Pharmacology - Wilkie Lab

Research Output 1984 2018

2018
1 Citation (Scopus)

Malnutrition in Pancreatic Ductal Adenocarcinoma (PDA): Dietary Pancreatic Enzymes Improve Short-Term Health but Stimulate Tumor Growth

Zolghadri, Y., Pal Choudhuri, S., Ocal, O., Layeghi-Ghalehsoukhteh, S., Berhe, F., Hale, M. A. & Wilkie, T. M., Mar 1 2018, In : American Journal of Pathology. 188, 3, p. 616-626 11 p.

Research output: Contribution to journalArticle

Malnutrition
Adenocarcinoma
Health
Enzymes
Growth

The curious case of Gαs gain-of-function in neoplasia

Innamorati, G., Wilkie, T. M., Kantheti, H. S., Valenti, M. T., Dalle Carbonare, L., Giacomello, L., Parenti, M., Melisi, D. & Bassi, C., Mar 15 2018, In : BMC Cancer. 18, 1, 293.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Polyostotic Fibrous Dysplasia
Phenotype
Poisons
2016
17 Citations (Scopus)

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity

Wieczorek, M., Tcherkezian, J., Bernier, C., Prota, A. E., Chaaban, S., Rolland, Y., Godbout, C., Hancock, M. A., Arezzo, J. C., Ocal, O., Rocha, C., Olieric, N., Hall, A., Ding, H., Bramoullé, A., Annis, M. G., Zogopoulos, G., Harran, P. G., Wilkie, T. M., Brekken, R. A. & 5 others, Siegel, P. M., Steinmetz, M. O., Shore, G. C., Brouhard, G. J. & Roulston, A., Nov 16 2016, In : Science Translational Medicine. 8, 365

Research output: Contribution to journalArticle

Microtubules
Tubulin
Vinca
Vinca Alkaloids
Safety
2015
7 Citations (Scopus)

A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics

Ocal, O., Pashkov, V., Kollipara, R. K., Zolghadri, Y., Cruz, V. H., Hale, M. A., Heath, B. R., Artyukhin, A. B., Christie, A. L., Tsoulfas, P., Lorens, J. B., Swift, G. H., Brekken, R. A. & Wilkie, T. M., Oct 1 2015, In : DMM Disease Models and Mechanisms. 8, 10, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

Tumors
Adenocarcinoma
Neoplasms
gemcitabine
G-Protein-Coupled Receptors
2013
6 Citations (Scopus)

The G protein Gα11 is essential for hypertrophic signalling in diabetic myocardium

Reuter, H., Seuthe, K., Korkmaz, Y., Grönke, S., Hoyer, D. P., Rottlaender, D., Zobel, C., Addicks, K., Hoyer, J., Grimminger, P., Brabender, J., Wilkie, T. M. & Erdmann, E., Aug 20 2013, In : International Journal of Cardiology. 167, 4, p. 1476-1485 10 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Knockout Mice
Myocardium
Calcineurin
Cardiomegaly
2011
26 Citations (Scopus)

Regulator of G protein signaling (Rgs16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner

Pashkov, V., Huang, J., Parameswara, V. K., Kedzierski, W., Kurrasch, D. M., Tall, G. G., Esser, V., Gerard, R. D., Uyeda, K., Towle, H. C. & Wilkie, T. M., Apr 29 2011, In : Journal of Biological Chemistry. 286, 17, p. 15116-15125 10 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Response Elements
Liver
Carrier Proteins
Fatty Acids
2010
17 Citations (Scopus)

Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes

Villasenor, A., Wang, Z. V., Rivera, L. B., Ocal, O., Asterholm, I. W., Scherer, P. E., Brekken, R. A., Cleaver, O. & Wilkie, T. M., Sep 2010, In : DMM Disease Models and Mechanisms. 3, 9-10, p. 567-580 14 p.

Research output: Contribution to journalArticle

Medical problems
Islets of Langerhans
GTP-Binding Protein Regulators
Insulin
Endocrine Cells
2006
19 Citations (Scopus)

Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes

Huang, J., Pashkov, V., Kurrasch, D. M., Yu, K., Gold, S. J. & Wilkie, T. M., Nov 23 2006, In : Comparative Hepatology. 5, 8.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Hepatocytes
Fasting
Liver
RGS Proteins
2005
53 Citations (Scopus)

New roles for Gα and RGS proteins: Communication continues despite pulling sisters apart

Wilkie, T. M. & Kinch, L., Oct 25 2005, In : Current Biology. 15, 20

Research output: Contribution to journalArticle

RGS Proteins
G-Protein-Coupled Receptors
G-proteins
Asymmetric Cell Division
GTP-Binding Proteins
2004
13 Citations (Scopus)

Allosteric regulation of GAP activity by phospholipids in regulators of G-protein signaling

Tu, Y. & Wilkie, T. M., 2004, In : Methods in Enzymology. 389, p. 89-105 17 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Allosteric Regulation
GTPase-Activating Proteins
Phosphatidic Acids
Phospholipids
56 Citations (Scopus)

Differentially Regulated Expression of Endogenous RGS4 and RGS7

Krumins, A. M., Barker, S. A., Huang, C., Sunahara, R. K., Yu, K., Wilkie, T. M., Gold, S. J. & Mumby, S. M., Jan 23 2004, In : Journal of Biological Chemistry. 279, 4, p. 2593-2599 7 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Proteolysis
Transfection
Proteins
Signal transduction
70 Citations (Scopus)

Quantitative real-time polymerase chain reaction measurement of regulators of G-protein signaling mRNA levels in mouse tissues

Kurrasch, D. M., Huang, J., Wilkie, T. M. & Repa, J. J., 2004, In : Methods in Enzymology. 389, p. 3-15 13 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Polymerase chain reaction
RGS Proteins
Real-Time Polymerase Chain Reaction
Tissue
2003
46 Citations (Scopus)

q and Gα11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme

Ivey, K., Tyson, B., Ukidwe, P., McFadden, D. G., Levi, G., Olson, E. N., Srivastava, D. & Wilkie, T. M., Mar 15 2003, In : Developmental Biology. 255, 2, p. 230-237 8 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Branchial Region
Neural Crest
Endothelin-1
Mesoderm
18 Citations (Scopus)

Methacholine-induced airway hyperresponsiveness is dependent on Gαq signaling

Borchers, M. T., Biechele, T., Justice, J. P., Ansay, T., Cormier, S., Mancino, V., Wilkie, T. M., Simon, M. I., Lee, N. A. & Lee, J. J., Jul 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 1 29-1

Research output: Contribution to journalArticle

Methacholine Chloride
Cholinergic Receptors
Allergens
Smooth Muscle
Gq-G11 GTP-Binding Protein alpha Subunits
2001
286 Citations (Scopus)

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes

Wettschureck, N., Rütten, H., Zywietz, A., Gehring, D., Wilkie, T. M., Chen, J., Chien, K. R. & Offermanns, S., 2001, In : Nature Medicine. 7, 11, p. 1236-1240 5 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Hypertrophy
Pressure
Gq-G11 GTP-Binding Protein alpha Subunits
Angiotensin Type 1 Receptor
44 Citations (Scopus)

Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase Cβ1

Dowal, L., Elliott, J., Popov, S., Wilkie, T. M. & Scarlata, S., Jan 16 2001, In : Biochemistry. 40, 2, p. 414-421 8 p.

Research output: Contribution to journalArticle

RGS Proteins
Protein Subunits
GTP-Binding Proteins
Proteins
Programmable logic controllers
69 Citations (Scopus)

Evolution of the regulators of G-protein signaling multigene family in mouse and human

Sierra, D. A., Gilbert, D. J., Householder, D., Grishin, N. V., Yu, K., Ukidwe, P., Barker, S. A., He, W., Wensel, T. G., Otero, G., Brown, G., Copeland, N. G., Jenkins, N. A. & Wilkie, T. M., 2001, In : Genomics. 79, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Multigene Family
RGS Proteins
Genes
Gq-G11 GTP-Binding Protein alpha Subunits
53 Citations (Scopus)

Polarized Expression of G Protein-coupled Receptors and an All-or-None Discharge of Ca2+ Pools at Initiation Sites of [Ca2+] i Waves in Polarized Exocrine Cells

Shin, D. M., Luo, X., Wilkie, T. M., Miller, L. J., Peck, A. B., Humphreys-Beher, M. G. & Muallem, S., Nov 23 2001, In : Journal of Biological Chemistry. 276, 47, p. 44146-44156 11 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Acinar Cells
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Inositol 1,4,5-Trisphosphate
Tight Junctions
44 Citations (Scopus)

RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes

Yowe, D., Weich, N., Prabhudas, M., Poisson, L., Errada, P., Kapeller, R., Yu, K., Faron, L., Shen, M., Cleary, J., Wilkie, T. M., Gutierrez-Ramos, C. & Hodge, M. R., Oct 1 2001, In : Biochemical Journal. 359, 1, p. 109-118 10 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Megakaryocytes
Yeast
RGS Proteins
Cells
2 Citations (Scopus)

RGS domain: Production and uses of recombinant protein

Yowe, D., Yu, K., Wilkie, T. M. & Popov, S., 2001, In : Methods in Enzymology. 344, p. 647-657 11 p.

Research output: Contribution to journalArticle

Recombinant Proteins
69 Citations (Scopus)

RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations

Luo, X., Popov, S., Bera, A. K., Wilkie, T. M. & Muallem, S., Mar 1 2001, In : Molecular Cell. 7, 3, p. 651-660 10 p.

Research output: Contribution to journalArticle

RGS Proteins
G-Protein-Coupled Receptors
Biophysical Phenomena
Biochemical Phenomena
Inositol 1,4,5-Trisphosphate Receptors
7 Citations (Scopus)

Treasures throughout the life-cycle of G-protein-coupled receptors

Wilkie, T. M., Aug 1 2001, In : Trends in Pharmacological Sciences. 22, 8, p. 396-397 2 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Life cycle
2000
101 Citations (Scopus)
GTP-Binding Protein Regulators
GTPase-Activating Proteins
Calmodulin
Lipoylation
GTP-Binding Proteins
16 Citations (Scopus)

G-protein signaling: Satisfying the basic necessities of life

Wilkie, T. M., Nov 30 2000, In : Current Biology. 10, 23

Research output: Contribution to journalArticle

RGS Proteins
regulatory proteins
Caenorhabditis elegans
G-proteins
GTP-Binding Proteins
848 Citations (Scopus)
RGS Proteins
GTP-Binding Protein Regulators
GTPase-Activating Proteins
Heterotrimeric GTP-Binding Proteins
GTP-Binding Proteins
37 Citations (Scopus)

Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Gα15 knockout mice

Davignon, I., Catalina, M. D., Smith, D., Montgomery, J., Swantek, J., Croy, J., Siegelman, M. & Wilkie, T. M., Feb 2000, In : Molecular and Cellular Biology. 20, 3, p. 797-804 8 p.

Research output: Contribution to journalArticle

Hematopoiesis
Knockout Mice
Thioglycolates
Macrophages
Gq-G11 GTP-Binding Protein alpha Subunits
40 Citations (Scopus)

Regulators of G-protein signaling in receptor complexes

Sierra, D. A., Popov, S. & Wilkie, T. M., 2000, In : Trends in Cardiovascular Medicine. 10, 6, p. 263-268 6 p.

Research output: Contribution to journalArticle

RGS Proteins
GTP-Binding Protein Regulators
GTP-Binding Proteins
GTP Phosphohydrolases
Gq-G11 GTP-Binding Protein alpha Subunits
1999
54 Citations (Scopus)

Alternate coupling of receptors to G(s) and G(i) in pancreatic and submandibular gland cells

Xiang, L., Zeng, W., Xu, X., Popov, S., Davignon, I., Wilkie, T. M., Mumby, S. M. & Muallem, S., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17684-17690 7 p.

Research output: Contribution to journalArticle

Submandibular Gland
Cyclic AMP-Dependent Protein Kinases
Adrenergic Receptors
Chemical activation
Heterotrimeric GTP-Binding Proteins
190 Citations (Scopus)

Differential involvement of Gα12 and Gα13 in receptor-mediated stress fiber formation

Gohla, A., Offermanns, S., Wilkie, T. M. & Schultz, G., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17901-17907 7 p.

Research output: Contribution to journalArticle

Stress Fibers
Fibers
Receptor, Serotonin, 5-HT2C
Endothelins
Gq-G11 GTP-Binding Protein alpha Subunits

Erratum: Differential involvement of Gα12 and Gα13 in receptor- mediated stress fiber formation (Journal of Biologist Chemistry (1999) 274 (17901-17907))

Gohla, A., Offermanns, S., Wilkie, T. M. & Schultz, G., Sep 3 1999, In : Journal of Biological Chemistry. 274, 36, p. 25958 1 p.

Research output: Contribution to journalArticle

Stress Fibers
Fibers
45 Citations (Scopus)

G protein-dependent Ca2+ signaling complexes in polarized cells

Muallem, S. & Wilkie, T. M., Nov 1999, In : Cell Calcium. 26, 5, p. 173-180 8 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
RGS Proteins
Inositol 1,4,5-Trisphosphate Receptors
Proteins
Endoplasmic Reticulum
3 Citations (Scopus)

G proteins, chemosensory perception, and the C. elegans genome project: An attractive story

Wilkie, T. M., Sep 1999, In : BioEssays. 21, 9, p. 713-717 5 p.

Research output: Contribution to journalArticle

G-proteins
GTP-Binding Proteins
Caenorhabditis elegans
Genes
Genome
23 Citations (Scopus)

Overexpression of G(11α) and isoforms of phospholipase C in islet β- cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion

Gasa, R., Trinh, K. Y., Yu, K., Wilkie, T. M. & Newgard, C. B., 1999, In : Diabetes. 48, 5, p. 1035-1044 10 p.

Research output: Contribution to journalArticle

Inositol Phosphates
Type C Phospholipases
Islets of Langerhans
Protein Isoforms
Insulin

Preface

Muallem, S. & Wilkie, T. M., 1999, In : Cell Calcium. 26, 5, p. 155 1 p.

Research output: Contribution to journalArticle

226 Citations (Scopus)

RGS proteins determine signaling specificity of G(q)-coupled receptors

Xu, X., Zeng, W., Popov, S., Berman, D. M., Davignon, I., Yu, K., Yowe, D., Offermanns, S., Muallem, S. & Wilkie, T. M., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3549-3556 8 p.

Research output: Contribution to journalArticle

RGS Proteins
Cholecystokinin
Carbachol
GTPase-Activating Proteins
Bombesin
1998
184 Citations (Scopus)

Embryonic cardiomyocyte hypoplasia and craniofacial defects in Gα(q)/Gα11-mutant mice

Offermanns, S., Zhao, L. P., Gohla, A., Sarosi, I., Simon, M. I. & Wilkie, T. M., Aug 3 1998, In : EMBO Journal. 17, 15, p. 4304-4312 9 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Genes
Defects
Alleles
Heterotrimeric GTP-Binding Proteins
19 Citations (Scopus)

Gonadotropin and gonadal steroid release in response to a gonadotropin- releasing hormone agonist in G(q)α and G11α knockout mice

Stanislaus, D., Janovick, J. A., Ji, T., Wilkie, T. M., Offermanns, S. & Conn, P. M., 1998, In : Endocrinology. 139, 6, p. 2710-2717 8 p.

Research output: Contribution to journalArticle

Buserelin
Gonadotropins
Knockout Mice
Gonadotropin-Releasing Hormone
Steroids
39 Citations (Scopus)

Promiscuous coupling of receptors to Gq class α subunits and effector proteins in pancreatic and submandibular gland cells

Xu, X., Croy, J. T., Zeng, W., Zhao, L., Davignon, I., Popov, S., Yu, K., Jiang, H., Offermanns, S., Muallem, S. & Wilkie, T. M., Oct 16 1998, In : Journal of Biological Chemistry. 273, 42, p. 27275-27279 5 p.

Research output: Contribution to journalArticle

Submandibular Gland
Protein Subunits
Muscarinic M3 Receptors
Bombesin
Cholecystokinin
216 Citations (Scopus)

The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

Zeng, W., Xu, X., Popov, S., Mukhopadhyay, S., Chidiac, P., Swistok, J., Danho, W., Yagaloff, K. A., Fisher, S. L., Ross, E. M., Muallem, S. & Wilkie, T. M., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 34687-34690 4 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Guanosine Triphosphate
GTP-Binding Proteins
Hydrolysis
RGS Proteins

The n terminal domain of RGS4 confers regulatory specificity in g protein-receptor signaling

Wilkie, T. M., Popov, S., Zeug, W., Xu, X. & Muallem, S., 1998, In : FASEB Journal. 12, 8

Research output: Contribution to journalArticle

Knockout Mice
receptors
GTPase-Activating Proteins
Proteins
proteins
1997
140 Citations (Scopus)
GTPase-Activating Proteins
GTP-Binding Proteins
RGS Proteins
Surface Plasmon Resonance
GTP Phosphohydrolases
1996
615 Citations (Scopus)

GAIP and RGS4 are GTPase-activating proteins for the G(i) subfamily of G protein α subunits

Berman, D. M., Wilkie, T. M. & Gilman, A. G., Aug 9 1996, In : Cell. 86, 3, p. 445-452 8 p.

Research output: Contribution to journalArticle

RGS Proteins
GTPase-Activating Proteins
Protein Subunits
GTP-Binding Proteins
GTP-Binding Protein Regulators
25 Citations (Scopus)

Gene structure of murine Gna11 and Gna15: Tandemly duplicated Gq class G protein α subunit genes

Davignon, I., Barnard, M., Gavrilova, O., Sweet, K. & Wilkie, T. M., Feb 1 1996, In : Genomics. 31, 3, p. 359-366 8 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Protein Subunits
Genes
Chromosomes, Human, Pair 10
Intergenic DNA
11 Citations (Scopus)

G protein alpha subunit multigene family in the Japanese puffer fish Fugu rubripes: PCR from a compact vertebrate genome

Sarwal, M. M., Sontag, J. M., Hoang, L., Brenner, S. & Wilkie, T. M., 1996, In : Genome Research. 6, 12, p. 1207-1215 9 p.

Research output: Contribution to journalArticle

Takifugu
Tetraodontiformes
GTP-Binding Protein alpha Subunits
Multigene Family
Vertebrates
1994
9 Citations (Scopus)

[26] Design of degenerate oligonucleotide primers for cloning of G- protein α subunits

Wilkie, T. M., Aragay, A. M., Watson, A. J. & Simon, M. I., 1994, In : Methods in Enzymology. 237, p. 327-344 18 p.

Research output: Contribution to journalArticle

GTP-Binding Protein alpha Subunits
DNA Primers
Antisense Oligonucleotides
Cloning
Polymerase chain reaction
35 Citations (Scopus)

Evolution of the G protein alpha subunit multigene family.

Wilkie, T. M. & Yokoyama, S., 1994, In : Society of General Physiologists Series. 49, p. 249-270 22 p.

Research output: Contribution to journalArticle

GTP-Binding Protein alpha Subunits
Multigene Family
G-proteins
multigene family
GTP-Binding Proteins
19 Citations (Scopus)

Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen

Wilkie, T. M., Schmidt, R. A., Baetscher, M. & Messing, A., Oct 1994, In : Oncogene. 9, 10, p. 2889-2895 7 p.

Research output: Contribution to journalArticle

Muscle Neoplasms
Polyomavirus Transforming Antigens
Bone Neoplasms
Transgenic Mice
Smooth Muscle
1993
55 Citations (Scopus)

Identification, Chromosomal Location, and Genome Organization of Mammalian G-Protein-Coupled Receptors

Wilkie, T. M., Chen, Y., Gilbert, D. J., Moore, K. J., Yu, L., Simon, M. I., Copeland, N. G. & Jenkins, N. A., Nov 1993, In : Genomics. 18, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Genome
Clone Cells
Chromosomes, Human, Pair 1
Interleukin-8 Receptors
31 Citations (Scopus)

Mutational analysis of G protein α subunit Goα expressed in Escherichia coli

Slepak, V. Z., Wilkie, T. M. & Simon, M. I., Jan 15 1993, In : Journal of Biological Chemistry. 268, 2, p. 1414-1423 10 p.

Research output: Contribution to journalArticle

Gi-Go GTP-Binding Protein alpha Subunits
GTP-Binding Proteins
Escherichia coli
Guanine Nucleotides
Adenosine Diphosphate
1992
195 Citations (Scopus)

Evolution of the mammalian G protein α subunit multigene family

Wilkie, T. M., Gilbert, D. J., Olsen, A. S., Chen, X. N., Amatruda, T. T., Korenberg, J. R., Trask, B. J., De Jong, P., Reed, R. R., Simon, M. I., Jenkins, N. A. & Copeland, N. G., May 1992, In : Nature Genetics. 1, 2, p. 85-91 7 p.

Research output: Contribution to journalArticle

Protein Subunits
Multigene Family
GTP-Binding Proteins
Genes
Guanine Nucleotides