Physiology - Division B

Research Output 1977 2018

2000
157 Citations (Scopus)

Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome

Strickland, E., Hakala, K., Thomas, P. J. & DeMartino, G. N., Feb 25 2000, In : Journal of Biological Chemistry. 275, 8, p. 5565-5572 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Polyubiquitin
Citrate (si)-Synthase
Agglomeration
Substrates
1999
47 Citations (Scopus)

26 S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate

Ben-Shahar, S., Komlosh, A., Nadav, E., Shaked, I., Ziv, T., Admon, A., DeMartino, G. N. & Reiss, Y., Jul 30 1999, In : Journal of Biological Chemistry. 274, 31, p. 21963-21972 10 p.

Research output: Contribution to journalArticle

Histocompatibility
Proteasome Endopeptidase Complex
Epitopes
Ovum
Antigen Presentation
395 Citations (Scopus)

Dynamic association of proteasomal machinery with the centrosome

Wigley, C. W., Fabunmi, R. P., Lee, M. G., Marino, C. R., Muallem, S., DeMartino, G. N. & Thomas, P. J., May 3 1999, In : Journal of Cell Biology. 145, 3, p. 481-490 10 p.

Research output: Contribution to journalArticle

Centrosome
Proteasome Endopeptidase Complex
Ubiquitin
HSP90 Heat-Shock Proteins
HEK293 Cells
371 Citations (Scopus)

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

Stenoien, D. L., Cummings, C. J., Adams, H. P., Mancini, M. G., Patel, K., Demartino, G. N., Marcelli, M., Weigel, N. L. & Mancini, M. A., 1999, In : Human Molecular Genetics. 8, 5, p. 731-741 11 p.

Research output: Contribution to journalArticle

Androgen Receptors
Proteasome Endopeptidase Complex
Heat-Shock Proteins
Nuclear Receptor Coactivator 1
Atrophic Muscular Disorders
469 Citations (Scopus)

The proteasome, a novel protease regulated by multiple mechanisms

DeMartino, G. N. & Slaughter, C. A., Aug 6 1999, In : Journal of Biological Chemistry. 274, 32, p. 22123-22126 4 p.

Research output: Contribution to journalArticle

Cysteine Endopeptidases
Ubiquitins
Multienzyme Complexes
Biological Models
Proteasome Endopeptidase Complex
1998
40 Citations (Scopus)

cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9)

Watanabe, T. K., Saito, A., Suzuki, M., Fujiwara, T., Takahashi, E. I., Slaughter, C. A., DeMartino, G. N., Hendil, K. B., Chung, C. H., Tanahashi, N. & Tanaka, K., Jun 1 1998, In : Genomics. 50, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

Organism Cloning
Complementary DNA
Yeasts
Chromosomes, Human, Pair 12
Proteins
70 Citations (Scopus)

cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome

Hori, T., Kato, S., Saeki, M., DeMartino, G. N., Slaughter, C. A., Takeuchi, J., Toh-e, A. & Tanaka, K., Aug 17 1998, In : Gene. 216, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

Organism Cloning
Complementary DNA
Yeasts
Ankyrin Repeat
Fungal Proteins
235 Citations (Scopus)

Cotranslational biogenesis of NF-κB p50 by the 26S proteasome

Lin, L., DeMartino, G. N. & Greene, W. C., Mar 20 1998, In : Cell. 92, 6, p. 819-828 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Processing
Gene expression
Genes
Proteins
43 Citations (Scopus)

Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity

Adams, G. M., Crotchett, B., Slaughter, C. A., DeMartino, G. N. & Gogol, E. P., Sep 15 1998, In : Biochemistry. 37, 37, p. 12927-12932 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Peptide Hydrolases
Chemical activation
Modulators
PA700 proteasome activator
27 Citations (Scopus)
Cysteine Endopeptidases
Ubiquitins
Muscular Atrophy
Proteasome Endopeptidase Complex
Ubiquitin
1997
22 Citations (Scopus)

cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome

Saito, A., Watanabe, T. K., Shimada, Y., Fujiwara, T., Slaughter, C. A., Demartino, G. N., Tanahashi, N. & Tanaka, K., Dec 12 1997, In : Gene. 203, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

Organism Cloning
Complementary DNA
Yeasts
Fungal Proteins
Isoelectric Point
329 Citations (Scopus)

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

Lam, Y. A., Xu, W., DeMartino, G. N. & Cohen, R. E., Feb 20 1997, In : Nature. 385, 6618, p. 737-740 4 p.

Research output: Contribution to journalArticle

Polyubiquitin
Ubiquitination
Ubiquitin
Proteolysis
Proteins
106 Citations (Scopus)

Molecular properties of the proteasome activator PA28 family proteins and γ-interferon regulation

Tanahashi, N., Yokota, K. Y., Ahn, J. Y., Chung, C. H., Fujiwara, T., Takahashi, E. I., DeMartino, G. N., Slaughter, C. A., Toyonaga, T., Yamamura, K. I., Shimbara, N. & Tanaka, K., 1997, In : Genes to Cells. 2, 3, p. 195-211 17 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Interferons
Proteins
Anti-Idiotypic Antibodies
Biological Phenomena
63 Citations (Scopus)

Relative functions of the α and β subunits of the proteasome activator, PA28

Song, X., Von Kampen, J., Slaughter, C. A. & DeMartino, G. N., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27994-28000 7 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Amino Acids
Tyrosine
Proteins
Molecules
92 Citations (Scopus)

Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes

Lam, Y. A., DeMartino, G. N., Pickart, C. M. & Cohen, R. E., Nov 7 1997, In : Journal of Biological Chemistry. 272, 45, p. 28438-28446 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Polyubiquitin
Substrates
PA700 proteasome activator
56 Citations (Scopus)

Structural and functional effects of PA700 and modulator protein on proteasomes

Adams, G. M., Falke, S., Goldberg, A. L., Slaughter, C. A., DeMartino, G. N. & Gogol, E. P., Oct 31 1997, In : Journal of Molecular Biology. 273, 3, p. 646-657 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Proteins
Electron Microscopy
Peptide Hydrolases
Ubiquitinated Proteins
87 Citations (Scopus)

Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1

Kominami, K. I., Okura, N., Kawamura, M., DeMartino, G. N., Slaughter, C. A., Shimbara, N., Chung, C. H., Fujimuro, M., Yokosawa, H., Shimizu, Y., Tanahashi, N., Tanaka, K. & Toh-e, A., Jan 1997, In : Molecular Biology of the Cell. 8, 1, p. 171-187 17 p.

Research output: Contribution to journalArticle

Yeasts
Amino Acids
Mutation
Density Gradient Centrifugation
Essential Genes
1996
66 Citations (Scopus)

A model for the quaternary structure of the proteasome activator PA28

Song, X., Mott, J. D., Von Kampen, J., Pramanik, B., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., 1996, In : Journal of Biological Chemistry. 271, 42, p. 26410-26417 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Antibodies
Proteins
Cathepsin A
Proteolysis
55 Citations (Scopus)

cDNA cloning and functional analysis of the p97 subunit of the 265 proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11

Tsurumi, C., Shimizu, Y., Saeki, M., Kato, S., Demartino, G. N., Slaughter, C. A., Fujimuro, M., Yokosawa, H., Yamasaki, M. O., Hendil, K. B., Toh-E, A., Tanahashi, N. & Tanaka, K., 1996, In : European Journal of Biochemistry. 239, 3, p. 912-921 10 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type I
Functional analysis
Cloning
Proteasome Endopeptidase Complex
Organism Cloning
53 Citations (Scopus)

cDNA cloning of p112, the largest regulatory subunit of the human 26S proteasome, and functional analysis of its yeast homologue, Sen3p

Yokota, K. Y., Kagawa, S., Shimizu, Y., Akioka, H., Tsurumi, C., Noda, C., Fujimuro, M., Yokosawa, H., Fujiwara, T., Takahashi, E. I., Ohba, M., Yamasaki, M. O., DeMartino, G. N., Slaughter, C. A., Toh-e, A. & Tanaka, K., Jun 1996, In : Molecular Biology of the Cell. 7, 6, p. 853-870 18 p.

Research output: Contribution to journalArticle

Organism Cloning
Complementary DNA
Yeasts
Temperature
Chromosomes, Human, Pair 2
23 Citations (Scopus)

CDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family

Fujiwara, T., Watanabe, T. K., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Jun 3 1996, In : FEBS Letters. 387, 2-3, p. 184-188 5 p.

Research output: Contribution to journalArticle

Cloning
Proteasome Endopeptidase Complex
Organism Cloning
Proteins
Modulators

Functional studies of the ATP-binding subunits of PA700, an activator of 20S proteasome

Zagnitko, O. P., DeMartino, G. N. & Slaughter, C. A., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

proteasome endopeptidase complex
Proteasome Endopeptidase Complex
Adenosine Triphosphate
adenosinetriphosphatase
Labeling
124 Citations (Scopus)

Identification, purification, and characterization of a PA700-dependent activator of the proteasome

DeMartino, G. N., Proske, R. J., Moomaw, C. R., Strong, A. A., Song, X., Hisamatsu, H., Tanaka, K. & Slaughter, C. A., Feb 9 1996, In : Journal of Biological Chemistry. 271, 6, p. 3112-3118 7 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Purification
Adenosine Triphosphate
Proteins
Modulators
42 Citations (Scopus)

The proteasome subunit, C2, contains an important site for binding of the PA28 (11S) activator

Kania, M. A., Demartino, G. N., Baumeister, W. & Goldberg, A. L., 1996, In : European Journal of Biochemistry. 236, 2, p. 510-516 7 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Binding Sites
Antibodies
Chemical activation
Peptide Hydrolases
1995
59 Citations (Scopus)

cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p

Akiyama, K. Y., Yokota, K. Y., Kagawa, S., Shimbara, N., DeMartino, G. N., Slaughter, C. A., Noda, C. & Tanaka, K., Apr 17 1995, In : FEBS Letters. 363, 1-2, p. 151-156 6 p.

Research output: Contribution to journalArticle

Cloning
Yeast
Adenosine Triphosphatases
Organism Cloning
Complementary DNA
28 Citations (Scopus)

cDNA Cloning of p40, a Regulatory Subunit of the Human 26S Proteasome, and a Homolog of the Mov-34 Gene Product

Tsurumi, C., Demartino, G. N., Slaughter, C. A., Shimbara, N. & Tanaka, K., May 16 1995, In : Biochemical and Biophysical Research Communications. 210, 2, p. 600-608 9 p.

Research output: Contribution to journalArticle

Cloning
Organism Cloning
Complementary DNA
Genes
Hepatoblastoma
92 Citations (Scopus)

Nin 1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae

Kominami, K. I., DeMartino, G. N., Moomaw, C. R., Slaughter, C. A., Shimbara, N., Fujimuro, M., Yokosawa, H., Hisamatsu, H., Tanahashi, N., Shimizu, Y., Tanaka, K. & Toh-e, A., 1995, In : EMBO Journal. 14, 13, p. 3105-3115 11 p.

Research output: Contribution to journalArticle

Yeast
Saccharomyces cerevisiae
Phosphotransferases
Chemical activation
Proteolysis
167 Citations (Scopus)

Primary structures of two homologous subunits of PA28, a γ-interferon-inducible protein activator of the 20S proteasome

Joon Young Ahn, Y. A., Nobuyuki Tanahashi, T., Kin-ya Akiyama, A., Hiroshi Hisamatsu, H., Chiseko Noda, N., Keiji Tanaka, T., Chin Ha Chung, H. C., Naoki Shibmara, S., Willy, P. J., Mott, J. D., Slaughter, C. A. & DeMartino, G. N., Jun 5 1995, In : FEBS Letters. 366, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Interferons
Messenger RNA
Proteins
Protein Subunits
1994
210 Citations (Scopus)

Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome

Chu-Ping, M., Vu, J. H., Proske, R. J., Slaughter, C. A. & DeMartino, G. N., Feb 4 1994, In : Journal of Biological Chemistry. 269, 5, p. 3539-3547 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Purification
Adenosine Triphosphate
Molecular Weight
Molecular weight
54 Citations (Scopus)

PA28, an activator of the 20 S proteasome, is composed of two nonidentical but homologous subunits

Mott, J. D., Pramanik, B. C., Moomaw, C. R., Afendis, S. J., DeMartino, G. N. & Slaughter, C. A., Dec 16 1994, In : Journal of Biological Chemistry. 269, 50, p. 31466-31471 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Protein Sequence Analysis
Oligomers
Amino Acids
Molecules
134 Citations (Scopus)

PA28 activator protein forms regulatory caps on proteasome stacked rings

Gray, C. W., Slaughter, C. A. & DeMartino, G. N., 1994, In : Journal of Molecular Biology. 236, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Proteins
Protein Subunits
Archaea
Eukaryota
190 Citations (Scopus)

PA700, an ATP-dependent activator of the 20 S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family

DeMartino, G. N., Moomaw, C. R., Zagnitko, O. P., Proske, R. J., Chu-Ping, M., Afendis, S. J., Swaffield, J. C. & Slaughter, C. A., Aug 19 1994, In : Journal of Biological Chemistry. 269, 33, p. 20878-20884 7 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Adenosine Triphosphatases
Carrier Proteins
Nucleotides
Adenosine Triphosphate
4 Citations (Scopus)

Proteasome Workshop at Colorado State University, Fort Collins, Colo., July 1-3, 1995

Mykles, D. L., DeMartino, G. N. & Kloetzel, P. M., 1994, In : Enzyme and Protein. 48, 5-6, p. 298-310 13 p.

Research output: Contribution to journalArticle

Posters
Proteasome Endopeptidase Complex
Education
Molecular biology
Enzymes
168 Citations (Scopus)

Proteolytic processing of ovalbumin and β-galactosidase by the proteasome to yield antigenic peptides

Dick, L. R., Aldrich, C., Jameson, S. C., Moomaw, C. R., Pramanik, B. C., Doyle, C. K., DeMartino, G. N., Bevan, M. J., Forman, J. M. & Slaughter, C. A., Apr 15 1994, In : Journal of Immunology. 152, 8, p. 3884-3894 11 p.

Research output: Contribution to journalArticle

Galactosidases
Ovalbumin
Proteasome Endopeptidase Complex
Peptides
Clone Cells
1993
61 Citations (Scopus)

PA28, an activator of the 20 S proteasome, is inactivated by proteolytic modification at its carboxyl terminus

Chu-Ping, M., Willy, P. J., Slaughter, C. A. & DeMartino, G. N., Oct 25 1993, In : Journal of Biological Chemistry. 268, 30, p. 22514-22519 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Carboxypeptidase B
Carboxypeptidases
Proteins
Molecular Weight
42 Citations (Scopus)

Regulatory proteins of the proteasome

DeMartino, G. N. & Slaughter, C. A., 1993, In : Enzyme and Protein. 47, 4-6, p. 314-324 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Proteins
Hydrolysis
Adenosine Triphosphate
Ubiquitinated Proteins
1992
360 Citations (Scopus)

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain)

Chu-Ping, M., Slaughter, C. A. & DeMartino, G. N., May 25 1992, In : Journal of Biological Chemistry. 267, 15, p. 10515-10523 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Purification
Proteins
Hydrolysis
Peptide Hydrolases
31 Citations (Scopus)

Identification and Localization of a Cysteinyl Residue Critical for the Trypsin-like Catalytic Activity of the Proteasome

Dick, L. R., Moomaw, C. R., Pramanik, B. C., DeMartino, G. N. & Slaughter, C. A., Feb 1 1992, In : Biochemistry. 31, 32, p. 7347-7355 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Trypsin
Catalyst activity
Peptide Hydrolases
Amino Acids
104 Citations (Scopus)

Purification and characterization of a protein inhibitor of the 20S proteasome (macropain)

Chu-Ping, M., Slaughter, C. A. & DeMartino, G. N., Mar 12 1992, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1119, 3, p. 303-311 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Purification
Proteins
Peptide Hydrolases
Hydrolysis
1991
13 Citations (Scopus)

ATP-stimulated degradation of endogenous proteins in cell free extracts of BHK 21/C13 fibroblasts A key role for the proteinase, macropain, in the ubiquitin-dependent degradation of short-lived proteins

DeMartino, G. N., McCullough, M. L., Reckelhoff, J. F., Cloall, D. E., Cicchanover, A. & McGuire, M. J., Mar 4 1991, In : BBA - General Subjects. 1073, 2, p. 299-308 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Fibroblasts
Ubiquitin
Cell Extracts
Cricetinae
756 Citations (Scopus)

Calcium-activated neutral protease (calpain) system: Structure, function, and regulation

Croall, D. E. & Demartino, G. N., Jul 1991, In : Physiological Reviews. 71, 3, p. 813-847 35 p.

Research output: Contribution to journalArticle

Calcium-Binding Proteins
Calpain
Calcium
Proteins
81 Citations (Scopus)

Degradation of oxidized insulin B chain by the multiproteinase complex macropain (Proteasome)

Dick, L. R., Moomaw, C. R., DeMartino, G. N. & Slaughter, C. A., 1991, In : Biochemistry®. 30, 10, p. 2725-2734 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Insulin
Degradation
Peptides
Antipain
40 Citations (Scopus)

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous

DeMartino, G. N., Orth, K., McCullough, M. L., Lee, L. W., Munn, T. Z., Moomaw, C. R., Dawson, P. A. & Slaughter, C. A., Aug 9 1991, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1079, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Peptide Hydrolases
Molecular Weight
Molecular weight
Genes
1990
56 Citations (Scopus)

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)

Lee, L. W., Moomaw, C. R., Orth, K., McGuire, M. J., DeMartino, G. N. & Slaughter, C. A., Feb 9 1990, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1037, 2, p. 178-185 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Peptide Hydrolases
Molecular Weight
Molecular weight
Peptide Mapping
1989
1 Citation (Scopus)

ATP-dependent mechanisms for protein degradation in mammalian cells.

DeMartino, G. N., McGuire, M. J., Reckelhoff, J. F., McCullough, M. L. & Croall, D. E., 1989, In : Revisiones sobre biologia celular : RBC. 20, p. 181-196 16 p.

Research output: Contribution to journalArticle

Proteolysis
Adenosine Triphosphate
Proteasome Endopeptidase Complex
Ubiquitin
Peptide Hydrolases
97 Citations (Scopus)

The high molecular weight multicatalytic proteinase, macropain, exists in a latent form in human erythrocytes

McGuire, M. J., McCullough, M. L., Croall, D. E. & DeMartino, G. N., Apr 6 1989, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 995, 2, p. 181-186 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Peptide Hydrolases
Erythrocytes
Molecular Weight
Molecular weight
32 Citations (Scopus)
ATP-Dependent Proteases
Proteolysis
Proteasome Endopeptidase Complex
Fibroblasts
Anti-Idiotypic Antibodies
1988
28 Citations (Scopus)
Proteasome Endopeptidase Complex
Fibroblasts
Ubiquitin
Adenosine Triphosphate
Molecular Weight
42 Citations (Scopus)
Proteolysis
Proteasome Endopeptidase Complex
Peptide Hydrolases
Adenosine Triphosphate
Molecular Weight
17 Citations (Scopus)

Proteolysis of the protein inhibitor of calcium-dependent proteases produces lower molecular weight fragments that retain inhibitory activity

DeMartino, G. N., Wachendorfer, R., McGuire, M. J. & Croall, D. E., 1988, In : Archives of Biochemistry and Biophysics. 262, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

Proteolysis
Cytidine Diphosphate
Molecular Weight
Molecular weight
Peptide Hydrolases