Physiology - Division C

Research Output

2020

Control of cardiac contraction by sodium: Promises, reckonings, and new beginnings

Hilgemann, D. W., Jan 2020, In : Cell Calcium. 85, 102129.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Regulation of ion transport from within ion transit pathways

Hilgemann, D. W., Jan 6 2020, In : Journal of General Physiology. 152, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its role in oxidative stress response

Laothamatas, I., Gao, P., Wickramaratne, A., Quintanilla, C. G., Dino, A., Khan, C. A., Liou, J. & Green, C. B., Jan 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 2, p. 993-999 7 p.

Research output: Contribution to journalArticle

Structural insights into group II TRP channels

Fine, M., Li, X. & Dang, S., Mar 2020, In : Cell Calcium. 86, 102107.

Research output: Contribution to journalReview article

TRP Channel: The structural era

Li, X. & Fine, M., May 2020, In : Cell Calcium. 87, 102191.

Research output: Contribution to journalEditorial

2019

Analysis of Phosphatidylinositol Transfer at ER-PM Junctions in Receptor-Stimulated Live Cells

Chang, C. L. & Liou, J., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1949, p. 1-11 11 p.

Research output: Contribution to journalArticle

Author Correction: TMEM16F activation by Ca 2+ triggers plasma membrane expansion and directs PD-1 trafficking (Scientific Reports, (2019), 9, 1, (619), 10.1038/s41598-018-37056-x)

Bricogne, C., Fine, M., Pereira, P. M., Sung, J., Tijani, M., Wang, Y., Henriques, R., Collins, M. K. & Hilgemann, D. W., Dec 1 2019, In : Scientific Reports. 9, 1, 7705.

Research output: Contribution to journalComment/debate

Open Access

Correction to: Myristoylation-Dependent Palmitoylation of the Receptor Tyrosine Kinase Adaptor FRS2α (Biochemistry (2019) 58:25 (2809−2813) DOI: 10.1021/acs.biochem.9b00299)

Barylko, B., Chen, Y. J., Hennen, J., Angert, I., Chen, Y., Mueller, J. D., Sun, H. Q., Taylor, C. A., Liou, J., Yin, H. & Albanesi, J. P., Dec 17 2019, In : Biochemistry. 58, 50, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

Li, J., Shang, G., Chen, Y. J., Brautigam, C. A., Liou, J., Zhang, X. & Bai, X. C., Sep 2019, In : eLife. 8, e47650.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access

Myristoylation-Dependent Palmitoylation of the Receptor Tyrosine Kinase Adaptor FRS2α

Barylko, B., Chen, Y. J., Hennen, J., Angert, I., Chen, Y., Mueller, J. D., Sun, H. Q., Taylor, C. A., Liou, J., Yin, H. & Albanesi, J. P., Jun 25 2019, In : Biochemistry. 58, 25, p. 2809-2813 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

On the existence of endocytosis driven by membrane phase separations

Hilgemann, D. W., Lin, M. J., Fine, M. & Deisl, C., Jan 1 2019, In : Biochimica et Biophysica Acta - Biomembranes.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

Recent insights into mammalian ER–PM junctions

Chen, Y. J., Quintanilla, C. G. & Liou, J., Apr 2019, In : Current Opinion in Cell Biology. 57, p. 99-105 7 p.

Research output: Contribution to journalReview article

5 Scopus citations

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

Wu, J., Chen, Y. J., Dobbs, N., Sakai, T., Liou, J., Miner, J. J. & Yan, N., Apr 1 2019, In : Journal of Experimental Medicine. 216, 4, p. 867-883 17 p.

Research output: Contribution to journalArticle

18 Scopus citations

TMEM16F activation by Ca2+ triggers plasma membrane expansion and directs PD-1 trafficking

Bricogne, C., Fine, M., Pereira, P. M., Sung, J., Tijani, M., Wang, Y., Henriques, R., Collins, M. K. & Hilgemann, D., Dec 1 2019, In : Scientific reports. 9, 1, 619.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Correction: Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis [150, 2, (2018)] doi: 10.1085/jgp.201711875

Hilgemann, D. W., Dai, G., Collins, A., Lariccia, V., Magi, S., Deisl, C. & Fine, M., Feb 1 2018, In : Journal of General Physiology. 150, 2, 1 p.

Research output: Contribution to journalComment/debate

EB1 binding restricts STIM1 translocation to ER-PM junctions and regulates store-operated Ca2+ entry

Chang, C. L., Chen, Y. J., Quintanilla, C. G., Hsieh, T. S. & Liou, J., Jun 1 2018, In : Journal of Cell Biology. 217, 6, p. 2047-2058 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis

Hilgemann, D. W., Dai, G., Collins, A., Lariccia, V., Magi, S., Deisl, C. & Fine, M., Feb 1 2018, In : Journal of General Physiology. 150, 2, p. 211-224 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Structural analyses of FERM domain-mediated membrane localization of FARP1

Kuo, Y. C., He, X., Coleman, A. J., Chen, Y. J., Dasari, P., Liou, J., Biederer, T. & Zhang, X., Dec 1 2018, In : Scientific reports. 8, 1, 10477.

Research output: Contribution to journalArticle

2 Scopus citations

Structural basis for PtdInsP2-mediated human TRPML1 regulation

Fine, M., Schmiege, P. & Li, X., Dec 1 2018, In : Nature communications. 9, 1, 4192.

Research output: Contribution to journalArticle

15 Scopus citations
2017

Cortical actin contributes to spatial organization of ER-PM junctions

Hsieh, T. S., Chen, Y. J., Chang, C. L., Lee, W. R. & Liou, J., Nov 7 2017, In : Molecular Biology of the Cell. 28, 23, p. 3171-3180 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

ER-plasma membrane junctions: Why and how do we study them?

Chang, C. L., Chen, Y. J. & Liou, J., Sep 1 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 9, p. 1494-1506 13 p.

Research output: Contribution to journalReview article

21 Scopus citations
14 Scopus citations

RAS SF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2

Chen, Y. J., Chang, C. L., Lee, W. R. & Liou, J., Jul 1 2017, In : Journal of Cell Biology. 216, 7, p. 2011-2025 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling

Dalton, G., An, S. W., Al-Juboori, S. I., Nischan, N., Yoon, J., Dobrinskikh, E., Hilgemann, D. W., Xie, J., Luby-Phelps, K., Kohler, J. J., Birnbaumer, L. & Huang, C. L., Jan 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. 752-757 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
2016

Measurement of rapid amiloride-dependent pH changes at the cell surface using a proton-sensitive field-effect transistor

Schaffhauser, D., Fine, M., Tabata, M., Goda, T. & Miyahara, Y., Jan 1 2016, In : Biosensors. 6, 2, 11.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes

Lu, F. M., Deisl, C. & Hilgemann, D. W., Sep 14 2016, In : eLife. 5, e19267.

Research output: Contribution to journalArticle

10 Scopus citations

S-palmitoylation and the regulation of NCX1

Fuller, W., Reilly, L. & Hilgemann, D. W., Jan 1 2016, In : Channels. 10, 2, p. 75-77 3 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance

Anderson, D. M., Anderson, K. M., Chang, C. L., Makarewich, C. A., Nelson, B. R., McAnally, J. R., Kasaragod, P., Shelton, J. M., Liou, J., Bassel-Duby, R. & Olson, E. N., Feb 12 2015, In : Cell. 160, 4, p. 595-606 12 p.

Research output: Contribution to journalArticle

465 Scopus citations

Homeostatic regulation of the PI(4,5)P2-Ca2+ signaling system at ER-PM junctions

Chang, C. L. & Liou, J., Dec 10 2015, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.

Research output: Contribution to journalArticle

25 Scopus citations

Molecular mechanisms of inter-organelle ER-PM contact sites

Henne, W. M., Liou, J. & Emr, S. D., Aug 1 2015, In : Current Opinion in Cell Biology. 35, p. 123-130 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

Reilly, L., Howie, J., Wypijewski, K., Ashford, M. L. J., Hilgemann, D. W. & Fuller, W., Nov 1 2015, In : FASEB Journal. 29, 11, p. 4532-4543 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
57 Scopus citations
2014
1 Scopus citations

Expression, purification, and structural insights for the human uric acid transporter, GLUT9, using the Xenopus laevis Oocytes System

Clémençon, B., Lüscher, B. P., Fine, M., Baumann, M. U., Surbek, D. V., Bonny, O. & Hediger, M. A., Oct 6 2014, In : PloS one. 9, 10, e108852.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Fishing for holes in transporters: How protons breach the Na/K pump security gates

Hilgemann, D. W., 2014, In : Journal of General Physiology. 143, 4, p. 437-441 5 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
2013

Feedback regulation of receptor-induced ca2+ signaling mediated by e-syt1 and nir2 at endoplasmic reticulum-plasma membrane junctions

Chang, C. L., Hsieh, T. S., Yang, T. T., Rothberg, K. G., Azizoglu, D. B., Volk, E., Liao, J. C. & Liou, J., Nov 7 2013, In : Cell Reports. 5, 3, p. 813-825 13 p.

Research output: Contribution to journalArticle

155 Scopus citations

Human-induced pluripotent stem cell-derived cardiomyocytes for studies of cardiac ion transporters

Fine, M., Lu, F. M., Lin, M. J., Moe, O., Wang, H. R. & Hilgemann, D. W., Sep 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 5, p. C481-C491

Research output: Contribution to journalArticle

21 Scopus citations

Massive endocytosis triggered by surface membrane palmitoylation under mitochondrial control in BHK fibroblasts

Hilgmann, D. W., Fine, M., Linder, M. E., Jennings, B. C. & Lin, M. J., Nov 26 2013, In : eLife. 2013, 2, e01293.

Research output: Contribution to journalArticle

38 Scopus citations

Massive palmitoylation-dependent endocytosis during reoxygenation of anoxic cardiac muscle

Lin, M. J., Fine, M., Lu, J. Y., Hofmann, S. L., Frazier, G. & Hilgemann, D. W., Nov 26 2013, In : eLife. 2013, 2, e01295.

Research output: Contribution to journalArticle

42 Scopus citations

Septins Set the Stage for Orai1 to Bind STIM1 at ER-PM Junctions

Liou, J. & Meyer, T., Jul 29 2013, In : Developmental cell. 26, 2, p. 116-118 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Toward an understanding of the complete NCX1 lifetime in the cardiac sarcolemma

Hilgemann, D. W., Lin, M. J., Fine, M., Frazier, G. & Wang, H. R., Feb 15 2013, Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications: Proceedings of the 6th International Conference on Sodium Calcium Exchange. Annunziato, L. (ed.). p. 345-352 8 p. (Advances in Experimental Medicine and Biology; vol. 961).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations
2012

Fitting KV potassium channels into the PIP2 puzzle: Hille group connects dots between illustrious HH groups

Hilgemann, D. W., Sep 1 2012, In : Journal of General Physiology. 140, 3, p. 245-248 4 p.

Research output: Contribution to journalComment/debate

17 Scopus citations
2011

Massive calcium-activated endocytosis without involvement of classical endocytic proteins

Lariccia, V., Fine, M., Magi, S., Lin, M. J., Yaradanakul, A., Llaguno, M. C. & Hilgemann, D. W., Jan 2011, In : Journal of General Physiology. 137, 1, p. 111-132 22 p.

Research output: Contribution to journalArticle

67 Scopus citations

Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: A new approach to membrane recycling and lipid domains

Fine, M., Llaguno, M. C., Lariccia, V., Lin, M. J., Yaradanakul, A. & Hilgemann, D. W., Feb 2011, In : Journal of General Physiology. 137, 2, p. 137-154 18 p.

Research output: Contribution to journalArticle

28 Scopus citations

Mechanistic analysis of massive endocytosis in relation to functionally defned surface membrane domains

Hilgemann, D. W. & Fine, M., Feb 1 2011, In : Journal of General Physiology. 137, 2, p. 155-172 18 p.

Research output: Contribution to journalArticle

25 Scopus citations

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development

Limnander, A., Depeille, P., Freedman, T. S., Liou, J., Leitges, M., Kurosaki, T., Roose, J. P. & Weiss, A., May 1 2011, In : Nature immunology. 12, 5, p. 425-433 9 p.

Research output: Contribution to journalArticle

81 Scopus citations
2008

Ca-dependent nonsecretory vesicle fusion in a secretory cell

Wang, T. M. & Hilgemann, D. W., Jul 2008, In : Journal of General Physiology. 132, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Massive Ca-induced membrane fusion and phospholipid changes triggered by reverse Na/Ca exchange in BHK fibroblasts

Yaradanakul, A., Wang, T. M., Lariccia, V., Lin, M. J., Shen, C., Liu, X. & Hilgemann, D. W., Jul 2008, In : Journal of General Physiology. 132, 1, p. 29-50 22 p.

Research output: Contribution to journalArticle

16 Scopus citations
39 Scopus citations