Research output per year
Research output per year
- 1 - 50 out of 102 results
Search results
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2024
Editorial: In silico gating mechanism studies and modulator discovery for MscL
Wang, J., Blount, P., Hou, T. & Sokabe, M., 2024, In: Frontiers in Chemistry. 12, 1376617.Research output: Contribution to journal › Editorial › peer-review
Open Access -
2023
Feeling the tension: the bacterial mechanosensitive channel of large conductance as a model system and drug target
Wang, J. & Blount, P., Feb 2023, In: Current Opinion in Physiology. 31, 100627.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
The Effects of Airflow on the Mechanosensitive Channels of Escherichia coli MG1655 and the Impact of Survival Mechanisms Triggered
Ramirez, V. I., Wray, R., Blount, P. & King, M. D., Sep 2023, In: Microorganisms. 11, 9, 2236.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2022
Activation of a Bacterial Mechanosensitive Channel, MscL, Underlies the Membrane Permeabilization of Dual-Targeting Antibacterial Compounds
Wray, R., Wang, J., Blount, P. & Iscla, I., Jul 2022, In: Antibiotics. 11, 7, 970.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
In Silico Screen Identifies a New Family of Agonists for the Bacterial Mechanosensitive Channel MscL
Wray, R., Blount, P., Wang, J. & Iscla, I., Apr 2022, In: Antibiotics. 11, 4, 433.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2021
A native cell membrane nanoparticles system allows for high-quality functional proteoliposome reconstitution
Yang, L., Catalano, C., Xu, Y., Qiu, W., Zhang, D., McDermott, A., Guo, Y. & Blount, P., Jan 2021, In: BBA Advances. 1, 100011.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Cryo-em structure of mechanosensitive channel ynai using sma2000: Challenges and opportunities
Catalano, C., Ben-Hail, D., Qiu, W., Blount, P., des Georges, A. & Guo, Y., Nov 2021, In: Membranes. 11, 11, 849.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Curcumin activation of a bacterial mechanosensitive channel underlies its membrane permeability and adjuvant properties
Wray, R., Iscla, I. & Blount, P., Dec 2021, In: PLoS pathogens. 17, 12, e1010198.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2020
Life with bacterial mechanosensitive channels, from discovery to physiology to pharmacological target
Blount, P. & Iscla, I., Mar 2020, In: Microbiology and Molecular Biology Reviews. 84, 1, e00055-19.Research output: Contribution to journal › Review article › peer-review
Open Access37 Scopus citations -
Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site
Wray, R., Wang, J., Iscla, I. & Blount, P., Jan 1 2020, In: PloS one. 15, 1, e0228153.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Spectrin couples cell shape, cortical tension, and hippo signaling in retinal epithelial morphogenesis
Deng, H., Yang, L., Wen, P., Lei, H., Blount, P. & Pan, D., 2020, In: Journal of Cell Biology. 219, 4, e201907018.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2019
An agonist of the MscL channel affects multiple bacterial species and increases membrane permeability and potency of common antibiotics
Wray, R., Herrera, N., Iscla, I., Wang, J. & Blount, P., Sep 1 2019, In: Molecular Microbiology. 112, 3, p. 896-905 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Human mutations highlight an intersubunit cation–π bond that stabilizes the closed but not open or inactivated states of TRPV channels
Teng, J., Anishkin, A., Kung, C. & Blount, P., May 7 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 19, p. 9410-9416 7 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets
Rasmussen, T., Rasmussen, A., Yang, L., Kaul, C., Black, S., Galbiati, H., Conway, S. J., Miller, S., Blount, P. & Booth, I. R., Aug 9 2019, In: Journal of Molecular Biology. 431, 17, p. 3339-3352 14 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Novel compounds that specifically bind and modulate MscL: insights into channel gating mechanisms
Wray, R., Iscla, I. R., Kovacs, Z., Wang, J. & Blount, P., Mar 1 2019, In: FASEB Journal. 33, 3, p. 3180-3189 10 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
2018
Effects of Low Intensity Focused Ultrasound on Liposomes Containing Channel proteins
Babakhanian, M., Yang, L., Nowroozi, B., Saddik, G., Boodaghians, L., Blount, P. & Grundfest, W., Dec 1 2018, In: Scientific reports. 8, 1, 17250.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Engineering a pH-Sensitive Liposomal MRI Agent by Modification of a Bacterial Channel
Yang, L. M., Zheng, H., Ratnakar, J. S., Adebesin, B. Y., Do, Q. N., Kovacs, Z. & Blount, P., May 9 2018, In: Small. 14, 19, 1704256.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
The phosphorylation site T613 in the β-subunit of rat epithelial Na + channel (ENaC) modulates channel inhibition by Nedd4-2
Krueger, B., Yang, L., Korbmacher, C. & Rauh, R., Apr 1 2018, In: Pflugers Archiv European Journal of Physiology. 470, 4, p. 649-660 12 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2016
Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore
Wray, R., Iscla, I., Gao, Y., Li, H., Wang, J. & Blount, P., Jun 9 2016, In: PLoS biology. 14, 6, e1002473.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
2015
A new antibiotic with potent activity targets MscL
Iscla, I., Wray, R., Blount, P., Larkins-Ford, J., Conery, A. L., Ausubel, F. M., Ramu, S., Kavanagh, A., Huang, J. X., Blaskovich, M. A., Cooper, M. A., Obregon-Henao, A., Orme, I., Tjandra, E. S., Stroeher, U. H., Brown, M. H., Macardle, C., Van Holst, N., Ling Tong, C., Slattery, A. D., & 3 others, Jul 29 2015, In: Journal of Antibiotics. 68, 7, p. 453-462 10 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
Mutations in a conserved domain of E. coli MscS to the most conserved superfamily residue leads to kinetic changes
Malcolm, H. R. & Blount, P., Sep 4 2015, In: PloS one. 10, 9, e0136756.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Scanning MscL channels with targeted post-translational modifications for functional alterations
Iscla, I., Wray, R., Eaton, C. & Blount, P., Sep 14 2015, In: PloS one. 10, 9, e0137994.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
The mechanosensitive channel of small conductance (MscS) functions as a Jack-In-The Box
Malcolm, H. R., Blount, P. & Maurer, J. A., Jan 2015, In: Biochimica et Biophysica Acta - Biomembranes. 1848, 1, p. 159-166 8 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2014
Dynamics of protein-protein interactions at the mscl periplasmic-lipid interface
Zhong, D., Yang, L. M. & Blount, P., Jan 21 2014, In: Biophysical journal. 106, 2, p. 375-381 7 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Electrostatics at the membrane define MscL channel mechanosensitivity and kinetics
Zhong, D. & Blount, P., Dec 1 2014, In: FASEB Journal. 28, 12, p. 5234-5241 8 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Streptomycin potency is dependent on MscL channel expression
Iscla, I., Wray, R., Wei, S., Posner, B. & Blount, P., 2014, In: Nature communications. 5, 4891.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
2013
Chimeras Reveal a Single Lipid-Interface Residue that Controls MscL Channel Kinetics as well as Mechanosensitivity
Yang, L. M., Zhong, D. & Blount, P., 2013, In: Cell Reports. 3, 2, p. 520-527 8 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Improving the design of a MscL-based triggered nanovalve
Iscla, I., Eaton, C., Parker, J., Wray, R., Kovács, Z. & Blount, P., Mar 2013, In: Biosensors. 3, 1, p. 171-184 14 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Phosphatidylinositol is crucial for the mechanosensitivity of mycobacterium tuberculosis MscL
Zhong, D. & Blount, P., Aug 13 2013, In: Biochemistry. 52, 32, p. 5415-5420 6 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
2012
Sensing and responding to membrane tension: The bacterial MscL channel as a model system
Iscla, I. & Blount, P., Jul 18 2012, In: Biophysical journal. 103, 2, p. 169-174 6 p.Research output: Contribution to journal › Review article › peer-review
64 Scopus citations -
Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance
Zhang, X., Wang, J., Feng, Y., Ge, J., Li, W., Sun, W., Iscla, I., Yu, J., Blount, P., Li, Y. & Yang, M., Oct 30 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 44, p. 18180-18185 6 p.Research output: Contribution to journal › Article › peer-review
51 Scopus citations -
The dynamics of protein-protein interactions between domains of MscL at the cytoplasmic-lipid interface
Iscla, I., Wray, R. & Blount, P., 2012, In: Channels. 6, 4Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
The MscS and MscL families of mechanosensitive channels act as microbial emergency release valves
Bootha, I. R. & Blount, P., Sep 2012, In: Journal of bacteriology. 194, 18, p. 4802-4809 8 p.Research output: Contribution to journal › Short survey › peer-review
Open Access159 Scopus citations -
Three routes to modulate the pore size of the Mscl channel/nanovalve
Yang, L. M., Wray, R., Parker, J., Wilson, D., Duran, R. S. & Blount, P., Feb 28 2012, In: ACS Nano. 6, 2, p. 1134-1141 8 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
2011
An in vivo screen reveals protein-lipid interactions crucial for gating a mechanosensitive channel
Iscla, I., Wray, R. & Blount, P., Feb 2011, In: FASEB Journal. 25, 2, p. 694-702 9 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Manipulating the permeation of charged compounds through the MscL nanovalve
Yang, L. M. & Blount, P., Jan 2011, In: FASEB Journal. 25, 1, p. 428-434 7 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo
Iscla, I., Wray, R. & Blount, P., Sep 2011, In: Protein Science. 20, 9, p. 1638-1642 5 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
2010
S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: Implications for detergent- solubilized membrane proteins
Dorwart, M. R., Wray, R., Brautigam, C. A., Jiang, Y. & Blount, P., Dec 2010, In: PLoS biology. 8, 12, e1000555.Research output: Contribution to journal › Article › peer-review
57 Scopus citations -
2009
An open-pore structure of the mechanosensitive channel MscL derived by determining transmembrane domain interactions upon gating
Li, Y., Wray, R., Eaton, C. & Blount, P., Jul 2009, In: FASEB Journal. 23, 7, p. 2197-2204 8 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1
Krueger, B., Haerteis, S., Yang, L., Hartner, A., Rauh, R., Korbmacher, C. & Diakov, A., 2009, In: Cellular Physiology and Biochemistry. 24, 5-6, p. 605-618 14 p.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
2008
On the structure of the N-terminal domain of the MscL channel: Helical bundle or membrane interface
Iscla, I., Wray, R. & Blount, P., Sep 1 2008, In: Biophysical journal. 95, 5, p. 2283-2291 9 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
Voltage-induced gating of the mechanosensitive MscL ion channel reconstituted in a tethered lipid bilayer membrane
Andersson, M., Okeyo, G., Wilson, D., Keizer, H., Moe, P., Blount, P., Fine, D., Dodabalapur, A. & Duran, R. S., Jan 18 2008, In: Biosensors and Bioelectronics. 23, 6, p. 919-923 5 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
2007
Disulfide trapping the mechanosensitive channel MscL into a gating-transition state
Iscla, I., Levin, G., Wray, R. & Blount, P., Feb 2007, In: Biophysical journal. 92, 4, p. 1224-1232 9 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
MscL: The Bacterial Mechanosensitive Channel of Large Conductance
Blount, P., Iscla, I., Moe, P. C. & Li, Y., 2007, In: Current Topics in Membranes. 58, p. 201-233 33 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
2006
Mechanosensitive channel gating transitions resolved by functional changes upon pore modification
Bartlett, J. L., Li, Y. & Blount, P., Nov 2006, In: Biophysical journal. 91, 10, p. 3684-3691 8 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's β- and γ-subunit
Yang, L. M., Rinke, R. & Korbmacher, C., Apr 14 2006, In: Journal of Biological Chemistry. 281, 15, p. 9859-9868 10 p.Research output: Contribution to journal › Article › peer-review
57 Scopus citations -
2005
Assessment of potential stimuli for mechano-dependent gating of MscL: Effects of pressure, tension, and lipid headgroups
Moe, P. & Blount, P., Sep 13 2005, In: Biochemistry. 44, 36, p. 12239-12244 6 p.Research output: Contribution to journal › Article › peer-review
160 Scopus citations -
Lactococcus lactis uses MscL as its principal mechanosensitive channel
Folgering, J. H. A., Moe, P. C., Schuurman-Wolters, G. K., Blount, P. & Poolman, B., Mar 11 2005, In: Journal of Biological Chemistry. 280, 10, p. 8784-8792 9 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel
Edwards, M. D., Li, Y., Kim, S., Miller, S., Bartlett, W., Black, S., Dennison, S., Iscla, I., Blount, P., Bowie, J. U. & Booth, I. R., Feb 20 2005, In: Nature Structural and Molecular Biology. 12, 2, p. 113-119 7 p.Research output: Contribution to journal › Article › peer-review
108 Scopus citations -
Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system
Calviño, M. A., Iscla, I. R. & Szczupak, L., May 2005, In: Journal of neurophysiology. 93, 5, p. 2644-2655 12 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations