Research Output

Filter
Article
2020

Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis

Deng, H., Yang, L., Wen, P., Lei, H., Blount, P. & Pan, D., Apr 6 2020, In : The Journal of cell biology. 219, 4

Research output: Contribution to journalArticle

Open Access
2019

CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D. H., Kim, J., Hyun Hwang, T. & Lum, L., Dec 1 2019, In : Nature communications. 10, 1, 4056.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Nerfin-1 represses transcriptional output of hippo signaling in cell competition

Guo, P., Lee, C. H., Lei, H., Zheng, Y., Prieto, K. D. P. & Pan, D., Mar 2019, In : eLife. 8, e38843.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2018

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

20 Scopus citations

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

Zhang, L. S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, J-S., Maire, P., Kim, J., Williams, N. S., Xu, J., Chen, C., Zhang, C. & Lum, L., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor

Wu, X., Zhang, L. S., Toombs, J., Kuo, Y. C., Piazza, J. T., Tuladhar, R., Barrett, Q., Fan, C. W., Zhang, X., Walensky, L. D., Kool, M., Cheng, S. Y., Brekken, R., Opferman, J. T., Green, D. R., Moldoveanu, T. & Lum, L., Sep 29 2017, In : Nature Cell Biology. 19, 10, p. 1226-1236 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation

Pimmett, V. L., Deng, H., Haskins, J. A., Mercier, R. J., LaPointe, P. & Simmonds, A. J., May 1 2017, In : Developmental Biology. 425, 1, p. 58-69 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2015

Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells

Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In : Molecular and Cellular Biology. 35, 14, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Erratum: The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation (Chemistry and Biology (2014) 21 (1680-689))

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Apr 23 2015, In : Chemistry and Biology. 22, 4, p. 559 1 p.

Research output: Contribution to journalArticle

2014

The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Dec 18 2014, In : Chemistry and Biology. 21, 12, p. 1680-1689 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2011

A novel KRAB domain-containing Zinc finger transcription factor ZNF431 directly represses Patched1 transcription

He, Z., Cai, J., Lim, J. W., Kroll, K. & Ma, L., Mar 4 2011, In : Journal of Biological Chemistry. 286, 9, p. 7279-7289 11 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling

Jacob, L. S., Wu, X., Dodge, M. E., Fan, C. W., Kulak, O., Chen, B., Tang, W., Wang, B., Amatruda, J. F. & Lum, L., Jan 25 2011, In : Science Signaling. 4, 157, ra4.

Research output: Contribution to journalArticle

68 Scopus citations

Msx2 and Foxn1 regulate nail homeostasis

Cai, J. & Ma, L., Jun 1 2011, In : Genesis. 49, 6, p. 449-459 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2010

Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos

Deng, H., Bell, J. B. & Simmonds, A. J., Oct 1 2010, In : Molecular biology of the cell. 21, 19, p. 3304-3316 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2009

Alternative requirements for vestigial, scalloped, and Dmef2 during muscle differentiation in drosophila melanogaster

Deng, H., Hughes, S. C., Bell, J. B. & Simmonds, A. J., Jan 1 2009, In : Molecular biology of the cell. 20, 1, p. 256-269 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation

Cai, J., Lee, J., Kopan, R. & Ma, L., Feb 15 2009, In : Developmental Biology. 326, 2, p. 420-430 11 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations
2008

Unique residues crucial for optimal editing in yeast cytoplasmic leucyl-tRNA synthetase are revealed by using a novel knockout yeast strain

Yao, P., Zhou, X. L., He, R., Xue, M. Q., Zheng, Y. G., Wang, Y. F. & Wang, E. D., Aug 15 2008, In : Journal of Biological Chemistry. 283, 33, p. 22591-22600 10 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
2006

Two forms of human cytoplasmic arginyl-tRNA synthetase produced from two translation initiations by a single mRNA

Zheng, Y. G., Wei, H., Ling, C., Xu, M. G. & Wang, E. D., Jan 31 2006, In : Biochemistry. 45, 4, p. 1338-1344 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
2005

Genetic/genomic evidence for a key role of polarized endocytosis in filamentous differentiation of S. cerevisiae

Wu, X. & Jiang, Y. W., Oct 30 2005, In : Yeast. 22, 14, p. 1143-1153 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Possible integration of upstream signals at Cdc42 in filamentous differentiation of S. cerevisiae

Wu, X. & Jiang, Y. W., Oct 15 2005, In : Yeast. 22, 13, p. 1069-1077 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structure and biosynthesis of the BT peptide antibiotic from Brevibacillus texasporus

Wu, X., Ballard, J. & Jiang, Y. W., Dec 1 2005, In : Applied and environmental microbiology. 71, 12, p. 8519-8530 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex

Ling, C., Yao, Y. N., Zheng, Y. G., Wei, H., Wang, L., Wu, X. F. & Wang, E. D., Oct 14 2005, In : Journal of Biological Chemistry. 280, 41, p. 34755-34763 9 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations
2004

High-level expression and single-step purification of leucyl-tRNA synthetase from Aquifex aeolicus

Ling, C., Zheng, Y. G. & Wang, E. D., Jul 1 2004, In : Protein Expression and Purification. 36, 1, p. 146-149 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Reduction of mitochondrial tRNA Leu(UUR) aminoacylation by some MELAS-associated mutations

Hao, R., Yao, Y. N., Zheng, Y. G., Xu, M. G. & Wang, E. D., Dec 3 2004, In : FEBS Letters. 578, 1-2, p. 135-139 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
2003

Autographa californica nucleopolyhedrovirus orf69 encodes an RNA cap (nucleoside-2′-O)-methyltransferase

Wu, X. & Guarino, L. A., Mar 1 2003, In : Journal of virology. 77, 6, p. 3430-3440 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2002

Apoptosis induced by Dioscin in Hela cells

Cai, J., Liu, M., Wang, Z. & Ju, Y., Feb 1 2002, In : Biological and Pharmaceutical Bulletin. 25, 2, p. 193-196 4 p.

Research output: Contribution to journalArticle

Open Access
104 Scopus citations

Expression of gene encoding GL-7ACA acylase in Escherichia coli

Wang, E. D., Zheng, Y. G., Li, Y., Jiang, W. H. & Yang, Y. L., Oct 30 2002, In : Acta Biochimica et Biophysica Sinica. 34, 4, p. 526-531 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2001

Two novel engineered bacteria for secretory expression of glutaryl 7-amino-cephalosporanic acid acylase

Zheng, Y. G., Li, Y., Chen, J. F., Jiang, W. H., Zhao, G. P. & Wang, E. D., Dec 1 2001, In : Biotechnology Letters. 23, 21, p. 1781-1787 7 p.

Research output: Contribution to journalArticle

10 Scopus citations