Pharmacology - Taussig Lab

Research Output 1983 2017

2017
6 Citations (Scopus)

Genetic and mechanistic analyses of the periplasmic domain of the enterohemorrhagic Escherichia coli QseC histidine sensor kinase

Parker, C. T., Russell, R., Njoroge, J. W., Jimenez, A. G., Taussig, R. & Sperandio, V., Apr 1 2017, In : Journal of Bacteriology. 199, 8, e00861-16.

Research output: Contribution to journalArticle

Shiga Toxin
Enterohemorrhagic Escherichia coli
Enterocytes
Amino Acids
Flagella
2015
32 Citations (Scopus)

The role of ventral striatal cAMP signaling in stress-induced behaviors

Plattner, F., Hayashi, K., Hernández, A., Benavides, D. R., Tassin, T. C., Tan, C., Day, J., Fina, M. W., Yuen, E. Y., Yan, Z., Goldberg, M. S., Nairn, A. C., Greengard, P., Nestler, E. J., Taussig, R., Nishi, A., Houslay, M. D. & Bibb, J. A., Aug 30 2015, In : Nature Neuroscience. 18, 8, p. 1094-1100 7 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Corpus Striatum
Cyclin-Dependent Kinases
Type 4 Cyclic Nucleotide Phosphodiesterase
Cyclic AMP-Dependent Protein Kinases
2014
50 Citations (Scopus)

QseC inhibitors as an antivirulence approach for gram-negative pathogens

Curtis, M. M., Russell, R., Moreira, C. G., Adebesin, A. M., Wang, C., Williams, N. S., Taussig, R., Stewart, D., Zimmern, P. E., Lu, B., Prasad, R. N., Zhu, C., Rasko, D. A., Huntley, J. F., Falck, J. R. & Sperandio, V., Oct 17 2014, In : mBio. 5, 6, e02165-14.

Research output: Contribution to journalArticle

Virulence
Information Science
Microbiota
Prodrugs
Structure-Activity Relationship
2013

Adenylyl Cyclases

Taussig, R., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 42-46 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Adenylyl Cyclases
Cyclic AMP
Cell growth
Second Messenger Systems
Blood Glucose
90 Citations (Scopus)
Glycogenolysis
Glucagon-Like Peptide 1
Bile Acids and Salts
Liver
Cholesterol
2012
84 Citations (Scopus)

G protein-coupled receptor-mediated activation of p110b by Gβγ is required for cellular transformation and invasiveness

Dbouk, H. A., Vadas, O., Shymanets, A., Burke, J. E., Salamon, R. S., Khalil, B. D., Barrett, M. O., Waldo, G. L., Surve, C., Hsueh, C., Perisic, O., Harteneck, C., Shepherd, P. R., Harden, T. K., Smrcka, A. V., Taussig, R., Bresnick, A. R., Nürnberg, B., Williams, R. L. & Backer, J. M., Dec 4 2012, In : Science Signaling. 5, 253, ra89.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
G-Protein-Coupled Receptors
Phosphatidylinositols
Chemical activation
Tumors
800 Citations (Scopus)

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., Kim, M. K., Beaven, M. A., Burgin, A. B., Manganiello, V. & Chung, J. H., Feb 3 2012, In : Cell. 148, 3, p. 421-433 13 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Aging of materials
Phenotype
Phosphodiesterase 4 Inhibitors
Rolipram
2009
29 Citations (Scopus)

Deciphering signaling outcomes from a system of complex networks

Hsueh, R. C., Natarajan, M., Fraser, I., Pond, B., Liu, J., Mumby, S., Han, H., Jiang, L. I., Simon, M. I., Taussig, R. & Sternweis, P. C., May 19 2009, In : Science Signaling. 2, 71

Research output: Contribution to journalArticle

Complex networks
Machinery
Cytokines
Ligands
Signal transduction
2008
309 Citations (Scopus)

Targeting QseC signaling and virulence for antibiotic development

Rasko, D. A., Moreira, C. G., De, R. L., Reading, N. C., Ritchie, J. M., Waldor, M. K., Williams, N. S., Taussig, R., Wei, S., Roth, M. G., Hughes, D. T., Huntley, J. F., Fina, M. W., Falck, J. R. & Sperandio, V., Aug 22 2008, In : Science. 321, 5892, p. 1078-1080 3 p.

Research output: Contribution to journalArticle

Virulence
Anti-Bacterial Agents
Poisons
Virulence Factors
Adrenergic Agents
2007
156 Citations (Scopus)

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

Jiang, L. I., Collins, J., Davis, R., Lin, K. M., DeCamp, D., Roach, T., Hsueh, R., Rebres, R. A., Ross, E. M., Taussig, R., Fraser, I. & Sternweis, P. C., Apr 6 2007, In : Journal of Biological Chemistry. 282, 14, p. 10576-10584 9 p.

Research output: Contribution to journalArticle

Bioluminescence
Energy Transfer
Adenosine
Energy transfer
Sensors
2006
230 Citations (Scopus)

A mechanism of cell death involving an adenylyl cyclase/PKA signaling pathway is induced by the Cry1Ab toxin of Bacillus thuringiensis

Zhang, X., Candas, M., Griko, N. B., Taussig, R. & Bulla, L. A., Jun 27 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 26, p. 9897-9902 6 p.

Research output: Contribution to journalArticle

Bacillus thuringiensis
Adenylyl Cyclases
Cell Death
Insects
Cyclic AMP-Dependent Protein Kinases
14 Citations (Scopus)

Dual ligand stimulation of RAW 264.7 cells uncovers feedback mechanisms that regulate TLR-mediated gene expression

Zhu, X., Chang, M. S., Hsueh, R. C., Taussig, R., Smith, K. D., Simon, M. I. & Choi, S., Oct 1 2006, In : Journal of Immunology. 177, 7, p. 4299-4310 12 p.

Research output: Contribution to journalArticle

Ligands
Gene Expression
Isoproterenol
Dinoprostone
Interleukin-10
6 Citations (Scopus)

The role of endogenous growth hormone-releasing hormone in acromegaly

Dimaraki, E. V., Chandler, W. F., Brown, M. B., Jaffe, C. A., Kim, S. Y., Taussig, R., Padmanabhan, V. & Barkan, A. L., 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 6, p. 2185-2190 6 p.

Research output: Contribution to journalArticle

Growth Hormone-Releasing Hormone
Acromegaly
Ants
Blood Group Antigens
Tumors
2005
60 Citations (Scopus)

A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen

Steegborn, C., Litvin, T. N., Hess, K. C., Capper, A. B., Taussig, R., Buck, J., Levin, L. R. & Wu, H., Sep 9 2005, In : Journal of Biological Chemistry. 280, 36, p. 31754-31759 6 p.

Research output: Contribution to journalArticle

Catechol Estrogens
Adenylyl Cyclases
Crystal structure
Substrates
Adenosine Triphosphate
2004
6 Citations (Scopus)

Assays of recombinant adenylyl cyclases expressed in Sf9 cells.

Taussig, R., 2004, In : Methods in molecular biology (Clifton, N.J.). 237, p. 77-85 9 p.

Research output: Contribution to journalArticle

Sf9 Cells
Adenylyl Cyclases
Membranes
Protein Isoforms
Enzymes
41 Citations (Scopus)

Raf kinase activation of adenylyl cyclases: Isoform-selective regulation

Ding, Q., Gros, R., Gray, I. D., Taussig, R., Ferguson, S. S. G. & Feldman, R. D., Oct 2004, In : Molecular Pharmacology. 66, 4, p. 921-928 8 p.

Research output: Contribution to journalArticle

raf Kinases
Adenylyl Cyclases
Protein Isoforms
Phosphorylation
Enzymes

The laboratory information management system (LIMS) for handling the heterogeneous data from high throughput experiments in the post-genome sequencing era

Madhusudan, Vadivelu, I., Krause, L., Ning, Y., Lyon, S., Morrison, P., Sorrells, L., Taussig, R. & Subramaniam, S., 2004, Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, METMBS'04. Valafar, F. & Valafar, H. (eds.). p. 98-104 7 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Information management
Genes
Throughput
Cell signaling
Software design
2002
297 Citations (Scopus)

Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.

Sunahara, R. K. & Taussig, R., Jun 2002, In : Mol Interv. 2, 3, p. 168-184 17 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Signal transduction
Cyclic AMP-Dependent Protein Kinases
GTP-Binding Proteins
Adenylyl Cyclases
108 Citations (Scopus)

Overview of the alliance for cellular signaling

Gilman, A. G., Dec 12 2002, In : Nature. 420, 6916, p. 703-706 4 p.

Research output: Contribution to journalArticle

Research
Cardiac Myocytes
Immune System
B-Lymphocytes
2001
19 Citations (Scopus)

Dopamine D2 receptor-induced heterologous sensitization of adenylyl cyclase requires Gαs: Characterization of Gαs-insensitive mutants of adenylyl cyclase V

Watts, V. J., Taussig, R., Neve, R. L. & Neve, K. A., 2001, In : Molecular Pharmacology. 60, 6, p. 1168-1172 5 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Adenylyl Cyclases
Colforsin
Quinpirole
Cyclic AMP
81 Citations (Scopus)

Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors

Scott, J. K., Huang, S. F., Gangadhar, B. P., Samoriski, G. M., Clapp, P., Gross, R. A., Taussig, R. & Smrcka, A. V., Feb 15 2001, In : EMBO Journal. 20, 4, p. 767-776 10 p.

Research output: Contribution to journalArticle

Heterotrimeric GTP-Binding Proteins
Protein Subunits
Peptides
GTP-Binding Proteins
Proteins

Genetic selection of regulatory mutants of mammalian adenylyl cyclases

Clapp, P., Capper, A. B. & Taussig, R., 2001, In : Methods in Enzymology. 345, p. 241-251 11 p.

Research output: Contribution to journalArticle

Genetic Selection
Adenylyl Cyclases
Binding Sites
Colforsin
Yeast
39 Citations (Scopus)

G Protein β Subunit Types Differentially Interact with a Muscarinic Receptor but Not Adenylyl Cyclase Type II or Phospholipase C-β2/3

Hou, Y., Chang, V., Capper, A. B., Taussig, R. & Gautam, N., Jun 8 2001, In : Journal of Biological Chemistry. 276, 23, p. 19982-19988 7 p.

Research output: Contribution to journalArticle

Protein Subunits
Type C Phospholipases
Muscarinic Receptors
GTP-Binding Proteins
Adenylyl Cyclases
2000

Synthesis and use of 3'-(Azidoiodosalicyl) derivatives of 2',5'- dideoxyadenosine as photoaffinity ligands for adenylyl cyclase

Shoshani, I., Taussig, R., Iyengar, R. & Johnson, R. A., Apr 1 2000, In : Archives of Biochemistry and Biophysics. 376, 1, p. 221-228 8 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Ligands
Derivatives
Adenosine Triphosphate
Membranes
1999
8 Citations (Scopus)

Activating mutation of adenylyl cyclase reverses its inhibition by G proteins

Zimmermann, G., Zhou, D. & Taussig, R., 1999, In : Molecular Pharmacology. 56, 5, p. 895-901 7 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Adenylyl Cyclases
Mutation
Colforsin
Genetic Selection
1998
141 Citations (Scopus)

A point mutation in Gα(o) and Gα(i1) blocks interaction with regulator of G protein signaling proteins

Lan, K. L., Sarvazyan, N. A., Taussig, R., Mackenzie, R. G., DiBello, P. R., Dohlman, H. G. & Neubig, R. R., May 22 1998, In : Journal of Biological Chemistry. 273, 21, p. 12794-12797 4 p.

Research output: Contribution to journalArticle

RGS Proteins
Guanosine Triphosphate
GTP-Binding Protein Regulators
Point Mutation
Hydrolysis
24 Citations (Scopus)

Genetic selection of mammalian adenylyl cyclases insensitive to stimulation by G(sα)

Zimmermann, G., Zhou, D. & Taussig, R., Mar 20 1998, In : Journal of Biological Chemistry. 273, 12, p. 6968-6975 8 p.

Research output: Contribution to journalArticle

Genetic Selection
Adenylyl Cyclases
Yeast
Yeasts
Colforsin
54 Citations (Scopus)

Mutations uncover a role for two magnesium ions in the catalytic mechanism of adenylyl cyclase

Zimmermann, G., Zhou, D. & Taussig, R., Jul 31 1998, In : Journal of Biological Chemistry. 273, 31, p. 19650-19655 6 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Magnesium
Ions
Mutation
Adenosine Triphosphate
47 Citations (Scopus)

Type-specific regulation of mammalian adenylyl cyclases by G protein pathways.

Taussig, R. & Zimmermann, G., 1998, In : Advances in second messenger and phosphoprotein research. 32, p. 81-98 18 p.

Research output: Contribution to journalArticle

Bordetella Virulence Factors
Adenylate Cyclase Toxin
Enzyme Activation
Colforsin
GTP-Binding Proteins
1997
91 Citations (Scopus)

Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3'-polyphosphates

Johnson, R. A., Désaubry, L., Bianchi, G., Shoshani, I., Lyons, E., Taussig, R., Watson, P. A., Cali, J. J., Krupinski, J., Pieroni, J. P. & Iyengar, R., Apr 4 1997, In : Journal of Biological Chemistry. 272, 14, p. 8962-8966 5 p.

Research output: Contribution to journalArticle

Polyphosphates
Adenine
Nucleosides
Adenylyl Cyclases
Isoenzymes
23 Citations (Scopus)

Regulation of human neuronal calcium channels by G protein βγ subunits expressed in human embryonic kidney 293 cells

Shekter, L. R., Taussig, R., Gillard, S. E. & Miller, R. J., Aug 1997, In : Molecular Pharmacology. 52, 2, p. 282-291 10 p.

Research output: Contribution to journalArticle

Protein Subunits
Calcium Channels
GTP-Binding Proteins
Kidney
Heterotrimeric GTP-Binding Proteins
1996

Bold G protein α and βγ subunit regulation of mammalian adenylyl cyclases is modulated by protein kinase C

Ziminermann, G., Kazanietz, M. G., Blumberg, P. M. & Taussig, R., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

adenylate cyclase
Protein Subunits
protein kinase C
G-proteins
GTP-Binding Proteins
25 Citations (Scopus)

Dopamine D(2L) receptor couples to gα(i2) and gα(i3) but not gα(i1), leading to the inhibition of adenylate cyclase in transfected cell lines

O'Hara, C. M., Tang, L., Taussig, R., Todd, R. D. & O'Malley, K. L., 1996, In : Journal of Pharmacology and Experimental Therapeutics. 278, 1, p. 354-360 7 p.

Research output: Contribution to journalArticle

Pertussis Toxin
Adenylyl Cyclases
Dopamine
GTP-Binding Proteins
Cell Line
114 Citations (Scopus)

Protein kinase C alters the responsiveness of adenylyl cyclases to G protein α and βγ subunits

Zimmermann, G. & Taussig, R., 1996, In : Journal of Biological Chemistry. 271, 43, p. 27161-27166 6 p.

Research output: Contribution to journalArticle

Protein Subunits
GTP-Binding Proteins
Adenylyl Cyclases
Protein Kinase C
Colforsin
1995
3 Citations (Scopus)

Azido-iodo-phenyl-analogs of 2′,5′-dideoxy-adenosine as photoaffinity ligands for adenylyl cyclase

Shoshani, I., Qui, H., Johnson, F., Taussig, R. & Johnson, R. A., Aug 17 1995, In : BBA - General Subjects. 1245, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Adenosine
Dideoxyadenosine
Ligands
Enzymes
421 Citations (Scopus)

Mammalian membrane-bound adenylyl cyclases

Taussig, R. & Gilman, A. G., 1995, In : Journal of Biological Chemistry. 270, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Protein Conformation
Adenylyl Cyclases
Mammals
Membrane Proteins
Membranes
1994
269 Citations (Scopus)

Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases

Taussig, R., Tang, W. J., Hepler, J. R. & Gilman, A. G., Feb 25 1994, In : Journal of Biological Chemistry. 269, 8, p. 6093-6100 8 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
GTP-Binding Proteins
Guanine Nucleotides
Carrier Proteins
Protein Subunits
20 Citations (Scopus)

Expression and purification of recombinant adenylyl cyclases in Sf9 cells

Taussig, R., Tang, W. J. & Gilman, A. G., 1994, In : Methods in Enzymology. 238, p. 95-108 14 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Purification
363 Citations (Scopus)

Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel

Wickman, K. D., Iñiguez-Lluhi, J. A., Davenport, P. A., Taussig, R., Krapivinsky, G. B., Linder, M. E., Gilmant, A. G. & Clapham, D. E., Mar 17 1994, In : Nature. 368, 6468, p. 255-257 3 p.

Research output: Contribution to journalArticle

Potassium Channels
Protein Subunits
GTP-Binding Proteins
Recombinant Proteins
Cholinergic Agents
1993
299 Citations (Scopus)

Inhibition of adenylyl cyclase by G

Taussig, R., Iñiguez-Lluhi, J. A. & Gilman, A. G., Jul 9 1993, In : Science. 261, 5118, p. 218-221 4 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Enzyme Activators
GTP-Binding Proteins
Carrier Proteins
275 Citations (Scopus)

Lipid modifications of G proteins: α subunits are palmitoylated

Linder, M. E., Middleton, P., Hepler, J. R., Taussig, R., Gilman, A. G. & Mumby, S. M., Apr 15 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 8, p. 3675-3679 5 p.

Research output: Contribution to journalArticle

Protein Subunits
GTP-Binding Proteins
Lipoylation
Palmitates
Lipids
192 Citations (Scopus)

Regulation of purified type I and type II adenylylcyclases by G protein βγ subunits

Taussig, R., Quarmby, L. M. & Gilman, A. G., Jan 5 1993, In : Journal of Biological Chemistry. 268, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

Protein Subunits
GTP-Binding Proteins
Enzymes
Sf9 Cells
Purification
129 Citations (Scopus)

Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq

Lustig, K. D., Conklin, B. R., Herzmark, P., Taussig, R. & Bourne, H. R., Jul 5 1993, In : Journal of Biological Chemistry. 268, 19, p. 13900-13905 6 p.

Research output: Contribution to journalArticle

Protein Kinase C
Phorbol Esters
Kidney
GTP-Binding Proteins
Chemical activation
1992
105 Citations (Scopus)

Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins

Taussig, R., Sanchez, S., Rifo, M., Gilman, A. G. & Belardetti, F., 1992, In : Neuron. 8, 4, p. 799-809 11 p.

Research output: Contribution to journalArticle

Conotoxins
Pertussis Toxin
GTP-Binding Proteins
Calcium
Bradykinin
105 Citations (Scopus)

The G226A mutant of G highlights the requirement for dissociation of G protein subunits

Lee, E., Taussig, R. & Gilman, A. G., Jan 15 1992, In : Journal of Biological Chemistry. 267, 2, p. 1212-1218 7 p.

Research output: Contribution to journalArticle

Protein Subunits
GTP-Binding Proteins
Guanine Nucleotides
Mutant Proteins
Guanosine 5'-O-(3-Thiotriphosphate)
1989
35 Citations (Scopus)

Modulation of ionic currents, in Aplysia motor neuron B15 by serotonin, neuropeptides, and second messengers

Taussig, R., Sweet-Cordero, A. & Scheller, R. H., 1989, In : Journal of Neuroscience. 9, 9, p. 3218-3229 12 p.

Research output: Contribution to journalArticle

FMRFamide
Arachidonic Acids
Aplysia
Enzyme Activation
Phospholipases
1988
17 Citations (Scopus)

Egg-laying hormone, serotonin, and cyclic nucleotide modulation of ionic currents in the identified motoneuron B16 of Aplysia

Kirk, M. D., Taussig, R. & Scheller, R. H., 1988, In : Journal of Neuroscience. 8, 4, p. 1181-1193 13 p.

Research output: Contribution to journalArticle

Invertebrate Hormones
8-Bromo Cyclic Adenosine Monophosphate
1-Methyl-3-isobutylxanthine
Aplysia
Electrophysiology
1986
91 Citations (Scopus)

The Aplysia FMRFamide gene encodes sequences related to mammalian brain peptides

Taussig, R. & Scheller, R. H., 1986, In : DNA. 5, 6, p. 453-461 9 p.

Research output: Contribution to journalArticle

Nerve Tissue Proteins
FMRFamide
Species Specificity
Aplysia
Protein Precursors
1985
129 Citations (Scopus)

Aplysia neurons express a gene encoding multiple FMRFamide neuropeptides

Schaefer, M., Picciotto, M. R., Kreiner, T., Kaldany, R. R., Taussig, R. & Scheller, R. H., 1985, In : Cell. 41, 2, p. 457-467 11 p.

Research output: Contribution to journalArticle

FMRFamide
Aplysia
Gene encoding
Neuropeptides
Neurons
16 Citations (Scopus)

Expression of the L11 neuropeptide gene in the Aplysia central nervous system

Taussig, R., Kaldany, R. R., Rothbard, J., Schoolnik, G. & Scheller, R. H., 1985, In : Journal of Comparative Neurology. 238, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

Aplysia
Neuropeptides
Ganglia
Central Nervous System
Complementary DNA