Pharmacology - Sternweis Lab

Research output

Research output per year 1974 1981 1990 1991 1992 1993 1994 1995 1997 2001 2004 2018

• 99 Article
• 8 Review article
• 3 Chapter
• 1 Letter

Research output per year

Research output per year

Search results

• 2018

  Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase

  Chen, Z., Gutowski, S. & Sternweis, P. C., Apr 2018, In: Data in Brief. 17, p. 356-362 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Pleckstrin Homology Domains 89%
  • GTP Phosphohydrolases 74%
  • rho GTP-Binding Proteins 65%
  • Manuscripts 15%
  5 Scopus citations

• Direct regulation of p190RhoGEF by activated Rho and Rac GTPases

  Dada, O., Gutowski, S., Brautigam, C. A., Chen, Z. & Sternweis, P. C., Apr 2018, In: Journal of Structural Biology. 202, 1, p. 13-24 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rho Guanine Nucleotide Exchange Factors 100%
  • rho GTP-Binding Proteins 81%
  • GTP Phosphohydrolases 74%
  • Pleckstrin Homology Domains 66%
  • Cell Shape 19%
  11 Scopus citations
• 2015

  Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZâ€"RhoGEF

  Pascoe, H. G., Gutowski, S., Chen, H., Brautigam, C. A., Chen, Z., Sternweis, P. C. & Zhang, X., Dec 1 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14852-14857 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • plexin 100%
  • Rho Guanine Nucleotide Exchange Factors 98%
  • PDZ Domains 88%
  • Binding Sites 49%
  • Ligands 15%
  13 Scopus citations
• 2014

  Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs)

  Carter, A. M., Gutowski, S. & Sternweis, P. C., Jul 11 2014, In: Journal of Biological Chemistry. 289, 28, p. 19737-19746 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • GTP-Binding Protein Regulators 96%
  • Guanine 63%
  • Nucleotide 53%
  • Protein 26%
  9 Scopus citations
• 2013

  Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

  Medina, F., Carter, A. M., Dada, O., Gutowski, S., Hadas, J., Chen, Z. & Sternweis, P. C., Apr 19 2013, In: Journal of Biological Chemistry. 288, 16, p. 11325-11333 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Pleckstrin Homology Domains 89%
  • GTP Phosphohydrolases 74%
  • Guanine 63%
  • Nucleotide 53%
  37 Scopus citations

• Regions on adenylyl cyclase VII required for selective regulation by the g13 pathways

  Jiang, L. I., Wang, J. E. & Sternweis, P. C., Mar 2013, In: Molecular Pharmacology. 83, 3, p. 587-593 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • adenylyl cyclase 7 100%
  • Protein Isoforms 40%
  • Second Messenger Systems 27%
  • Adenylyl Cyclases 25%
  • Mutagenesis 24%
  5 Scopus citations

• Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation

  Jiang, L. I., Sternweis, P. C. & Wang, J. E., May 2013, In: Molecular Immunology. 54, 1, p. 14-22 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • adenylyl cyclase 7 100%
  • Zymosan 62%
  • Cyclic AMP-Dependent Protein Kinases 52%
  • Innate Immunity 46%
  • Inflammation 29%
  23 Scopus citations
• 2012

  Activation of p115-RhoGEF requires direct association of Gα₁₃and the Dbl homology domain

  Chen, Z., Guo, L., Hadas, J., Gutowski, S., Sprang, S. R. & Sternweis, P. C., Jul 20 2012, In: Journal of Biological Chemistry. 287, 30, p. 25490-25500 11 p.

  Research output: Contribution to journal › Article › peer-review

  • G12 100%
  • Rho Guanine Nucleotide Exchange Factors 92%
  • Guanine 58%
  • Mutation 50%
  • Nucleotide 49%
  33 Scopus citations
• 2011

  Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

  Chen, Z., Guo, L., Sprang, S. R. & Sternweis, P. C., Jan 2011, In: Protein Science. 20, 1, p. 107-117 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Guanine Nucleotides 80%
  • Guanine 63%
  • Nucleotide 53%
  • G12 36%
  30 Scopus citations
• 2010

  Activated RhoA binds to the Pleckstrin Homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation

  Chen, Z., Medina, F., Liu, M. Y., Thomas, C., Sprang, S. R. & Sternweis, P. C., Jul 2 2010, In: Journal of Biological Chemistry. 285, 27, p. 21070-21081 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Pleckstrin Homology Domains 89%
  • GDP 82%
  • Guanosine 71%
  • platelet protein P47 65%
  48 Scopus citations

• Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice

  Duan, B., Davis, R., Sadat, E. L., Collins, J., Sternweis, P. C., Yuan, D. & Jiang, L. I., Jul 1 2010, In: Journal of Immunology. 185, 1, p. 335-344 10 p.

  Research output: Contribution to journal › Article › peer-review

  • adenylyl cyclase 7 100%
  • Protein Isoforms 32%
  • T-Lymphocytes 31%
  • Immune System 24%
  • Second Messenger Systems 22%
  66 Scopus citations

• Modeling species-specific diacylglycerol dynamics in the RAW 264.7 macrophage

  Callender, H. L., Horn, M. A., DeCamp, D. L., Sternweis, P. C. & Alex Brown, H., Feb 2010, In: Journal of Theoretical Biology. 262, 4, p. 679-690 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Macrophages 100%
  • Macrophage 92%
  • Diglycerides 71%
  • diacylglycerols 64%
  • macrophages 53%
  3 Scopus citations
• 2009

  Deciphering signaling outcomes from a system of complex networks

  Hsueh, R. C., Natarajan, M., Fraser, I., Pond, B., Liu, J., Mumby, S., Han, H., Jiang, L. I., Simon, M. I., Taussig, R. & Sternweis, P. C., May 19 2009, In: Science signaling. 2, 71, p. ra22

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ligands 100%
  • Cytokines 87%
  • Toll-Like Receptor 4 81%
  • Signal Transduction 76%
  • Cyclic AMP 69%
  32 Scopus citations

• Suppression of LPS-induced TNF-α production in macrophages by cAMP Is mediated by PKA-AKAP95-p105

  Wall, E. A., Zavzavadjian, J. R., Mi, C. S., Randhawa, B., Zhu, X., Hsueh, R. C., Liu, J., Driver, A., Bao, X. R., Sternweis, P. C., Simon, M. I. & Fraser, I. D. C., Jun 16 2009, In: Science signaling. 2, 75, p. ra28

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclic AMP 100%
  • Protein Kinases 93%
  • Macrophages 71%
  • RNA Interference 48%
  • Protein 41%
  152 Scopus citations
• 2008

  Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF

  Chen, Z., Singer, W. D., Danesh, S. M., Sternweis, P. C. & Sprang, S. R., Oct 8 2008, In: Structure. 16, 10, p. 1532-1543 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • GTPase-Activating Proteins 87%
  • Binding Sites 33%
  • Heterotrimeric GTP-Binding Proteins 28%
  • Protein Binding 21%
  39 Scopus citations

• Regulation of cAMP responses by the G_12-13 pathway converges on adenylyl cyclase VII

  Jiang, L. I., Collins, J., Davis, R., Fraser, I. D. & Sternweis, P. C., Aug 22 2008, In: Journal of Biological Chemistry. 283, 34, p. 23429-23439 11 p.

  Research output: Contribution to journal › Article › peer-review

  • adenylyl cyclase 7 100%
  • Second Messenger Systems 55%
  • HEK293 Cells 54%
  • Protein Isoforms 40%
  • Macrophages 35%
  49 Scopus citations

• Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCβ3 to regulate intracellular free calcium

  Roach, T. I. A., Rebres, R. A., Fraser, I. D. C., DeCamp, D. L., Lin, K. M., Sternweis, P. C., Simon, M. I. & Seaman, W. E., Jun 20 2008, In: Journal of Biological Chemistry. 283, 25, p. 17351-17361 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Uridine Diphosphate 100%
  • Uridine 86%
  • Calcium(0) 59%
  • Macrophages 54%
  • Calcium 52%
  38 Scopus citations
• 2007

  Regulation of Rho Guanine Nucleotide Exchange Factors by G Proteins

  Sternweis, P. C., Carter, A. M., Chen, Z., Danesh, S. M., Hsiung, Y. F. & Singer, W. D., 2007, In: Advances in Protein Chemistry. 74, p. 189-228 40 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • GTP-Binding Proteins 64%
  • Guanine 63%
  • Nucleotide 53%
  • G12-G13 GTP-Binding Protein alpha Subunits 46%
  46 Scopus citations

• Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

  Jiang, L. I., Collins, J., Davis, R., Lin, K. M., DeCamp, D., Roach, T., Hsueh, R., Rebres, R. A., Ross, E. M., Taussig, R., Fraser, I. & Sternweis, P. C., Apr 6 2007, In: Journal of Biological Chemistry. 282, 14, p. 10576-10584 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sphingosine 1-Phosphate 100%
  • Energy Transfer 83%
  • sphingosine 1-phosphate 82%
  • Bioluminescence 75%
  • Fluorescence Resonance Energy Transfer 62%
  260 Scopus citations
• 2006

  A global analysis of cross-talk in a mammalian cellular signalling network

  Natarajan, M., Lin, K. M., Hsueh, R. C., Sternweis, P. C. & Ranganathan, R., Jun 2006, In: Nature cell biology. 8, 6, p. 571-580 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Electronic Data Processing 100%
  • Ligands 69%
  • Macrophages 68%
  • Phosphorylation 67%
  • Cytokines 61%
  198 Scopus citations
• 2005

  Structure of the p115RhoGEF rgRGS domain-Gα13/i1 chimera complex suggests convergent evolution of a GTPase activator

  Chen, Z., Singer, W. D., Sternweis, P. C. & Sprang, S. R., Feb 20 2005, In: Nature Structural and Molecular Biology. 12, 2, p. 191-197 7 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP Phosphohydrolase Activators 100%
  • Rho Guanine Nucleotide Exchange Factors 83%
  • GTP-Binding Protein Regulators 32%
  • GTPase-Activating Proteins 29%
  • Guanine Nucleotide Exchange Factors 28%
  90 Scopus citations
• 2004

  Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands

  Zhu, X., Hart, R., Chang, M. S., Kim, J. W., Lee, S. Y., Cao, Y. A., Mock, D., Ke, E., Saunders, B., Alexander, A., Grossoehme, J., Lin, K. M., Yan, Z., Hsueh, R., Lee, J., Scheuermann, R. H., Fruman, D. A., Seaman, W., Subramaniam, S., Sternweis, P., & 2 othersSimon, M. I. & Choi, S., Dec 15 2004, In: Journal of Immunology. 173, 12, p. 7141-7149 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • B-Lymphocytes 100%
  • CD40 Ligand 96%
  • Ligands 91%
  • Gene Expression 77%
  • Interleukin-4 72%
  43 Scopus citations

• RhoA Binds to the Amino Terminus of MEKK1 and Regulates Its Kinase Activity

  Gallagher, E. D., Gutowski, S., Sternweis, P. C. & Cobb, M. H., Jan 16 2004, In: Journal of Biological Chemistry. 279, 3, p. 1872-1877 6 p.

  Research output: Contribution to journal › Article › peer-review

  • PHD Zinc Fingers 100%
  • rho GTP-Binding Proteins 77%
  • JNK Mitogen-Activated Protein Kinases 69%
  • MAP Kinase Signaling System 68%
  • Mitogen-Activated Protein Kinase Kinases 67%
  66 Scopus citations

• Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins

  Wang, Q., Liu, M., Kozasa, T., Rothestein, J. D., Sternweis, P. C. & Neubig, R. R., 2004, In: Methods in Enzymology. 389, p. 244-265 22 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Small Interfering RNA 89%
  • Catalytic RNA 85%
  • Protein 26%
  • Proteins 23%
  9 Scopus citations

• Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells

  Wang, Q., Liu, M., Kozasa, T., Rothstein, J. D., Sternweis, P. C. & Neubig, R. R., Jul 9 2004, In: Journal of Biological Chemistry. 279, 28, p. 28831-28834 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Lysophosphatidic Acid 100%
  • Rho Guanine Nucleotide Exchange Factors 99%
  • Lysophosphatidic Acid Receptors 97%
  • Thrombin 69%
  • Guanine 62%
  62 Scopus citations
• 2003

  Mapping the Gα₁₃ binding interface of the rgRGS domain of p115RhoGEF

  Chen, Z., Singer, W. D., Wells, C. D., Sprang, S. R. & Sternweis, P. C., Mar 14 2003, In: Journal of Biological Chemistry. 278, 11, p. 9912-9919 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Protein Domains 65%
  • GTP-Binding Proteins 64%
  • GTPase-Activating Proteins 43%
  • Protein 26%
  37 Scopus citations

• Phospholipase D

  Sternweis, P. C., Jan 1 2003, Handbook of Cell Signaling: Volume 1-3. Elsevier, Vol. 1-3. p. 237-241 5 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2002

  Mechanisms for reversible regulation between G₁₃ and Rho exchange factors

  Wells, C. D., Liu, M. Y., Jackson, M., Gutowski, S., Sternweis, P. M., Rothstein, J. D., Kozasa, T. & Sternweis, P. C., Jan 11 2002, In: Journal of Biological Chemistry. 277, 2, p. 1174-1181 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Factor 100%
  • GTP-Binding Protein Regulators 86%
  • Rho Guanine Nucleotide Exchange Factors 76%
  • GTPase-Activating Proteins 44%
  • Protein 23%
  92 Scopus citations

• Overview of the alliance for cellular signaling

  Gilman, A. G., Dec 12 2002, In: Nature. 420, 6916, p. 703-706 4 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Cardiac Myocytes 100%
  • Immune System 85%
  • B-Lymphocytes 82%
  118 Scopus citations

• p115 Rho GTPase activating protein interacts with MEKK1

  Christerson, L. B., Gallagher, E., Vanderbilt, C. A., Whitehurst, A. W., Wells, C., Kazempour, R., Sternweis, P. C. & Cobb, M. H., 2002, In: Journal of cellular physiology. 192, 2, p. 200-208 9 p.

  Research output: Contribution to journal › Article › peer-review

  • MAP Kinase Kinase Kinase 1 100%
  • rho GTPase-activating protein 98%
  • Protein 24%
  • Transcription Factor AP-1 18%
  • Cell Movement 8%
  26 Scopus citations
• 2001

  Assays and characterization of mammalian phosphatidylinositol 4,5-bisphosphate-sensitive phospholipase D

  Jiang, X., Gutowski, S., Singer, W. D. & Sternweis, P. C., 2001, In: Methods in Enzymology. 345, p. 328-334 7 p.

  Research output: Contribution to journal › Article › peer-review
  9 Scopus citations

• Functional characterization of p115 RhoGEF

  Wells, C., Jiang, X., Gutowski, S. & Sternweis, P. C., 2001, In: Methods in Enzymology. 345, p. 371-382 12 p.

  Research output: Contribution to journal › Article › peer-review
  13 Scopus citations

• Identification of Potential Mechanisms for Regulation of p115 RhoGEF through Analysis of Endogenous and Mutant Forms of the Exchange Factor

  Wells, C. D., Gutowski, S., Bollag, G. & Sternweis, P. C., Aug 3 2001, In: Journal of Biological Chemistry. 276, 31, p. 28897-28905 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Lysophosphatidic Acid 100%
  • Rho Guanine Nucleotide Exchange Factors 99%
  • Sphingosine 1-Phosphate 50%
  • Agonist 30%
  • Pleckstrin Homology Domains 25%
  66 Scopus citations

• Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins

  Jackson, M., Song, W., Liu, M. Y., Jin, L., Dykes-Hoberg, M., Lin, C. L. G., Bowers, W. J., Federoff, H. J., Sternweis, P. C. & Rothstein, J. D., Mar 1 2001, In: Nature. 410, 6824, p. 89-93 5 p.

  Research output: Contribution to journal › Letter › peer-review

  • Amino Acid Transport System X-AG 100%
  • Glutamic Acid 66%
  • Glutamate Plasma Membrane Transport Proteins 46%
  • Proteins 27%
  • Cerebellum 23%
  210 Scopus citations

• Structure of the rgRGs domain of p115RhoGEF

  Chen, Z., Wells, C. D., Sternweis, P. C. & Sprang, S. R., 2001, In: Nature Structural Biology. 8, 9, p. 805-809 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • GTPase-Activating Proteins 58%
  • Protein Domains 43%
  • GTP-Binding Proteins 43%
  • G-substrate 42%
  53 Scopus citations

• The C Terminus of Mammalian Phospholipase D Is Required for Catalytic Activity

  Liu, M. Y., Gutowski, S. & Sternweis, P. C., Feb 23 2001, In: Journal of Biological Chemistry. 276, 8, p. 5556-5562 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Phospholipase D 100%
  • 4 alpha-glucanotransferase 62%
  • Threonine 55%
  • Peptide 43%
  • Enzymes 40%
  24 Scopus citations
• 1999

  The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae

  Faulkner, A., Chen, X., Rush, J., Horazdovsky, B., Waechter, C. J., Carman, G. M. & Sternweis, P. C., May 21 1999, In: Journal of Biological Chemistry. 274, 21, p. 14831-14837 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Isoprenoid Phosphate 100%
  • Polyisoprenyl Phosphates 92%
  • dolichol monophosphate 82%
  • Dolichyl Phosphate 76%
  • geranylgeranyl pyrophosphate 73%
  114 Scopus citations
• 1998

  Direct stimulation of the guanine nucleotide exchange activity of p115 RoGEF by Gα₁₃

  Hart, M. J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W. D., Gilman, A. G., Sternweis, P. C. & Bollag, G., Jun 26 1998, In: Science. 280, 5372, p. 2112-2114 3 p.

  Research output: Contribution to journal › Review article › peer-review

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Guanine Nucleotides 80%
  • G12-G13 GTP-Binding Protein alpha Subunits 58%
  • Guanosine 40%
  • Heterotrimeric GTP-Binding Proteins 21%
  682 Scopus citations

• p115 RhoGEF, a GTPase activating protein for Gα₁₂ and Gα₁₃

  Kozasa, T., Jiang, X., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G. & Sternweis, P. C., Jun 26 1998, In: Science. 280, 5372, p. 2109-2111 3 p.

  Research output: Contribution to journal › Review article › peer-review

  • G12-G13 GTP-Binding Protein alpha Subunits 100%
  • Rho Guanine Nucleotide Exchange Factors 85%
  • Guanosine 69%
  • GTP-Binding Proteins 36%
  • RGS Proteins 28%
  746 Scopus citations

• Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects

  Xie, Z., Fang, M., Rivas, M. P., Faulkner, A. J., Sternweis, P. C., Engebrecht, J. & Bankaitis, V. A., Oct 13 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 21, p. 12346-12351 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phospholipid Transfer Proteins 100%
  • Phospholipase D 89%
  • Fungal Proteins 83%
  • Yeasts 36%
  • Phosphatidic Acids 14%
  147 Scopus citations
• 1997

  Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997)

  Taylor, P., Ross, E. M., Sternweis, P. C., Neubig, R. R. & McCammon, J. A., Jan 1 1997, In: Molecular Pharmacology. 52, 1, p. 1-5 5 p.

  Research output: Contribution to journal › Article › peer-review

• Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D

  Singer, W. D., Brown, H. A. & Sternweis, P. C., 1997, In: Annual review of biochemistry. 66, p. 475-509 35 p.

  Research output: Contribution to journal › Review article › peer-review

  • Phosphoinositide Phospholipase C 100%
  • Phospholipase D 94%
  • Phosphoinositide 47%
  • Phosphatidic Acid 44%
  • Inositol 41%
  355 Scopus citations

• Regulation of phospholipase d and its role in membrane traffic

  Sternweis, P. C., Brown, H. A., Singer, W. D., Jiang, X., Faulkner, A., Wells, C., Roth, M. G., Ktistakis, N. T. & Bi, K., 1997, In: FASEB Journal. 11, 9, p. A874

  Research output: Contribution to journal › Article › peer-review

  • Phospholipase D 100%
  • Phosphatidic Acid 95%
  • Phospholipases 90%
  • Phosphatidic Acids 56%
  • Membranes 44%

• The monomeric G-proteins Rac1 and/or Cdc42 are required for the inhibition of voltage-dependent calcium current by bradykinin

  Wilk-Blaszczak, M. A., Singer, W. D., Quill, T., Miller, B., Frost, J. A., Sternweis, P. C. & Belardetti, F., 1997, In: Journal of Neuroscience. 17, 11, p. 4094-4100 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Monomeric GTP-Binding Proteins 100%
  • Bradykinin 95%
  • Psychological Inhibition 69%
  • Calcium 58%
  • rho-Specific Guanine Nucleotide Dissociation Inhibitors 25%
  40 Scopus citations

• The role of lipid signaling in constitutive membrane traffic

  Roth, M. G. & Sternweis, P. C., Aug 1997, In: Current Opinion in Cell Biology. 9, 4, p. 519-526 8 p.

  Research output: Contribution to journal › Article › peer-review

  • ADP-Ribosylation Factors 100%
  • Adaptor Protein Complex 2 60%
  • Phospholipase D 43%
  • Dynamins 43%
  • Phosphatidic Acids 43%
  93 Scopus citations
• 1996

  Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles

  Ktistakis, N. T., Brown, H. A., Waters, M. G., Sternweis, P. C. & Roth, M. G., Jul 1996, In: Journal of Cell Biology. 134, 2, p. 295-306 12 p.

  Research output: Contribution to journal › Article › peer-review

  • ADP-Ribosylation Factors 100%
  • Coated Vesicles 95%
  • Phospholipase D 87%
  • COP-Coated Vesicles 78%
  • Phosphatidic Acids 57%
  331 Scopus citations

• Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity

  Singer, W. D., Brown, H. A., Jiang, X. & Sternweis, P. C., Feb 23 1996, In: Journal of Biological Chemistry. 271, 8, p. 4504-4510 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ADP-Ribosylation Factors 100%
  • Phospholipase D 87%
  • Protein Kinase C 61%
  • Protein Kinases 60%
  • Protein 26%
  237 Scopus citations
• 1995

  Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain

  Brown, H. A., Gutowski, S., Kahn, R. A. & Sternweis, P. C., Jun 23 1995, In: Journal of Biological Chemistry. 270, 25, p. 14935-14943 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Phospholipase D 100%
  • Swine 59%
  • Purification 50%
  • Chromatography 38%
  • Brain 36%
  134 Scopus citations

• Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A

  Ktistakis, N. T., Brown, H. A., Sternweis, P. C. & Roth, M. G., May 23 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 11, p. 4952-4956 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ADP-Ribosylation Factors 100%
  • Brefeldin A 90%
  • Phospholipase D 87%
  • Membranes 38%
  • Guanosine Triphosphate 34%
  183 Scopus citations

• Resolved phospholipase D activity is modulated by cytosolic factors other than Arf

  Singer, W. D., Brown, H. A., Bokoch, G. M. & Sternweis, P. C., Jun 23 1995, In: Journal of Biological Chemistry. 270, 25, p. 14944-14950 7 p.

  Research output: Contribution to journal › Article › peer-review

  • 1-dodecylpyridoxal 100%
  • Phospholipase D 85%
  • Monomeric GTP-Binding Proteins 21%
  • Protein 19%
  • Guanosine 17%
  129 Scopus citations