Physiology - Division B

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Article
2019

Celebrating science’s next generation

Gierasch, L. M. & De Martino, G., Mar 1 2019, In : Journal of Biological Chemistry. 294, 9, p. 3323-3324 2 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2016

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

Signer, R. A. J., Qi, L., Zhao, Z., Thompson, D., Sigova, A. A., Fan, Z. P., Demartino, G. N., Young, R. A., Sonenberg, N. & Morrison, S. J., Aug 1 2016, In : Genes and Development. 30, 15, p. 1698-1703 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Molecular and cellular roles of PI31 (PSMF1) protein in regulation of proteasome function

Li, X., Thompson, D., Kumar, B. & DeMartino, G. N., Jun 20 2014, In : Journal of Biological Chemistry. 289, 25, p. 17392-17405 14 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome

Kim, Y. C., Li, X., Thompson, D. & Demartino, G. N., Feb 1 2013, In : Journal of Biological Chemistry. 288, 5, p. 3334-3345 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

Tsai, N. P., Wilkerson, J. R., Guo, W., Maksimova, M. A., Demartino, G. N., Cowan, C. W. & Huber, K. M., Dec 21 2012, In : Cell. 151, 7, p. 1581-1594 14 p.

Research output: Contribution to journalArticle

159 Scopus citations
2011

C termini of proteasomal ATpases play nonequivalent roles in cellular assembly of mammalian 26 S proteasome

Kim, Y. C. & DeMartino, G. N., Jul 29 2011, In : Journal of Biological Chemistry. 286, 30, p. 26652-26666 15 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010
16 Scopus citations

PSMB8 encoding the β5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome

Agarwal, A. K., Xing, C., Demartino, G. N., Mizrachi, D., Hernandez, M. D., Sousa, A. B., Martínez De Villarreal, L., Dos Santos, H. G. & Garg, A., Dec 10 2010, In : American Journal of Human Genetics. 87, 6, p. 866-872 7 p.

Research output: Contribution to journalArticle

179 Scopus citations
21 Scopus citations
2009
27 Scopus citations

Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II

Djakovic, S. N., Schwarz, L. A., Barylko, B., DeMartino, G. N. & Patrick, G. N., Sep 25 2009, In : Journal of Biological Chemistry. 284, 39, p. 26655-26665 11 p.

Research output: Contribution to journalArticle

143 Scopus citations
46 Scopus citations

Variably modulated gating of the 26S proteasome by ATP and polyubiquitin

Li, X. & DeMartino, G. N., Aug 1 2009, In : Biochemical Journal. 421, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

39 Scopus citations
2008

Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and Activation of the 26 S proteasome

Gillette, T. G., Kumar, B., Thompson, D., Slaughter, C. A. & DeMartino, G. N., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31813-31822 10 p.

Research output: Contribution to journalArticle

113 Scopus citations

JAMP optimizes ERAD to protect cells from unfolded proteins

Tcherpakov, M., Broday, L., Delaunay, A., Kadoya, T., Khurana, A., Erdjument-Bromage, H., Tempst, P., Qiu, X. B., Demartino, G. N. & Ronai, Z., Nov 1 2008, In : Molecular biology of the cell. 19, 11, p. 5019-5028 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

Koulich, E., Li, X. & DeMartino, G. N., Mar 1 2008, In : Molecular biology of the cell. 19, 3, p. 1072-1082 11 p.

Research output: Contribution to journalArticle

154 Scopus citations
2007

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response

Gerdes, J. M., Liu, Y., Zaghloul, N. A., Leitch, C. C., Lawson, S. S., Kato, M., Beachy, P. A., Beales, P. L., DeMartino, G. N., Fisher, S., Badano, J. L. & Katsanis, N., Nov 1 2007, In : Nature genetics. 39, 11, p. 1350-1360 11 p.

Research output: Contribution to journalArticle

288 Scopus citations

Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System

Wahlman, J., DeMartino, G. N., Skach, W. R., Bulleid, N. J., Brodsky, J. L. & Johnson, AE., Jun 1 2007, In : Cell. 129, 5, p. 943-955 13 p.

Research output: Contribution to journalArticle

102 Scopus citations
2006

ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome

Liu, C. W., Li, X., Thompson, D., Wooding, K., Chang, T. L., Tang, Z., Yu, H., Thomas, P. J. & DeMartino, G. N., Oct 6 2006, In : Molecular cell. 24, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

129 Scopus citations

Modification of Cul1 regulates its association with proteasomal subunits

Bloom, J., Peschiaroli, A., DeMartino, G. & Pagano, M., Apr 28 2006, In : Cell Division. 1, 5.

Research output: Contribution to journalArticle

4 Scopus citations

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1

Yao, T., Song, L., Xu, W., DeMartino, G. N., Florens, L., Swanson, S. K., Washburn, M. P., Conaway, R. C., Conaway, J. W. & Cohen, R. E., Sep 1 2006, In : Nature cell biology. 8, 9, p. 994-1002 9 p.

Research output: Contribution to journalArticle

221 Scopus citations

Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells

Wójcik, C., Rowicka, M., Kudlicki, A., Nowis, D., McConnell, E., Kujawa, M. & DeMartino, G. N., Nov 1 2006, In : Molecular biology of the cell. 17, 11, p. 4606-4618 13 p.

Research output: Contribution to journalArticle

135 Scopus citations
2005

A precipitating role for truncated α-synuclein and the proteasome in α-synuclein aggregation: Implications for pathogenesis of parkinson disease

Liu, C. W., Giasson, B. I., Lewis, K. A., Lee, V. M., DeMartino, G. N. & Thomas, P. J., Jun 17 2005, In : Journal of Biological Chemistry. 280, 24, p. 22670-22678 9 p.

Research output: Contribution to journalArticle

180 Scopus citations

Modulation of gene expression by RNAi.

Wójcik, C., Fabunmi, R. & DeMartino, G. N., 2005, In : Methods in molecular medicine. 108, p. 381-393 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
11 Scopus citations
2004

RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis

Wójcik, C., Yano, M. & DeMartino, G. N., Jan 15 2004, In : Journal of cell science. 117, 2, p. 281-292 12 p.

Research output: Contribution to journalArticle

192 Scopus citations

Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein

Lee, R. J., Liu, C. W., Harty, C., McCracken, A. A., Latterich, M., Römisch, K., DeMartino, G. N., Thomas, P. J. & Brodsky, J. L., Jun 2 2004, In : EMBO Journal. 23, 11, p. 2206-2215 10 p.

Research output: Contribution to journalArticle

94 Scopus citations
2003

Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes

Puttaparthi, K., Wojcik, C., Rajendran, B., DeMartino, G. N. & Elliott, J. L., Nov 1 2003, In : Journal of Neurochemistry. 87, 4, p. 851-860 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Endoproteolytic activity of the proteasome

Liu, C. W., Corboy, M. J., DeMartino, G. N. & Thomas, P. J., Jan 17 2003, In : Science. 299, 5605, p. 408-411 4 p.

Research output: Contribution to journalArticle

316 Scopus citations

Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation

Bloom, J., Amador, V., Bartolini, F., DeMartino, G. & Pagano, M., Oct 3 2003, In : Cell. 115, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

243 Scopus citations
2002

Analysis of Drosophila 26 S proteasome using RNA interference

Wójcikb, C. & Demartino, G. N., Feb 22 2002, In : Journal of Biological Chemistry. 277, 8, p. 6188-6197 10 p.

Research output: Contribution to journalArticle

88 Scopus citations

Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome

Liu, C. W., Millen, L., Roman, T. B., Xiong, H., Gilbert, H. F., Noiva, R., Demartino, G. N. & Thomas, P. J., Jul 26 2002, In : Journal of Biological Chemistry. 277, 30, p. 26815-26820 6 p.

Research output: Contribution to journalArticle

65 Scopus citations
2001

Interferon γ regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies

Fabunmi, R. P., Christian Wigley, W., Thomas, P. J. & DeMartino, G. N., Feb 15 2001, In : Journal of cell science. 114, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

69 Scopus citations
2000

Activity and regulation of the centrosome-associated proteasome

Fabunmi, R. P., Wigley, W. C., Thomas, P. J. & DeMartino, G. N., Jan 7 2000, In : Journal of Biological Chemistry. 275, 1, p. 409-413 5 p.

Research output: Contribution to journalArticle

132 Scopus citations

cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome

McCutchen-Maloney, S. L., Matsuda, K., Shimbara, N., Binns, D. D., Tanaka, K., Slaughter, C. A. & DeMartino, G. N., Jun 16 2000, In : Journal of Biological Chemistry. 275, 24, p. 18557-18565 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

Chronic contractile activity upregulates the proteasome system in rabbit skeletal muscle

Ordway, G. A., Neufer, P. D., Chin, E. R. & DeMartino, G. N., Mar 1 2000, In : Journal of applied physiology. 88, 3, p. 1134-1141+1133

Research output: Contribution to journalArticle

40 Scopus citations

Cotranslatioaal dimerization of the Rel homology domain of NF-κB1 generates p50-p105 heterodimers and is required for effective p50 production

Lin, L., DeMartino, G. N. & Greene, W. C., Sep 1 2000, In : EMBO Journal. 19, 17, p. 4712-4722 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome

Strickland, E., Hakala, K., Thomas, P. J. & DeMartino, G. N., Feb 25 2000, In : Journal of Biological Chemistry. 275, 8, p. 5565-5572 8 p.

Research output: Contribution to journalArticle

158 Scopus citations
1999

26 S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate

Ben-Shahar, S., Komlosh, A., Nadav, E., Shaked, I., Ziv, T., Admon, A., DeMartino, G. N. & Reiss, Y., Jul 30 1999, In : Journal of Biological Chemistry. 274, 31, p. 21963-21972 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Dynamic association of proteasomal machinery with the centrosome

Wigley, C. W., Fabunmi, R. P., Lee, M. G., Marino, C. R., Muallem, S., DeMartino, G. N. & Thomas, P. J., May 3 1999, In : Journal of Cell Biology. 145, 3, p. 481-490 10 p.

Research output: Contribution to journalArticle

400 Scopus citations

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

Stenoien, D. L., Cummings, C. J., Adams, H. P., Mancini, M. G., Patel, K., Demartino, G. N., Marcelli, M., Weigel, N. L. & Mancini, M. A., Jan 1 1999, In : Human molecular genetics. 8, 5, p. 731-741 11 p.

Research output: Contribution to journalArticle

Open Access
376 Scopus citations
1998

9 ubiquitin-proteasome pathway of intracellular protein degradation

DeMartino, G. N. & Ordway, G. A., Jan 1998, In : Exercise and Sport Sciences Reviews. 26, 1, p. 219-252 34 p.

Research output: Contribution to journalArticle

28 Scopus citations

cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9)

Watanabe, T. K., Saito, A., Suzuki, M., Fujiwara, T., Takahashi, E. I., Slaughter, C. A., DeMartino, G. N., Hendil, K. B., Chung, C. H., Tanahashi, N. & Tanaka, K., Jun 1 1998, In : Genomics. 50, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome

Hori, T., Kato, S., Saeki, M., DeMartino, G. N., Slaughter, C. A., Takeuchi, J., Toh-e, A. & Tanaka, K., Aug 17 1998, In : Gene. 216, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

Cotranslational biogenesis of NF-κB p50 by the 26S proteasome

Lin, L., DeMartino, G. N. & Greene, W. C., Mar 20 1998, In : Cell. 92, 6, p. 819-828 10 p.

Research output: Contribution to journalArticle

237 Scopus citations

Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity

Adams, G. M., Crotchett, B., Slaughter, C. A., DeMartino, G. N. & Gogol, E. P., Sep 15 1998, In : Biochemistry. 37, 37, p. 12927-12932 6 p.

Research output: Contribution to journalArticle

43 Scopus citations
1997

cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome

Saito, A., Watanabe, T. K., Shimada, Y., Fujiwara, T., Slaughter, C. A., Demartino, G. N., Tanahashi, N. & Tanaka, K., Dec 12 1997, In : Gene. 203, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

Lam, Y. A., Xu, W., DeMartino, G. N. & Cohen, R. E., Feb 20 1997, In : Nature. 385, 6618, p. 737-740 4 p.

Research output: Contribution to journalArticle

337 Scopus citations

Molecular properties of the proteasome activator PA28 family proteins and γ-interferon regulation

Tanahashi, N., Yokota, K. Y., Ahn, J. Y., Chung, C. H., Fujiwara, T., Takahashi, E. I., DeMartino, G. N., Slaughter, C. A., Toyonaga, T., Yamamura, K. I., Shimbara, N. & Tanaka, K., Jan 1 1997, In : Genes to Cells. 2, 3, p. 195-211 17 p.

Research output: Contribution to journalArticle

107 Scopus citations

Relative functions of the α and β subunits of the proteasome activator, PA28

Song, X., Von Kampen, J., Slaughter, C. A. & DeMartino, G. N., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27994-28000 7 p.

Research output: Contribution to journalArticle

64 Scopus citations