Physiology - Division C

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1977

The opposed influences of β-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs

Hilgemann, D., Englert, R. & Mensing, H. J., Dec 1 1977, In : Experientia. 33, 12, p. 1629-1631 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
1980
1981

Inotropic effects of activation and pharmacological mechanisms in cardiac muscle

Joachim Mensing, H. & Hilgemann, D. W., 1981, In : Trends in Pharmacological Sciences. 2, C, p. 303-307 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
1983

Activation-dependent cumulative depletions of extracellular free calcium in guinea pig atrium measured with antipyrylazo III and tetramethylmurexide

Hilgemann, D. W., Delay, M. J. & Langer, G. A., Jan 1 1983, In : Circulation research. 53, 6, p. 779-793 15 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations
1984

Extracellular calcium transients in frog ventricle measured with antipyrylazo III and tetramethylmurexide

Hilgemann, D. W. & Langer, G. A., Jan 1 1984, In : Federation Proceedings. 43, 4, p. No. 3130

Research output: Contribution to journalArticle

2 Scopus citations
Open Access
16 Scopus citations
1986
Open Access
45 Scopus citations
Open Access
38 Scopus citations
1989
96 Scopus citations
7 Scopus citations
1990

Regulation and deregulation of cardiac Na+-Ca2+ exchange in giant excised sarcolemmal membrane patches

Hilgemann, D. W., Jan 1 1990, In : Nature. 344, 6263, p. 242-245 4 p.

Research output: Contribution to journalArticle

240 Scopus citations

Sodium-calcium exchange current in giant excised cardiac sarcolemmal membrane patches from guinea-pig

Collins, A. & Hilgemann, D. W., Jan 1 1990, In : Journal of Physiology. 420, p. 85P

Research output: Contribution to journalArticle

1991

Cardiac Na+ ‐Ca2+ Exchange System in Giant Membrane Patches

Hilgemann, D. W., Collins, A., Cash, D. P. & Nagel, G. A., Dec 1991, In : Annals of the New York Academy of Sciences. 639, 1, p. 126-139 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Charge movement during Na+ translocation by native and cloned cardiac Na+/Ca2+ exchanger

Hilgemann, D. W., Nicoll, D. A. & Philipson, K. D., Jan 1 1991, In : Nature. 352, 6337, p. 715-718 4 p.

Research output: Contribution to journalArticle

168 Scopus citations

Identification of a peptide inhibitor of the cardiac sarcolemmal Na+-Ca2+ exchanger

Li, Z., Nicoll, D. A., Collins, A., Hilgemann, D. W., Filoteo, A. G., Penniston, J. T., Weise, J. N., Tomich, J. M. & Philipson, K. D., Feb 19 1991, In : Journal of Biological Chemistry. 266, 2, p. 1014-1020 7 p.

Research output: Contribution to journalArticle

217 Scopus citations
72 Scopus citations
Open Access
115 Scopus citations

Steady-state and dynamic properties of cardiac sodium-calcium exchange: Secondary modulation by cytoplasmic calcium and ATP

Hilgemann, D. W., Collins, A. & Matsuoka, S., Dec 1 1992, In : Journal of General Physiology. 100, 6, p. 933-961 29 p.

Research output: Contribution to journalArticle

Open Access
205 Scopus citations

Steady-state and dynamic properties of cardiac sodium-calcium exchange: Sodium-dependent inactivation

Hilgemann, D. W., Matsuoka, S., Nagel, G. A. & Collins, A., Dec 1 1992, In : Journal of General Physiology. 100, 6, p. 905-932 28 p.

Research output: Contribution to journalArticle

Open Access
226 Scopus citations

The giant cardiac membrane patch method: stimulation of outward Na(+)‐Ca2+ exchange current by MgATP.

Collins, A., Somlyo, A. V. & Hilgemann, D. W., Aug 1 1992, In : The Journal of Physiology. 454, 1, p. 27-57 31 p.

Research output: Contribution to journalArticle

123 Scopus citations
1993
13 Scopus citations

Initial localization of regulatory regions of the cardiac sarcolemmal Na+-Ca2+ exchanger

Matsuoka, S., Nicoll, D. A., Reilly, R. F., Hilgemann, D. W. & Philipson, K. D., Jan 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 9, p. 3870-3874 5 p.

Research output: Contribution to journalArticle

Open Access
192 Scopus citations
1994

Channel-like function of the Na,K pump probed at microsecond resolution in giant membrane patches

Hilgemann, D. W., Jan 1 1994, In : Science. 263, 5152, p. 1429-1432 4 p.

Research output: Contribution to journalArticle

152 Scopus citations

Inactivation of outward Na(+)‐Ca2+ exchange current in guinea‐pig ventricular myocytes.

Matsuoka, S. & Hilgemann, D. W., May 1 1994, In : The Journal of Physiology. 476, 3, p. 443-458 16 p.

Research output: Contribution to journalArticle

65 Scopus citations
1995

Membrane transport mechanisms probed by capacitance measurements with megahertz voltage clamp

Lu, C. C., Kabakov, A., Markin, V. S., Mager, S., Frazier, G. A. & Hilgemann, D. W., Nov 21 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 24, p. 11220-11224 5 p.

Research output: Contribution to journalArticle

64 Scopus citations

Modulation of Na+,Ca2+ exchange current by EGTA calcium buffering in giant cardiac membrane patches

Kabakov, A. Y. & Hilgemann, D. W., Dec 13 1995, In : BBA - Biomembranes. 1240, 2, p. 142-148 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
1996

Multiple functional states of the cardiac Na+-Ca2+ exchanger: Whole-cell, native-excised, and cloned-excised properties

Matsuoka, S., Philipson, K. D. & Hilgemann, D. W., Jan 1 1996, In : Annals of the New York Academy of Sciences. 779, p. 159-170 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Na-Ca exchange studies in sarcolemmal skeletal muscle

Gonzalez-Serratos, H., Hilgemann, D. W., Rozycka, M., Gauthier, A. & Rasgado-Flores, H., Jan 1 1996, In : Annals of the New York Academy of Sciences. 779, p. 556-560 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Regulation of cardiac Na+,Ca2+ exchange and K(ATP) potassium channels by PIP2

Hilgemann, D. W. & Ball, R., Aug 16 1996, In : Science. 273, 5277, p. 956-959 4 p.

Research output: Contribution to journalArticle

520 Scopus citations

The cardiac Na-Ca exchanger in giant membrane patches

Hilgemann, D. W., Jan 1 1996, In : Annals of the New York Academy of Sciences. 779, p. 136-158 23 p.

Research output: Contribution to journalArticle

38 Scopus citations
Open Access
61 Scopus citations
1997

Recent electrical snapshots of the cardiac Na,K pump

Hilgemann, D. W., Jan 1 1997, In : Annals of the New York Academy of Sciences. 834, p. 260-269 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
1998

Cloning, expression, and characterization of the squid Na+-Ca2+ exchanger (NCX-SQ1)

He, Z., Tong, Q., Quednau, B. D., Philipson, K. D. & Hilgemann, D. W., Jun 1 1998, In : Journal of General Physiology. 111, 6, p. 857-873 17 p.

Research output: Contribution to journalArticle

43 Scopus citations

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

Huang, C. L., Feng, S. & Hilgemann, D. W., Feb 19 1998, In : Nature. 391, 6669, p. 803-806 4 p.

Research output: Contribution to journalArticle

693 Scopus citations

Functional comparison of the three isoforms of the Na+/Ca2+ exchanger (NCX1, NCX2, NCX3)

Linck, B., Qiu, Z., He, Z., Tong, Q., Hilgemann, D. W. & Philipson, K. D., Feb 1998, In : American Journal of Physiology - Cell Physiology. 274, 2 43-2, p. C415-C423

Research output: Contribution to journalArticle

182 Scopus citations

Giant membrane patches: Improvements and applications

Hilgemann, D. W. & Lu, C. C., Jan 1 1998, In : Methods in Enzymology. 293, p. 267-280 14 p.

Research output: Contribution to journalArticle

52 Scopus citations
1999

Cloning and characterization of a novel Mg2+/H+ exchanger

Shaul, O., Hilgemann, D. W., De-Almeida-Engler, J., Van Montagu, M., Inzé, D. & Galili, G., Jul 15 1999, In : EMBO Journal. 18, 14, p. 3973-3980 8 p.

Research output: Contribution to journalArticle

178 Scopus citations

GAT1 (GABA:Na+:Cl-) cotransport function: Kinetic studies in giant Xenopus oocyte membrane patches

Lu, C. C. & Hilgemann, D. W., Sep 1 1999, In : Journal of General Physiology. 114, 3, p. 445-457 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

GAT1 (GABA:Na+:Cl-) cotransport function: Steady state studies in giant Xenopus oocyte membrane patches

Lu, C. C. & Hilgemann, D. W., Sep 1 1999, In : Journal of General Physiology. 114, 3, p. 429-444 16 p.

Research output: Contribution to journalArticle

96 Scopus citations

GAT1 (GABA:Na+:Cl-) cotransport function: Database reconstruction with an alternating access model

Hilgemann, D. W. & Lu, C. C., Sep 1 1999, In : Journal of General Physiology. 114, 3, p. 459-475 17 p.

Research output: Contribution to journalArticle

87 Scopus citations
2000

Do phosphatidylinositides modulate vertebrate phototransduction?

Womack, K. B., Gordon, S. E., He, F., Wensel, T. G., Lu, C. C. & Hilgemann, D. W., Apr 15 2000, In : Journal of Neuroscience. 20, 8, p. 2792-2799 8 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1

Liou, J., Kiefer, F., Dang, A., Hashimoto, A., Cobb, M. H., Kurosaki, T. & Weiss, A., 2000, In : Immunity. 12, 4, p. 399-408 10 p.

Research output: Contribution to journalArticle

Open Access
86 Scopus citations

Interaction of PIP2 with the XIP region of the cardiac Na/Ca exchanger

He, Z., Feng, S., Tong, Q., Hilgemann, D. W. & Philipson, K. D., 2000, In : American Journal of Physiology - Cell Physiology. 278, 4 47-4, p. C661-C666

Research output: Contribution to journalArticle

76 Scopus citations
2001

Caspase-mediated Cleavage of Hematopoietic Progenitor Kinase 1 (HPK1) Converts an Activator of NFκB into an Inhibitor of NFκB

Arnold, R., Liou, J., Drexler, H. C. A., Weiss, A. & Kiefer, F., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 14675-14684 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes

Sauer, K., Liou, J., Singh, S. B., Yablonski, D., Weiss, A. & Perlmutter, R. M., Nov 30 2001, In : Journal of Biological Chemistry. 276, 48, p. 45207-45216 10 p.

Research output: Contribution to journalArticle

74 Scopus citations

Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells

Yamamoto, M., Hilgemann, D. H., Feng, S., Bito, H., Ishihara, H., Shibasaki, Y. & Yin, H. L., Mar 5 2001, In : Journal of Cell Biology. 152, 5, p. 867-876 10 p.

Research output: Contribution to journalArticle

100 Scopus citations
2002

Modulation of cardiac PIP2 by cardioactive hormones and other physiologically relevant interventions

Nasuhoglu, C., Feng, S., Mao, Y., Shammat, I., Yamamato, M., Earnest, S., Lemmon, M. & Hilgemann, D. W., Jan 1 2002, In : American Journal of Physiology - Cell Physiology. 283, 1 52-1, p. C223-C234

Research output: Contribution to journalArticle

72 Scopus citations
100 Scopus citations

Sodium-calcium exchange stoichiometry: Is the noose tightening?

Kang, T. M., Steciuk, M. & Hilgemann, D. W., 2002, In : Annals of the New York Academy of Sciences. 976, p. 142-151 10 p.

Research output: Contribution to journalArticle

2 Scopus citations