Research Output

2018

RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes

de Jong, A. P. H., Roggero, C. M., Ho, M. R., Wong, M. Y., Brautigam, C. A., Rizo-Rey, J. & Kaeser, P. S., Jan 1 2018, (Accepted/In press) In : Neuron.

Research output: Contribution to journalArticle

17 Scopus citations

Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting

Luo, J., Attard, G., Balk, S. P., Bevan, C., Burnstein, K., Cato, L., Cherkasov, A., De Bono, J. S., Dong, Y., Gao, A. C., Gleave, M., Heemers, H., Kanayama, M., Kittler, R., Lang, J. M., Lee, R. J., Logothetis, C. J., Matusik, R., Plymate, S., Sawyers, C. L. & 7 others, Selth, L. A., Soule, H., Tilley, W., Weigel, N. L., Zoubeidi, A., Dehm, S. M. & Raj, G. V., May 2018, In : European urology. 73, 5, p. 715-723 9 p.

Research output: Contribution to journalArticle

45 Scopus citations
13 Scopus citations

Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis

Zhu, Y. H., Hyun, J., Pan, Y. Z., Hopper, J. E., Rizo-Rey, J. & Wu, J. Q., Sep 15 2018, In : Molecular Biology of the Cell. 29, 19, p. 2259-2279 21 p.

Research output: Contribution to journalArticle

4 Scopus citations

Roux-en-Y gastric bypass compared with equivalent diet restriction: Mechanistic insights into diabetes remission

Pop, L. M., Mari, A., Zhao, T. J., Mitchell, L., Burgess, S., Li, X., Adams-Huet, B. & Lingvay, I., Jul 2018, In : Diabetes, Obesity and Metabolism. 20, 7, p. 1710-1721 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Scc2 Is a Potent Activator of Cohesin's ATPase that Promotes Loading by Binding Scc1 without Pds5

Petela, N. J., Gligoris, T. G., Metson, J., Lee, B. G., Voulgaris, M., Hu, B., Kikuchi, S., Chapard, C., Chen, W., Rajendra, E., Srinivisan, M., Yu, H., Löwe, J. & Nasmyth, K. A., Jun 21 2018, In : Molecular cell. 70, 6, p. 1134-1148.e7

Research output: Contribution to journalArticle

31 Scopus citations

SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation

Yu, X., Lao, Y., Teng, X. L., Li, S., Zhou, Y., Wang, F., Guo, X., Deng, S., Chang, Y., Wu, X., Liu, Z., Chen, L., Lu, L. M., Cheng, J., Li, B., Su, B., Jiang, J., Li, H. B., Huang, C., Yi, J. & 1 others, Zou, Q., Dec 1 2018, In : Nature communications. 9, 1, 3157.

Research output: Contribution to journalArticle

15 Scopus citations

Silencing the snail-dependent RNA splice regulator ESRP1 drives malignant transformation of human pulmonary epithelial cells

Walser, T. C., Jing, Z., Tran, L. M., Lin, Y. Q., Yakobian, N., Wang, G., Krysan, K., Zhu, L. X., Sharma, S., Lee, M. H., Belperio, J. A., Ooi, A. T., Gomperts, B. N., Shay, J. W., Larsen, J. E., Minna, J. D., Hong, L. S., Fishbein, M. C. & Dubinett, S. M., Apr 15 2018, In : Cancer research. 78, 8, p. 1986-1999 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sitravatinib potentiates immune checkpoint blockade in refractory cancer models

Du, W., Huang, H., Sorrelle, N. & Brekken, R. A., Nov 2 2018, In : JCI insight. 3, 21

Research output: Contribution to journalArticle

19 Scopus citations

Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes

Zhang, W., Girard, L., Zhang, Y. A., Haruki, T., Papari-Zareei, M., Stastny, V., Ghayee, H. K., Pacak, K., Oliver, T. G., Minna, J. D. & Gazdar, A. F., Feb 1 2018, In : Translational Lung Cancer Research. 7, 1, p. 32-49 18 p.

Research output: Contribution to journalArticle

26 Scopus citations

Small-molecule inhibition of Axl targets tumor immune suppression and enhances chemotherapy in pancreatic cancer

Ludwig, K. F., Du, W., Sorrelle, N. B., Wnuk-Lipinska, K., Topalovski, M., Toombs, J. E., Cruz, V. H., Yabuuchi, S., Rajeshkumar, N. V., Maitra, A., Lorens, J. B. & Brekken, R. A., Jan 1 2018, In : Cancer research. 78, 1, p. 246-255 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase

Volkov, O. A., Brockway, A. J., Wring, S. A., Peel, M., Chen, Z., Phillips, M. A. & De Brabander, J. K., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1182-1203 22 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structural analyses of FERM domain-mediated membrane localization of FARP1

Kuo, Y. C., He, X., Coleman, A. J., Chen, Y. J., Dasari, P., Liou, J., Biederer, T. & Zhang, X., Dec 1 2018, In : Scientific reports. 8, 1, 10477.

Research output: Contribution to journalArticle

2 Scopus citations

Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression

Zhang, K., Shang, G., Padavannil, A., Wang, J., Sakthivel, R., Chen, X., Kim, M., Thompson, M. G., García-Sastre, A., Lynch, K. W., Chen, Z., Chook, Y. M. & Fontoura, B. M., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. E12218-E12227

Research output: Contribution to journalArticle

2 Scopus citations

SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation

Yu, F., Shi, G., Cheng, S., Chen, J., Wu, S. Y., Wang, Z., Xia, N., Zhai, Y., Wang, Z., Peng, Y., Wang, D., Du, J. X., Liao, L., Duan, S. Z., Shi, T., Cheng, J., Chiang, C. M., Li, J. & Wong, J., Jun 1 2018, In : Cell Research. 28, 6, p. 670-685 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Sumoylation promotes optimal apc/c activation and timely anaphase

Lee, C. C., Li, B., Yu, H. & Matunis, M. J., Mar 8 2018, In : eLife. 7, e29539.

Research output: Contribution to journalArticle

9 Scopus citations

Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway

Gaspari, S., Purushothaman, I., Cogliani, V., Sakloth, F., Neve, R. L., Howland, D., Ring, R. H., Ross, E. M., Shen, L. & Zachariou, V., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. E2085-E2094

Research output: Contribution to journalArticle

8 Scopus citations

Targeting the turnover of oncoproteins as a new avenue for therapeutics development in castration-resistant prostate cancer

Wang, S., Ekoue, D. N., Raj, G. V. & Kittler, R., Dec 1 2018, In : Cancer Letters. 438, p. 86-96 11 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance

Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T. P., Batten, K., Cornelius, C., Dalvi, M. P., Ramirez, M., Du, W., Wu, L. F., Altschuler, S. J., Brekken, R., Martinez, E. D., Minna, J. D., Wright, W. E. & Shay, J. W., Aug 1 2018, In : Neoplasia (United States). 20, 8, p. 826-837 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

The assembly of lipid droplets and their roles in challenged cells

Henne, W. M., Reese, M. L. & Goodman, J. M., Jun 15 2018, In : EMBO Journal. 37, 12, e98947.

Research output: Contribution to journalReview article

48 Scopus citations

The BUB3-BUB1 Complex Promotes Telomere DNA Replication

Li, F., Kim, H., Ji, Z., Zhang, T., Chen, B., Ge, Y., Hu, Y., Feng, X., Han, X., Xu, H., Zhang, Y., Yu, H., Liu, D., Ma, W. & Songyang, Z., Jan 1 2018, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

13 Scopus citations

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation

Lee, H. S., Lin, Z., Chae, S., Yoo, Y. S., Kim, B. G., Lee, Y., Johnson, J. L., Kim, Y. S., Cantley, L. C., Lee, C. W., Yu, H. & Cho, H., Dec 1 2018, In : Nature communications. 9, 1, 3848.

Research output: Contribution to journalArticle

5 Scopus citations

The curious case of Gαs gain-of-function in neoplasia

Innamorati, G., Wilkie, T. M., Kantheti, H. S., Valenti, M. T., Dalle Carbonare, L., Giacomello, L., Parenti, M., Melisi, D. & Bassi, C., Mar 15 2018, In : BMC Cancer. 18, 1, 293.

Research output: Contribution to journalArticle

3 Scopus citations

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors

He, M., Liu, S., Gallolu Kankanamalage, S., Borromeo, M. D., Girard, L., Gazdar, A. F., Minna, J. D., Johnson, J. E. & Cobb, M. H., Apr 1 2018, In : Translational Oncology. 11, 2, p. 292-299 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol

Song, P., Zechner, C. P. G., Hernandez, G., Cánovas, J., Xie, Y., Sondhi, V., Wagner, M., Stadlbauer, V., Horvath, A., Leber, B., Hu, M. C., Moe, O. W., Mangelsdorf, D. J. & Kliewer, S. A., Jun 5 2018, In : Cell Metabolism. 27, 6, p. 1338-1347.e4

Research output: Contribution to journalArticle

23 Scopus citations

The impact of smoking and tp53 mutations in lung adenocarcinoma patients with targetable mutations—the lung cancer mutation consortium (LCMC2)

Aisner, D. L., Sholl, L. M., Berry, L. D., Rossi, M. R., Chen, H., Fujimoto, J., Moreira, A. L., Ramalingam, S. S., Villaruz, L. C., Otterson, G. A., Haura, E., Politi, K., Glisson, B., Cetnar, J., Garon, E. B., Schiller, J., Waqar, S. N., Sequist, L. V., Brahmer, J., Shyr, Y. & 7 others, Kugler, K., Wistuba, I. I., Johnson, B. E., Minna, J. D., Kris, M. G., Bunn, P. A. & Kwiatkowski, D. J., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1038-1047 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

The Lec5 glycosylation mutant links homeobox genes with cholesterol and lipid-linked oligosaccharides

Lu, H., Sathe, A. A., Xing, C. & Lehrman, M. A., Nov 2 2018, In : Glycobiology. 29, 2, p. 106-109 4 p.

Research output: Contribution to journalArticle

The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans

Wu, H., Yesilyurt, H. G., Yoon, J. & Terman, J. R., Dec 1 2018, In : Scientific reports. 8, 1, 937.

Research output: Contribution to journalArticle

6 Scopus citations

The molecular biology of lung cancer

Larsen, J. E. & Minna, J. D., Nov 16 2018, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 607-618 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The Requirement for GW182 Scaffolding Protein Depends on Whether Argonaute Is Mediating Translation, Transcription, or Splicing

Liu, J., Liu, Z. & Corey, D. R., Sep 4 2018, In : Biochemistry. 57, 35, p. 5247-5256 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer

Gong, K., Guo, G., Gerber, D. E., Gao, B., Peyton, M., Huang, C., Minna, J. D., Hatanpaa, K. J., Kernstine, K., Cai, L., Xie, Y., Zhu, H., Fattah, F. J., Zhang, S., Takahashi, M., Mukherjee, B., Burma, S., Dowell, J., Dao, K., Papadimitrakopoulou, V. A. & 4 others, Olivas, V., Bivona, T. G., Zhao, D. & Habib, A. A., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2500-2518 19 p.

Research output: Contribution to journalArticle

17 Scopus citations

Toward a chemical vaccine for malaria A high-throughput screen puts us on the road to protecting populations against malaria

Phillips, M. A. & Goldberg, D. E., Dec 7 2018, In : Science. 362, 6419, p. 1112-1113 2 p.

Research output: Contribution to journalShort survey

Transcriptome signature identifies distinct cervical pathways induced in lipopolysaccharide-mediated preterm birth

Willcockson, A. R., Nandu, T., Liu, C. L., Nallasamy, S., Kraus, W. L. & Mahendroo, M., Mar 1 2018, In : Biology of Reproduction. 98, 3, p. 408-421 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

Updegraff, B. L., Zhou, X., Guo, Y., Padanad, M. S., Chen, P. H., Yang, C., Sudderth, J., Rodriguez-Tirado, C., Girard, L., Minna, J. D., Mishra, P., DeBerardinis, R. J. & O'Donnell-Mendell, K. A., Jan 1 2018, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

7 Scopus citations

Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs

Afanador, G. A., Tomchick, D. R. & Phillips, M. A., Nov 6 2018, In : Structure. 26, 11, p. 1499-1512.e5

Research output: Contribution to journalArticle

5 Scopus citations

Understanding the Lipid Droplet Proteome and Protein Targeting

Goodman, J. M., Jan 8 2018, In : Developmental cell. 44, 1, p. 1-2 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations

WNK pathways in cancer signaling networks 06 Biological Sciences 0601 Biochemistry and Cell Biology

Gallolu Kankanamalage, S., Karra, A. S. & Cobb, M. H., Nov 3 2018, In : Cell Communication and Signaling. 16, 1, 72.

Research output: Contribution to journalReview article

7 Scopus citations

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis

Chen, Y., Zhang, B., Bao, L., Jin, L., Yang, M., Peng, Y., Kumar, A., Wang, J. E., Wang, C., Zou, X., Xing, C., Wang, Y. & Luo, W., May 1 2018, In : Journal of Clinical Investigation. 128, 5, p. 1937-1955 19 p.

Research output: Contribution to journalArticle

23 Scopus citations

ZMYND8 is a primary HIF coactivator that mediates breast cancer progression

Chen, Y., Wang, Y. & Luo, W., Jul 4 2018, In : Molecular and Cellular Oncology. 5, 4, e1479619.

Research output: Contribution to journalArticle

2 Scopus citations
2017

12-O-tetradecanoylphorbol-13-acetate (TPA) increases murine intestinal crypt stem cell survival following radiation injury

Liang, Y., Zhou, H., Yao, Y., Deng, A., Wang, Z., Gao, B., Zhou, M., Cui, Y., Wang, L., Zhou, L., Wang, B., Wang, L., Liu, A., Qiu, L., Qian, K., Lu, Y., Deng, W., Zheng, X., Han, Z., Li, Y. & 1 others, Sun, J., 2017, In : Oncotarget. 8, 28, p. 45566-45576 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

A cascade of multiple proteins and lipids catalyzes membrane fusion

Wickner, W. & Rizo-Rey, J., Mar 15 2017, In : Molecular biology of the cell. 28, 6, p. 707-711 5 p.

Research output: Contribution to journalReview article

37 Scopus citations

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

Kim, C. W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Chakravarthy, M., Previs, S., Milstein, S., Fitzgerald, K., Kelley, D. E. & Horton, J. D., Aug 1 2017, In : Cell Metabolism. 26, 2, p. 394-406.e6

Research output: Contribution to journalArticle

72 Scopus citations

A comprehensive analysis of myocardial substrate preference emphasizes the need for a synchronized fluxomic/metabolomic research design

Ragavan, M., Kirpich, A., Fu, X., Burgess, S. C., McIntyre, L. M. & Merritt, M. E., 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 6, p. H1215-H1223

Research output: Contribution to journalArticle

4 Scopus citations

A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas

Thu, K. L., Papari-Zareei, M., Stastny, V., Song, K., Peyton, M., Martinez, V. D., Zhang, Y. A., Castro, I. B., Varella-Garcia, M., Liang, H., Xing, C., Kittler, R., Milchgrub, S., Castrillon, D. H., Davidson, H. L., Reynolds, C. P., Lam, W. L., Lea, J. & Gazdar, A. F., Feb 7 2017, In : Oncotarget. 8, 31, p. 50489-50499 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis

Morris, E. M., McCoin, C. S., Allen, J. A., Gastecki, M. L., Koch, L. G., Britton, S. L., Fletcher, J. A., Fu, X., Ding, W. X., Burgess, S. C., Rector, R. S. & Thyfault, J. P., Jul 15 2017, In : Journal of Physiology. 595, 14, p. 4909-4926 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors

Yan, Y., Zhou, K., Xiong, H., Miller, J. B., Motea, E. A., Boothman, D. A., Liu, L. & Siegwart, D. J., Feb 1 2017, In : Biomaterials. 118, p. 84-93 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Amplification of F-Actin Disassembly and Cellular Repulsion by Growth Factor Signaling

Yoon, J., Kim, S. B., Ahmed, G., Shay, J. W. & Terman, J. R., 2017, (Accepted/In press) In : Developmental Cell.

Research output: Contribution to journalArticle

12 Scopus citations

An adipo-biliary-uridine axis that regulates energy homeostasis

Deng, Y., Wang, Z., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., De Brabander, J. K., Elmquist, J. K., Horton, J. D., Hill, J. A., Klein, S. & Scherer, P. E., Mar 17 2017, In : Science. 355, 6330, eaaf5375.

Research output: Contribution to journalArticle

37 Scopus citations

An inducible form of Nrf2 confers enhanced protection against acute oxidative stresses in RPE cells

Vu, K. T. & Hulleman, J. D., Nov 1 2017, In : Experimental Eye Research. 164, p. 31-36 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species

Afanador, G. A., Guerra, A. J., Swift, R. P., Rodriguez, R. E., Bartee, D., Matthews, K. A., Schön, A., Freire, E., Freel Meyers, C. L. & Prigge, S. T., Nov 2017, In : Molecular Microbiology. 106, 3, p. 439-451 13 p.

Research output: Contribution to journalArticle

4 Scopus citations