Physiology - Division E

Research Output

2000

nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle

Lau, K. S., Grange, R. W., Isotani, E., Sarelius, I. H., Kamm, K. E., Huang, P. L. & Stull, J. T., May 2000, In : Physiological genomics. 2000, 2, p. 21-27 7 p.

Research output: Contribution to journalArticle

126 Scopus citations
2001

Activation of Myosin Light Chain Kinase Requires Translocation of Bound Calmodulin

Krueger, J. K., Gallagher, S. C., Zhi, G., Geguchadze, R., Persechini, A., Stull, J. T. & Trewhella, J., Feb 16 2001, In : Journal of Biological Chemistry. 276, 7, p. 4535-4538 4 p.

Research output: Contribution to journalArticle

32 Scopus citations
57 Scopus citations

Ca2+-independent activity of nitric oxide synthase

Lee, S. J., Beckingham, K. & Stull, J. T., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 284, 2, p. 526-530 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Dedicated Myosin Light Chain Kinases with Diverse Cellular Functions

Kamm, K. E. & Stull, J. T., Feb 16 2001, In : Journal of Biological Chemistry. 276, 7, p. 4527-4530 4 p.

Research output: Contribution to journalShort survey

440 Scopus citations

Familial Hypertrophic Cardiomyopathy Mutations in the Regulatory Light Chains of Myosin Affect their Structure, Ca2+ Binding, and Phosphorylation

Szczesna, D., Ghosh, D., Li, Q., Gomes, A. V., Guzman, G., Arana, C., Zhi, G., Stull, J. T. & Potter, J. D., Mar 9 2001, In : Journal of Biological Chemistry. 276, 10, p. 7086-7092 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice

Grange, R. W., Meeson, A., Chin, E. V. A., Lau, K. S., Stull, J. T., Shelton, J. M., Williams, R. S. & Garry, D. J., 2001, In : American Journal of Physiology - Cell Physiology. 281, 5 50-5, p. C1487-C1494

Research output: Contribution to journalArticle

72 Scopus citations

Myosin light chain kinase- and PKC-dependent contraction of LES and esophageal smooth muscle

Sohn, U. D., Cao, W., Tang, D. C., Stull, J. T., Haeberle, J. R., Wang, C. L. A., Harnett, K. M., Behar, J. & Biancani, P., 2001, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 281, 2 44-2, p. G467-G478

Research output: Contribution to journalArticle

30 Scopus citations

Myosin light chain kinase binding to a unique site on F-actin revealed by three-dimensional image reconstruction

Hatch, V., Zhi, G., Smith, L., Stull, J. T., Craig, R. & Lehman, W., Aug 6 2001, In : Journal of Cell Biology. 154, 3, p. 611-617 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles

Grange, R. W., Isotani, E., Lau, K. S., Kamm, K. E., Huang, P. L. & Stull, J. T., Jun 2001, In : Physiological genomics. 2001, 5, p. 35-44 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

Structure and regulation of calcium/calmodulin-dependent protein kinases

Soderling, T. R. & Stull, J. T., Aug 1 2001, In : Chemical Reviews. 101, 8, p. 2341-2351 11 p.

Research output: Contribution to journalReview article

151 Scopus citations

The power stroke causes changes in the orientation and mobility of the termini of essential light chain 1 of myosin

Borejdo, J., Ushakov, D. S., Moreland, R., Akopova, I., Reshetnyak, Y., Saraswat, L. D., Kamm, K. & Lowey, S., Apr 3 2001, In : Biochemistry. 40, 13, p. 3796-3803 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Thrombin-mediated permeability of human microvascular pulmonary endothelial cells is calcium dependent

Murphy, J. T., Duffy, S. L., Hybki, D. L. & Kamm, K., 2001, In : Journal of Trauma - Injury, Infection and Critical Care. 50, 2, p. 213-222 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2002

Fast-twitch skeletal muscles of dystrophic mouse pups are resistant to injury from acute mechanical stress

Grange, R. W., Gainer, T. G., Marschner, K. M., Talmadge, R. J. & Stull, J. T., Oct 2002, In : American Journal of Physiology - Cell Physiology. 283, 4 52-4, p. C1090-C1101

Research output: Contribution to journalArticle

61 Scopus citations

Navigating the signalling network in mouse cardiac myocytes

Sambrano, G. R., Frasert, I., Han, H., Ni, Y., O'Connell, T., Yan, Z. & Stull, J. T., Dec 12 2002, In : Nature. 420, 6916, p. 712-714 3 p.

Research output: Contribution to journalReview article

72 Scopus citations

Overview of the alliance for cellular signaling

Gilman, A. G., Dec 12 2002, In : Nature. 420, 6916, p. 703-706 4 p.

Research output: Contribution to journalReview article

109 Scopus citations

Phosphorylation of the regulatory light chains of myosin affects Ca2+ sensitivity of skeletal muscle contraction

Szczesna, D., Zhao, J., Jones, M., Zhi, G., Stull, J. & Potter, J. D., 2002, In : Journal of applied physiology. 92, 4, p. 1661-1670 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Properties of long myosin light chain kinase binding to F-actin in vitro and in vivo

Smith, L., Parizi-Robinson, M., Zhu, M. S., Zhi, G., Fukui, R., Kamm, K. E. & Stull, J. T., Sep 20 2002, In : Journal of Biological Chemistry. 277, 38, p. 35597-35604 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2003
48 Scopus citations

Skeletal muscle basement membrane-sarcolemma-cytoskeleton interaction minireview series

Campbell, K. P. & Stull, J. T., Apr 11 2003, In : Journal of Biological Chemistry. 278, 15, p. 12599-12600 2 p.

Research output: Contribution to journalShort survey

47 Scopus citations
2004

Quantitative measurements of Ca2+/calmodulin binding and activation of myosin light chain kinase in cells

Geguchadze, R., Zhi, G., Lau, K. S., Isotani, E., Persechini, A., Kamm, K. E. & Stull, J. T., Jan 16 2004, In : FEBS Letters. 557, 1-3, p. 121-124 4 p.

Research output: Contribution to journalArticle

37 Scopus citations

Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse

Isotani, E., Zhi, G., Lau, K. S., Huang, J., Mizuno, Y., Persechini, A., Geguchadze, R., Kamm, K. E. & Stull, J. T., Apr 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 16, p. 6279-6284 6 p.

Research output: Contribution to journalArticle

91 Scopus citations
2005

Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway

Matsumoto, H., Kamm, K. E., Stull, J. T. & Azuma, H., Mar 2005, In : Experimental Eye Research. 80, 3, p. 313-322 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in α-tropomyosin

Chang, A. N., Harada, K., Ackerman, M. J. & Potter, J. D., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 34343-34349 7 p.

Research output: Contribution to journalArticle

70 Scopus citations

Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction

Zhi, G., Ryder, J. W., Huang, J., Ding, P., Chen, Y., Zhao, Y., Kamm, K. E. & Stull, J. T., Nov 29 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 48, p. 17519-17524 6 p.

Research output: Contribution to journalArticle

135 Scopus citations
56 Scopus citations

Sarcomeric protein mutations in dilated cardiomyopathy

Chang, A. N. & Potter, J. D., Sep 1 2005, In : Heart Failure Reviews. 10, 3, p. 225-235 11 p.

Research output: Contribution to journalReview article

101 Scopus citations
2006

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

Huang, G., Yao, J., Zeng, W., Mizuno, Y., Kamm, K. E., Stull, J. T., Harding, H. P., Ron, D. & Muallem, S., Jan 1 2006, In : Journal of cell science. 119, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
2007

Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation-contraction coupling

Huang, G., Kim, J. Y., Dehoff, M., Mizuno, Y., Kamm, K. E., Worley, P. F., Muallem, S. & Zeng, W., May 11 2007, In : Journal of Biological Chemistry. 282, 19, p. 14283-14290 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Enhanced skeletal muscle contraction with myosin light chain phosphorylation by a calmodulin-sensing kinase

Ryder, J. W., Lau, K. S., Kamm, K. E. & Stull, J. T., Jul 13 2007, In : Journal of Biological Chemistry. 282, 28, p. 20447-20454 8 p.

Research output: Contribution to journalArticle

71 Scopus citations
2008

Functional skeletal muscle regeneration from differentiating embryonic stem cells

Darabi, R., Gehlbach, K., Bachoo, R. M., Kamath, S., Osawa, M., Kamm, K. E., Kyba, M. & Perlingeiro, R. C. R., Feb 1 2008, In : Nature medicine. 14, 2, p. 134-143 10 p.

Research output: Contribution to journalArticle

231 Scopus citations

Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo

Mizuno, Y., Isotani, E., Huang, J., Ding, H., Stull, J. T. & Kamm, K. E., Aug 2008, In : American Journal of Physiology - Cell Physiology. 295, 2, p. C358-C364

Research output: Contribution to journalArticle

70 Scopus citations

Myosin Light Chain Kinase Is Central to Smooth Muscle Contraction and Required for Gastrointestinal Motility in Mice

He, W. Q., Peng, Y. J., Zhang, W. C., Lv, N., Tang, J., Chen, C., Zhang, C. H., Gao, S., Chen, H. Q., Zhi, G., Feil, R., Kamm, K. E., Stull, J. T., Gao, X. & Zhu, M. S., Aug 2008, In : Gastroenterology. 135, 2, p. 610-620.e2

Research output: Contribution to journalArticle

111 Scopus citations

Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy

Huang, J., Shelton, J. M., Richardson, J. A., Kamm, K. E. & Stull, J. T., Jul 11 2008, In : Journal of Biological Chemistry. 283, 28, p. 19748-19756 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Troponin and cardiomyopathy

Chang, A. N., Parvatiyar, M. S. & Potter, J. D., Apr 25 2008, In : Biochemical and Biophysical Research Communications. 369, 1, p. 74-81 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2009

Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery

Gang, E. J., Darabi, R., Bosnakovski, D., Xu, Z., Kamm, K. E., Kyba, M. & Perlingeiro, R. C. R., Sep 10 2009, In : Experimental Cell Research. 315, 15, p. 2624-2636 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Signaling processes for initiating smooth muscle contraction upon neural stimulation

Ding, H. L., Ryder, J. W., Stull, J. T. & Kamm, K. E., Jun 5 2009, In : Journal of Biological Chemistry. 284, 23, p. 15541-15548 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2010

Cardiac myosin is a substrate for Zipper-interacting Protein Kinase (ZIPK)

Chang, A. N., Chen, G., Gerard, R. D., Kamm, K. E. & Stull, J. T., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5122-5126 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo

Ding, P., Huang, J., Battiprolu, P. K., Hill, J. A., Kamm, K. E. & Stull, J. T., Dec 24 2010, In : Journal of Biological Chemistry. 285, 52, p. 40819-40829 11 p.

Research output: Contribution to journalArticle

85 Scopus citations

Mutations in myosin light chain kinase cause familial aortic dissections

Wang, L., Guo, D. C., Cao, J., Gong, L., Kamm, K. E., Regalado, E., Li, L., Shete, S., He, W. Q., Zhu, M. S., Offermanns, S., Gilchrist, D., Elefteriades, J., Stull, J. T. & Milewicz, D. M., Nov 12 2010, In : American Journal of Human Genetics. 87, 5, p. 701-707 7 p.

Research output: Contribution to journalArticle

180 Scopus citations

Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function?

Willott, R. H., Gomes, A. V., Chang, A. N., Parvatiyar, M. S., Pinto, J. R. & Potter, J. D., May 1 2010, In : Journal of Molecular and Cellular Cardiology. 48, 5, p. 882-892 11 p.

Research output: Contribution to journalReview article

140 Scopus citations

Myosin light chain kinase is necessary for tonic airway smooth muscle contraction

Zhang, W. C., Peng, Y. J., Zhang, G. S., He, W. Q., Qiao, Y. N., Dong, Y. Y., Gao, Y. Q., Chen, C., Zhang, C. H., Li, W., Shen, H. H., Ning, W., Kamm, K. E., Stull, J. T., Gao, X. & Zhu, M. S., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5522-5531 10 p.

Research output: Contribution to journalArticle

47 Scopus citations
2011

Erratum: Mutations in myosin light chain kinase cause familial aortic dissections (American Journal of Human Genetics (2010) 87 (701-707))

Wang, L., Guo, D. C., Cao, J., Gong, L., Kamm, K. E., Regalado, E., Li, L., Shete, S., He, W. Q., Zhu, M. S., Offermanns, S., Gilchrist, D., Elefteriades, J., Stull, J. T. & Milewicz, D. M., Apr 8 2011, In : American Journal of Human Genetics. 88, 4, p. 516 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle

Stull, J. T., Kamm, K. E. & Vandenboom, R., Jun 15 2011, In : Archives of Biochemistry and Biophysics. 510, 2, p. 120-128 9 p.

Research output: Contribution to journalReview article

88 Scopus citations

Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension

He, W. Q., Qiao, Y. N., Zhang, C. H., Peng, Y. J., Chen, C., Wang, P., Gao, Y. Q., Chen, C., Chen, X., Tao, T., Su, X. H., Li, C. J., Kamm, K. E., Stull, J. T. & Zhu, M. S., Aug 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 2, p. H584-H591

Research output: Contribution to journalArticle

43 Scopus citations

Sensitive and reproducible intact mass analysis of complex protein mixtures with superficially porous capillary reversed-phase liquid chromatography mass spectrometry

Roth, M. J., Plymire, D. A., Chang, A. N., Kim, J., Maresh, E. M., Larson, S. E. & Patrie, S. M., Dec 15 2011, In : Analytical chemistry. 83, 24, p. 9586-9592 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Signaling to myosin regulatory light chain in sarcomeres

Kamm, K. E. & Stull, J. T., Mar 25 2011, In : Journal of Biological Chemistry. 286, 12, p. 9941-9947 7 p.

Research output: Contribution to journalShort survey

69 Scopus citations

Thematic minireview series on signaling in cardiac sarcomeres in health and disease

Solaro, R. J. & Stull, J. T., Mar 25 2011, In : Journal of Biological Chemistry. 286, 12, p. 9895 1 p.

Research output: Contribution to journalShort survey

1 Scopus citations
2012

Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells

Kuang, S. Q., Kwartler, C. S., Byanova, K. L., Pham, J., Gong, L., Prakash, S. K., Huang, J., Kamm, K. E., Stull, J. T., Sweeney, H. L. & Milewicz, D. M., May 25 2012, In : Circulation research. 110, 11, p. 1411-1422 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Signalling to contractile proteins by muscarinic and purinergic pathways in neurally stimulated bladder smooth muscle

Tsai, M. H., Kamm, K. E. & Stull, J. T., Oct 1 2012, In : Journal of Physiology. 590, 20, p. 5107-5121 15 p.

Research output: Contribution to journalArticle

20 Scopus citations