Physiology - Division B

Research Output 1977 2018

2018
1 Citation (Scopus)

2019 Herbert Tabor Young Investigator Awards: Call for nominations

DeMartino, G. N., Sep 14 2018, In : The Journal of biological chemistry. 293, 37, 1 p.

Research output: Contribution to journalEditorial

Open Access
Research Personnel
2 Citations (Scopus)

Introduction to the Thematic Minireview Series: Autophagy

DeMartino, G. N., Jan 1 2018, In : Journal of Biological Chemistry. 293, 15, p. 5384-5385 2 p.

Research output: Contribution to journalReview article

Autophagy
Health
Lysosomes
Research
2 Citations (Scopus)

The herbert tabor young investigator awards: Meet the awardees!

Gierasch, L. M. & DeMartino, G., Jan 1 2018, In : Journal of Biological Chemistry. 293, 9, p. 3468-3469 2 p.

Research output: Contribution to journalEditorial

Biochemistry
2017
3 Citations (Scopus)

The Herbert Tabor Best Paper Awards: Celebrating young authors who contribute top content to JBC

Gierasch, L. M. & DeMartino, G., 2017, In : Journal of Biological Chemistry. 292, 41, 1 p.

Research output: Contribution to journalEditorial

Biochemistry
2016
20 Citations (Scopus)

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

Signer, R. A. J., Qi, L., Zhao, Z., Thompson, D., Sigova, A. A., Fan, Z. P., Demartino, G. N., Young, R. A., Sonenberg, N. & Morrison, S. J., Aug 1 2016, In : Genes and Development. 30, 15, p. 1698-1703 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Adult Stem Cells
Carrier Proteins
Proteins
Eukaryotic Initiation Factor-4E
2014
28 Citations (Scopus)

Molecular and cellular roles of PI31 (PSMF1) protein in regulation of proteasome function

Li, X., Thompson, D., Kumar, B. & DeMartino, G. N., Jun 20 2014, In : Journal of Biological Chemistry. 289, 25, p. 17392-17405 14 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Proteins
Amino Acids
Amino Acid Motifs
RNA Interference
2013
23 Citations (Scopus)

ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome

Kim, Y. C., Li, X., Thompson, D. & Demartino, G. N., Feb 1 2013, In : Journal of Biological Chemistry. 288, 5, p. 3334-3345 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Adenosine Triphosphatases
Adenosine Triphosphate
Substrates
Proteolysis
2012
150 Citations (Scopus)

Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

Tsai, N. P., Wilkerson, J. R., Guo, W., Maksimova, M. A., Demartino, G. N., Cowan, C. W. & Huber, K. M., Dec 21 2012, In : Cell. 151, 7, p. 1581-1594 14 p.

Research output: Contribution to journalArticle

MEF2 Transcription Factors
Fragile X Mental Retardation Protein
Autistic Disorder
Scaffolds
Synapses
3 Citations (Scopus)

Reconstitution of PA700, the 19S regulatory particle, from purified precursor complexes

Demartino, G. N., 2012, Methods in Molecular Biology. Vol. 832. p. 443-452 10 p. (Methods in Molecular Biology; vol. 832).

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteasome Endopeptidase Complex
Adenosine Triphosphatases
Adenosine Triphosphate
In Vitro Techniques
ATP dependent 26S protease
2011
26 Citations (Scopus)

C termini of proteasomal ATpases play nonequivalent roles in cellular assembly of mammalian 26 S proteasome

Kim, Y. C. & DeMartino, G. N., Jul 29 2011, In : Journal of Biological Chemistry. 286, 30, p. 26652-26666 15 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Adenosine Triphosphatases
RNA Interference
Tyrosine
Cells
2010
16 Citations (Scopus)
Synucleins
Proteasome Endopeptidase Complex
Mutation
Parkinson Disease
Amyloid
169 Citations (Scopus)

PSMB8 encoding the β5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome

Agarwal, A. K., Xing, C., Demartino, G. N., Mizrachi, D., Hernandez, M. D., Sousa, A. B., Martínez De Villarreal, L., Dos Santos, H. G. & Garg, A., Dec 10 2010, In : American Journal of Human Genetics. 87, 6, p. 866-872 7 p.

Research output: Contribution to journalArticle

Panniculitis
Lipodystrophy
Muscular Atrophy
Contracture
Proteasome Endopeptidase Complex
19 Citations (Scopus)
Proteasome Endopeptidase Complex
Adenosine Triphosphatases
Chemical activation
HEK293 Cells
Adenosine Triphosphate
2009
5 Citations (Scopus)

PUPylation: something old, something new, something borrowed, something Glu

DeMartino, G. N., Apr 2009, In : Trends in Biochemical Sciences. 34, 4, p. 155-158 4 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Ubiquitins
Proteolysis
Proteins
24 Citations (Scopus)
Endoplasmic Reticulum-Associated Degradation
Proteasome Endopeptidase Complex
Sterols
Membranes
Degradation
133 Citations (Scopus)

Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II

Djakovic, S. N., Schwarz, L. A., Barylko, B., DeMartino, G. N. & Patrick, G. N., Sep 25 2009, In : Journal of Biological Chemistry. 284, 39, p. 26655-26665 11 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
46 Citations (Scopus)
Proteasome Endopeptidase Complex
Adenosine Triphosphatases
Chemical activation
Carboxypeptidases
Peptide Hydrolases
37 Citations (Scopus)

Variably modulated gating of the 26S proteasome by ATP and polyubiquitin

Li, X. & DeMartino, G. N., Aug 1 2009, In : Biochemical Journal. 421, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

Polyubiquitin
Hydrolysis
Adenosine Triphosphate
Proteolysis
Proteasome Endopeptidase Complex
2008
110 Citations (Scopus)

Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and Activation of the 26 S proteasome

Gillette, T. G., Kumar, B., Thompson, D., Slaughter, C. A. & DeMartino, G. N., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31813-31822 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Chemical activation
Peptides
Hydrolysis
Substrates
9 Citations (Scopus)

JAMP optimizes ERAD to protect cells from unfolded proteins

Tcherpakov, M., Broday, L., Delaunay, A., Kadoya, T., Khurana, A., Erdjument-Bromage, H., Tempst, P., Qiu, X. B., Demartino, G. N. & Ronai, Z., Nov 2008, In : Molecular Biology of the Cell. 19, 11, p. 5019-5028 10 p.

Research output: Contribution to journalArticle

Protein Unfolding
Proteins
Ubiquitin-Protein Ligases
Ubiquitination
Caenorhabditis elegans
152 Citations (Scopus)

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

Koulich, E., Li, X. & DeMartino, G. N., Mar 2008, In : Molecular Biology of the Cell. 19, 3, p. 1072-1082 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide
RNA Interference
Proteolysis
Proteins
2007
283 Citations (Scopus)

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response

Gerdes, J. M., Liu, Y., Zaghloul, N. A., Leitch, C. C., Lawson, S. S., Kato, M., Beachy, P. A., Beales, P. L., DeMartino, G. N., Fisher, S., Badano, J. L. & Katsanis, N., Nov 2007, In : Nature Genetics. 39, 11, p. 1350-1360 11 p.

Research output: Contribution to journalArticle

Basal Bodies
Catenins
Zebrafish
Mammalian Embryo
TCF Transcription Factors

Proteasome Regulator, PA700 (19S Regulatory Particle)

DeMartino, G. N. & Wojcik, C., Dec 14 2007, Protein Degradation. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 1. p. 288-316 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteasome Endopeptidase Complex
Proteolysis
156 Citations (Scopus)

Proteasomes: Machines for All Reasons

DeMartino, G. N. & Gillette, T. G., May 18 2007, In : Cell. 129, 4, p. 659-662 4 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Homeostasis
Chemical analysis
Proteins
100 Citations (Scopus)

Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System

Wahlman, J., DeMartino, G. N., Skach, W. R., Bulleid, N. J., Brodsky, J. L. & Johnson, AE., Jun 1 2007, In : Cell. 129, 5, p. 943-955 13 p.

Research output: Contribution to journalArticle

Fluorescence
Degradation
Substrates
Microsomes
Proteins
2006
123 Citations (Scopus)

ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome

Liu, C. W., Li, X., Thompson, D., Wooding, K., Chang, T. L., Tang, Z., Yu, H., Thomas, P. J. & DeMartino, G. N., Oct 6 2006, In : Molecular Cell. 24, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

Hydrolysis
Adenosine Triphosphate
Proteasome Endopeptidase Complex
Proteolysis
Proteins
4 Citations (Scopus)

Modification of Cul1 regulates its association with proteasomal subunits

Bloom, J., Peschiaroli, A., DeMartino, G. & Pagano, M., Apr 28 2006, In : Cell Division. 1, 5.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
F-Box Proteins
Association reactions
Ubiquitination
Degradation
208 Citations (Scopus)

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1

Yao, T., Song, L., Xu, W., DeMartino, G. N., Florens, L., Swanson, S. K., Washburn, M. P., Conaway, R. C., Conaway, J. W. & Cohen, R. E., Sep 2006, In : Nature Cell Biology. 8, 9, p. 994-1002 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin Thiolesterase
Polyubiquitin
Ubiquitin
Saccharomyces cerevisiae
129 Citations (Scopus)

Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells

Wójcik, C., Rowicka, M., Kudlicki, A., Nowis, D., McConnell, E., Kujawa, M. & DeMartino, G. N., Nov 2006, In : Molecular Biology of the Cell. 17, 11, p. 4606-4618 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Ubiquitin
RNA Interference
Proteasome Endopeptidase Complex
Proteolysis
2005
171 Citations (Scopus)

A precipitating role for truncated α-synuclein and the proteasome in α-synuclein aggregation: Implications for pathogenesis of parkinson disease

Liu, C. W., Giasson, B. I., Lewis, K. A., Lee, V. M., DeMartino, G. N. & Thomas, P. J., Jun 17 2005, In : Journal of Biological Chemistry. 280, 24, p. 22670-22678 9 p.

Research output: Contribution to journalArticle

Synucleins
Proteasome Endopeptidase Complex
Parkinson Disease
Agglomeration
Proteins
9 Citations (Scopus)

Modulation of gene expression by RNAi.

Wójcik, C., Fabunmi, R. & DeMartino, G. N., 2005, In : Methods in molecular medicine. 108, p. 381-393 13 p.

Research output: Contribution to journalArticle

RNA Interference
Small Interfering RNA
Gene Expression
Gene Knockdown Techniques
Double-Stranded RNA
3 Citations (Scopus)

Proteasome Regulator, PA700 (19S Regulatory Particle)

Demartino, G. N. & Wojcik, C., Nov 18 2005, Protein Degradation: Ubiquitin and the Chemistry of Life. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 1. p. 288-316 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteasome Endopeptidase Complex
Proteolysis
24 Citations (Scopus)

Purification of PA700, the 19S regulatory complex of the 26S proteasome

DeMartino, G. N., 2005, In : Methods in Enzymology. 398, p. 295-306 12 p.

Research output: Contribution to journalArticle

Purification
Proteasome Endopeptidase Complex
Polyubiquitin
Proteolysis
Ubiquitin
11 Citations (Scopus)
Polyubiquitin
Proteasome Endopeptidase Complex
Proteolysis
Adenosine Triphosphatases
Proteins
2004
205 Citations (Scopus)

Lewy-body formation is an aggresome-related process: A hypothesis

Olanow, C. W., Perl, D. P., DeMartino, G. N. & McNaught, K. S. P., Aug 1 2004, In : Lancet Neurology. 3, 8, p. 496-503 8 p.

Research output: Contribution to journalArticle

Lewy Bodies
Parkinson Disease
Centrosome
Neurodegenerative Diseases
Proteins
2 Citations (Scopus)
Proteasome Endopeptidase Complex
Ubiquitin
Cell Cycle Proteins
Proteasome Inhibitors
Critical Pathways
189 Citations (Scopus)

RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis

Wójcik, C., Yano, M. & DeMartino, G. N., Jan 15 2004, In : Journal of Cell Science. 117, 2, p. 281-292 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
RNA Interference
Proteolysis
HeLa Cells
92 Citations (Scopus)

Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein

Lee, R. J., Liu, C. W., Harty, C., McCracken, A. A., Latterich, M., Römisch, K., DeMartino, G. N., Thomas, P. J. & Brodsky, J. L., Jun 2 2004, In : EMBO Journal. 23, 11, p. 2206-2215 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum-Associated Degradation
Proteasome Endopeptidase Complex
Degradation
Endoplasmic Reticulum
Cytosol
3 Citations (Scopus)

Varshavsky's contributions [3]

Baumeister, W., Bachmair, A., Chau, V., Cohen, R., Coffino, P., Demartino, G., Deshaies, R., Dohmen, J., Emr, S., Finley, D., Hampton, R., Hill, C., Hochstrasser, M., Huber, R., Jackson, P., Jentsch, S., Johnson, E., Kwon, Y. T., Pagano, M., Pickart, C. & 9 others, Rechsteiner, M., Scheffner, M., Sommer, T., Tansey, W., Tyers, M., Vierstra, R., Weissman, A., Wilkinson, K. D. & Wolf, D., Nov 19 2004, In : Science. 306, 5700, p. 1290-1292 3 p.

Research output: Contribution to journalArticle

21st Century History
Ubiquitin-Protein Ligase Complexes
20th Century History
Nobel Prize
Proteasome Endopeptidase Complex
2003
53 Citations (Scopus)

Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes

Puttaparthi, K., Wojcik, C., Rajendran, B., DeMartino, G. N. & Elliott, J. L., Nov 2003, In : Journal of Neurochemistry. 87, 4, p. 851-860 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Transgenic Mice
Spinal Cord
Tissue
Proteolysis
310 Citations (Scopus)

Endoproteolytic activity of the proteasome

Liu, C. W., Corboy, M. J., DeMartino, G. N. & Thomas, P. J., Jan 17 2003, In : Science. 299, 5605, p. 408-411 4 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Catalytic Domain
Proteins
Transcription Factors
Peptides
252 Citations (Scopus)

Intracellular localization of proteasomes

Wójcik, C. & DeMartino, G. N., May 1 2003, In : International Journal of Biochemistry and Cell Biology. 35, 5, p. 579-589 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Cytoplasm
Ubiquitinated Proteins
Proteolysis
Centrosome
240 Citations (Scopus)

Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation

Bloom, J., Amador, V., Bartolini, F., DeMartino, G. & Pagano, M., Oct 3 2003, In : Cell. 115, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Lysine
Degradation
2002
87 Citations (Scopus)

Analysis of Drosophila 26 S proteasome using RNA interference

Wójcikb, C. & Demartino, G. N., Feb 22 2002, In : Journal of Biological Chemistry. 277, 8, p. 6188-6197 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
RNA Interference
Drosophila
RNA
Proteasome Inhibitors
65 Citations (Scopus)

Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome

Liu, C. W., Millen, L., Roman, T. B., Xiong, H., Gilbert, H. F., Noiva, R., Demartino, G. N. & Thomas, P. J., Jul 26 2002, In : Journal of Biological Chemistry. 277, 30, p. 26815-26820 6 p.

Research output: Contribution to journalArticle

Pancreatic Ribonuclease
Tetrahydrofolate Dehydrogenase
Chymotrypsin
Disulfides
Proteolysis
2001
67 Citations (Scopus)

Interferon γ regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies

Fabunmi, R. P., Christian Wigley, W., Thomas, P. J. & DeMartino, G. N., 2001, In : Journal of Cell Science. 114, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Proteasome Endopeptidase Complex
Interferons
Leukemia
Acute Promyelocytic Leukemia
2000
131 Citations (Scopus)

Activity and regulation of the centrosome-associated proteasome

Fabunmi, R. P., Wigley, W. C., Thomas, P. J. & DeMartino, G. N., Jan 7 2000, In : Journal of Biological Chemistry. 275, 1, p. 409-413 5 p.

Research output: Contribution to journalArticle

Centrosome
Proteasome Endopeptidase Complex
Proteasome Inhibitors
Proteolysis
Proteins
88 Citations (Scopus)

cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome

McCutchen-Maloney, S. L., Matsuda, K., Shimbara, N., Binns, D. D., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Jun 16 2000, In : Journal of Biological Chemistry. 275, 24, p. 18557-18565 9 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Cloning
Proteasome Endopeptidase Complex
Proline
Organism Cloning
39 Citations (Scopus)

Chronic contractile activity upregulates the proteasome system in rabbit skeletal muscle

Ordway, G. A., Neufer, P. D., Chin, E. R. & DeMartino, G. N., Mar 2000, In : Journal of Applied Physiology. 88, 3

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Skeletal Muscle
Up-Regulation
Rabbits
Ubiquitin
78 Citations (Scopus)

Cotranslatioaal dimerization of the Rel homology domain of NF-κB1 generates p50-p105 heterodimers and is required for effective p50 production

Lin, L., DeMartino, G. N. & Greene, W. C., Sep 1 2000, In : EMBO Journal. 19, 17, p. 4712-4722 11 p.

Research output: Contribution to journalArticle

Dimerization
Proteasome Endopeptidase Complex
Processing
Transcription Factors
Genes