Physiology - Division C

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2020

Control of cardiac contraction by sodium: Promises, reckonings, and new beginnings

Hilgemann, D. W., Jan 2020, In : Cell Calcium. 85, 102129.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its role in oxidative stress response

Laothamatas, I., Gao, P., Wickramaratne, A., Quintanilla, C. G., Dino, A., Khan, C. A., Liou, J. & Green, C. B., Jan 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 2, p. 993-999 7 p.

Research output: Contribution to journalArticle

2019

Analysis of Phosphatidylinositol Transfer at ER-PM Junctions in Receptor-Stimulated Live Cells

Chang, C. L. & Liou, J., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1949, p. 1-11 11 p.

Research output: Contribution to journalArticle

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

Li, J., Shang, G., Chen, Y. J., Brautigam, C. A., Liou, J., Zhang, X. & Bai, X. C., Sep 2019, In : eLife. 8, e47650.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access

Myristoylation-Dependent Palmitoylation of the Receptor Tyrosine Kinase Adaptor FRS2α

Barylko, B., Chen, Y. J., Hennen, J., Angert, I., Chen, Y., Mueller, J. D., Sun, H. Q., Taylor, C. A., Liou, J., Yin, H. & Albanesi, J. P., Jun 25 2019, In : Biochemistry. 58, 25, p. 2809-2813 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

Wu, J., Chen, Y. J., Dobbs, N., Sakai, T., Liou, J., Miner, J. J. & Yan, N., Apr 1 2019, In : Journal of Experimental Medicine. 216, 4, p. 867-883 17 p.

Research output: Contribution to journalArticle

13 Scopus citations

TMEM16F activation by Ca2+ triggers plasma membrane expansion and directs PD-1 trafficking

Bricogne, C., Fine, M., Pereira, P. M., Sung, J., Tijani, M., Wang, Y., Henriques, R., Collins, M. K. & Hilgemann, D., Dec 1 2019, In : Scientific reports. 9, 1, 619.

Research output: Contribution to journalArticle

10 Scopus citations
2018

EB1 binding restricts STIM1 translocation to ER-PM junctions and regulates store-operated Ca2+ entry

Chang, C. L., Chen, Y. J., Quintanilla, C. G., Hsieh, T. S. & Liou, J., Jun 1 2018, In : Journal of Cell Biology. 217, 6, p. 2047-2058 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis

Hilgemann, D. W., Dai, G., Collins, A., Lariccia, V., Magi, S., Deisl, C. & Fine, M., Feb 1 2018, In : Journal of General Physiology. 150, 2, p. 211-224 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Structural analyses of FERM domain-mediated membrane localization of FARP1

Kuo, Y. C., He, X., Coleman, A. J., Chen, Y. J., Dasari, P., Liou, J., Biederer, T. & Zhang, X., Dec 1 2018, In : Scientific reports. 8, 1, 10477.

Research output: Contribution to journalArticle

1 Scopus citations

Structural basis for PtdInsP2-mediated human TRPML1 regulation

Fine, M., Schmiege, P. & Li, X., Dec 1 2018, In : Nature communications. 9, 1, 4192.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Cortical actin contributes to spatial organization of ER-PM junctions

Hsieh, T. S., Chen, Y. J., Chang, C. L., Lee, W. R. & Liou, J., Nov 7 2017, In : Molecular Biology of the Cell. 28, 23, p. 3171-3180 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
14 Scopus citations

RAS SF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2

Chen, Y. J., Chang, C. L., Lee, W. R. & Liou, J., Jul 1 2017, In : Journal of Cell Biology. 216, 7, p. 2011-2025 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling

Dalton, G., An, S. W., Al-Juboori, S. I., Nischan, N., Yoon, J., Dobrinskikh, E., Hilgemann, D. W., Xie, J., Luby-Phelps, K., Kohler, J. J., Birnbaumer, L. & Huang, C. L., Jan 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. 752-757 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
2016

Measurement of rapid amiloride-dependent pH changes at the cell surface using a proton-sensitive field-effect transistor

Schaffhauser, D., Fine, M., Tabata, M., Goda, T. & Miyahara, Y., Jan 1 2016, In : Biosensors. 6, 2, 11.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes

Lu, F. M., Deisl, C. & Hilgemann, D. W., Sep 14 2016, In : eLife. 5

Research output: Contribution to journalArticle

10 Scopus citations

S-palmitoylation and the regulation of NCX1

Fuller, W., Reilly, L. & Hilgemann, D. W., Jan 1 2016, In : Channels. 10, 2, p. 75-77 3 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance

Anderson, D. M., Anderson, K. M., Chang, C. L., Makarewich, C. A., Nelson, B. R., McAnally, J. R., Kasaragod, P., Shelton, J. M., Liou, J., Bassel-Duby, R. & Olson, E. N., Feb 12 2015, In : Cell. 160, 4, p. 595-606 12 p.

Research output: Contribution to journalArticle

451 Scopus citations

Homeostatic regulation of the PI(4,5)P2-Ca2+ signaling system at ER-PM junctions

Chang, C. L. & Liou, J., Dec 10 2015, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.

Research output: Contribution to journalArticle

25 Scopus citations

Molecular mechanisms of inter-organelle ER-PM contact sites

Henne, W. M., Liou, J. & Emr, S. D., Aug 1 2015, In : Current Opinion in Cell Biology. 35, p. 123-130 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

Reilly, L., Howie, J., Wypijewski, K., Ashford, M. L. J., Hilgemann, D. W. & Fuller, W., Nov 1 2015, In : FASEB Journal. 29, 11, p. 4532-4543 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
56 Scopus citations
2013

Feedback regulation of receptor-induced ca2+ signaling mediated by e-syt1 and nir2 at endoplasmic reticulum-plasma membrane junctions

Chang, C. L., Hsieh, T. S., Yang, T. T., Rothberg, K. G., Azizoglu, D. B., Volk, E., Liao, J. C. & Liou, J., Nov 7 2013, In : Cell Reports. 5, 3, p. 813-825 13 p.

Research output: Contribution to journalArticle

154 Scopus citations

Human-induced pluripotent stem cell-derived cardiomyocytes for studies of cardiac ion transporters

Fine, M., Lu, F. M., Lin, M. J., Moe, O., Wang, H. R. & Hilgemann, D. W., Sep 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 5, p. C481-C491

Research output: Contribution to journalArticle

21 Scopus citations

Massive endocytosis triggered by surface membrane palmitoylation under mitochondrial control in BHK fibroblasts

Hilgmann, D. W., Fine, M., Linder, M. E., Jennings, B. C. & Lin, M. J., Nov 26 2013, In : eLife. 2013, 2, e01293.

Research output: Contribution to journalArticle

35 Scopus citations

Massive palmitoylation-dependent endocytosis during reoxygenation of anoxic cardiac muscle

Lin, M. J., Fine, M., Lu, J. Y., Hofmann, S. L., Frazier, G. & Hilgemann, D. W., Nov 26 2013, In : eLife. 2013, 2, e01295.

Research output: Contribution to journalArticle

41 Scopus citations
2011

Massive calcium-activated endocytosis without involvement of classical endocytic proteins

Lariccia, V., Fine, M., Magi, S., Lin, M. J., Yaradanakul, A., Llaguno, M. C. & Hilgemann, D. W., Jan 1 2011, In : Journal of General Physiology. 137, 1, p. 111-132 22 p.

Research output: Contribution to journalArticle

67 Scopus citations

Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: A new approach to membrane recycling and lipid domains

Fine, M., Llaguno, M. C., Lariccia, V., Lin, M. J., Yaradanakul, A. & Hilgemann, D. W., Feb 1 2011, In : Journal of General Physiology. 137, 2, p. 137-154 18 p.

Research output: Contribution to journalArticle

28 Scopus citations

Mechanistic analysis of massive endocytosis in relation to functionally defned surface membrane domains

Hilgemann, D. W. & Fine, M., Feb 1 2011, In : Journal of General Physiology. 137, 2, p. 155-172 18 p.

Research output: Contribution to journalArticle

25 Scopus citations

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development

Limnander, A., Depeille, P., Freedman, T. S., Liou, J., Leitges, M., Kurosaki, T., Roose, J. P. & Weiss, A., May 1 2011, In : Nature immunology. 12, 5, p. 425-433 9 p.

Research output: Contribution to journalArticle

79 Scopus citations
2008

Ca-dependent nonsecretory vesicle fusion in a secretory cell

Wang, T. M. & Hilgemann, D. W., Jul 1 2008, In : Journal of General Physiology. 132, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Massive Ca-induced membrane fusion and phospholipid changes triggered by reverse Na/Ca exchange in BHK fibroblasts

Yaradanakul, A., Wang, T. M., Lariccia, V., Lin, M. J., Shen, C., Liu, X. & Hilgemann, D. W., Jul 1 2008, In : Journal of General Physiology. 132, 1, p. 29-50 22 p.

Research output: Contribution to journalArticle

16 Scopus citations
39 Scopus citations
2007

Dual control of cardiac Na+-Ca2+ exchange by PIP2: Analysis of the surface membrane fraction by extracellular cysteine PEGylation

Shen, C., Lin, M. J., Yaradanakul, A., Lariccia, V., Hill, J. A. & Hilgemann, D. W., Aug 1 2007, In : Journal of Physiology. 582, 3, p. 1011-1026 16 p.

Research output: Contribution to journalArticle

20 Scopus citations

Dual control of cardiac Na+-Ca2+ exchange by PIP2: Electrophysiological analysis of direct and indirect mechanisms

Yaradanakul, A., Feng, S., Shen, C., Lariccia, V., Lin, M. J., Yang, J., Dong, P., Yin, H. L., Albanesi, J. P. & Hilgemann, D. W., Aug 1 2007, In : Journal of Physiology. 582, 3, p. 991-1010 20 p.

Research output: Contribution to journalArticle

44 Scopus citations
460 Scopus citations
18 Scopus citations

siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake

Galvez, T., Teruel, M. N., Heo, W. D., Jones, J. T., Kim, M. L., Liou, J., Myers, J. W. & Meyer, T., Jul 19 2007, In : Genome biology. 8, 7, R142.

Research output: Contribution to journalArticle

43 Scopus citations

STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels

Brandman, O., Liou, J., Park, W. S. & Meyer, T., Dec 28 2007, In : Cell. 131, 7, p. 1327-1339 13 p.

Research output: Contribution to journalArticle

475 Scopus citations

Unrestricted diffusion of exogenous and endogenous PIP2 in baby hamster kidney and Chinese hamster ovary cell plasmalemma

Yaradanakul, A. & Hilgemann, D. W., Dec 2007, In : Journal of Membrane Biology. 220, 1-3, p. 53-67 15 p.

Research output: Contribution to journalArticle

16 Scopus citations
2006

Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels

Zaika, O., Lara, L. S., Gamper, N., Hilgemann, D. W., Jaffe, D. B. & Shapiro, M. S., Aug 1 2006, In : Journal of Physiology. 575, 1, p. 49-67 19 p.

Research output: Contribution to journalArticle

69 Scopus citations

Molecular control of cardiac sodium homeostasis in health and disease

Hilgemann, D. W., Yaradanakul, A., Wang, Y. & Fuster, D., May 1 2006, In : Journal of Cardiovascular Electrophysiology. 17, SUPPL. 1, p. S47-S56

Research output: Contribution to journalArticle

38 Scopus citations
2005

Phospholipase C in living cells: Activation, inhibition, Ca2+ requirement, and regulation of M current

Horowitz, L. F., Hirdes, W., Suh, B. C., Hilgemann, D. W., Mackie, K. & Hille, B., Sep 1 2005, In : Journal of General Physiology. 126, 3, p. 243-262 20 p.

Research output: Contribution to journalArticle

242 Scopus citations

Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate

Li, Y., Gamper, N., Hilgemann, D. W. & Shapiro, M. S., Oct 26 2005, In : Journal of Neuroscience. 25, 43, p. 9825-9835 11 p.

Research output: Contribution to journalArticle

175 Scopus citations

STIM is a Ca2+ sensor essential for Ca2+-store- depletion-triggered Ca2+ influx

Liou, J., Kim, M. L., Won, D. H., Jones, J. T., Myers, J. W., Ferrell, J. E. & Meyer, T., Jul 12 2005, In : Current Biology. 15, 13, p. 1235-1241 7 p.

Research output: Contribution to journalArticle

1517 Scopus citations
2004
66 Scopus citations

Multiple transport modes of the cardiac Na+/Ca2+ exchanger

Kang, T. M. & Hilgemann, D. W., Feb 5 2004, In : Nature. 427, 6974, p. 544-548 5 p.

Research output: Contribution to journalArticle

113 Scopus citations
2003

Ion fluxes in giant excised cardiac membrane patches detected and quantified with ion-selective microelectrodes

Kang, T. M., Markin, V. S. & Hilgemann, D. W., Apr 1 2003, In : Journal of General Physiology. 121, 4, p. 325-347 23 p.

Research output: Contribution to journalArticle

23 Scopus citations