Pharmacology - Smith Lab

Research Output

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Article
2020

Multiple channels of DEET repellency in Drosophila

Guo, H., Kunwar, K. & Smith, D., Mar 1 2020, In : Pest Management Science. 76, 3, p. 880-887 8 p.

Research output: Contribution to journalArticle

2019

Odor-specific deactivation defects in a drosophila odorant-binding protein mutant

Scheuermann, E. A. & Smith, D. P., Jan 1 2019, In : Genetics. 213, 3, p. 897-909 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2017

Odorant receptor desensitization in insects

Guo, H. & Smith, D. P., Jan 1 2017, In : Journal of Experimental Neuroscience. 11

Research output: Contribution to journalArticle

5 Scopus citations

Odorant receptor sensitivity modulation in Drosophila

Guo, H., Kunwar, K. & Smith, D., Sep 27 2017, In : Journal of Neuroscience. 37, 39, p. 9465-9473 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2016

A broadly tuned odorant receptor in neurons of trichoid sensilla in locust, Locusta migratoria

You, Y., Smith, D. P., Lv, M. & Zhang, L., Dec 1 2016, In : Insect Biochemistry and Molecular Biology. 79, p. 66-72 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Odorant responses and courtship behaviors influenced by at4 neurons in Drosophila

Pitts, S., Pelser, E., Meeks, J. & Smith, D., Sep 1 2016, In : PLoS One. 11, 9, e0162761.

Research output: Contribution to journalArticle

7 Scopus citations
2015

TAF11 Assembles the RISC Loading Complex to Enhance RNAi Efficiency

Liang, C., Wang, Y., Murota, Y., Liu, X., Smith, D., Siomi, M. C. & Liu, Q., Sep 3 2015, In : Molecular Cell. 59, 5, p. 807-818 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Farnesol-detecting olfactory neurons in drosophila

Ronderos, D. S., Lin, C. C., Potter, C. J. & Smith, D. P., Jan 1 2014, In : Journal of Neuroscience. 34, 11, p. 3959-3968 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Lipid flippase modulates olfactory receptor expression and odorant sensitivity in Drosophila

Ha, T. S., Xia, R., Zhang, H., Jin, X. & Smith, D. P., May 27 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 21, p. 7831-7836 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Combinatorial rules of precursor specification underlying olfactory neuron diversity

Li, Q., Ha, T. S., Okuwa, S., Wang, Y., Wang, Q., Millard, S. S., Smith, D. P. & Volkan, P. C., Dec 16 2013, In : Current Biology. 23, 24, p. 2481-2490 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Lump is a putative Double-Stranded RNA binding protein required for male fertility in Drosophila melanogaster

Sanders, C. & Smith, D. P., Sep 6 2011, In : PloS one. 6, 8, e24151.

Research output: Contribution to journalArticle

5 Scopus citations
2010
36 Scopus citations

Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal

Kwon, Y., Kim, S. H., Ronderos, D. S., Lee, Y., Akitake, B., Woodward, O. M., Guggino, W. B., Smith, D. P. & Montell, C., Sep 3 2010, In : Current Biology. 20, 18, p. 1672-1678 7 p.

Research output: Contribution to journalArticle

101 Scopus citations

Sensory components of behavioral isolation between Zimbabwe and cosmopolitan Drosophila melanogaster

Ma, D., Smith, D., Zheng, Z. & Michalak, P., Dec 1 2010, In : Israel Journal of Ecology and Evolution. 56, 2, p. 197-206 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2009

Diverse signaling mechanisms mediate volatile odorant detection in Drosophila

Ronderos, D. S. & Smith, D. P., Jan 1 2009, In : Fly. 3, 4

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2008

Activation of Pheromone-Sensitive Neurons Is Mediated by Conformational Activation of Pheromone-Binding Protein

Laughlin, J. D., Ha, T. S., Jones, D. N. M. & Smith, D. P., Jun 27 2008, In : Cell. 133, 7, p. 1255-1265 11 p.

Research output: Contribution to journalArticle

301 Scopus citations

Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1

Kalidas, S., Sanders, C., Ye, X., Strauss, T., Kuhn, M., Liu, Q. & Smith, D. P., May 1 2008, In : Mechanisms of Development. 125, 5-6, p. 475-485 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

SNMP is a signaling component required for pheromone sensitivity in Drosophila

Jin, X., Tal, S. H. & Smith, D. P., Aug 5 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 31, p. 10996-11001 6 p.

Research output: Contribution to journalArticle

184 Scopus citations
2006

A pheromone receptor mediates 11-cis-vaccenyl acetate-induced responses in Drosophila

Tal, S. H. & Smith, D. P., Aug 23 2006, In : Journal of Neuroscience. 26, 34, p. 8727-8733 7 p.

Research output: Contribution to journalArticle

174 Scopus citations

Dicer-2 and R2D2 coordinately bind siRNA to promote assembly of the siRISC complexes

Liu, X., Jiang, F., Kalidas, S., Smith, D. & Liu, Q., Aug 3 2006, In : RNA. 12, 8, p. 1514-1520 7 p.

Research output: Contribution to journalArticle

116 Scopus citations
2005

Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons

Xu, P., Atkinson, R., Jones, D. N. M. & Smith, D. P., Jan 20 2005, In : Neuron. 45, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

358 Scopus citations

Three odorant-binding proteins are co-expressed in sensilla trichodea of Drosophila melanogaster

Shanbhag, S. R., Smith, D. P. & Steinbrecht, R. A., Apr 2005, In : Arthropod Structure and Development. 34, 2, p. 153-165 13 p.

Research output: Contribution to journalArticle

25 Scopus citations
2003

Functional genomics, fragile X syndrome, and RNA interference

Kalidas, S. & Smith, D. P., Sep 1 2003, In : Archives of neurology. 60, 9, p. 1197-1200 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae

Xu, P. X., Zwiebelt, L. J. & Smith, D. P., Dec 1 2003, In : Insect Molecular Biology. 12, 6, p. 549-560 12 p.

Research output: Contribution to journalArticle

147 Scopus citations

R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway

Liu, Q., Rand, T. A., Kalidas, S., Du, F., Kim, H. E., Smith, D. P. & Wang, X., Sep 26 2003, In : Science. 301, 5641, p. 1921-1925 5 p.

Research output: Contribution to journalArticle

504 Scopus citations

Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster

Kruse, S. W., Zhao, R., Smith, D. P. & Jones, D. N. M., Sep 1 2003, In : Nature Structural Biology. 10, 9, p. 694-700 7 p.

Research output: Contribution to journalArticle

174 Scopus citations

Targeted Mutation of a Drosophila Odor Receptor Defines Receptor Requirement in a Novel Class of Sensillum

Elmore, T., Ignell, R., Carlson, J. R. & Smith, D. P., Oct 29 2003, In : Journal of Neuroscience. 23, 30, p. 9906-9912 7 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations
2002

Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila

Kalidas, S. & Smith, D. P., Jan 17 2002, In : Neuron. 33, 2, p. 177-184 8 p.

Research output: Contribution to journalArticle

179 Scopus citations
2001

A large family of divergent Drosophila odorant-binding proteins expressed in gustatory and olfactory sensilla

Galindo, K. & Smith, D. P., Dec 1 2001, In : Genetics. 159, 3, p. 1059-1072 14 p.

Research output: Contribution to journalArticle

204 Scopus citations

Expression mosaic of odorant-binding proteins in Drosophila olfactory organs

Shanbhag, S. R., Hekmat-Scafe, D., Kim, M. S., Park, S. K., Carlson, J. R., Pikielny, C., Smith, D. P. & Steinbrecht, R. A., Dec 1 2001, In : Microscopy Research and Technique. 55, 5, p. 297-306 10 p.

Research output: Contribution to journalArticle

88 Scopus citations

Genetic manipulation of the odor-evoked distributed neural activity in the Drosophila mushroom body

Wang, Y., Wright, N. J. D., Guo, H. F., Xie, Z., Svoboda, K., Malinow, R., Smith, D. P. & Zhong, Y., Jan 1 2001, In : Neuron. 29, 1, p. 267-276 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Putative drosophila odor receptor OR43b localizes to dendrites of olfactory neurons

Elmore, T. & Smith, D. P., Jun 22 2001, In : Insect Biochemistry and Molecular Biology. 31, 8, p. 791-798 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

The invertebrate odorant-binding protein LUSH is required for normal olfactory behavior in Drosophila

Kim, M. S. & Smith, D. P., Jan 1 2001, In : Chemical Senses. 26, 2, p. 195-199 5 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations
1998

dRGS7 encodes a Drosophila homolog of EGL-10 and vertebrate RGS7

Elmore, T., Rodriguez, A. & Smith, D. P., Jan 1 1998, In : DNA and Cell Biology. 17, 11, p. 983-989 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster

Kim, M. S., Repp, A. & Smith, D. P., Oct 20 1998, In : Genetics. 150, 2, p. 711-721 11 p.

Research output: Contribution to journalArticle

196 Scopus citations
1996

Olfactory mechanisms in Drosophila melanogaster

Smith, D. P., Aug 1996, In : Current Opinion in Neurobiology. 6, 4, p. 500-505 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
1995
Open Access
71 Scopus citations
1992

Ectopic expression of ultraviolet-rhodopsins in the blue photoreceptor cells of Drosophila: Visual physiology and photochemistry of transgenic animals

Feiler, R., Bjornson, R., Kirschfeld, K., Mismer, D., Rubin, G. M., Smith, D. P., Socolich, M. & Zuker, C. S., Jan 1 1992, In : Journal of Neuroscience. 12, 10, p. 3862-3868 7 p.

Research output: Contribution to journalArticle

103 Scopus citations
1991

Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C

Smith, D. P., Ranganathan, R., Hardy, R. W., Marx, J., Tsuchida, T. & Zuker, C. S., Jan 1 1991, In : Science. 254, 5037, p. 1478-1484 7 p.

Research output: Contribution to journalArticle

207 Scopus citations
1990

Isolation and structure of an arrestin gene from Drosophila

Smith, D. P., Shieh, B. H. & Zuker, C. S., Jan 1 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 3, p. 1003-1007 5 p.

Research output: Contribution to journalArticle

Open Access
109 Scopus citations

Isolation of a novel visual-system-specific arrestin: an in vivo substrate for light-dependent phosphorylation

LeVine, H., Smith, D. P., Whitney, M., Malicki, D. M., Dolph, P. J., Smith, G. F. H., Burkhart, W. & Zuker, C. S., Dec 1990, In : Mechanisms of Development. 33, 1, p. 19-25 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

Opsin of Calliphora peripheral photoreceptors R1-6: Homology with Drosophila Rh1 and posttranslational processing

Huber, A., Smith, D. P., Zuker, C. S. & Paulsen, R., Nov 12 1990, In : Journal of Biological Chemistry. 265, 29, p. 17906-17910 5 p.

Research output: Contribution to journalArticle

64 Scopus citations
1989

Isolation and characterization of two new Drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells

Schaeffer, E., Smith, D., Mardon, G., Quinn, W. & Zuker, C., May 5 1989, In : Cell. 57, 3, p. 403-412 10 p.

Research output: Contribution to journalArticle

114 Scopus citations