Physiology - Division C

Research Output 1977 2019

  • 114 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Conference contribution
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Article
2019

Analysis of Phosphatidylinositol Transfer at ER-PM Junctions in Receptor-Stimulated Live Cells

Chang, C. L. & Liou, J., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1949, p. 1-11 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Endoplasmic Reticulum
Cell Membrane
Phospholipid Transfer Proteins
Spatio-Temporal Analysis

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

Li, J., Shang, G., Chen, Y. J., Brautigam, C. A., Liou, J., Zhang, X. & Bai, X. C., Sep 2019, In : eLife. 8, e47650.

Research output: Contribution to journalArticle

Open Access
Receptor Protein-Tyrosine Kinases
Chemical activation
Ligands
Glial Cell Line-Derived Neurotrophic Factor
Phosphorylation
Open Access
Diglycerides
Ouabain
Cardiac Myocytes
Hypertrophy
Feedback

Myristoylation-Dependent Palmitoylation of the Receptor Tyrosine Kinase Adaptor FRS2α

Barylko, B., Chen, Y. J., Hennen, J., Angert, I., Chen, Y., Mueller, J. D., Sun, H. Q., Taylor, C. A., Liou, J., Yin, H. & Albanesi, J. P., Jun 25 2019, In : Biochemistry. 58, 25, p. 2809-2813 5 p.

Research output: Contribution to journalArticle

Lipoylation
Receptor Protein-Tyrosine Kinases
Fibroblast Growth Factor Receptors
Substrates
Tyrosine
3 Citations (Scopus)

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

Wu, J., Chen, Y. J., Dobbs, N., Sakai, T., Liou, J., Miner, J. J. & Yan, N., Apr 1 2019, In : The Journal of experimental medicine. 216, 4, p. 867-883 17 p.

Research output: Contribution to journalArticle

Homeostasis
Cell Death
Calcium
T-Lymphocytes
Unfolded Protein Response
7 Citations (Scopus)

TMEM16F activation by Ca2+ triggers plasma membrane expansion and directs PD-1 trafficking

Bricogne, C., Fine, M., Pereira, P. M., Sung, J., Tijani, M., Wang, Y., Henriques, R., Collins, M. K. & Hilgemann, D. W., Dec 1 2019, In : Scientific Reports. 9, 1, 619.

Research output: Contribution to journalArticle

Cell-Derived Microparticles
Ionophores
Cell Membrane
Membranes
T-Lymphocytes
2018
9 Citations (Scopus)

EB1 binding restricts STIM1 translocation to ER-PM junctions and regulates store-operated Ca2+ entry

Chang, C. L., Chen, Y. J., Quintanilla, C. G., Hsieh, T. S. & Liou, J., Jun 1 2018, In : Journal of Cell Biology. 217, 6, p. 2047-2058 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Cell Membrane
Microtubules
Homeostasis
8 Citations (Scopus)

Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis

Hilgemann, D. W., Dai, G., Collins, A., Lariccia, V., Magi, S., Deisl, C. & Fine, M., Feb 1 2018, In : Journal of General Physiology. 150, 2, p. 211-224 14 p.

Research output: Contribution to journalArticle

Second Messenger Systems
Endocytosis
Membrane Proteins
Lipids
Membranes

Structural analyses of FERM domain-mediated membrane localization of FARP1

Kuo, Y. C., He, X., Coleman, A. J., Chen, Y. J., Dasari, P., Liou, J., Biederer, T. & Zhang, X., Dec 1 2018, In : Scientific Reports. 8, 1, 10477.

Research output: Contribution to journalArticle

Zebrafish
Medicago
Membranes
Phospholipids
Membrane Proteins
2017
11 Citations (Scopus)

Cortical actin contributes to spatial organization of ER-PM junctions

Hsieh, T. S., Chen, Y. J., Chang, C. L., Lee, W. R. & Liou, J., Nov 7 2017, In : Molecular Biology of the Cell. 28, 23, p. 3171-3180 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Actins
Cell Membrane
Microscopy
Phosphatidylinositols
10 Citations (Scopus)
Veratridine
Cardiac Myocytes
Ions
Nystatin
Patch-Clamp Techniques
17 Citations (Scopus)

RAS SF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2

Chen, Y. J., Chang, C. L., Lee, W. R. & Liou, J., Jul 1 2017, In : Journal of Cell Biology. 216, 7, p. 2011-2025 15 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Cell Membrane
Adenosine Diphosphate
Synaptotagmins
Physiological Phenomena
23 Citations (Scopus)

Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling

Dalton, G., An, S. W., Al-Juboori, S. I., Nischan, N., Yoon, J., Dobrinskikh, E., Hilgemann, D. W., Xie, J., Luby-Phelps, K., Kohler, J. J., Birnbaumer, L. & Huang, C. L., Jan 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 4, p. 752-757 6 p.

Research output: Contribution to journalArticle

Membrane Microdomains
Phosphatidylinositol 3-Kinases
Intercellular Signaling Peptides and Proteins
Lipids
Gangliosides
2016
7 Citations (Scopus)

Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes

Lu, F. M., Deisl, C. & Hilgemann, D. W., Sep 14 2016, In : eLife. 5

Research output: Contribution to journalArticle

Sarcolemma
Cardiac Myocytes
Protein Kinases
Muscle Cells
Pumps
7 Citations (Scopus)

S-palmitoylation and the regulation of NCX1

Fuller, W., Reilly, L. & Hilgemann, D. W., Jan 1 2016, In : Channels. 10, 2, p. 75-77 3 p.

Research output: Contribution to journalArticle

Signal Transducing Adaptor Proteins
Sodium-Calcium Exchanger
Phosphatidylinositol 4,5-Diphosphate
Acyltransferases
Acylation
2015
371 Citations (Scopus)

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance

Anderson, D. M., Anderson, K. M., Chang, C. L., Makarewich, C. A., Nelson, B. R., McAnally, J. R., Kasaragod, P., Shelton, J. M., Liou, J., Bassel-Duby, R. & Olson, E. N., Feb 12 2015, In : Cell. 160, 4, p. 595-606 12 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Muscle
Skeletal Muscle
Muscles
Sarcoplasmic Reticulum
22 Citations (Scopus)

Homeostatic regulation of the PI(4,5)P2-Ca2+ signaling system at ER-PM junctions

Chang, C. L. & Liou, J., Dec 10 2015, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.

Research output: Contribution to journalArticle

Phosphatidylinositols
Endoplasmic Reticulum
Cell Membrane
Synaptotagmins
Phospholipid Transfer Proteins
55 Citations (Scopus)

Molecular mechanisms of inter-organelle ER-PM contact sites

Henne, W. M., Liou, J. & Emr, S. D., Aug 1 2015, In : Current Opinion in Cell Biology. 35, p. 123-130 8 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Organelles
Cell Membrane
Membranes
Lipids
17 Citations (Scopus)

Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

Reilly, L., Howie, J., Wypijewski, K., Ashford, M. L. J., Hilgemann, D. W. & Fuller, W., Nov 1 2015, In : FASEB Journal. 29, 11, p. 4532-4543 12 p.

Research output: Contribution to journalArticle

Lipoylation
Membranes
Cysteine
Anchors
GTP-Binding Proteins
49 Citations (Scopus)
Cell membranes
Phosphatidylinositols
Endoplasmic Reticulum
Homeostasis
Cell Membrane
2014
1 Citation (Scopus)
Cardiac Electrophysiology
Myocardial Contraction
Ventricular Function
Cardiac Myocytes
Angiotensin II
2 Citations (Scopus)

Fishing for holes in transporters: How protons breach the Na/K pump security gates

Hilgemann, D. W., 2014, In : Journal of General Physiology. 143, 4, p. 437-441 5 p.

Research output: Contribution to journalArticle

Xenopus Proteins
Proton Pumps
Sodium-Potassium-Exchanging ATPase
Protons
2013
138 Citations (Scopus)

Feedback regulation of receptor-induced ca2+ signaling mediated by e-syt1 and nir2 at endoplasmic reticulum-plasma membrane junctions

Chang, C. L., Hsieh, T. S., Yang, T. T., Rothberg, K. G., Azizoglu, D. B., Volk, E., Liao, J. C. & Liou, J., 2013, In : Cell Reports. 5, 3, p. 813-825 13 p.

Research output: Contribution to journalArticle

Cell membranes
Endoplasmic Reticulum
Cell Membrane
Feedback
Phospholipid Transfer Proteins
19 Citations (Scopus)

Human-induced pluripotent stem cell-derived cardiomyocytes for studies of cardiac ion transporters

Fine, M., Lu, F. M., Lin, M. J., Moe, O., Wang, H. R. & Hilgemann, D. W., Sep 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 5

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cardiac Myocytes
Ions
Small Interfering RNA
Transfection
29 Citations (Scopus)

Massive endocytosis triggered by surface membrane palmitoylation under mitochondrial control in BHK fibroblasts

Hilgmann, D. W., Fine, M., Linder, M. E., Jennings, B. C. & Lin, M. J., Nov 26 2013, In : eLife. 2013, 2, e01293.

Research output: Contribution to journalArticle

Lipoylation
Acyl Coenzyme A
Fibroblasts
Endocytosis
Coenzyme A
33 Citations (Scopus)

Massive palmitoylation-dependent endocytosis during reoxygenation of anoxic cardiac muscle

Lin, M. J., Fine, M., Lu, J. Y., Hofmann, S. L., Frazier, G. & Hilgemann, D. W., Nov 26 2013, In : eLife. 2013, 2, e01295.

Research output: Contribution to journalArticle

Lipoylation
Endocytosis
Muscle
Myocardium
Pumps
2 Citations (Scopus)

Septins Set the Stage for Orai1 to Bind STIM1 at ER-PM Junctions

Liou, J. & Meyer, T., Jul 29 2013, In : Developmental Cell. 26, 2, p. 116-118 3 p.

Research output: Contribution to journalArticle

Septins
Cell membranes
Endoplasmic Reticulum
Cell Membrane
Ion Channels
2012
16 Citations (Scopus)
Phosphatidylinositol 4,5-Diphosphate
Voltage-Gated Potassium Channels
Potassium Channels
2011
60 Citations (Scopus)

Massive calcium-activated endocytosis without involvement of classical endocytic proteins

Lariccia, V., Fine, M., Magi, S., Lin, M. J., Yaradanakul, A., Llaguno, M. C. & Hilgemann, D. W., Jan 2011, In : Journal of General Physiology. 137, 1, p. 111-132 22 p.

Research output: Contribution to journalArticle

Endocytosis
Calcium
Adenosine Triphosphate
Proteins
Exocytosis
27 Citations (Scopus)

Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: A new approach to membrane recycling and lipid domains

Fine, M., Llaguno, M. C., Lariccia, V., Lin, M. J., Yaradanakul, A. & Hilgemann, D. W., Feb 2011, In : Journal of General Physiology. 137, 2, p. 137-154 18 p.

Research output: Contribution to journalArticle

Recycling
Membrane Lipids
Endocytosis
Detergents
HEK293 Cells
23 Citations (Scopus)

Mechanistic analysis of massive endocytosis in relation to functionally defned surface membrane domains

Hilgemann, D. W. & Fine, M., Feb 2011, In : Journal of General Physiology. 137, 2, p. 155-172 18 p.

Research output: Contribution to journalArticle

Endocytosis
Membranes
Anions
Coloring Agents
Dynamins
78 Citations (Scopus)

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development

Limnander, A., Depeille, P., Freedman, T. S., Liou, J., Leitges, M., Kurosaki, T., Roose, J. P. & Weiss, A., May 2011, In : Nature Immunology. 12, 5, p. 425-433 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
B-Lymphocytes
Autoimmunity
Clonal Deletion
Guanine Nucleotide Exchange Factors
2008
18 Citations (Scopus)

Ca-dependent nonsecretory vesicle fusion in a secretory cell

Wang, T. M. & Hilgemann, D. W., Jul 2008, In : Journal of General Physiology. 132, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

Synaptotagmins
Membrane Fusion
Membranes
Cell Fusion
Secretory Vesicles
15 Citations (Scopus)

Massive Ca-induced membrane fusion and phospholipid changes triggered by reverse Na/Ca exchange in BHK fibroblasts

Yaradanakul, A., Wang, T. M., Lariccia, V., Lin, M. J., Shen, C., Liu, X. & Hilgemann, D. W., Jul 2008, In : Journal of General Physiology. 132, 1, p. 29-50 22 p.

Research output: Contribution to journalArticle

Membrane Fusion
Cricetinae
Phospholipids
Fibroblasts
Phosphatidylserines
36 Citations (Scopus)
Sodium-Hydrogen Antiporter
Protons
Protein Isoforms
Fibroblasts
Opossums
2007
18 Citations (Scopus)

Dual control of cardiac Na+-Ca2+ exchange by PIP2: Analysis of the surface membrane fraction by extracellular cysteine PEGylation

Shen, C., Lin, M. J., Yaradanakul, A., Lariccia, V., Hill, J. A. & Hilgemann, D. W., Aug 1 2007, In : Journal of Physiology. 582, 3, p. 1011-1026 16 p.

Research output: Contribution to journalArticle

Cysteine
Clathrin
Membranes
Carbachol
Light
40 Citations (Scopus)

Dual control of cardiac Na+-Ca2+ exchange by PIP2: Electrophysiological analysis of direct and indirect mechanisms

Yaradanakul, A., Feng, S., Shen, C., Lariccia, V., Lin, M. J., Yang, J., Dong, P., Yin, H. L., Albanesi, J. P. & Hilgemann, D. W., Aug 1 2007, In : Journal of Physiology. 582, 3, p. 991-1010 20 p.

Research output: Contribution to journalArticle

Membranes
Phosphatidylinositols
Cytoskeleton
Phosphotransferases
Adenylyl Imidodiphosphate
441 Citations (Scopus)
Endoplasmic Reticulum
Cell Membrane
Stromal Interaction Molecule 1
Fluorescence Recovery After Photobleaching
Ion Channels
66 Citations (Scopus)

Local PIP2 signals: When, where, and how?

Hilgemann, D. W., Oct 2007, In : Pflugers Archiv European Journal of Physiology. 455, 1, p. 55-67 13 p.

Research output: Contribution to journalArticle

Second Messenger Systems
Phospholipids
Proteins
Diglycerides
Guanosine Triphosphate
18 Citations (Scopus)
Biophysics
KATP Channels
Cell Biology
Sarcolemma
Ion Channels
42 Citations (Scopus)

siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake

Galvez, T., Teruel, M. N., Heo, W. D., Jones, J. T., Kim, M. L., Liou, J., Myers, J. W. & Meyer, T., Jul 19 2007, In : Genome Biology. 8, 7, R142.

Research output: Contribution to journalArticle

transferrin
Proteome
Transferrin
small interfering RNA
proteome
447 Citations (Scopus)

STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels

Brandman, O., Liou, J., Park, W. S. & Meyer, T., Dec 28 2007, In : Cell. 131, 7, p. 1327-1339 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Feedback
Proteome
Cell membranes
Small Interfering RNA
16 Citations (Scopus)

Unrestricted diffusion of exogenous and endogenous PIP2 in baby hamster kidney and Chinese hamster ovary cell plasmalemma

Yaradanakul, A. & Hilgemann, D. W., Dec 2007, In : Journal of Membrane Biology. 220, 1-3, p. 53-67 15 p.

Research output: Contribution to journalArticle

Cricetulus
Cricetinae
Ovary
Kidney
Lipids
2006
68 Citations (Scopus)

Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels

Zaika, O., Lara, L. S., Gamper, N., Hilgemann, D. W., Jaffe, D. B. & Shapiro, M. S., Aug 2006, In : Journal of Physiology. 575, 1, p. 49-67 19 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Angiotensin II
Superior Cervical Ganglion
Cricetulus
Neurons
35 Citations (Scopus)

Molecular control of cardiac sodium homeostasis in health and disease

Hilgemann, D. W., Yaradanakul, A., Wang, Y. & Fuster, D., May 2006, In : Journal of Cardiovascular Electrophysiology. 17, SUPPL. 1

Research output: Contribution to journalArticle

Muscle Cells
Homeostasis
Sodium
Ions
Health
2005
241 Citations (Scopus)

Phospholipase C in living cells: Activation, inhibition, Ca2+ requirement, and regulation of M current

Horowitz, L. F., Hirdes, W., Suh, B. C., Hilgemann, D. W., Mackie, K. & Hille, B., Sep 2005, In : Journal of General Physiology. 126, 3, p. 243-262 20 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Calcium
Phosphatidylinositols
Cholinergic Agents
Muscarinic M1 Receptors
166 Citations (Scopus)

Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate

Li, Y., Gamper, N., Hilgemann, D. W. & Shapiro, M. S., Oct 26 2005, In : Journal of Neuroscience. 25, 43, p. 9825-9835 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Muscarinic Receptors
Cricetulus
Cholinergic Agents
Ovary
1464 Citations (Scopus)

STIM is a Ca2+ sensor essential for Ca2+-store- depletion-triggered Ca2+ influx

Liou, J., Kim, M. L., Won, D. H., Jones, J. T., Myers, J. W., Ferrell, J. E. & Meyer, T., Jul 12 2005, In : Current Biology. 15, 13, p. 1235-1241 7 p.

Research output: Contribution to journalArticle

calcium
Sensors
Cell membranes
Proteins
Cell Membrane
2004
62 Citations (Scopus)
Sodium-Hydrogen Antiporter
Lipids
Perfusion
Opossums
Adenosine Triphosphate