Physiology - Division B

Research Output

2019

2019 Herbert Tabor Young Investigator Awards: Call for nominations

DeMartino, G. N., Jan 1 2019, In : Journal of Biological Chemistry. 293, 37, 1 p.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

2020 Herbert Tabor Early Career Investigator Awards: Call for nominations

Gierasch, L. M. & DeMartino, G. N., Sep 6 2019, In : Journal of Biological Chemistry. 294, 36, 1 p.

Research output: Contribution to journalEditorial

Open Access

Celebrating science’s next generation

Gierasch, L. M. & De Martino, G., Mar 1 2019, In : Journal of Biological Chemistry. 294, 9, p. 3323-3324 2 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Introduction to the Thematic Minireview Series: Autophagy

DeMartino, G. N., Apr 13 2018, In : Journal of Biological Chemistry. 293, 15, p. 5384-5385 2 p.

Research output: Contribution to journalReview article

2 Scopus citations

The herbert tabor young investigator awards: Meet the awardees!

Gierasch, L. M. & DeMartino, G., Mar 2 2018, In : Journal of Biological Chemistry. 293, 9, p. 3468-3469 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations
2017

The Herbert Tabor Best Paper Awards: Celebrating young authors who contribute top content to JBC

Gierasch, L. M. & DeMartino, G., Oct 13 2017, In : Journal of Biological Chemistry. 292, 41, 1 p.

Research output: Contribution to journalEditorial

4 Scopus citations
2016

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

Signer, R. A. J., Qi, L., Zhao, Z., Thompson, D., Sigova, A. A., Fan, Z. P., Demartino, G. N., Young, R. A., Sonenberg, N. & Morrison, S. J., Aug 1 2016, In : Genes and Development. 30, 15, p. 1698-1703 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Molecular and cellular roles of PI31 (PSMF1) protein in regulation of proteasome function

Li, X., Thompson, D., Kumar, B. & DeMartino, G. N., Jun 20 2014, In : Journal of Biological Chemistry. 289, 25, p. 17392-17405 14 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome

Kim, Y. C., Li, X., Thompson, D. & Demartino, G. N., Feb 1 2013, In : Journal of Biological Chemistry. 288, 5, p. 3334-3345 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

Tsai, N. P., Wilkerson, J. R., Guo, W., Maksimova, M. A., Demartino, G. N., Cowan, C. W. & Huber, K. M., Dec 21 2012, In : Cell. 151, 7, p. 1581-1594 14 p.

Research output: Contribution to journalArticle

159 Scopus citations

Reconstitution of PA700, the 19S regulatory particle, from purified precursor complexes

Demartino, G. N., Mar 19 2012, Ubiquitin Family Modifiers and the Proteasome: Reviews and Protocols. Dohmen, J. & Scheffner, M. (eds.). p. 443-452 10 p. (Methods in Molecular Biology; vol. 832).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2011

C termini of proteasomal ATpases play nonequivalent roles in cellular assembly of mammalian 26 S proteasome

Kim, Y. C. & DeMartino, G. N., Jul 29 2011, In : Journal of Biological Chemistry. 286, 30, p. 26652-26666 15 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010
16 Scopus citations

PSMB8 encoding the β5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome

Agarwal, A. K., Xing, C., Demartino, G. N., Mizrachi, D., Hernandez, M. D., Sousa, A. B., Martínez De Villarreal, L., Dos Santos, H. G. & Garg, A., Dec 10 2010, In : American Journal of Human Genetics. 87, 6, p. 866-872 7 p.

Research output: Contribution to journalArticle

179 Scopus citations
21 Scopus citations
2009

PUPylation: something old, something new, something borrowed, something Glu

DeMartino, G. N., Apr 1 2009, In : Trends in Biochemical Sciences. 34, 4, p. 155-158 4 p.

Research output: Contribution to journalShort survey

7 Scopus citations
27 Scopus citations

Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II

Djakovic, S. N., Schwarz, L. A., Barylko, B., DeMartino, G. N. & Patrick, G. N., Sep 25 2009, In : Journal of Biological Chemistry. 284, 39, p. 26655-26665 11 p.

Research output: Contribution to journalArticle

143 Scopus citations
46 Scopus citations

Variably modulated gating of the 26S proteasome by ATP and polyubiquitin

Li, X. & DeMartino, G. N., Aug 1 2009, In : Biochemical Journal. 421, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

39 Scopus citations
2008

Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and Activation of the 26 S proteasome

Gillette, T. G., Kumar, B., Thompson, D., Slaughter, C. A. & DeMartino, G. N., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31813-31822 10 p.

Research output: Contribution to journalArticle

113 Scopus citations

JAMP optimizes ERAD to protect cells from unfolded proteins

Tcherpakov, M., Broday, L., Delaunay, A., Kadoya, T., Khurana, A., Erdjument-Bromage, H., Tempst, P., Qiu, X. B., Demartino, G. N. & Ronai, Z., Nov 1 2008, In : Molecular biology of the cell. 19, 11, p. 5019-5028 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

Koulich, E., Li, X. & DeMartino, G. N., Mar 1 2008, In : Molecular biology of the cell. 19, 3, p. 1072-1082 11 p.

Research output: Contribution to journalArticle

154 Scopus citations
2007

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response

Gerdes, J. M., Liu, Y., Zaghloul, N. A., Leitch, C. C., Lawson, S. S., Kato, M., Beachy, P. A., Beales, P. L., DeMartino, G. N., Fisher, S., Badano, J. L. & Katsanis, N., Nov 1 2007, In : Nature genetics. 39, 11, p. 1350-1360 11 p.

Research output: Contribution to journalArticle

288 Scopus citations

Proteasome Regulator, PA700 (19S Regulatory Particle)

DeMartino, G. N. & Wojcik, C., Dec 14 2007, Protein Degradation. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 1. p. 288-316 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteasomes: Machines for All Reasons

DeMartino, G. N. & Gillette, T. G., May 18 2007, In : Cell. 129, 4, p. 659-662 4 p.

Research output: Contribution to journalShort survey

158 Scopus citations

Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System

Wahlman, J., DeMartino, G. N., Skach, W. R., Bulleid, N. J., Brodsky, J. L. & Johnson, AE., Jun 1 2007, In : Cell. 129, 5, p. 943-955 13 p.

Research output: Contribution to journalArticle

102 Scopus citations
2006

ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome

Liu, C. W., Li, X., Thompson, D., Wooding, K., Chang, T. L., Tang, Z., Yu, H., Thomas, P. J. & DeMartino, G. N., Oct 6 2006, In : Molecular cell. 24, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

129 Scopus citations

Modification of Cul1 regulates its association with proteasomal subunits

Bloom, J., Peschiaroli, A., DeMartino, G. & Pagano, M., Apr 28 2006, In : Cell Division. 1, 5.

Research output: Contribution to journalArticle

4 Scopus citations

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1

Yao, T., Song, L., Xu, W., DeMartino, G. N., Florens, L., Swanson, S. K., Washburn, M. P., Conaway, R. C., Conaway, J. W. & Cohen, R. E., Sep 1 2006, In : Nature cell biology. 8, 9, p. 994-1002 9 p.

Research output: Contribution to journalArticle

221 Scopus citations

Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells

Wójcik, C., Rowicka, M., Kudlicki, A., Nowis, D., McConnell, E., Kujawa, M. & DeMartino, G. N., Nov 1 2006, In : Molecular biology of the cell. 17, 11, p. 4606-4618 13 p.

Research output: Contribution to journalArticle

135 Scopus citations
2005

A precipitating role for truncated α-synuclein and the proteasome in α-synuclein aggregation: Implications for pathogenesis of parkinson disease

Liu, C. W., Giasson, B. I., Lewis, K. A., Lee, V. M., DeMartino, G. N. & Thomas, P. J., Jun 17 2005, In : Journal of Biological Chemistry. 280, 24, p. 22670-22678 9 p.

Research output: Contribution to journalArticle

180 Scopus citations

Modulation of gene expression by RNAi.

Wójcik, C., Fabunmi, R. & DeMartino, G. N., 2005, In : Methods in molecular medicine. 108, p. 381-393 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Proteasome Regulator, PA700 (19S Regulatory Particle)

Demartino, G. N. & Wojcik, C., Nov 18 2005, Protein Degradation: Ubiquitin and the Chemistry of Life. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 1. p. 288-316 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Purification of PA700, the 19S regulatory complex of the 26S proteasome

DeMartino, G. N., Nov 16 2005, In : Methods in Enzymology. 398, p. 295-306 12 p.

Research output: Contribution to journalReview article

24 Scopus citations
11 Scopus citations
2004

Lewy-body formation is an aggresome-related process: A hypothesis

Olanow, C. W., Perl, D. P., DeMartino, G. N. & McNaught, K. S. P., Aug 1 2004, In : Lancet Neurology. 3, 8, p. 496-503 8 p.

Research output: Contribution to journalComment/debate

214 Scopus citations

Proteasome inhibition: mechanism of action.

DeMartino, G. N., Nov 2004, In : Journal of the National Comprehensive Cancer Network : JNCCN. 2 Suppl 4, p. S5-9

Research output: Contribution to journalReview article

2 Scopus citations

RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis

Wójcik, C., Yano, M. & DeMartino, G. N., Jan 15 2004, In : Journal of cell science. 117, 2, p. 281-292 12 p.

Research output: Contribution to journalArticle

192 Scopus citations

Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein

Lee, R. J., Liu, C. W., Harty, C., McCracken, A. A., Latterich, M., Römisch, K., DeMartino, G. N., Thomas, P. J. & Brodsky, J. L., Jun 2 2004, In : EMBO Journal. 23, 11, p. 2206-2215 10 p.

Research output: Contribution to journalArticle

94 Scopus citations

Varshavsky's contributions [3]

Baumeister, W., Bachmair, A., Chau, V., Cohen, R., Coffino, P., Demartino, G., Deshaies, R., Dohmen, J., Emr, S., Finley, D., Hampton, R., Hill, C., Hochstrasser, M., Huber, R., Jackson, P., Jentsch, S., Johnson, E., Kwon, Y. T., Pagano, M., Pickart, C. & 9 others, Rechsteiner, M., Scheffner, M., Sommer, T., Tansey, W., Tyers, M., Vierstra, R., Weissman, A., Wilkinson, K. D. & Wolf, D., Nov 19 2004, In : Science. 306, 5700, p. 1290-1292 3 p.

Research output: Contribution to journalLetter

3 Scopus citations
2003

Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes

Puttaparthi, K., Wojcik, C., Rajendran, B., DeMartino, G. N. & Elliott, J. L., Nov 1 2003, In : Journal of Neurochemistry. 87, 4, p. 851-860 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Endoproteolytic activity of the proteasome

Liu, C. W., Corboy, M. J., DeMartino, G. N. & Thomas, P. J., Jan 17 2003, In : Science. 299, 5605, p. 408-411 4 p.

Research output: Contribution to journalArticle

316 Scopus citations

Intracellular localization of proteasomes

Wójcik, C. & DeMartino, G. N., May 1 2003, In : International Journal of Biochemistry and Cell Biology. 35, 5, p. 579-589 11 p.

Research output: Contribution to journalReview article

255 Scopus citations

Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation

Bloom, J., Amador, V., Bartolini, F., DeMartino, G. & Pagano, M., Oct 3 2003, In : Cell. 115, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

243 Scopus citations
2002

Analysis of Drosophila 26 S proteasome using RNA interference

Wójcikb, C. & Demartino, G. N., Feb 22 2002, In : Journal of Biological Chemistry. 277, 8, p. 6188-6197 10 p.

Research output: Contribution to journalArticle

88 Scopus citations

Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome

Liu, C. W., Millen, L., Roman, T. B., Xiong, H., Gilbert, H. F., Noiva, R., Demartino, G. N. & Thomas, P. J., Jul 26 2002, In : Journal of Biological Chemistry. 277, 30, p. 26815-26820 6 p.

Research output: Contribution to journalArticle

65 Scopus citations
2001

Interferon γ regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies

Fabunmi, R. P., Christian Wigley, W., Thomas, P. J. & DeMartino, G. N., Feb 15 2001, In : Journal of cell science. 114, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

69 Scopus citations
2000

Activity and regulation of the centrosome-associated proteasome

Fabunmi, R. P., Wigley, W. C., Thomas, P. J. & DeMartino, G. N., Jan 7 2000, In : Journal of Biological Chemistry. 275, 1, p. 409-413 5 p.

Research output: Contribution to journalArticle

132 Scopus citations

cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome

McCutchen-Maloney, S. L., Matsuda, K., Shimbara, N., Binns, D. D., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Jun 16 2000, In : Journal of Biological Chemistry. 275, 24, p. 18557-18565 9 p.

Research output: Contribution to journalArticle

92 Scopus citations