Pharmacology - Taussig Lab

Research Output

2017

Genetic and mechanistic analyses of the periplasmic domain of the enterohemorrhagic Escherichia coli QseC histidine sensor kinase

Parker, C. T., Russell, R., Njoroge, J. W., Jimenez, A. G., Taussig, R. & Sperandio, V., Apr 1 2017, In : Journal of Bacteriology. 199, 8, e00861-16.

Research output: Contribution to journalArticle

8 Scopus citations
2015

The role of ventral striatal cAMP signaling in stress-induced behaviors

Plattner, F., Hayashi, K., Hernández, A., Benavides, D. R., Tassin, T. C., Tan, C., Day, J., Fina, M. W., Yuen, E. Y., Yan, Z., Goldberg, M. S., Nairn, A. C., Greengard, P., Nestler, E. J., Taussig, R., Nishi, A., Houslay, M. D. & Bibb, J. A., Aug 30 2015, In : Nature Neuroscience. 18, 8, p. 1094-1100 7 p.

Research output: Contribution to journalArticle

34 Scopus citations
2014

QseC inhibitors as an antivirulence approach for gram-negative pathogens

Curtis, M. M., Russell, R., Moreira, C. G., Adebesin, A. M., Wang, C., Williams, N. S., Taussig, R., Stewart, D., Zimmern, P. E., Lu, B., Prasad, R. N., Zhu, C., Rasko, D. A., Huntley, J. F., Falck, J. R. & Sperandio, V., Oct 17 2014, In : mBio. 5, 6, e02165-14.

Research output: Contribution to journalArticle

53 Scopus citations
2013

Adenylyl Cyclases

Taussig, R., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 42-46 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

Potthoff, M. J., Potts, A., He, T., Duarte, J. A. G., Taussig, R., Mangelsdorf, D. J., Kliewer, S. A. & Burgess, S. C., Feb 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 4, p. G371-G380

Research output: Contribution to journalArticle

96 Scopus citations
2012

G protein-coupled receptor-mediated activation of p110b by Gβγ is required for cellular transformation and invasiveness

Dbouk, H. A., Vadas, O., Shymanets, A., Burke, J. E., Salamon, R. S., Khalil, B. D., Barrett, M. O., Waldo, G. L., Surve, C., Hsueh, C., Perisic, O., Harteneck, C., Shepherd, P. R., Harden, T. K., Smrcka, A. V., Taussig, R., Bresnick, A. R., Nürnberg, B., Williams, R. L. & Backer, J. M., Dec 4 2012, In : Science Signaling. 5, 253, ra89.

Research output: Contribution to journalArticle

86 Scopus citations

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., Kim, M. K., Beaven, M. A., Burgin, A. B., Manganiello, V. & Chung, J. H., Feb 3 2012, In : Cell. 148, 3, p. 421-433 13 p.

Research output: Contribution to journalArticle

851 Scopus citations
2009

Deciphering signaling outcomes from a system of complex networks

Hsueh, R. C., Natarajan, M., Fraser, I., Pond, B., Liu, J., Mumby, S., Han, H., Jiang, L. I., Simon, M. I., Taussig, R. & Sternweis, P. C., May 19 2009, In : Science Signaling. 2, 71, p. ra22

Research output: Contribution to journalArticle

30 Scopus citations
2008

Targeting QseC signaling and virulence for antibiotic development

Rasko, D. A., Moreira, C. G., De, R. L., Reading, N. C., Ritchie, J. M., Waldor, M. K., Williams, N. S., Taussig, R., Wei, S., Roth, M. G., Hughes, D. T., Huntley, J. F., Fina, M. W., Falck, J. R. & Sperandio, V., Aug 22 2008, In : Science. 321, 5892, p. 1078-1080 3 p.

Research output: Contribution to journalArticle

327 Scopus citations
2007

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

Jiang, L. I., Collins, J., Davis, R., Lin, K. M., DeCamp, D., Roach, T., Hsueh, R., Rebres, R. A., Ross, E. M., Taussig, R., Fraser, I. & Sternweis, P. C., Apr 6 2007, In : Journal of Biological Chemistry. 282, 14, p. 10576-10584 9 p.

Research output: Contribution to journalArticle

173 Scopus citations
2006

A mechanism of cell death involving an adenylyl cyclase/PKA signaling pathway is induced by the Cry1Ab toxin of Bacillus thuringiensis

Zhang, X., Candas, M., Griko, N. B., Taussig, R. & Bulla, L. A., Jun 27 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 26, p. 9897-9902 6 p.

Research output: Contribution to journalArticle

243 Scopus citations

Dual ligand stimulation of RAW 264.7 cells uncovers feedback mechanisms that regulate TLR-mediated gene expression

Zhu, X., Chang, M. S., Hsueh, R. C., Taussig, R., Smith, K. D., Simon, M. I. & Choi, S., Oct 1 2006, In : Journal of Immunology. 177, 7, p. 4299-4310 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

The role of endogenous growth hormone-releasing hormone in acromegaly

Dimaraki, E. V., Chandler, W. F., Brown, M. B., Jaffe, C. A., Kim, S. Y., Taussig, R., Padmanabhan, V. & Barkan, A. L., Jun 15 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 6, p. 2185-2190 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2005

A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen

Steegborn, C., Litvin, T. N., Hess, K. C., Capper, A. B., Taussig, R., Buck, J., Levin, L. R. & Wu, H., Sep 9 2005, In : Journal of Biological Chemistry. 280, 36, p. 31754-31759 6 p.

Research output: Contribution to journalArticle

61 Scopus citations
2004

Assays of recombinant adenylyl cyclases expressed in Sf9 cells.

Taussig, R., 2004, In : Methods in molecular biology (Clifton, N.J.). 237, p. 77-85 9 p.

Research output: Contribution to journalReview article

6 Scopus citations

Raf kinase activation of adenylyl cyclases: Isoform-selective regulation

Ding, Q., Gros, R., Gray, I. D., Taussig, R., Ferguson, S. S. G. & Feldman, R. D., Oct 1 2004, In : Molecular Pharmacology. 66, 4, p. 921-928 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

The laboratory information management system (LIMS) for handling the heterogeneous data from high throughput experiments in the post-genome sequencing era

Madhusudan, Vadivelu, I., Krause, L., Ning, Y., Lyon, S., Morrison, P., Sorrells, L., Taussig, R. & Subramaniam, S., Dec 1 2004, Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, METMBS'04. Valafar, F. & Valafar, H. (eds.). p. 98-104 7 p. (Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, METMBS'04).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2002

Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.

Sunahara, R. K. & Taussig, R., Jun 2002, In : Molecular interventions. 2, 3, p. 168-184 17 p.

Research output: Contribution to journalReview article

303 Scopus citations

Overview of the alliance for cellular signaling

Gilman, A. G., Dec 12 2002, In : Nature. 420, 6916, p. 703-706 4 p.

Research output: Contribution to journalReview article

109 Scopus citations
2001

Dopamine D2 receptor-induced heterologous sensitization of adenylyl cyclase requires Gαs: Characterization of Gαs-insensitive mutants of adenylyl cyclase V

Watts, V. J., Taussig, R., Neve, R. L. & Neve, K. A., Jan 1 2001, In : Molecular Pharmacology. 60, 6, p. 1168-1172 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors

Scott, J. K., Huang, S. F., Gangadhar, B. P., Samoriski, G. M., Clapp, P., Gross, R. A., Taussig, R. & Smrcka, A. V., Feb 15 2001, In : EMBO Journal. 20, 4, p. 767-776 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Genetic selection of regulatory mutants of mammalian adenylyl cyclases

Clapp, P., Capper, A. B. & Taussig, R., 2001, In : Methods in Enzymology. 345, p. 241-251 11 p.

Research output: Contribution to journalArticle

G Protein β Subunit Types Differentially Interact with a Muscarinic Receptor but Not Adenylyl Cyclase Type II or Phospholipase C-β2/3

Hou, Y., Chang, V., Capper, A. B., Taussig, R. & Gautam, N., Jun 8 2001, In : Journal of Biological Chemistry. 276, 23, p. 19982-19988 7 p.

Research output: Contribution to journalArticle

39 Scopus citations
2000

Synthesis and use of 3'-(Azidoiodosalicyl) derivatives of 2',5'- dideoxyadenosine as photoaffinity ligands for adenylyl cyclase

Shoshani, I., Taussig, R., Iyengar, R. & Johnson, R. A., Apr 1 2000, In : Archives of Biochemistry and Biophysics. 376, 1, p. 221-228 8 p.

Research output: Contribution to journalArticle

1999

Activating mutation of adenylyl cyclase reverses its inhibition by G proteins

Zimmermann, G., Zhou, D. & Taussig, R., Jan 1 1999, In : Molecular Pharmacology. 56, 5, p. 895-901 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
1998

A point mutation in Gα(o) and Gα(i1) blocks interaction with regulator of G protein signaling proteins

Lan, K. L., Sarvazyan, N. A., Taussig, R., Mackenzie, R. G., DiBello, P. R., Dohlman, H. G. & Neubig, R. R., May 22 1998, In : Journal of Biological Chemistry. 273, 21, p. 12794-12797 4 p.

Research output: Contribution to journalArticle

142 Scopus citations

Genetic selection of mammalian adenylyl cyclases insensitive to stimulation by G(sα)

Zimmermann, G., Zhou, D. & Taussig, R., Mar 20 1998, In : Journal of Biological Chemistry. 273, 12, p. 6968-6975 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mutations uncover a role for two magnesium ions in the catalytic mechanism of adenylyl cyclase

Zimmermann, G., Zhou, D. & Taussig, R., Jul 31 1998, In : Journal of Biological Chemistry. 273, 31, p. 19650-19655 6 p.

Research output: Contribution to journalArticle

56 Scopus citations
1997

4 Type-specific regulation of mammalian adenylyl cyclases by G protein pathways

Taussig, R. & Zimmermann, G., Jan 1 1997, In : Advances in Second Messenger and Phosphoprotein Research. 32, C, p. 81-98 18 p.

Research output: Contribution to journalArticle

47 Scopus citations

Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3'-polyphosphates

Johnson, R. A., Désaubry, L., Bianchi, G., Shoshani, I., Lyons, E., Taussig, R., Watson, P. A., Cali, J. J., Krupinski, J., Pieroni, J. P. & Iyengar, R., Apr 4 1997, In : Journal of Biological Chemistry. 272, 14, p. 8962-8966 5 p.

Research output: Contribution to journalArticle

91 Scopus citations

Regulation of human neuronal calcium channels by G protein βγ subunits expressed in human embryonic kidney 293 cells

Shekter, L. R., Taussig, R., Gillard, S. E. & Miller, R. J., Aug 1997, In : Molecular Pharmacology. 52, 2, p. 282-291 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
1996

Bold G protein α and βγ subunit regulation of mammalian adenylyl cyclases is modulated by protein kinase C

Ziminermann, G., Kazanietz, M. G., Blumberg, P. M. & Taussig, R., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1086

Research output: Contribution to journalArticle

Dopamine D2L receptor couples to Gαi2 and Gαi3 but not Gαi1, leading to the inhibition of adenylate cyclase in transfected cell lines

O'Hara, C. M., Tang, L., Taussig, R., Todd, R. D. & O'Malley, K. L., Jul 1996, In : Journal of Pharmacology and Experimental Therapeutics. 278, 1, p. 354-360 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Protein kinase C alters the responsiveness of adenylyl cyclases to G protein α and βγ subunits

Zimmermann, G. & Taussig, R., Nov 6 1996, In : Journal of Biological Chemistry. 271, 43, p. 27161-27166 6 p.

Research output: Contribution to journalArticle

115 Scopus citations
1995

Azido-iodo-phenyl-analogs of 2′,5′-dideoxy-adenosine as photoaffinity ligands for adenylyl cyclase

Shoshani, I., Qui, H., Johnson, F., Taussig, R. & Johnson, R. A., Aug 17 1995, In : BBA - General Subjects. 1245, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mammalian membrane-bound adenylyl cyclases

Taussig, R. & Gilman, A. G., Jan 1 1995, In : Journal of Biological Chemistry. 270, 1, p. 1-4 4 p.

Research output: Contribution to journalShort survey

423 Scopus citations
1994

Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases

Taussig, R., Tang, W. J., Hepler, J. R. & Gilman, A. G., Feb 25 1994, In : Journal of Biological Chemistry. 269, 8, p. 6093-6100 8 p.

Research output: Contribution to journalArticle

270 Scopus citations

Expression and purification of recombinant adenylyl cyclases in Sf9 cells

Taussig, R., Tang, W. J. & Gilman, A. G., Jan 1 1994, In : Methods in Enzymology. 238, C, p. 95-108 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel

Wickman, K. D., Iñiguez-Lluhi, J. A., Davenport, P. A., Taussig, R., Krapivinsky, G. B., Linder, M. E., Gilmant, A. G. & Clapham, D. E., Jan 1 1994, In : Nature. 368, 6468, p. 255-257 3 p.

Research output: Contribution to journalArticle

366 Scopus citations
1993

Inhibition of adenylyl cyclase by G

Taussig, R., Iñiguez-Lluhi, J. A. & Gilman, A. G., Jan 1 1993, In : Science. 261, 5118, p. 218-221 4 p.

Research output: Contribution to journalArticle

303 Scopus citations

Lipid modifications of G proteins: α Subunits are palmitoylated

Linder, M. E., Middleton, P., Hepler, J. R., Taussig, R., Gilman, A. G. & Mumby, S. M., Jan 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 8, p. 3675-3679 5 p.

Research output: Contribution to journalArticle

Open Access
278 Scopus citations

Regulation of purified type I and type II adenylylcyclases by G protein βγ subunits

Taussig, R., Quarmby, L. M. & Gilman, A. G., Jan 1 1993, In : Journal of Biological Chemistry. 268, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

192 Scopus citations

Type II adenylylcyclase integrates coincident signals from G(s), G(i), and G(q)

Lustig, K. D., Conklin, B. R., Herzmark, P., Taussig, R. & Bourne, H. R., Jan 1 1993, In : Journal of Biological Chemistry. 268, 19, p. 13900-13905 6 p.

Research output: Contribution to journalArticle

133 Scopus citations
1992

Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins

Taussig, R., Sanchez, S., Rifo, M., Gilman, A. G. & Belardetti, F., Apr 1992, In : Neuron. 8, 4, p. 799-809 11 p.

Research output: Contribution to journalArticle

105 Scopus citations

The G226A mutant of G(sα) highlights the requirements for dissociation of G protein subunits

Lee, E., Taussig, R. & Gilman, A. G., Jan 1 1992, In : Journal of Biological Chemistry. 267, 2, p. 1212-1218 7 p.

Research output: Contribution to journalArticle

108 Scopus citations
1989

Modulation of ionic currents, in Aplysia motor neuron B15 by serotonin, neuropeptides, and second messengers

Taussig, R., Sweet-Cordero, A. & Scheller, R. H., Jan 1 1989, In : Journal of Neuroscience. 9, 9, p. 3218-3229 12 p.

Research output: Contribution to journalArticle

36 Scopus citations
1988

Egg-laying hormone, serotonin, and cyclic nucleotide modulation of ionic currents in the identified motoneuron B16 of Aplysia

Kirk, M. D., Taussig, R. & Scheller, R. H., 1988, In : Journal of Neuroscience. 8, 4, p. 1181-1193 13 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
1986

The Aplysia FMRFamide Gene Encodes Sequences Related to Mammalian Brain Peptides

Taussig, R. & Scheller, R. H., Dec 1986, In : DNA. 5, 6, p. 453-461 9 p.

Research output: Contribution to journalArticle

91 Scopus citations
1985

Aplysia neurons express a gene encoding multiple FMRFamide neuropeptides

Schaefer, M., Picciotto, M. R., Kreiner, T., Kaldany, R. R., Taussig, R. & Scheller, R. H., Jun 1985, In : Cell. 41, 2, p. 457-467 11 p.

Research output: Contribution to journalArticle

131 Scopus citations

Expression of the L11 neuropeptide gene in the Aplysia central nervous system

Taussig, R., Kaldany, R. R., Rothbard, J., Schoolnik, G. & Scheller, R. H., Aug 1 1985, In : Journal of Comparative Neurology. 238, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

16 Scopus citations