Research Output

2010

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

Cai, J., Zhang, N., Zheng, Y., De Wilde, R. F., Maitra, A. & Pan, D., Nov 1 2010, In : Genes and Development. 24, 21, p. 2383-2388 6 p.

Research output: Contribution to journalArticle

293 Scopus citations

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A. & Pan, D., Jul 1 2010, In : Developmental cell. 19, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

410 Scopus citations
2009

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

Alarcón, C., Zaromytidou, A. I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., Sapkota, G., Pan, D. & Massagué, J., Nov 13 2009, In : Cell. 139, 4, p. 757-769 13 p.

Research output: Contribution to journalArticle

470 Scopus citations
2008

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A. P., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Nov 2008, In : Human Pathology. 39, 11, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

381 Scopus citations

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.

Wu, S., Liu, Y., Zheng, Y., Dong, J. & Pan, D., Mar 2008, In : Developmental cell. 14, 3, p. 388-398 11 p.

Research output: Contribution to journalArticle

413 Scopus citations
2007

Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, MF., Anders, R. A., Maitra, A. & Pan Ph.D., D., Sep 21 2007, In : Cell. 130, 6, p. 1120-1133 14 p.

Research output: Contribution to journalArticle

1391 Scopus citations

Fat flies expanded the hippo pathway: a matter of size control.

Yin, F. & Pan, D., Apr 21 2007, In : Science's STKE : signal transduction knowledge environment. 2007, 380, p. pe12

Research output: Contribution to journalArticle

15 Scopus citations

Hippo signaling in organ size control

Pan, D., Apr 15 2007, In : Genes and Development. 21, 8, p. 886-897 12 p.

Research output: Contribution to journalReview article

432 Scopus citations
2006

Drosophila target of rapamycin kinase functions as a multimer

Zhang, Y., Billington, C. J., Pan, D. & Neufeld, T. P., Jan 2006, In : Genetics. 172, 1, p. 355-362 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: A novel oncogenic pathway

Lam-Himlin, D. M., Daniels, J. A., Gayyed, M. F., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Dec 1 2006, In : International Journal of Gastrointestinal Cancer. 37, 4, p. 103-109 7 p.

Research output: Contribution to journalArticle

60 Scopus citations
2005

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP

Huang, J., Wu, S., Barrera, J., Matthews, K. & Pan, D., Aug 12 2005, In : Cell. 122, 3, p. 421-434 14 p.

Research output: Contribution to journalArticle

1037 Scopus citations

The phosphatase subunit Tap42 functions independently of target of rapamycin to regulate cell division and survival in drosophila

Cygnar, K. D., Gao, X., Pan, D. & Neufeld, T. P., Jun 2005, In : Genetics. 170, 2, p. 733-740 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2004

Size matters. Workshop on growth control in development and disease

Pan, D., Feb 1 2004, In : EMBO Reports. 5, 2, p. 136-139 4 p.

Research output: Contribution to journalArticle

Tsc2 is not a critical target of Akt during normal Drosophila development

Dong, J. & Pan, D., Oct 15 2004, In : Genes and Development. 18, 20, p. 2479-2484 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Tuberous sclerosis complex: From Drosophila to human disease

Pan, D., Dong, J., Zhang, Y. & Gao, X., Feb 2004, In : Trends in Cell Biology. 14, 2, p. 78-85 8 p.

Research output: Contribution to journalReview article

130 Scopus citations
2003

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

Wu, S., Huang, J., Dong, J. & Pan, D., Aug 22 2003, In : Cell. 114, 4, p. 445-456 12 p.

Research output: Contribution to journalArticle

676 Scopus citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A. & Pan, D., Jun 1 2003, In : Nature Cell Biology. 5, 6, p. 578-581 4 p.

Research output: Contribution to journalArticle

644 Scopus citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

Saucedo, L. J., Gao, X., Chiarelli, D. A., Li, L., Pan, D. & Edgar, B. A., Jun 1 2003, In : Nature Cell Biology. 5, 6, p. 566-571 6 p.

Research output: Contribution to journalArticle

490 Scopus citations
2002

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R. S., Ru, B. & Pan, D., Sep 2002, In : Nature cell biology. 4, 9, p. 699-704 6 p.

Research output: Contribution to journalArticle

540 Scopus citations
2001

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

Gao, X. & Pan, D., Jun 21 2001, In : Genes and Development. 15, 11, p. 1383-1392 10 p.

Research output: Contribution to journalArticle

368 Scopus citations
2000

A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1

Mumm, J. S., Schroeter, E. H., Saxena, M. T., Griesemer, A., Tian, X., Pan, D. J., Ray, W. J. & Kopan, R., Jan 1 2000, In : Molecular cell. 5, 2, p. 197-206 10 p.

Research output: Contribution to journalArticle

Open Access
650 Scopus citations

Drosophila PTEN regulates cell growth and proliferation through PI3K- dependent and -independent pathways

Gao, X., Neufeld, T. P. & Pan, D., May 15 2000, In : Developmental Biology. 221, 2, p. 404-418 15 p.

Research output: Contribution to journalArticle

203 Scopus citations
1998

Targeted expression of teashirt induces ectopic eyes in Drosophila

Pan, D. & Rubin, G. M., Dec 22 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 26, p. 15508-15512 5 p.

Research output: Contribution to journalArticle

77 Scopus citations
1997

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

Duojia, P. & Rubin, G. M., Jul 25 1997, In : Cell. 90, 2, p. 271-280 10 p.

Research output: Contribution to journalArticle

337 Scopus citations
1996

KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis

Rooke, J., Pan, D., Xu, T. & Rubin, G. M., 1996, In : Science. 273, 5279, p. 1227-1231 5 p.

Research output: Contribution to journalArticle

290 Scopus citations

The cell surface metalloprotease/disintegrin kuzbanian is required for axonal extension in Drosophila

Fambrough, D., Pan, D., Rubin, G. M. & Goodman, C. S., Nov 12 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 23, p. 13233-13238 6 p.

Research output: Contribution to journalArticle

151 Scopus citations
1995

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

Pan, D. & Rubin, G. M., Feb 24 1995, In : Cell. 80, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

212 Scopus citations
1994

The bipartite D. melanogaster twist promoter is reorganized in D. virilis

Pan, D., Valentine, S. A. & Courey, A. J., Apr 1994, In : Mechanisms of Development. 46, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
1992

The same dorsal binding site mediates both activation and repression in a context-dependent manner

Pan, D. & Courey, A. J., Jan 1 1992, In : EMBO Journal. 11, 5, p. 1837-1842 6 p.

Research output: Contribution to journalArticle

58 Scopus citations
1991

Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region

Pan, D., Huang, J. D. & Courey, A. J., Oct 1991, In : Genes and Development. 5, 10, p. 1892-1901 10 p.

Research output: Contribution to journalArticle

88 Scopus citations