Physiology - Division B

Research Output

2000

Chronic contractile activity upregulates the proteasome system in rabbit skeletal muscle

Ordway, G. A., Neufer, P. D., Chin, E. R. & DeMartino, G. N., Mar 1 2000, In : Journal of applied physiology. 88, 3, p. 1134-1141+1133

Research output: Contribution to journalArticle

40 Scopus citations

Cotranslatioaal dimerization of the Rel homology domain of NF-κB1 generates p50-p105 heterodimers and is required for effective p50 production

Lin, L., DeMartino, G. N. & Greene, W. C., Sep 1 2000, In : EMBO Journal. 19, 17, p. 4712-4722 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome

Strickland, E., Hakala, K., Thomas, P. J. & DeMartino, G. N., Feb 25 2000, In : Journal of Biological Chemistry. 275, 8, p. 5565-5572 8 p.

Research output: Contribution to journalArticle

158 Scopus citations
1999

26 S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate

Ben-Shahar, S., Komlosh, A., Nadav, E., Shaked, I., Ziv, T., Admon, A., DeMartino, G. N. & Reiss, Y., Jul 30 1999, In : Journal of Biological Chemistry. 274, 31, p. 21963-21972 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Dynamic association of proteasomal machinery with the centrosome

Wigley, C. W., Fabunmi, R. P., Lee, M. G., Marino, C. R., Muallem, S., DeMartino, G. N. & Thomas, P. J., May 3 1999, In : Journal of Cell Biology. 145, 3, p. 481-490 10 p.

Research output: Contribution to journalArticle

400 Scopus citations

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

Stenoien, D. L., Cummings, C. J., Adams, H. P., Mancini, M. G., Patel, K., Demartino, G. N., Marcelli, M., Weigel, N. L. & Mancini, M. A., Jan 1 1999, In : Human molecular genetics. 8, 5, p. 731-741 11 p.

Research output: Contribution to journalArticle

Open Access
376 Scopus citations

The proteasome, a novel protease regulated by multiple mechanisms

DeMartino, G. N. & Slaughter, C. A., Aug 6 1999, In : Journal of Biological Chemistry. 274, 32, p. 22123-22126 4 p.

Research output: Contribution to journalShort survey

473 Scopus citations
1998

9 ubiquitin-proteasome pathway of intracellular protein degradation

DeMartino, G. N. & Ordway, G. A., Jan 1998, In : Exercise and Sport Sciences Reviews. 26, 1, p. 219-252 34 p.

Research output: Contribution to journalArticle

28 Scopus citations

cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9)

Watanabe, T. K., Saito, A., Suzuki, M., Fujiwara, T., Takahashi, E. I., Slaughter, C. A., DeMartino, G. N., Hendil, K. B., Chung, C. H., Tanahashi, N. & Tanaka, K., Jun 1 1998, In : Genomics. 50, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome

Hori, T., Kato, S., Saeki, M., DeMartino, G. N., Slaughter, C. A., Takeuchi, J., Toh-e, A. & Tanaka, K., Aug 17 1998, In : Gene. 216, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

Cotranslational biogenesis of NF-κB p50 by the 26S proteasome

Lin, L., DeMartino, G. N. & Greene, W. C., Mar 20 1998, In : Cell. 92, 6, p. 819-828 10 p.

Research output: Contribution to journalArticle

237 Scopus citations

Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity

Adams, G. M., Crotchett, B., Slaughter, C. A., DeMartino, G. N. & Gogol, E. P., Sep 15 1998, In : Biochemistry. 37, 37, p. 12927-12932 6 p.

Research output: Contribution to journalArticle

43 Scopus citations
1997

cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome

Saito, A., Watanabe, T. K., Shimada, Y., Fujiwara, T., Slaughter, C. A., Demartino, G. N., Tanahashi, N. & Tanaka, K., Dec 12 1997, In : Gene. 203, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

Lam, Y. A., Xu, W., DeMartino, G. N. & Cohen, R. E., Feb 20 1997, In : Nature. 385, 6618, p. 737-740 4 p.

Research output: Contribution to journalArticle

337 Scopus citations

Molecular properties of the proteasome activator PA28 family proteins and γ-interferon regulation

Tanahashi, N., Yokota, K. Y., Ahn, J. Y., Chung, C. H., Fujiwara, T., Takahashi, E. I., DeMartino, G. N., Slaughter, C. A., Toyonaga, T., Yamamura, K. I., Shimbara, N. & Tanaka, K., Jan 1 1997, In : Genes to Cells. 2, 3, p. 195-211 17 p.

Research output: Contribution to journalArticle

107 Scopus citations

Relative functions of the α and β subunits of the proteasome activator, PA28

Song, X., Von Kampen, J., Slaughter, C. A. & DeMartino, G. N., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27994-28000 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes

Lam, Y. A., DeMartino, G. N., Pickart, C. M. & Cohen, R. E., Nov 7 1997, In : Journal of Biological Chemistry. 272, 45, p. 28438-28446 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

Structural and functional effects of PA700 and modulator protein on proteasomes

Adams, G. M., Falke, S., Goldberg, A. L., Slaughter, C. A., DeMartino, G. N. & Gogol, E. P., Oct 31 1997, In : Journal of Molecular Biology. 273, 3, p. 646-657 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1

Kominami, K. I., Okura, N., Kawamura, M., DeMartino, G. N., Slaughter, C. A., Shimbara, N., Chung, C. H., Fujimuro, M., Yokosawa, H., Shimizu, Y., Tanahashi, N., Tanaka, K. & Toh-e, A., Jan 1997, In : Molecular biology of the cell. 8, 1, p. 171-187 17 p.

Research output: Contribution to journalArticle

87 Scopus citations
1996

A model for the quaternary structure of the proteasome activator PA28

Song, X., Mott, J. D., Von Kampen, J., Pramanik, B., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Oct 30 1996, In : Journal of Biological Chemistry. 271, 42, p. 26410-26417 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

cDNA cloning and functional analysis of the p97 subunit of the 265 proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11

Tsurumi, C., Shimizu, Y., Saeki, M., Kato, S., Demartino, G. N., Slaughter, C. A., Fujimuro, M., Yokosawa, H., Yamasaki, M. O., Hendil, K. B., Toh-E, A., Tanahashi, N. & Tanaka, K., Jan 1 1996, In : European Journal of Biochemistry. 239, 3, p. 912-921 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

cDNA cloning of p112, the largest regulatory subunit of the human 26S proteasome, and functional analysis of its yeast homologue, Sen3p

Yokota, K. Y., Kagawa, S., Shimizu, Y., Akioka, H., Tsurumi, C., Noda, C., Fujimuro, M., Yokosawa, H., Fujiwara, T., Takahashi, E. I., Ohba, M., Yamasaki, M. O., DeMartino, G. N., Slaughter, C. A., Toh-e, A. & Tanaka, K., Jun 1996, In : Molecular biology of the cell. 7, 6, p. 853-870 18 p.

Research output: Contribution to journalArticle

53 Scopus citations

CDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family

Fujiwara, T., Watanabe, T. K., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Jun 3 1996, In : FEBS Letters. 387, 2-3, p. 184-188 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Functional studies of the ATP-binding subunits of PA700, an activator of 20S proteasome

Zagnitko, O. P., DeMartino, G. N. & Slaughter, C. A., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1510

Research output: Contribution to journalArticle

Identification, purification, and characterization of a PA700-dependent activator of the proteasome

DeMartino, G. N., Proske, R. J., Moomaw, C. R., Strong, A. A., Song, X., Hisamatsu, H., Tanaka, K. & Slaughter, C. A., Feb 9 1996, In : Journal of Biological Chemistry. 271, 6, p. 3112-3118 7 p.

Research output: Contribution to journalArticle

124 Scopus citations

The proteasome subunit, C2, contains an important site for binding of the PA28 (11S) activator

Kania, M. A., Demartino, G. N., Baumeister, W. & Goldberg, A. L., Jan 1 1996, In : European Journal of Biochemistry. 236, 2, p. 510-516 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
1995

cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p

Akiyama, K. Y., Yokota, K. Y., Kagawa, S., Shimbara, N., DeMartino, G. N., Slaughter, C. A., Noda, C. & Tanaka, K., Apr 17 1995, In : FEBS Letters. 363, 1-2, p. 151-156 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

cDNA cloning of p40, a regulatory subunit of the human 26S proteasome, and a homolog of the Mov-34 gene product

Tsurumi, C., Demartino, G. N., Slaughter, C. A., Shimbara, N. & Tanaka, K., May 16 1995, In : Biochemical and Biophysical Research Communications. 210, 2, p. 600-608 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae

Kominami, K. I., DeMartino, G. N., Moomaw, C. R., Slaughter, C. A., Shimbara, N., Fujimuro, M., Yokosawa, H., Hisamatsu, H., Tanahashi, N., Shimizu, Y., Tanaka, K. & Toh-e, A., Jan 1 1995, In : EMBO Journal. 14, 13, p. 3105-3115 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

Primary structures of two homologous subunits of PA28, a γ-interferon-inducible protein activator of the 20S proteasome

Joon Young Ahn, Y. A., Nobuyuki Tanahashi, T., Kin-ya Akiyama, A., Hiroshi Hisamatsu, H., Chiseko Noda, N., Keiji Tanaka, T., Chin Ha Chung, H. C., Naoki Shibmara, S., Willy, P. J., Mott, J. D., Slaughter, C. A. & DeMartino, G. N., Jun 5 1995, In : FEBS Letters. 366, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

168 Scopus citations
1994

Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome

Chu-Ping, M., Vu, J. H., Proske, R. J., Slaughter, C. A. & DeMartino, G. N., Feb 4 1994, In : Journal of Biological Chemistry. 269, 5, p. 3539-3547 9 p.

Research output: Contribution to journalArticle

213 Scopus citations

PA28, an activator of the 20 S proteasome, is composed of two nonidentical but homologous subunits

Mott, J. D., Pramanik, B. C., Moomaw, C. R., Afendis, S. J., DeMartino, G. N. & Slaughter, C. A., Dec 16 1994, In : Journal of Biological Chemistry. 269, 50, p. 31466-31471 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

PA28 activator protein forms regulatory caps on proteasome stacked rings

Gray, C. W., Slaughter, C. A. & DeMartino, G. N., Feb 10 1994, In : Journal of Molecular Biology. 236, 1, p. 7-15 9 p.

Research output: Contribution to journalEditorial

134 Scopus citations

PA700, an ATP-dependent activator of the 20 S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family

DeMartino, G. N., Moomaw, C. R., Zagnitko, O. P., Proske, R. J., Chu-Ping, M., Afendis, S. J., Swaffield, J. C. & Slaughter, C. A., Aug 19 1994, In : Journal of Biological Chemistry. 269, 33, p. 20878-20884 7 p.

Research output: Contribution to journalArticle

190 Scopus citations

Proteasome Workshop at Colorado State University, Fort Collins, Colo., July 1-3, 1995

Mykles, D. L., DeMartino, G. N. & Kloetzel, P. M., Jan 1 1994, In : Enzyme and Protein. 48, 5-6, p. 298-310 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Proteolytic processing of ovalbumin and β-galactosidase by the proteasome to yield antigenic peptides

Dick, L. R., Aldrich, C., Jameson, S. C., Moomaw, C. R., Pramanik, B. C., Doyle, C. K., DeMartino, G. N., Bevan, M. J., Forman, J. M. & Slaughter, C. A., Apr 15 1994, In : Journal of Immunology. 152, 8, p. 3884-3894 11 p.

Research output: Contribution to journalArticle

168 Scopus citations
1993

PA28, an activator of the 20 S proteasome, is inactivated by proteolytic modification at its carboxyl terminus

Chu-Ping, M., Willy, P. J., Slaughter, C. A. & DeMartino, G. N., Jan 1 1993, In : Journal of Biological Chemistry. 268, 30, p. 22514-22519 6 p.

Research output: Contribution to journalArticle

63 Scopus citations

Regulatory proteins of the proteasome

DeMartino, G. N. & Slaughter, C. A., Dec 1 1993, In : Enzyme and Protein. 47, 4-6, p. 314-324 11 p.

Research output: Contribution to journalReview article

42 Scopus citations
1992

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain)

Chu-Ping, M., Slaughter, C. A. & DeMartino, G. N., Jan 1 1992, In : Journal of Biological Chemistry. 267, 15, p. 10515-10523 9 p.

Research output: Contribution to journalArticle

365 Scopus citations

Identification and Localization of a Cysteinyl Residue Critical for the Trypsin-like Catalytic Activity of the Proteasome

Dick, L. R., Moomaw, C. R., Pramanik, B. C., DeMartino, G. N. & Slaughter, C. A., Feb 1 1992, In : Biochemistry. 31, 32, p. 7347-7355 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Purification and characterization of a protein inhibitor of the 20S proteasome (macropain)

Chu-Ping, M., Slaughter, C. A. & DeMartino, G. N., Mar 12 1992, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1119, 3, p. 303-311 9 p.

Research output: Contribution to journalArticle

105 Scopus citations
1991

ATP-stimulated degradation of endogenous proteins in cell free extracts of BHK 21/C13 fibroblasts A key role for the proteinase, macropain, in the ubiquitin-dependent degradation of short-lived proteins

DeMartino, G. N., McCullough, M. L., Reckelhoff, J. F., Cloall, D. E., Cicchanover, A. & McGuire, M. J., Mar 4 1991, In : BBA - General Subjects. 1073, 2, p. 299-308 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Calcium-activated neutral protease (calpain) system: Structure, function, and regulation

Croall, D. E. & Demartino, G. N., Jan 1 1991, In : Physiological Reviews. 71, 3, p. 813-847 35 p.

Research output: Contribution to journalReview article

756 Scopus citations

Degradation of Oxidized Insulin B Chain by the Multiproteinase Complex Macropain (Proteasome)

Dick, L. R., Moomaw, C. R., DeMartino, G. N. & Slaughter, C. A., Mar 1 1991, In : Biochemistry. 30, 10, p. 2725-2734 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous

DeMartino, G. N., Orth, K., McCullough, M. L., Lee, L. W., Munn, T. Z., Moomaw, C. R., Dawson, P. A. & Slaughter, C. A., Aug 9 1991, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1079, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
1990

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)

Lee, L. W., Moomaw, C. R., Orth, K., McGuire, M. J., DeMartino, G. N. & Slaughter, C. A., Feb 9 1990, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1037, 2, p. 178-185 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
1989

ATP-dependent mechanisms for protein degradation in mammalian cells.

DeMartino, G. N., McGuire, M. J., Reckelhoff, J. F., McCullough, M. L. & Croall, D. E., Dec 1 1989, In : Revisiones sobre biologia celular : RBC. 20, p. 181-196 16 p.

Research output: Contribution to journalReview article

1 Scopus citations

The high molecular weight multicatalytic proteinase, macropain, exists in a latent form in human erythrocytes

McGuire, M. J., McCullough, M. L., Croall, D. E. & DeMartino, G. N., Apr 6 1989, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 995, 2, p. 181-186 6 p.

Research output: Contribution to journalArticle

97 Scopus citations
32 Scopus citations
1988
28 Scopus citations