruoho, A. E. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 17, p. 7925-7928 4 p.

Research output: Contribution to journalArticle

85 Scopus citations

β-Adrenergic receptors display intramolecular disulfide bridges in situ: Analysis by immunoblotting and functional reconstitution

Moxham, C. P., Ross, E. M., George, S. T. & Malbon, C. C., Jan 1 1988, In : Molecular Pharmacology. 33, 5, p. 486-492 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
1987

The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins

Higashijima, T., Ferguson, K. M., Sternweis, P. C., Ross, E. M., Smigel, M. D. & Gilman, A. G., Mar 26 1987, In : Journal of Biological Chemistry. 262, 2, p. 752-756 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

The hydrophobic tryptic core of the β-adrenergic receptor retains G(s) regulatory activity in response to agonists and thiols

Rubenstein, R. C., Wong, S. K. F. & Ross, E. M., Dec 1 1987, In : Journal of Biological Chemistry. 262, 34, p. 16655-16662 8 p.

Research output: Contribution to journalArticle

50 Scopus citations
1986
142 Scopus citations

Effect of Al3+ plus F- on the Catecholamine-Stimulated GTPase Activity of Purified and Reconstituted Gs

Brandt, D. R. & Ross, E. M., Nov 1986, In : Biochemistry. 25, 22, p. 7036-7041 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
1985

beta-Adrenergic receptors and regulatory GTP-binding proteins: reconstitution of coupling in phospholipid vesicles.

Asano, T., Brandt, D. R., Pedersen, S. E. & Ross, E. M., Jan 1 1985, In : Advances in cyclic nucleotide and protein phosphorylation research. 19, p. 47-56 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Functional activation of β-adrenergic receptors by thiols in the presence or absence of agonists

Pedersen, S. E. & Ross, E. M., Dec 1 1985, In : Journal of Biological Chemistry. 260, 26, p. 14150-14157 8 p.

Research output: Contribution to journalArticle

63 Scopus citations
91 Scopus citations

Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins

May, D. C., Ross, E. M., Gilman, A. G. & Smigel, M. D., Dec 1 1985, In : Journal of Biological Chemistry. 260, 29, p. 15829-15833 5 p.

Research output: Contribution to journalArticle

105 Scopus citations
1984

Activation of the inhibitory GTP-binding protein of adenylate cyclase, G(i), by β-adrenergic receptors in reconstituted phospholipid vesicles

Asano, T., Katada, T., Gilman, A. G. & Ross, E. M., Jan 1 1984, In : Journal of Biological Chemistry. 259, 15, p. 9351-9354 4 p.

Research output: Contribution to journalArticle

92 Scopus citations
29 Scopus citations

Reconstitution of Catecholamine-Stimulated Binding of Guanosine 5’ -O-(3-Thiotnphosphate) to the Stimulatory GTP-Binding Protein of Adenylate Cyclase

Asano, T., Pedersen, S. E., Scott, C. W. & Ross, E. M., Nov 1984, In : Biochemistry. 23, 23, p. 5460-5467 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

Regulatory activities of reconstituted β-adrenergic receptors

Ross, E. M., Asano, T., Pedersen, S. E. & Brandt, D. R., Jan 1 1984, In : Federation Proceedings. 43, 6, p. no. 462

Research output: Contribution to journalArticle

1983

Hormone-Sensitive Adenylate Cyclase: Identity, Function, and Regulation of the Protein Components

Ross, E. M., Pedersen, S. E. & Florio, V. A., Jan 1 1983, In : Current Topics in Membranes and Transport. 18, C, p. 109-142 34 p.

Research output: Contribution to journalArticle

12 Scopus citations

Reconstitution of Catecholamine-Stimulated Guanosinetriphosphatase Activity

Brandt, D. R., Asano, T., Pedersen, S. E. & Ross, E. M., Jan 1 1983, In : Biochemistry. 22, 19, p. 4357-4362 6 p.

Research output: Contribution to journalArticle

107 Scopus citations
69 Scopus citations
Open Access
57 Scopus citations

Phosphatidylcholine-promoted interaction of the catalytic and regulatory proteins of adenylate cyclase

Ross, E. M., Dec 1 1982, In : Journal of Biological Chemistry. 257, 18, p. 10751-10758 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Radioimmunoassay of digitonin

Brooker, G., Fleming, J. W. & Ross, E. M., Feb 8 1982, In : BBA - Biomembranes. 685, 1, p. 39-43 5 p.

Research output: Contribution to journalArticle

1981

Alteration in the protein components of catecholamine-sensitive adenylate cyclase during maturation of rat reticulocytes.

Larner, A. C. & Ross, E. M., Sep 25 1981, In : Journal of Biological Chemistry. 256, 18, p. 9551-9557 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Modulation of the protein components of β-adrenergic adenylate cyclase (AC) during maturation of rat reticulocytes

Larner, A. C. & Ross, E. M., Jan 1 1981, In : Federation Proceedings. 40, 3 I, p. No. 2421

Research output: Contribution to journalArticle

Physical separation of the catalytic and regulatory proteins of hepatic adenylate cyclase

Ross, E. M., Jan 1 1981, In : Journal of Biological Chemistry. 256, 4, p. 1949-1953 5 p.

Research output: Contribution to journalArticle

30 Scopus citations
1980

Purification of the regulatory component of adenylate cyclase

Northup, J. K., Sternweis, P. C., Smigel, M. D., Schleifer, L. S., Ross, E. M. & Gilman, A. G., 1980, In : Proceedings of the National Academy of Sciences of the United States of America. 77, 11 I, p. 6516-6520 5 p.

Research output: Contribution to journalArticle

310 Scopus citations
16 Scopus citations
1978

Hormone-sensitive adenylate cyclase: resolution and reconstitution of some components necessary for regulation of the enzyme.

Ross, E. M., Haga, T., Howlett, A. C., Schwarzmeier, J., Schleifer, L. S. & Gilman, A. G., Jan 1 1978, In : Advances in cyclic nucleotide research. 9, p. 53-68 16 p.

Research output: Contribution to journalArticle

22 Scopus citations