Physiology - Division E

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2019

The dominant protein phosphatase PP1c isoform in smooth muscle cells, PP1cβ, is essential for smooth muscle contraction

Chang, A. N., Gao, N., Liu, Z., Huang, J., Nairn, A. C., Kamm, K. E. & Stull, J. T., Oct 26 2019, In : Journal of Biological Chemistry. 293, 43, p. 16677-16686 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Genetic approaches to identify pathological limitations in aortic smooth muscle contraction

Huang, J., Gao, N., Wang, S., Milewicz, D. M., Kamm, K. E. & Stull, J. T., Mar 1 2018, In : PLoS One. 13, 3, e0193769.

Research output: Contribution to journalArticle

1 Scopus citations

Similar biophysical abnormalities in glomeruli and podocytes from two distinct models

Embry, A. E., Liu, Z., Henderson, J. M., Byfield, F. J., Liu, L., Yoon, J., Wu, Z., Cruz, K., Moradi, S., Gillombardo, C. B., Hussain, R. Z., Doelger, R., Stuve, O., Chang, A. N., Janmey, P. A., Bruggeman, L. A. & Miller, R. T., May 2018, In : Journal of the American Society of Nephrology. 29, 5, p. 1501-1512 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Variants of Unknown Significance in Genes Associated with Heritable Thoracic Aortic Disease Can Be Low Penetrant “Risk Variants”

Kwartler, C. S., Gong, L., Chen, J., Wang, S., Kulmacz, R., Duan, X. Y., Janda, A., Huang, J., Kamm, K. E., Stull, J. T., Guo, D. & Milewicz, D. M., Jul 5 2018, In : American Journal of Human Genetics. 103, 1, p. 138-143 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Physiological vs. pharmacological signalling to myosin phosphorylation in airway smooth muscle

Gao, N., Tsai, M. H., Chang, A. N., He, W., Chen, C. P., Zhu, M., Kamm, K. E. & Stull, J. T., Oct 1 2017, In : Journal of Physiology. 595, 19, p. 6231-6247 17 p.

Research output: Contribution to journalArticle

8 Scopus citations
4 Scopus citations
2016

Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections

Milewicz, D. M., Trybus, K. M., Guo, D., Sweeney, L. L., Regalado, E., Kamm, K. & Stull, J. T., Nov 22 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

53 Scopus citations

Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities

Chang, A. N., Mahajan, P., Knapp, S., Barton, H., Sweeney, H. L., Kamm, K. E. & Stull, J. T., Jul 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 27, p. E3824-E3833

Research output: Contribution to journalArticle

14 Scopus citations

Interaction of posttetanic potentiation and the catchlike property in mouse skeletal muscle

Gittings, W., Bunda, J., Stull, J. T. & Vandenboom, R., Aug 1 2016, In : Muscle and Nerve. 54, 2, p. 308-316 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Physiological signalling to myosin phosphatase targeting subunit-1 phosphorylation in ileal smooth muscle

Gao, N., Chang, A. N., He, W., Chen, C. P., Qiao, Y. N., Zhu, M., Kamm, K. E. & Stull, J. T., Jun 15 2016, In : Journal of Physiology. 594, 12, p. 3209-3225 17 p.

Research output: Contribution to journalArticle

13 Scopus citations
7 Scopus citations
2015

Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo

Chang, A. N., Battiprolu, P. K., Cowley, P. M., Chen, G., Gerard, R. D., Pinto, J. R., Hill, J. A., Baker, A. J., Kamm, K. E. & Stull, J. T., Apr 24 2015, In : Journal of Biological Chemistry. 290, 17, p. 10703-10716 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction

Chen, C. P., Chen, X., Qiao, Y. N., Wang, P., He, W. Q., Zhang, C. H., Zhao, W., Gao, Y. Q., Chen, C., Tao, T., Sun, J., Wang, Y., Gao, N., Kamm, K. E., Stull, J. T. & Zhu, M. S., Feb 1 2015, In : Journal of Physiology. 593, 3, p. 681-700 20 p.

Research output: Contribution to journalArticle

35 Scopus citations

The α<inf>1</inf>A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium

Cowley, P. M., Wang, G., Chang, A. N., Makwana, O., Swigart, P. M., Lovett, D. H., Stull, J. T., Simpson, P. C. & Baker, A. J., Sep 3 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 5, p. H888-H896

Research output: Contribution to journalArticle

12 Scopus citations
2014

Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle

Tsai, M. H., Chang, A. N., Huang, J., He, W., Sweeney, H. L., Zhu, M., Kamm, K. E. & Stull, J. T., Jul 15 2014, In : Journal of Physiology. 592, 14, p. 3031-3051 21 p.

Research output: Contribution to journalArticle

19 Scopus citations

Long term ablation of protein Kinase a (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy

Dweck, D., Sanchez-Gonzalez, M. A., Chang, A. N., Dulce, R. A., Badger, C. D., Koutnik, A. P., Ruiz, E. L., Griffin, B., Liang, J., Kabbaj, M., Fincham, F. D., Hare, J. M., Michael Overton, J. & Pinto, J. R., Aug 15 2014, In : Journal of Biological Chemistry. 289, 33, p. 23097-23111 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

Qiao, Y. N., He, W. Q., Chen, C. P., Zhang, C. H., Zhao, W., Wang, P., Zhang, L., Wu, Y. Z., Yang, X., Peng, Y. J., Gao, J. M., Kamm, K. E., Stull, J. T. & Zhu, M. S., Aug 8 2014, In : Journal of Biological Chemistry. 289, 32, p. 22512-22523 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice

Reuter, S., Soonpaa, M. H., Firulli, A. B., Chang, A. N. & Field, L. J., Dec 29 2014, In : PloS one. 9, 12, e115871.

Research output: Contribution to journalArticle

35 Scopus citations

Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin

Chang, A. N., Greenfield, N. J., Singh, A., Potter, J. D. & Pinto, J. R., 2014, In : Frontiers in Physiology. 5, DEC, 460.

Research output: Contribution to journalArticle

8 Scopus citations

The force dependence of isometric and concentric potentiation in mouse muscle with and without skeletal myosin light chain kinase

Gittings, W., Aggarwal, H., Stull, J. T. & Vandenboom, R., Oct 14 2014, In : Canadian Journal of Physiology and Pharmacology. 93, 1, p. 23-32 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

Velasquez, L. S., Sutherland, L. B., Liu, Z., Grinnell, F., Kamm, K. E., Schneider, J. W., Olson, E. N. & Small, E. M., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 16850-16855 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1

He, W. Q., Qiao, Y. N., Peng, Y. J., Zha, J. M., Zhang, C. H., Chen, C., Chen, C. P., Wang, P., Yang, X., Li, C. J., Kamm, K. E., Stull, J. T. & Zhu, M. S., Jun 2013, In : Gastroenterology. 144, 7, p. 1456-1465.e5

Research output: Contribution to journalArticle

37 Scopus citations

Signaling through myosin light chain kinase in smooth muscles

Gao, N., Huang, J., He, W., Zhu, M., Kamm, K. E. & Stull, J. T., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7596-7605 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

The Effects of Neuregulin on Cardiac Myosin Light Chain Kinase Gene-Ablated Hearts

Chang, A. N., Huang, J., Battiprolu, P. K., Hill, J. A., Kamm, K. E. & Stull, J. T., Jun 11 2013, In : PloS one. 8, 6, e66720.

Research output: Contribution to journalArticle

9 Scopus citations

Top-down mass spectrometry on tissue extracts and biofluids with isoelectric focusing and superficially porous silica liquid chromatography

Zhang, J., Roth, M. J., Chang, A. N., Plymire, D. A., Corbett, J. R., Greenberg, B. M. & Patrie, S. M., Nov 5 2013, In : Analytical chemistry. 85, 21, p. 10377-10384 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells

Kuang, S. Q., Kwartler, C. S., Byanova, K. L., Pham, J., Gong, L., Prakash, S. K., Huang, J., Kamm, K. E., Stull, J. T., Sweeney, H. L. & Milewicz, D. M., May 25 2012, In : Circulation research. 110, 11, p. 1411-1422 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Signalling to contractile proteins by muscarinic and purinergic pathways in neurally stimulated bladder smooth muscle

Tsai, M. H., Kamm, K. E. & Stull, J. T., Oct 1 2012, In : Journal of Physiology. 590, 20, p. 5107-5121 15 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension

He, W. Q., Qiao, Y. N., Zhang, C. H., Peng, Y. J., Chen, C., Wang, P., Gao, Y. Q., Chen, C., Chen, X., Tao, T., Su, X. H., Li, C. J., Kamm, K. E., Stull, J. T. & Zhu, M. S., Aug 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 2, p. H584-H591

Research output: Contribution to journalArticle

43 Scopus citations

Sensitive and reproducible intact mass analysis of complex protein mixtures with superficially porous capillary reversed-phase liquid chromatography mass spectrometry

Roth, M. J., Plymire, D. A., Chang, A. N., Kim, J., Maresh, E. M., Larson, S. E. & Patrie, S. M., Dec 15 2011, In : Analytical chemistry. 83, 24, p. 9586-9592 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2010

Cardiac myosin is a substrate for Zipper-interacting Protein Kinase (ZIPK)

Chang, A. N., Chen, G., Gerard, R. D., Kamm, K. E. & Stull, J. T., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5122-5126 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo

Ding, P., Huang, J., Battiprolu, P. K., Hill, J. A., Kamm, K. E. & Stull, J. T., Dec 24 2010, In : Journal of Biological Chemistry. 285, 52, p. 40819-40829 11 p.

Research output: Contribution to journalArticle

82 Scopus citations

Mutations in myosin light chain kinase cause familial aortic dissections

Wang, L., Guo, D. C., Cao, J., Gong, L., Kamm, K. E., Regalado, E., Li, L., Shete, S., He, W. Q., Zhu, M. S., Offermanns, S., Gilchrist, D., Elefteriades, J., Stull, J. T. & Milewicz, D. M., Nov 12 2010, In : American Journal of Human Genetics. 87, 5, p. 701-707 7 p.

Research output: Contribution to journalArticle

177 Scopus citations

Myosin light chain kinase is necessary for tonic airway smooth muscle contraction

Zhang, W. C., Peng, Y. J., Zhang, G. S., He, W. Q., Qiao, Y. N., Dong, Y. Y., Gao, Y. Q., Chen, C., Zhang, C. H., Li, W., Shen, H. H., Ning, W., Kamm, K. E., Stull, J. T., Gao, X. & Zhu, M. S., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5522-5531 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2009

Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery

Gang, E. J., Darabi, R., Bosnakovski, D., Xu, Z., Kamm, K. E., Kyba, M. & Perlingeiro, R. C. R., Sep 10 2009, In : Experimental Cell Research. 315, 15, p. 2624-2636 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Signaling processes for initiating smooth muscle contraction upon neural stimulation

Ding, H. L., Ryder, J. W., Stull, J. T. & Kamm, K. E., Jun 5 2009, In : Journal of Biological Chemistry. 284, 23, p. 15541-15548 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2008

Functional skeletal muscle regeneration from differentiating embryonic stem cells

Darabi, R., Gehlbach, K., Bachoo, R. M., Kamath, S., Osawa, M., Kamm, K. E., Kyba, M. & Perlingeiro, R. C. R., Feb 1 2008, In : Nature medicine. 14, 2, p. 134-143 10 p.

Research output: Contribution to journalArticle

226 Scopus citations

Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo

Mizuno, Y., Isotani, E., Huang, J., Ding, H., Stull, J. T. & Kamm, K. E., Aug 1 2008, In : American Journal of Physiology - Cell Physiology. 295, 2, p. C358-C364

Research output: Contribution to journalArticle

70 Scopus citations

Myosin Light Chain Kinase Is Central to Smooth Muscle Contraction and Required for Gastrointestinal Motility in Mice

He, W. Q., Peng, Y. J., Zhang, W. C., Lv, N., Tang, J., Chen, C., Zhang, C. H., Gao, S., Chen, H. Q., Zhi, G., Feil, R., Kamm, K. E., Stull, J. T., Gao, X. & Zhu, M. S., Aug 2008, In : Gastroenterology. 135, 2, p. 610-620.e2

Research output: Contribution to journalArticle

107 Scopus citations

Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy

Huang, J., Shelton, J. M., Richardson, J. A., Kamm, K. E. & Stull, J. T., Jul 11 2008, In : Journal of Biological Chemistry. 283, 28, p. 19748-19756 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Troponin and cardiomyopathy

Chang, A. N., Parvatiyar, M. S. & Potter, J. D., Apr 25 2008, In : Biochemical and Biophysical Research Communications. 369, 1, p. 74-81 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2007

Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation-contraction coupling

Huang, G., Kim, J. Y., Dehoff, M., Mizuno, Y., Kamm, K. E., Worley, P. F., Muallem, S. & Zeng, W., May 11 2007, In : Journal of Biological Chemistry. 282, 19, p. 14283-14290 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Enhanced skeletal muscle contraction with myosin light chain phosphorylation by a calmodulin-sensing kinase

Ryder, J. W., Lau, K. S., Kamm, K. E. & Stull, J. T., Jul 13 2007, In : Journal of Biological Chemistry. 282, 28, p. 20447-20454 8 p.

Research output: Contribution to journalArticle

69 Scopus citations
2006

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

Huang, G., Yao, J., Zeng, W., Mizuno, Y., Kamm, K. E., Stull, J. T., Harding, H. P., Ron, D. & Muallem, S., Jan 1 2006, In : Journal of cell science. 119, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2005

Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway

Matsumoto, H., Kamm, K. E., Stull, J. T. & Azuma, H., Mar 2005, In : Experimental Eye Research. 80, 3, p. 313-322 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in α-tropomyosin

Chang, A. N., Harada, K., Ackerman, M. J. & Potter, J. D., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 34343-34349 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction

Zhi, G., Ryder, J. W., Huang, J., Ding, P., Chen, Y., Zhao, Y., Kamm, K. E. & Stull, J. T., Nov 29 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 48, p. 17519-17524 6 p.

Research output: Contribution to journalArticle

131 Scopus citations
55 Scopus citations
2004

Quantitative measurements of Ca2+/calmodulin binding and activation of myosin light chain kinase in cells

Geguchadze, R., Zhi, G., Lau, K. S., Isotani, E., Persechini, A., Kamm, K. E. & Stull, J. T., Jan 16 2004, In : FEBS Letters. 557, 1-3, p. 121-124 4 p.

Research output: Contribution to journalArticle

37 Scopus citations

Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse

Isotani, E., Zhi, G., Lau, K. S., Huang, J., Mizuno, Y., Persechini, A., Geguchadze, R., Kamm, K. E. & Stull, J. T., Apr 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 16, p. 6279-6284 6 p.

Research output: Contribution to journalArticle

91 Scopus citations
2003
48 Scopus citations