Research Output

2020
Open Access
2019

CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D. H., Kim, J., Hyun Hwang, T. & Lum, L., Dec 1 2019, In : Nature communications. 10, 1, 4056.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

The Hippo Signaling Pathway in Development and Disease

Zheng, Y. & Pan, D., Aug 5 2019, In : Developmental cell. 50, 3, p. 264-282 19 p.

Research output: Contribution to journalReview article

38 Scopus citations
2018

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

26 Scopus citations

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

Zhang, L. S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, J-S., Maire, P., Kim, J., Williams, N. S., Xu, J., Chen, C., Zhang, C. & Lum, L., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor

Wu, X., Zhang, L. S., Toombs, J., Kuo, Y. C., Piazza, J. T., Tuladhar, R., Barrett, Q., Fan, C. W., Zhang, X., Walensky, L. D., Kool, M., Cheng, S. Y., Brekken, R., Opferman, J. T., Green, D. R., Moldoveanu, T. & Lum, L., Sep 29 2017, In : Nature Cell Biology. 19, 10, p. 1226-1236 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation

Pimmett, V. L., Deng, H., Haskins, J. A., Mercier, R. J., LaPointe, P. & Simmonds, A. J., May 1 2017, In : Developmental Biology. 425, 1, p. 58-69 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2015

Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells

Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In : Molecular and Cellular Biology. 35, 14, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Erratum: The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation (Chemistry and Biology (2014) 21 (1680-689))

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Apr 23 2015, In : Chemistry and Biology. 22, 4, p. 559 1 p.

Research output: Contribution to journalArticle

2014

The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Dec 18 2014, In : Chemistry and Biology. 21, 12, p. 1680-1689 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling

Jacob, L. S., Wu, X., Dodge, M. E., Fan, C. W., Kulak, O., Chen, B., Tang, W., Wang, B., Amatruda, J. F. & Lum, L., Jan 25 2011, In : Science Signaling. 4, 157, ra4.

Research output: Contribution to journalArticle

68 Scopus citations
2005

Genetic/genomic evidence for a key role of polarized endocytosis in filamentous differentiation of S. cerevisiae

Wu, X. & Jiang, Y. W., Oct 30 2005, In : Yeast. 22, 14, p. 1143-1153 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Possible integration of upstream signals at Cdc42 in filamentous differentiation of S. cerevisiae

Wu, X. & Jiang, Y. W., Oct 15 2005, In : Yeast. 22, 13, p. 1069-1077 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structure and biosynthesis of the BT peptide antibiotic from Brevibacillus texasporus

Wu, X., Ballard, J. & Jiang, Y. W., Dec 1 2005, In : Applied and environmental microbiology. 71, 12, p. 8519-8530 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex

Ling, C., Yao, Y. N., Zheng, Y. G., Wei, H., Wang, L., Wu, X. F. & Wang, E. D., Oct 14 2005, In : Journal of Biological Chemistry. 280, 41, p. 34755-34763 9 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations
2003

Autographa californica nucleopolyhedrovirus orf69 encodes an RNA cap (nucleoside-2′-O)-methyltransferase

Wu, X. & Guarino, L. A., Mar 1 2003, In : Journal of virology. 77, 6, p. 3430-3440 11 p.

Research output: Contribution to journalArticle

22 Scopus citations