Pharmacology - Sternweis Lab

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2018

Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase

Chen, Z., Gutowski, S. & Sternweis, P. C., Apr 1 2018, In : Data in Brief. 17, p. 356-362 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Direct regulation of p190RhoGEF by activated Rho and Rac GTPases

Dada, O., Gutowski, S., Brautigam, C. A., Chen, Z. & Sternweis, P. C., Apr 2018, In : Journal of Structural Biology. 202, 1, p. 13-24 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015
6 Scopus citations
2014
6 Scopus citations
2013

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Medina, F., Carter, A. M., Dada, O., Gutowski, S., Hadas, J., Chen, Z. & Sternweis, P. C., Apr 19 2013, In : Journal of Biological Chemistry. 288, 16, p. 11325-11333 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Regions on adenylyl cyclase VII required for selective regulation by the g13 pathways

Jiang, L. I., Wang, J. E. & Sternweis, P. C., Mar 1 2013, In : Molecular Pharmacology. 83, 3, p. 587-593 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation

Jiang, L. I., Sternweis, P. C. & Wang, J. E., May 1 2013, In : Molecular Immunology. 54, 1, p. 14-22 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2012

Activation of p115-RhoGEF requires direct association of Gα13and the Dbl homology domain

Chen, Z., Guo, L., Hadas, J., Gutowski, S., Sprang, S. R. & Sternweis, P. C., Jul 20 2012, In : Journal of Biological Chemistry. 287, 30, p. 25490-25500 11 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

Chen, Z., Guo, L., Sprang, S. R. & Sternweis, P. C., Jan 1 2011, In : Protein Science. 20, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2010

Activated RhoA binds to the Pleckstrin Homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation

Chen, Z., Medina, F., Liu, M. Y., Thomas, C., Sprang, S. R. & Sternweis, P. C., Jul 2 2010, In : Journal of Biological Chemistry. 285, 27, p. 21070-21081 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice

Duan, B., Davis, R., Sadat, E. L., Collins, J., Sternweis, P. C., Yuan, D. & Jiang, L. I., Jul 1 2010, In : Journal of Immunology. 185, 1, p. 335-344 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Modeling species-specific diacylglycerol dynamics in the RAW 264.7 macrophage

Callender, H. L., Horn, M. A., DeCamp, D. L., Sternweis, P. C. & Alex Brown, H., Feb 1 2010, In : Journal of Theoretical Biology. 262, 4, p. 679-690 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2009

Deciphering signaling outcomes from a system of complex networks

Hsueh, R. C., Natarajan, M., Fraser, I., Pond, B., Liu, J., Mumby, S., Han, H., Jiang, L. I., Simon, M. I., Taussig, R. & Sternweis, P. C., May 19 2009, In : Science Signaling. 2, 71, p. ra22

Research output: Contribution to journalArticle

30 Scopus citations

Suppression of LPS-induced TNF-α production in macrophages by cAMP Is mediated by PKA-AKAP95-p105

Wall, E. A., Zavzavadjian, J. R., Mi, C. S., Randhawa, B., Zhu, X., Hsueh, R. C., Liu, J., Driver, A., Bao, X. R., Sternweis, P. C., Simon, M. I. & Fraser, I. D. C., Jun 16 2009, In : Science Signaling. 2, 75, p. ra28

Research output: Contribution to journalArticle

129 Scopus citations
2008

Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF

Chen, Z., Singer, W. D., Danesh, S. M., Sternweis, P. C. & Sprang, S. R., Oct 8 2008, In : Structure. 16, 10, p. 1532-1543 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Regulation of cAMP responses by the G12-13 pathway converges on adenylyl cyclase VII

Jiang, L. I., Collins, J., Davis, R., Fraser, I. D. & Sternweis, P. C., Aug 22 2008, In : Journal of Biological Chemistry. 283, 34, p. 23429-23439 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCβ3 to regulate intracellular free calcium

Roach, T. I. A., Rebres, R. A., Fraser, I. D. C., DeCamp, D. L., Lin, K. M., Sternweis, P. C., Simon, M. I. & Seaman, W. E., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17351-17361 11 p.

Research output: Contribution to journalArticle

30 Scopus citations
2007

Regulation of Rho Guanine Nucleotide Exchange Factors by G Proteins

Sternweis, P. C., Carter, A. M., Chen, Z., Danesh, S. M., Hsiung, Y. F. & Singer, W. D., 2007, In : Advances in Protein Chemistry. 74, p. 189-228 40 p.

Research output: Contribution to journalArticle

44 Scopus citations

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

Jiang, L. I., Collins, J., Davis, R., Lin, K. M., DeCamp, D., Roach, T., Hsueh, R., Rebres, R. A., Ross, E. M., Taussig, R., Fraser, I. & Sternweis, P. C., Apr 6 2007, In : Journal of Biological Chemistry. 282, 14, p. 10576-10584 9 p.

Research output: Contribution to journalArticle

173 Scopus citations
2006

A global analysis of cross-talk in a mammalian cellular signalling network

Natarajan, M., Lin, K. M., Hsueh, R. C., Sternweis, P. C. & Ranganathan, R., Jun 1 2006, In : Nature Cell Biology. 8, 6, p. 571-580 10 p.

Research output: Contribution to journalArticle

182 Scopus citations
2005

Structure of the p115RhoGEF rgRGS domain-Gα13/i1 chimera complex suggests convergent evolution of a GTPase activator

Chen, Z., Singer, W. D., Sternweis, P. C. & Sprang, S. R., Feb 20 2005, In : Nature Structural and Molecular Biology. 12, 2, p. 191-197 7 p.

Research output: Contribution to journalArticle

78 Scopus citations
2004

Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands

Zhu, X., Hart, R., Chang, M. S., Kim, J. W., Lee, S. Y., Cao, Y. A., Mock, D., Ke, E., Saunders, B., Alexander, A., Grossoehme, J., Lin, K. M., Yan, Z., Hsueh, R., Lee, J., Scheuermann, R. H., Fruman, D. A., Seaman, W., Subramaniam, S., Sternweis, P. & 2 others, Simon, M. I. & Choi, S., Dec 15 2004, In : Journal of Immunology. 173, 12, p. 7141-7149 9 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

RhoA Binds to the Amino Terminus of MEKK1 and Regulates Its Kinase Activity

Gallagher, E. D., Gutowski, S., Sternweis, P. C. & Cobb, M. H., Jan 16 2004, In : Journal of Biological Chemistry. 279, 3, p. 1872-1877 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins

Wang, Q., Liu, M., Kozasa, T., Rothestein, J. D., Sternweis, P. C. & Neubig, R. R., Jan 1 2004, In : Methods in Enzymology. 389, p. 244-265 22 p.

Research output: Contribution to journalArticle

9 Scopus citations

Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells

Wang, Q., Liu, M., Kozasa, T., Rothstein, J. D., Sternweis, P. C. & Neubig, R. R., Jul 9 2004, In : Journal of Biological Chemistry. 279, 28, p. 28831-28834 4 p.

Research output: Contribution to journalArticle

55 Scopus citations
2003

Mapping the Gα13 binding interface of the rgRGS domain of p115RhoGEF

Chen, Z., Singer, W. D., Wells, C. D., Sprang, S. R. & Sternweis, P. C., Mar 14 2003, In : Journal of Biological Chemistry. 278, 11, p. 9912-9919 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2002

Mechanisms for reversible regulation between G13 and Rho exchange factors

Wells, C. D., Liu, M. Y., Jackson, M., Gutowski, S., Sternweis, P. M., Rothstein, J. D., Kozasa, T. & Sternweis, P. C., Jan 11 2002, In : Journal of Biological Chemistry. 277, 2, p. 1174-1181 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

p115 Rho GTPase activating protein interacts with MEKK1

Christerson, L. B., Gallagher, E., Vanderbilt, C. A., Whitehurst, A. W., Wells, C., Kazempour, R., Sternweis, P. C. & Cobb, M. H., Jul 20 2002, In : Journal of cellular physiology. 192, 2, p. 200-208 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2001

Assays and characterization of mammalian phosphatidylinositol 4,5-bisphosphate-sensitive phospholipase D

Jiang, X., Gutowski, S., Singer, W. D. & Sternweis, P. C., 2001, In : Methods in Enzymology. 345, p. 328-334 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Functional characterization of p115 RhoGEF

Wells, C., Jiang, X., Gutowski, S. & Sternweis, P. C., 2001, In : Methods in Enzymology. 345, p. 371-382 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of Potential Mechanisms for Regulation of p115 RhoGEF through Analysis of Endogenous and Mutant Forms of the Exchange Factor

Wells, C. D., Gutowski, S., Bollag, G. & Sternweis, P. C., Aug 3 2001, In : Journal of Biological Chemistry. 276, 31, p. 28897-28905 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Structure of the rgRGs domain of p115RhoGEF

Chen, Z., Wells, C. D., Sternweis, P. C. & Sprang, S. R., Sep 12 2001, In : Nature Structural Biology. 8, 9, p. 805-809 5 p.

Research output: Contribution to journalArticle

50 Scopus citations

The C Terminus of Mammalian Phospholipase D Is Required for Catalytic Activity

Liu, M. Y., Gutowski, S. & Sternweis, P. C., Feb 23 2001, In : Journal of Biological Chemistry. 276, 8, p. 5556-5562 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
1999

The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae

Faulkner, A., Chen, X., Rush, J., Horazdovsky, B., Waechter, C. J., Carman, G. M. & Sternweis, P. C., May 21 1999, In : Journal of Biological Chemistry. 274, 21, p. 14831-14837 7 p.

Research output: Contribution to journalArticle

87 Scopus citations
1998

Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects

Xie, Z., Fang, M., Rivas, M. P., Faulkner, A. J., Sternweis, P. C., Engebrecht, J. & Bankaitis, V. A., Oct 13 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 21, p. 12346-12351 6 p.

Research output: Contribution to journalArticle

140 Scopus citations
1997

Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997)

Taylor, P., Ross, E. M., Sternweis, P. C., Neubig, R. R. & McCammon, J. A., Jan 1 1997, In : Molecular Pharmacology. 52, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Regulation of phospholipase d and its role in membrane traffic

Sternweis, P. C., Brown, H. A., Singer, W. D., Jiang, X., Faulkner, A., Wells, C., Roth, M. G., Ktistakis, N. T. & Bi, K., Dec 1 1997, In : FASEB Journal. 11, 9, p. A874

Research output: Contribution to journalArticle

The monomeric G-proteins Rac1 and/or Cdc42 are required for the inhibition of voltage-dependent calcium current by bradykinin

Wilk-Blaszczak, M. A., Singer, W. D., Quill, T., Miller, B., Frost, J. A., Sternweis, P. C. & Belardetti, F., 1997, In : Journal of Neuroscience. 17, 11, p. 4094-4100 7 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

The role of lipid signaling in constitutive membrane traffic

Roth, M. G. & Sternweis, P. C., Aug 1997, In : Current Opinion in Cell Biology. 9, 4, p. 519-526 8 p.

Research output: Contribution to journalArticle

91 Scopus citations
1996

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles

Ktistakis, N. T., Brown, H. A., Waters, M. G., Sternweis, P. C. & Roth, M. G., Jul 1 1996, In : Journal of Cell Biology. 134, 2, p. 295-306 12 p.

Research output: Contribution to journalArticle

323 Scopus citations

Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity

Singer, W. D., Brown, H. A., Jiang, X. & Sternweis, P. C., Feb 23 1996, In : Journal of Biological Chemistry. 271, 8, p. 4504-4510 7 p.

Research output: Contribution to journalArticle

Open Access
230 Scopus citations
1995

Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain

Brown, H. A., Gutowski, S., Kahn, R. A. & Sternweis, P. C., Jan 1 1995, In : Journal of Biological Chemistry. 270, 25, p. 14935-14943 9 p.

Research output: Contribution to journalArticle

129 Scopus citations
181 Scopus citations

Resolved phospholipase D activity is modulated by cytosolic factors other than Arf

Singer, W. D., Brown, H. A., Bokoch, G. M. & Sternweis, P. C., Jan 1 1995, In : Journal of Biological Chemistry. 270, 25, p. 14944-14950 7 p.

Research output: Contribution to journalArticle

124 Scopus citations

Stimulation of phospholipase D by ADP-ribosylation factor

Brown, H. A. & Sternweis, P. C., Jan 1 1995, In : Methods in Enzymology. 257, C, p. 313-324 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
1994

[13] Synthesis and applications of affinity matrix containing immobilized βγ subunits of G proteins

Pang, I. H., Smrcka, A. V. & Sternweis, P. C., Aug 19 1994, In : Methods in Enzymology. 237, p. 154-174 21 p.

Research output: Contribution to journalArticle

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

Stephens, L., Smrcka, A., Cooke, F. T., Jackson, T. R., Sternweis, P. C. & Hawkins, P. T., Apr 8 1994, In : Cell. 77, 1, p. 83-93 11 p.

Research output: Contribution to journalArticle

501 Scopus citations

Bradykinin modulates potassium and calcium currents in neuroblastoma hybrid cells via different pertussis toxin-insensitive pathways

Wilk-Blaszczak, M. A., Gutowski, S., Sternweis, P. C. & Belardetti, F., Jan 1994, In : Neuron. 12, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Purification and characterization of the α subunit of G13

Singer, W. D., Miller, R. T. & Sternweis, P. C., Jan 1 1994, In : Journal of Biological Chemistry. 269, 31, p. 19796-19802 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Synthesis and applications of affinity matrix containing immobilized βγ subunits of G proteins

Pang, I. H., Smrcka, A. V. & Sternweis, P. C., Jan 1 1994, In : Methods in Enzymology. 237, C, p. 164-174 11 p.

Research output: Contribution to journalArticle

5 Scopus citations