Physiology - Division D

Research Output

ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kildalton protein

Phillips, W. D., Kopta, C., Blount, P., Gardner, P. D., Steinbach, J. H. & Merlie, J. P., Feb 1 1991, In : Science. 251, 4993, p. 568-570 3 p.

Research output: Contribution to journalArticle

185 Scopus citations

A large-conductance mechanosensitive channel in E. coli encoded by mscL alone

Sukharev, S. I., Blount, P., Martinac, B., Blattner, F. R. & Kung, C., Jan 1 1994, In : Nature. 368, 6468, p. 265-268 4 p.

Research output: Contribution to journalArticle

533 Scopus citations
6 Scopus citations

An agonist of the MscL channel affects multiple bacterial species and increases membrane permeability and potency of common antibiotics

Wray, R., Herrera, N., Iscla, I., Wang, J. & Blount, P., Sep 1 2019, In : Molecular Microbiology. 112, 3, p. 896-905 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Analysis of persistent virus infections by in situ hybridization to whole-mouse sections

Southern, P. J., Blount, P. & Oldstone, M. B. A., Dec 1 1984, In : Nature. 312, 5994, p. 555-558 4 p.

Research output: Contribution to journalArticle

41 Scopus citations

A new antibiotic with potent activity targets MscL

Iscla, I., Wray, R., Blount, P., Larkins-Ford, J., Conery, A. L., Ausubel, F. M., Ramu, S., Kavanagh, A., Huang, J. X., Blaskovich, M. A., Cooper, M. A., Obregon-Henao, A., Orme, I., Tjandra, E. S., Stroeher, U. H., Brown, M. H., Macardle, C., Van Holst, N., Ling Tong, C., Slattery, A. D. & 3 others, Gibson, C. T., Raston, C. L. & Boulos, R. A., Jul 29 2015, In : Journal of Antibiotics. 68, 7, p. 453-462 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

An in vivo assay identifies changes in residue accessibility on mechanosensitive channel gating

Bartlett, J. L., Levin, G. & Blount, P., Jul 6 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 27, p. 10161-10165 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

An in vivo screen reveals protein-lipid interactions crucial for gating a mechanosensitive channel

Iscla, I., Wray, R. & Blount, P., Feb 1 2011, In : FASEB Journal. 25, 2, p. 694-702 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

An open-pore structure of the mechanosensitive channel MscL derived by determining transmembrane domain interactions upon gating

Li, Y., Wray, R., Eaton, C. & Blount, P., Jul 1 2009, In : FASEB Journal. 23, 7, p. 2197-2204 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts

Blount, P., Smith, M. M. & Merlie, J. P., 1990, In : Journal of Cell Biology. 111, 6 I, p. 2601-2611 11 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

Assessment of potential stimuli for mechano-dependent gating of MscL: Effects of pressure, tension, and lipid headgroups

Moe, P. & Blount, P., Sep 13 2005, In : Biochemistry. 44, 36, p. 12239-12244 6 p.

Research output: Contribution to journalArticle

132 Scopus citations

Bacterial mechanosensitive channels: Integrating physiology, structure and function

Blount, P. & Moe, P. C., Oct 1 1999, In : Trends in Microbiology. 7, 10, p. 420-424 5 p.

Research output: Contribution to journalReview article

93 Scopus citations

Biogenesis of the mouse muscle nicotinic acetylcholine receptor

Blount, P. & Merlie, J. P., 1991, C ed. Unknown Publisher. 18 p. (Current Topics in Membranes; vol. 39, no. C)

Research output: Book/ReportBook

5 Scopus citations

Bip associates with newly synthesized subunits of the mouse muscle nicotinic receptor

Blount, P. & Merlie, J. P., 1991, In : Journal of Cell Biology. 113, 5, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Channels in microbes: So many holes to fill

Kung, C. & Blount, P., Jul 1 2004, In : Molecular Microbiology. 53, 2, p. 373-380 8 p.

Research output: Contribution to journalShort survey

33 Scopus citations

Characterization of an adult muscle acetylcholine receptor subunit by expression in fibroblasts

Blount, P. & Merlie, J. P., Dec 1 1991, In : Journal of Biological Chemistry. 266, 22, p. 14692-14696 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Chimeras Reveal a Single Lipid-Interface Residue that Controls MscL Channel Kinetics as well as Mechanosensitivity

Yang, L. M., Zhong, D. & Blount, P., Feb 15 2013, In : Cell Reports. 3, 2, p. 520-527 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1

Krueger, B., Haerteis, S., Yang, L., Hartner, A., Rauh, R., Korbmacher, C. & Diakov, A., 2009, In : Cellular Physiology and Biochemistry. 24, 5-6, p. 605-618 14 p.

Research output: Contribution to journalArticle

43 Scopus citations

Clearance of viral nucleic acid sequences from persistently infected host by virus specific H-2 restricted lymphocytes

Blount, P., Ahmed, R., Southern, P. & Oldstone, M. B. A., Jan 1 1985, In : Federation Proceedings. 44, 5, p. No. 6567

Research output: Contribution to journalArticle

Correlating a protein structure with function of a bacterial mechanosensitive channel

Moe, P. C., Levin, G. & Blount, P., Oct 6 2000, In : Journal of Biological Chemistry. 275, 40, p. 31121-31127 7 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Cysteine Scanning of MscL Transmembrane Domains Reveals Residues Critical for Mechanosensitive Channel Gating

Levin, G. & Blount, P., May 2004, In : Biophysical journal. 86, 5, p. 2862-2870 9 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system

Oldstone, M. B. A., Blount, P., Southern, P. J. & Lampert, P. W., Dec 1 1986, In : Nature. 321, 6067, p. 239-243 5 p.

Research output: Contribution to journalArticle

186 Scopus citations

Defining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites

Iscla, I., Levin, G., Wray, R., Reynolds, R. & Blount, P., Nov 2004, In : Biophysical journal. 87, 5, p. 3172-3180 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Differential channeling of sensory stimuli onto a motor neuron in the leech

Iscla, I., Arini, P. D. & Szczupak, L., Feb 1 1999, In : Journal of Comparative Physiology - A Sensory, Neural, and Behavioral Physiology. 184, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore

Wray, R., Iscla, I., Gao, Y., Li, H., Wang, J. & Blount, P., Jun 9 2016, In : PLoS biology. 14, 6, e1002473.

Research output: Contribution to journalArticle

13 Scopus citations

Dissecting the molecular anatomy of persistent infection with lymphocytic choriomeningitis virus

Valsamakis, V., Southern, P., Blount, P., Ahmed, R., Buchmeier, M. J. & Oldstone, M. B. A., May 1 1986, In : Medical Microbiology and Immunology. 175, 2-3, p. 97-99 3 p.

Research output: Contribution to journalArticle

Dissecting the molecular anatomy of the nervous system: Analysis of RNA and protein expression in whole body sections of laboratory animals

Blount, P., Elder, J., Ian Lipkin, W., Southern, P. J., Buchmeier, M. J. & Oldstone, M. B. A., Sep 24 1986, In : Brain Research. 382, 2, p. 257-265 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Disulfide trapping the mechanosensitive channel MscL into a gating-transition state

Iscla, I., Levin, G., Wray, R. & Blount, P., Feb 2007, In : Biophysical journal. 92, 4, p. 1224-1232 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Dynamics of protein-protein interactions at the mscl periplasmic-lipid interface

Zhong, D., Yang, L. M. & Blount, P., Jan 21 2014, In : Biophysical Journal. 106, 2, p. 375-381 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effects of Low Intensity Focused Ultrasound on Liposomes Containing Channel proteins

Babakhanian, M., Yang, L., Nowroozi, B., Saddik, G., Boodaghians, L., Blount, P. & Grundfest, W., Dec 1 2018, In : Scientific reports. 8, 1, 17250.

Research output: Contribution to journalArticle

6 Scopus citations

Electrostatics at the membrane define MscL channel mechanosensitivity and kinetics

Zhong, D. & Blount, P., Dec 1 2014, In : FASEB Journal. 28, 12, p. 5234-5241 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Engineering a pH-Sensitive Liposomal MRI Agent by Modification of a Bacterial Channel

Yang, L. M., Zheng, H., Ratnakar, J. S., Adebesin, B. Y., Do, Q. N., Kovacs, Z. & Blount, P., Jan 1 2018, (Accepted/In press) In : Small.

Research output: Contribution to journalArticle

7 Scopus citations

Expression of macrophage inflammatory protein 1 alpha in the endothelial cells exposed to diamide.

Yang, L., Zhu, X., Zhao, X. & Deng, Z., 2003, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 3 ed. Vol. 23. p. 219-222, 233

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Family ties of gated pores: Evolution of the sensor module

Kumánovics, A., Levin, G. & Blount, P., Oct 2002, In : FASEB Journal. 16, 12, p. 1623-1629 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation

Woe, P. C., Blount, P. & Kung, C., May 25 1998, In : Molecular Microbiology. 28, 3, p. 583-592 10 p.

Research output: Contribution to journalArticle

109 Scopus citations

Functional design of bacterial mechanosensitive channels. Comparisons and contrasts illuminated by random mutagenesis

Okada, K., Moe, P. C. & Blount, P., Aug 2 2002, In : Journal of Biological Chemistry. 277, 31, p. 27682-27688 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

Functional nonequivalence of structurally homologous domains of neurokinin-1 and neurokinin-2 type tachykinin receptors

Blount, P. & Krause, J. E., Jan 1 1993, In : Journal of Biological Chemistry. 268, 22, p. 16388-16395 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Functional reconstitution as an assay for biochemical isolation of channel proteins: Application to the molecular identification of a bacterial mechanosensitive channel

Sukharev, S. I., Martinac, B., Blount, P. & Kung, C., Mar 1994, In : Methods. 6, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Helicity, membrane incorporation, orientation and thermal stability of the large conductance mechanosensitive ion channel from E. coli

Arkin, I. T., Sukharev, S. I., Blount, P., Kung, C. & Brünger, A. T., Feb 2 1998, In : Biochimica et Biophysica Acta - Biomembranes. 1369, 1, p. 131-140 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

How do membrane proteins sense water stress?

Poolman, B., Blount, P., Folgering, J. H. A., Friesen, R. H. E., Moe, P. C. & Van Der Heide, T., May 30 2002, In : Molecular Microbiology. 44, 4, p. 889-902 14 p.

Research output: Contribution to journalShort survey

103 Scopus citations
1 Scopus citations

Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity

Yoshimura, K., Batiza, A., Schroeder, M., Blount, P. & Kung, C., Oct 1999, In : Biophysical journal. 77, 4, p. 1960-1972 13 p.

Research output: Contribution to journalArticle

Open Access
149 Scopus citations

Improving the design of a MscL-based triggered nanovalve

Iscla, I., Eaton, C., Parker, J., Wray, R., Kovács, Z. & Blount, P., Mar 2013, In : Biosensors. 3, 1, p. 171-184 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Inhibition of magnesium lithospermate B on the c-Jun N-terminal kinase 3 mRNA expression in cardiomyocytes encountered ischemia/reperfusion injury

Yang, L. M., Xiao, Y. L. & Ou-Yang, J. H., Jul 1 2003, In : Yaoxue Xuebao. 38, 7, p. 487-491 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets

Rasmussen, T., Rasmussen, A., Yang, L., Kaul, C., Black, S., Galbiati, H., Conway, S. J., Miller, S., Blount, P. & Booth, I. R., Aug 9 2019, In : Journal of Molecular Biology. 431, 17, p. 3339-3352 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Intragenic suppression of gain-of-function mutations in the Escherichia coli mechanosensitive channel, MscL

Li, Y., Wray, R. & Blount, P., Jul 1 2004, In : Molecular Microbiology. 53, 2, p. 485-495 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Ion channels of microbes.

Saimi, Y., Martinac, B., Preston, R. R., Zhou, X. L., Sukharev, S., Blount, P. & Kung, C., 1994, In : Society of General Physiologists series. 49, p. 179-195 17 p.

Research output: Contribution to journalReview article

8 Scopus citations

Ionic regulation of MSCk, a mechanosensitive channel from Escherichia coli

Li, Y., Moe, P. C., Chandrasekaran, S., Booth, I. R. & Blount, P., Oct 15 2002, In : EMBO Journal. 21, 20, p. 5323-5330 8 p.

Research output: Contribution to journalArticle

100 Scopus citations

Lactococcus lactis uses MscL as its principal mechanosensitive channel

Folgering, J. H. A., Moe, P. C., Schuurman-Wolters, G. K., Blount, P. & Poolman, B., Mar 11 2005, In : Journal of Biological Chemistry. 280, 10, p. 8784-8792 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
2 Scopus citations