Research Output 2003 2019

2019

CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D. H., Kim, J., Hyun Hwang, T. & Lum, L., Dec 1 2019, In : Nature communications. 10, 1, 4056.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
mutagenesis
deletion
Mutagenesis
insertion
2018
13 Citations (Scopus)

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

Lung Neoplasms
Neoplasms
Oncology
Biosynthesis
Small Molecule Libraries
1 Citation (Scopus)

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

Zhang, L. S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, J-S., Maire, P., Kim, J., Williams, N. S., Xu, J., Chen, C., Zhang, C. & Lum, L., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Catenins
Acute Myeloid Leukemia
Neoplasms
Proteins
Genetic Translocation
2017
11 Citations (Scopus)

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor

Wu, X., Zhang, L. S., Toombs, J., Kuo, Y. C., Piazza, J. T., Tuladhar, R., Barrett, Q., Fan, C. W., Zhang, X., Walensky, L. D., Kool, M., Cheng, S. Y., Brekken, R., Opferman, J. T., Green, D. R., Moldoveanu, T. & Lum, L., Sep 29 2017, In : Nature Cell Biology. 19, 10, p. 1226-1236 11 p.

Research output: Contribution to journalArticle

Neoplasms
Proteins
Mitochondrial Membranes
DNA-Binding Proteins
Growth
2015
31 Citations (Scopus)

Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells

Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In : Molecular and Cellular Biology. 35, 14, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

Tankyrases
Catenins
Telomere Homeostasis
Telomere
Porcupines

Erratum: The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation (Chemistry and Biology (2014) 21 (1680-689))

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Apr 23 2015, In : Chemistry and Biology. 22, 4, p. 559 1 p.

Research output: Contribution to journalArticle

2014
12 Citations (Scopus)

The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Dec 18 2014, In : Chemistry and Biology. 21, 12, p. 1680-1689 10 p.

Research output: Contribution to journalArticle

Cilia
Phosphatidylinositol-4-Phosphate 3-Kinase
Hedgehog Proteins
Chemical activation
Cell membranes
2011
68 Citations (Scopus)

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling

Jacob, L. S., Wu, X., Dodge, M. E., Fan, C. W., Kulak, O., Chen, B., Tang, W., Wang, B., Amatruda, J. F. & Lum, L., Jan 25 2011, In : Science Signaling. 4, 157, ra4.

Research output: Contribution to journalArticle

Hedgehogs
RNA Interference
Genes
Genome
Wnt Signaling Pathway
2005
2 Citations (Scopus)

Genetic/genomic evidence for a key role of polarized endocytosis in filamentous differentiation of S. cerevisiae

Wu, X. & Jiang, Y. W., Oct 30 2005, In : Yeast. 22, 14, p. 1143-1153 11 p.

Research output: Contribution to journalArticle

endocytosis
Endocytosis
starvation
Saccharomyces cerevisiae
exocytosis
4 Citations (Scopus)

Possible integration of upstream signals at Cdc42 in filamentous differentiation of S. cerevisiae

Wu, X. & Jiang, Y. W., Oct 15 2005, In : Yeast. 22, 13, p. 1069-1077 9 p.

Research output: Contribution to journalArticle

hydroxyurea
Hydroxyurea
Starvation
starvation
Saccharomyces cerevisiae
9 Citations (Scopus)

Structure and biosynthesis of the BT peptide antibiotic from Brevibacillus texasporus

Wu, X., Ballard, J. & Jiang, Y. W., Dec 1 2005, In : Applied and Environmental Microbiology. 71, 12, p. 8519-8530 12 p.

Research output: Contribution to journalArticle

Brevibacillus
peptide antibiotics
Peptide Synthases
antibiotics
peptide
2003
22 Citations (Scopus)

Autographa californica nucleopolyhedrovirus orf69 encodes an RNA cap (nucleoside-2′-O)-methyltransferase

Wu, X. & Guarino, L. A., Mar 1 2003, In : Journal of Virology. 77, 6, p. 3430-3440 11 p.

Research output: Contribution to journalArticle

RNA Caps
Autographa californica
Nucleopolyhedrovirus
nucleosides
Baculoviridae