Physiology - Division D

Research Output

2003
1 Scopus citations

Molecular Mechanisms of Mechanosensation: Big Lessons from Small Cells

Blount, P., Mar 6 2003, In : Neuron. 37, 5, p. 731-734 4 p.

Research output: Contribution to journalShort survey

31 Scopus citations
2002

Family ties of gated pores: Evolution of the sensor module

Kumánovics, A., Levin, G. & Blount, P., Oct 2002, In : FASEB Journal. 16, 12, p. 1623-1629 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Functional design of bacterial mechanosensitive channels. Comparisons and contrasts illuminated by random mutagenesis

Okada, K., Moe, P. C. & Blount, P., Aug 2 2002, In : Journal of Biological Chemistry. 277, 31, p. 27682-27688 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

How do membrane proteins sense water stress?

Poolman, B., Blount, P., Folgering, J. H. A., Friesen, R. H. E., Moe, P. C. & Van Der Heide, T., May 30 2002, In : Molecular Microbiology. 44, 4, p. 889-902 14 p.

Research output: Contribution to journalShort survey

103 Scopus citations

Ionic regulation of MSCk, a mechanosensitive channel from Escherichia coli

Li, Y., Moe, P. C., Chandrasekaran, S., Booth, I. R. & Blount, P., Oct 15 2002, In : EMBO Journal. 21, 20, p. 5323-5330 8 p.

Research output: Contribution to journalArticle

100 Scopus citations

The effect of diamide on the expression of macrophage inflammatory protein-1 alpha in endothelial cells

Yang, L., Zhu, X., Zhao, X. & Deng, Z., Oct 2002, In : Zhonghua bing li xue za zhi Chinese journal of pathology. 31, 5, p. 427-431 5 p.

Research output: Contribution to journalArticle

2000

Correlating a protein structure with function of a bacterial mechanosensitive channel

Moe, P. C., Levin, G. & Blount, P., Oct 6 2000, In : Journal of Biological Chemistry. 275, 40, p. 31121-31127 7 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations
1999

Bacterial mechanosensitive channels: Integrating physiology, structure and function

Blount, P. & Moe, P. C., Oct 1 1999, In : Trends in Microbiology. 7, 10, p. 420-424 5 p.

Research output: Contribution to journalReview article

93 Scopus citations

Differential channeling of sensory stimuli onto a motor neuron in the leech

Iscla, I., Arini, P. D. & Szczupak, L., Feb 1 1999, In : Journal of Comparative Physiology - A Sensory, Neural, and Behavioral Physiology. 184, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity

Yoshimura, K., Batiza, A., Schroeder, M., Blount, P. & Kung, C., Oct 1999, In : Biophysical journal. 77, 4, p. 1960-1972 13 p.

Research output: Contribution to journalArticle

Open Access
149 Scopus citations

Mechanosensitive channels of bacteria

Blount, P., Sukharev, S. I., Moe, P. C., Martinac, B. & Kung, C., Jan 1 1999, In : Methods in Enzymology. 294, p. 458-482 25 p.

Research output: Contribution to journalArticle

110 Scopus citations
1998

Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation

Woe, P. C., Blount, P. & Kung, C., May 25 1998, In : Molecular Microbiology. 28, 3, p. 583-592 10 p.

Research output: Contribution to journalArticle

109 Scopus citations

Helicity, membrane incorporation, orientation and thermal stability of the large conductance mechanosensitive ion channel from E. coli

Arkin, I. T., Sukharev, S. I., Blount, P., Kung, C. & Brünger, A. T., Feb 2 1998, In : Biochimica et Biophysica Acta - Biomembranes. 1369, 1, p. 131-140 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

One face of a transmembrane helix is crucial in mechanosensitive channel gating

Ou, X., Blount, P., Hoffman, R. J. & Kung, C., Sep 15 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 19, p. 11471-11475 5 p.

Research output: Contribution to journalArticle

161 Scopus citations
1997
6 Scopus citations

Mechanosensitive channels of E. coli: A genetic and molecular dissection

Blount, P., Sukharev, S. I., Moe, P. & Kung, C., Feb 1 1997, In : Biological Bulletin. 192, 1, p. 126-130 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mechanosensitive channels of Escherichia coli: The MscL gene, protein, and activities

Sukharev, S. I., Blount, P., Martinac, B. & Kung, C., Apr 11 1997, In : Annual Review of Physiology. 59, p. 633-657 25 p.

Research output: Contribution to journalReview article

243 Scopus citations

Mutations in a bacterial mechanosensitive channel change the cellular response to osmotic stress

Blount, P., Schroeder, M. J. & Kung, C., Dec 19 1997, In : Journal of Biological Chemistry. 272, 51, p. 32150-32157 8 p.

Research output: Contribution to journalArticle

90 Scopus citations
1996

Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli

Blount, P., Sukharev, S. I., Moe, P. C., Schroeder, M. J., Guy, H. R. & Kung, C., Sep 16 1996, In : EMBO Journal. 15, 18, p. 4798-4805 8 p.

Research output: Contribution to journalArticle

155 Scopus citations

MscL: a mechanosensitive channel in Escherichia coli.

Sukharev, S. I., Blount, P., Martinac, B., Guy, H. R. & Kung, C., 1996, In : Society of General Physiologists series. 51, p. 133-141 9 p.

Research output: Contribution to journalReview article

21 Scopus citations

Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli

Blount, P., Sukharev, S. I., Schroeder, M. J., Nagle, S. K. & Kung, C., Oct 15 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 21, p. 11652-11657 6 p.

Research output: Contribution to journalArticle

173 Scopus citations

Towards an understanding of the structural and functional properties of MscL, a mechanosensitive channel in bacteria

Blount, P., Sukharev, S. I., Moe, P. C., Nagle, S. K. & Kung, C., Jan 1 1996, In : Biology of the Cell. 87, 1-2, p. 1-8 8 p.

Research output: Contribution to journalReview article

49 Scopus citations
1994

A large-conductance mechanosensitive channel in E. coli encoded by mscL alone

Sukharev, S. I., Blount, P., Martinac, B., Blattner, F. R. & Kung, C., Jan 1 1994, In : Nature. 368, 6468, p. 265-268 4 p.

Research output: Contribution to journalArticle

533 Scopus citations

Functional reconstitution as an assay for biochemical isolation of channel proteins: Application to the molecular identification of a bacterial mechanosensitive channel

Sukharev, S. I., Martinac, B., Blount, P. & Kung, C., Mar 1994, In : Methods. 6, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Ion channels of microbes.

Saimi, Y., Martinac, B., Preston, R. R., Zhou, X. L., Sukharev, S., Blount, P. & Kung, C., 1994, In : Society of General Physiologists series. 49, p. 179-195 17 p.

Research output: Contribution to journalReview article

8 Scopus citations
1993

Functional nonequivalence of structurally homologous domains of neurokinin-1 and neurokinin-2 type tachykinin receptors

Blount, P. & Krause, J. E., Jan 1 1993, In : Journal of Biological Chemistry. 268, 22, p. 16388-16395 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Structure, expression and second messenger-mediated regulation of the human and rat substance P receptors and their genes

Krause, J. E., Bu, J. Y., Takeda, Y., Blount, P., Raddatz, R., Sachais, B. S., Chou, K. B., Takeda, J., McCarson, K. & DiMaggio, D., Jul 2 1993, In : Regulatory Peptides. 46, 1-2, p. 59-66 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
1992
75 Scopus citations
1991

ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kildalton protein

Phillips, W. D., Kopta, C., Blount, P., Gardner, P. D., Steinbach, J. H. & Merlie, J. P., Feb 1 1991, In : Science. 251, 4993, p. 568-570 3 p.

Research output: Contribution to journalArticle

185 Scopus citations

Biogenesis of the mouse muscle nicotinic acetylcholine receptor

Blount, P. & Merlie, J. P., 1991, C ed. Unknown Publisher. 18 p. (Current Topics in Membranes; vol. 39, no. C)

Research output: Book/ReportBook

5 Scopus citations

Bip associates with newly synthesized subunits of the mouse muscle nicotinic receptor

Blount, P. & Merlie, J. P., 1991, In : Journal of Cell Biology. 113, 5, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Characterization of an adult muscle acetylcholine receptor subunit by expression in fibroblasts

Blount, P. & Merlie, J. P., Dec 1 1991, In : Journal of Biological Chemistry. 266, 22, p. 14692-14696 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
1990

Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts

Blount, P., Smith, M. M. & Merlie, J. P., 1990, In : Journal of Cell Biology. 111, 6 I, p. 2601-2611 11 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

Mutational analysis of muscle nicotinic acetylcholine receptor subunit assembly

Blount, P. & Merlie, J. P., Dec 1 1990, In : Journal of Cell Biology. 111, 6 I, p. 2613-2622 10 p.

Research output: Contribution to journalArticle

Open Access
89 Scopus citations
1989

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

Blount, P. & Merlie, J. P., Sep 1989, In : Neuron. 3, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

217 Scopus citations
1988

Native folding of an acetylcholine receptor α subunit expressed in the absence of other receptor subunits

Blount, P. & Merlie, J. P., Jan 1 1988, In : Journal of Biological Chemistry. 263, 2, p. 1072-1080 9 p.

Research output: Contribution to journalArticle

79 Scopus citations
1986

Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system

Oldstone, M. B. A., Blount, P., Southern, P. J. & Lampert, P. W., Dec 1 1986, In : Nature. 321, 6067, p. 239-243 5 p.

Research output: Contribution to journalArticle

186 Scopus citations

Dissecting the molecular anatomy of persistent infection with lymphocytic choriomeningitis virus

Valsamakis, V., Southern, P., Blount, P., Ahmed, R., Buchmeier, M. J. & Oldstone, M. B. A., May 1 1986, In : Medical Microbiology and Immunology. 175, 2-3, p. 97-99 3 p.

Research output: Contribution to journalArticle

Dissecting the molecular anatomy of the nervous system: Analysis of RNA and protein expression in whole body sections of laboratory animals

Blount, P., Elder, J., Ian Lipkin, W., Southern, P. J., Buchmeier, M. J. & Oldstone, M. B. A., Sep 24 1986, In : Brain Research. 382, 2, p. 257-265 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
1985

Clearance of viral nucleic acid sequences from persistently infected host by virus specific H-2 restricted lymphocytes

Blount, P., Ahmed, R., Southern, P. & Oldstone, M. B. A., Jan 1 1985, In : Federation Proceedings. 44, 5, p. No. 6567

Research output: Contribution to journalArticle

Perturbation of differentiated functions during viral infectionin Vivo I. Relationship of lymphocytic choriomeningitis virus and host strains to growth hormone deficiency

Oldstone, M. B. A., Ahmed, R., Buchmeier, M. J., Blount, P. & Tishon, A., Apr 15 1985, In : Virology. 142, 1, p. 158-174 17 p.

Research output: Contribution to journalArticle

44 Scopus citations
1984

Analysis of persistent virus infections by in situ hybridization to whole-mouse sections

Southern, P. J., Blount, P. & Oldstone, M. B. A., Dec 1 1984, In : Nature. 312, 5994, p. 555-558 4 p.

Research output: Contribution to journalArticle

41 Scopus citations
1982

Virus-induced alterations in homeostasis: Alterations in differentiated functions of infected cells in vivo

Oldstone, M. B. A., Sinha, Y. N., Blount, P., Tishon, A., Rodriguez, M., Von Wedel, R. & Lampert, P. W., Jan 1 1982, In : Science. 218, 4577, p. 1125-1127 3 p.

Research output: Contribution to journalArticle

141 Scopus citations