Pharmacology - Wilkie Lab

Research Output

2018

Malnutrition in Pancreatic Ductal Adenocarcinoma (PDA): Dietary Pancreatic Enzymes Improve Short-Term Health but Stimulate Tumor Growth

Zolghadri, Y., Pal Choudhuri, S., Ocal, O., Layeghi-Ghalehsoukhteh, S., Berhe, F., Hale, M. A. & Wilkie, T. M., Mar 1 2018, In : American Journal of Pathology. 188, 3, p. 616-626 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

The curious case of Gαs gain-of-function in neoplasia

Innamorati, G., Wilkie, T. M., Kantheti, H. S., Valenti, M. T., Dalle Carbonare, L., Giacomello, L., Parenti, M., Melisi, D. & Bassi, C., Mar 15 2018, In : BMC Cancer. 18, 1, 293.

Research output: Contribution to journalArticle

3 Scopus citations
2016

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity

Wieczorek, M., Tcherkezian, J., Bernier, C., Prota, A. E., Chaaban, S., Rolland, Y., Godbout, C., Hancock, M. A., Arezzo, J. C., Ocal, O., Rocha, C., Olieric, N., Hall, A., Ding, H., Bramoullé, A., Annis, M. G., Zogopoulos, G., Harran, P. G., Wilkie, T. M., Brekken, R. A. & 5 others, Siegel, P. M., Steinmetz, M. O., Shore, G. C., Brouhard, G. J. & Roulston, A., Nov 16 2016, In : Science Translational Medicine. 8, 365

Research output: Contribution to journalArticle

21 Scopus citations
2015

A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics

Ocal, O., Pashkov, V., Kollipara, R. K., Zolghadri, Y., Cruz, V. H., Hale, M. A., Heath, B. R., Artyukhin, A. B., Christie, A. L., Tsoulfas, P., Lorens, J. B., Swift, G. H., Brekken, R. A. & Wilkie, T. M., Oct 1 2015, In : DMM Disease Models and Mechanisms. 8, 10, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

The G protein Gα11 is essential for hypertrophic signalling in diabetic myocardium

Reuter, H., Seuthe, K., Korkmaz, Y., Grönke, S., Hoyer, D. P., Rottlaender, D., Zobel, C., Addicks, K., Hoyer, J., Grimminger, P., Brabender, J., Wilkie, T. M. & Erdmann, E., Aug 20 2013, In : International Journal of Cardiology. 167, 4, p. 1476-1485 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Regulator of G protein signaling (Rgs16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner

Pashkov, V., Huang, J., Parameswara, V. K., Kedzierski, W., Kurrasch, D. M., Tall, G. G., Esser, V., Gerard, R. D., Uyeda, K., Towle, H. C. & Wilkie, T. M., Apr 29 2011, In : Journal of Biological Chemistry. 286, 17, p. 15116-15125 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2010

Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes

Villasenor, A., Wang, Z. V., Rivera, L. B., Ocal, O., Asterholm, I. W., Scherer, P. E., Brekken, R. A., Cleaver, O. & Wilkie, T. M., Sep 1 2010, In : DMM Disease Models and Mechanisms. 3, 9-10, p. 567-580 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
2006

Feeding and fasting controls liver expression of a regulator of G protein signaling (Rgs16) in periportal hepatocytes

Huang, J., Pashkov, V., Kurrasch, D. M., Yu, K., Gold, S. J. & Wilkie, T. M., Nov 23 2006, In : Comparative Hepatology. 5, 8.

Research output: Contribution to journalArticle

19 Scopus citations
2005

New roles for Gα and RGS proteins: Communication continues despite pulling sisters apart

Wilkie, T. M. & Kinch, L., Oct 25 2005, In : Current Biology. 15, 20, p. R843-R854

Research output: Contribution to journalReview article

57 Scopus citations
2004

Allosteric regulation of GAP activity by phospholipids in regulators of G-protein signaling

Tu, Y. & Wilkie, T. M., Jan 1 2004, In : Methods in Enzymology. 389, p. 89-1005 917 p.

Research output: Contribution to journalArticle

14 Scopus citations

Differentially Regulated Expression of Endogenous RGS4 and RGS7

Krumins, A. M., Barker, S. A., Huang, C., Sunahara, R. K., Yu, K., Wilkie, T. M., Gold, S. J. & Mumby, S. M., Jan 23 2004, In : Journal of Biological Chemistry. 279, 4, p. 2593-2599 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Quantitative real-time polymerase chain reaction measurement of regulators of G-protein signaling mRNA levels in mouse tissues

Kurrasch, D. M., Huang, J., Wilkie, T. M. & Repa, J. J., Sep 3 2004, In : Methods in Enzymology. 389, p. 3-15 13 p.

Research output: Contribution to journalArticle

70 Scopus citations
2003

q and Gα11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme

Ivey, K., Tyson, B., Ukidwe, P., McFadden, D. G., Levi, G., Olson, E. N., Srivastava, D. & Wilkie, T. M., Mar 15 2003, In : Developmental Biology. 255, 2, p. 230-237 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Methacholine-induced airway hyperresponsiveness is dependent on Gαq signaling

Borchers, M. T., Biechele, T., Justice, J. P., Ansay, T., Cormier, S., Mancino, V., Wilkie, T. M., Simon, M. I., Lee, N. A. & Lee, J. J., Jul 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 1 29-1, p. L114-L120

Research output: Contribution to journalArticle

18 Scopus citations
2002

Evolution of the regulators of G-protein signaling multigene family in mouse and human

Sierra, D. A., Gilbert, D. J., Householder, D., Grishin, N. V., Yu, K., Ukidwe, P., Barker, S. A., He, W., Wensel, T. G., Otero, G., Brown, G., Copeland, N. G., Jenkins, N. A. & Wilkie, T. M., Feb 2002, In : Genomics. 79, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

71 Scopus citations
2001

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes

Wettschureck, N., Rütten, H., Zywietz, A., Gehring, D., Wilkie, T. M., Chen, J., Chien, K. R. & Offermanns, S., Nov 26 2001, In : Nature medicine. 7, 11, p. 1236-1240 5 p.

Research output: Contribution to journalArticle

289 Scopus citations

Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase Cβ1

Dowal, L., Elliott, J., Popov, S., Wilkie, T. M. & Scarlata, S., Jan 16 2001, In : Biochemistry. 40, 2, p. 414-421 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Polarized Expression of G Protein-coupled Receptors and an All-or-None Discharge of Ca2+ Pools at Initiation Sites of [Ca2+] i Waves in Polarized Exocrine Cells

Shin, D. M., Luo, X., Wilkie, T. M., Miller, L. J., Peck, A. B., Humphreys-Beher, M. G. & Muallem, S., Nov 23 2001, In : Journal of Biological Chemistry. 276, 47, p. 44146-44156 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes

Yowe, D., Weich, N., Prabhudas, M., Poisson, L., Errada, P., Kapeller, R., Yu, K., Faron, L., Shen, M., Cleary, J., Wilkie, T. M., Gutierrez-Ramos, C. & Hodge, M. R., Oct 1 2001, In : Biochemical Journal. 359, 1, p. 109-118 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

RGS domain: Production and uses of recombinant protein

Yowe, D., Yu, K., Wilkie, T. M. & Popov, S., 2001, In : Methods in Enzymology. 344, p. 647-657 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations

Luo, X., Popov, S., Bera, A. K., Wilkie, T. M. & Muallem, S., Mar 1 2001, In : Molecular cell. 7, 3, p. 651-660 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Treasures throughout the life-cycle of G-protein-coupled receptors

Wilkie, T. M., Aug 1 2001, In : Trends in Pharmacological Sciences. 22, 8, p. 396-397 2 p.

Research output: Contribution to journalArticle

7 Scopus citations
2000
101 Scopus citations

G-protein signaling: Satisfying the basic necessities of life

Wilkie, T. M., Nov 30 2000, In : Current Biology. 10, 23, p. R853-R856

Research output: Contribution to journalReview article

16 Scopus citations
861 Scopus citations

Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Gα15 knockout mice

Davignon, I., Catalina, M. D., Smith, D., Montgomery, J., Swantek, J., Croy, J., Siegelman, M. & Wilkie, T. M., Feb 1 2000, In : Molecular and cellular biology. 20, 3, p. 797-804 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Regulators of G-protein signaling in receptor complexes

Sierra, D. A., Popov, S. & Wilkie, T. M., Dec 1 2000, In : Trends in Cardiovascular Medicine. 10, 6, p. 263-268 6 p.

Research output: Contribution to journalReview article

40 Scopus citations
1999

Alternate coupling of receptors to G(s) and G(i) in pancreatic and submandibular gland cells

Xiang, L., Zeng, W., Xu, X., Popov, S., Davignon, I., Wilkie, T. M., Mumby, S. M. & Muallem, S., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17684-17690 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Differential involvement of Gα12 and Gα13 in receptor-mediated stress fiber formation

Gohla, A., Offermanns, S., Wilkie, T. M. & Schultz, G., Jun 18 1999, In : Journal of Biological Chemistry. 274, 25, p. 17901-17907 7 p.

Research output: Contribution to journalArticle

192 Scopus citations

G protein-dependent Ca2+ signaling complexes in polarized cells

Muallem, S. & Wilkie, T. M., Nov 1999, In : Cell Calcium. 26, 5, p. 173-180 8 p.

Research output: Contribution to journalReview article

45 Scopus citations

G proteins, chemosensory perception, and the C. elegans genome project: An attractive story

Wilkie, T. M., Jan 1 1999, In : BioEssays. 21, 9, p. 713-717 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Overexpression of G(11α) and isoforms of phospholipase C in islet β- cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion

Gasa, R., Trinh, K. Y., Yu, K., Wilkie, T. M. & Newgard, C. B., May 25 1999, In : Diabetes. 48, 5, p. 1035-1044 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Preface

Muallem, S. & Wilkie, T. M., Jan 1 1999, In : Cell Calcium. 26, 5, 1 p.

Research output: Contribution to journalEditorial

RGS proteins determine signaling specificity of G(q)-coupled receptors

Xu, X., Zeng, W., Popov, S., Berman, D. M., Davignon, I., Yu, K., Yowe, D., Offermanns, S., Muallem, S. & Wilkie, T. M., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3549-3556 8 p.

Research output: Contribution to journalArticle

227 Scopus citations
1998

Embryonic cardiomyocyte hypoplasia and craniofacial defects in Gα(q)/Gα11-mutant mice

Offermanns, S., Zhao, L. P., Gohla, A., Sarosi, I., Simon, M. I. & Wilkie, T. M., Aug 3 1998, In : EMBO Journal. 17, 15, p. 4304-4312 9 p.

Research output: Contribution to journalArticle

190 Scopus citations

Gonadotropin and gonadal steroid release in response to a gonadotropin- releasing hormone agonist in G(q)α and G11α knockout mice

Stanislaus, D., Janovick, J. A., Ji, T., Wilkie, T. M., Offermanns, S. & Conn, P. M., 1998, In : Endocrinology. 139, 6, p. 2710-2717 8 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Promiscuous coupling of receptors to Gq class α subunits and effector proteins in pancreatic and submandibular gland cells

Xu, X., Croy, J. T., Zeng, W., Zhao, L., Davignon, I., Popov, S., Yu, K., Jiang, H., Offermanns, S., Muallem, S. & Wilkie, T. M., Oct 16 1998, In : Journal of Biological Chemistry. 273, 42, p. 27275-27279 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

Zeng, W., Xu, X., Popov, S., Mukhopadhyay, S., Chidiac, P., Swistok, J., Danho, W., Yagaloff, K. A., Fisher, S. L., Ross, E. M., Muallem, S. & Wilkie, T. M., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 34687-34690 4 p.

Research output: Contribution to journalArticle

218 Scopus citations

The n terminal domain of RGS4 confers regulatory specificity in g protein-receptor signaling

Wilkie, T. M., Popov, S., Zeug, W., Xu, X. & Muallem, S., Dec 1 1998, In : FASEB Journal. 12, 8, p. A1314

Research output: Contribution to journalArticle

1997
142 Scopus citations
1996

GAIP and RGS4 are GTPase-activating proteins for the G(i) subfamily of G protein α subunits

Berman, D. M., Wilkie, T. M. & Gilman, A. G., Aug 9 1996, In : Cell. 86, 3, p. 445-452 8 p.

Research output: Contribution to journalArticle

623 Scopus citations

Gene structure of murine Gna11 and Gna15: Tandemly duplicated Gq class G protein α subunit genes

Davignon, I., Barnard, M., Gavrilova, O., Sweet, K. & Wilkie, T. M., Feb 1 1996, In : Genomics. 31, 3, p. 359-366 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

G protein alpha subunit multigene family in the Japanese puffer fish Fugu rubripes: PCR from a compact vertebrate genome

Sarwal, M. M., Sontag, J. M., Hoang, L., Brenner, S. & Wilkie, T. M., Dec 1 1996, In : Genome Research. 6, 12, p. 1207-1215 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
1994

Design of degenerate oligonucleotide primers for cloning of G-protein a subunits

Wilkie, T. M., Aragay, A. M., Watson, A. J. & Simon, M. I., Jan 1 1994, In : Methods in Enzymology. 237, C, p. 327-344 18 p.

Research output: Contribution to journalArticle

9 Scopus citations

Evolution of the G protein alpha subunit multigene family.

Wilkie, T. M. & Yokoyama, S., 1994, In : Society of General Physiologists series. 49, p. 249-270 22 p.

Research output: Contribution to journalReview article

35 Scopus citations

Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen

Wilkie, T. M., Schmidt, R. A., Baetscher, M. & Messing, A., Oct 1 1994, In : Oncogene. 9, 10, p. 2889-2895 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
1993

Identification, chromosomal location, and genome organization of mammalian g-protein-coupled receptors

Wilkie, T. M., Chen, Y., Gilbert, D. J., Moore, K. J., Yu, L., Simon, M. I., Copeland, N. G. & Jenkins, N. A., Nov 1993, In : Genomics. 18, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Mutational analysis of G protein α subunit G(o)α expressed in Escherichia coli

Slepak, V. Z., Wilkie, T. M. & Simon, M. I., Jan 1 1993, In : Journal of Biological Chemistry. 268, 2, p. 1414-1423 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
1992

Evolution of the mammalian G protein α subunit multigene family

Wilkie, T. M., Gilbert, D. J., Olsen, A. S., Chen, X. N., Amatruda, T. T., Korenberg, J. R., Trask, B. J., De Jong, P., Reed, R. R., Simon, M. I., Jenkins, N. A. & Copeland, N. G., May 1992, In : Nature genetics. 1, 2, p. 85-91 7 p.

Research output: Contribution to journalArticle

200 Scopus citations