Physiology - Division T

Research Output 1990 2018

2018
12 Citations (Scopus)

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Pinarbasi, E. S., Caǧatay, T., Fung, H. Y. J., Li, Y. C., Chook, Y. M. & Thomas, P. J., Dec 1 2018, In : Scientific Reports. 8, 1, 7083.

Research output: Contribution to journalArticle

Nuclear Export Signals
Cell Nucleus Active Transport
Nuclear Fusion
Karyopherins
RNA-Binding Proteins
22 Citations (Scopus)

CFTR modulator theratyping: Current status, gaps and future directions

Clancy, J. P., Cotton, C. U., Donaldson, S. H., Solomon, G. M., VanDevanter, D. R., Boyle, M. P., Gentzsch, M., Nick, J. A., Illek, B., Wallenburg, J. C., Sorscher, E. J., Amaral, M. D., Beekman, J. M., Naren, A. P., Bridges, R. J., Thomas, P. J., Cutting, G., Rowe, S., Durmowicz, A. G., Mense, M. & 8 others, Boeck, K. D., Skach, W., Penland, C., Joseloff, E., Bihler, H., Mahoney, J., Borowitz, D. & Tuggle, K. L., Jan 1 2018, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Direction compound
Pharmaceutical Preparations
Education
3 Citations (Scopus)

Isogenic cell models of cystic fibrosis-causing variants in natively expressing pulmonary epithelial cells

Valley, H. C., Bukis, K. M., Bell, A., Cheng, Y., Wong, E., Jordan, N. J., Allaire, N. E., Sivachenko, A., Liang, F., Bihler, H., Thomas, P. J., Mahiou, J. & Mense, M., Jan 1 2018, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Epithelial Cells
Nonsense Mediated mRNA Decay
Lung

Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function

Peters-Hall, J. R., Coquelin, M. L., Torres, M. J., Laranger, R., Alabi, B. R., Sho, S., Calva-Moreno, J. F., Thomas, P. J. & Shay, J. W., Aug 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 315, 2, p. L313-L327

Research output: Contribution to journalArticle

CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats
Multipotent Stem Cells
3T3 Cells
Cystic Fibrosis Transmembrane Conductance Regulator
5 Citations (Scopus)

Pathogenic Signal Sequence Mutations in Progranulin Disrupt SRP Interactions Required for mRNA Stability

Pinarbasi, E. S., Karamyshev, A. L., Tikhonova, E. B., Wu, I. H., Hudson, H. & Thomas, P. J., Jan 1 2018, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

Signal Recognition Particle
Particle interactions
RNA Stability
Protein Sorting Signals
Frontotemporal Lobar Degeneration
2017
9 Citations (Scopus)

17β-Estradiol dysregulates innate immune responses to Pseudomonas aeruginosa respiratory infection and is modulated by estrogen receptor antagonism

Abid, S., Xie, S. K., Bose, M., Shaul, P. W., Terada, L. S., Brody, S. L., Thomas, P. J., Katzenellenbogen, J. A., Kim, S. H., Greenberg, D. E. & Jain, R., 2017, In : Infection and Immunity. 85, 10, e00422-17.

Research output: Contribution to journalArticle

Innate Immunity
Respiratory Tract Infections
Estrogen Receptors
Pseudomonas aeruginosa
Estradiol
20 Citations (Scopus)

Direct binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric coupling between the Binding site and the NBD1:CL4 Interface s

Hudson, R. P., Dawson, J. E., Chong, P. A., Yang, Z., Millen, L., Thomas, P. J., Brouillette, C. G. & Forman-Kay, J. D., Aug 1 2017, In : Molecular Pharmacology. 92, 2, p. 124-135 12 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Binding Sites
S 10
Temperature
Freezing
2016
17 Citations (Scopus)

Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding

Huerta, C., Jiang, X., Trevino, I., Bender, C. F., Ferguson, D. A., Probst, B., Swinger, K. K., Stoll, V. S., Thomas, P. J., Dulubova, I., Visnick, M. & Wigley, W. C., Nov 1 2016, In : Biochimica et Biophysica Acta - General Subjects. 1860, 11, p. 2537-2552 16 p.

Research output: Contribution to journalArticle

Modulators
Antioxidants
Inflammation
Molecules
Cysteine

N-alpha-acetyltransferases and regulation of CFTR expression

Vetter, A. J., Karamyshev, A. L., Patrick, A. E., Hudson, H. & Thomas, P. J., May 1 2016, In : PLoS One. 11, 5, e0155430.

Research output: Contribution to journalArticle

N-Terminal Acetyltransferases
Cystic Fibrosis Transmembrane Conductance Regulator
acetyltransferases
cystic fibrosis
Acetylation
2014
29 Citations (Scopus)

Inefficient SRP interaction with a nascent chain triggers a MRNA quality control pathway

Karamyshev, A. L., Patrick, A. E., Karamysheva, Z. N., Griesemer, D. S., Hudson, H., Tjon-Kon-Sang, S., Nilsson, I., Otto, H., Liu, Q., Rospert, S., Von Heijne, G., Johnson, A. E. & Thomas, P. J., 2014, In : Cell. 156, 1-2, p. 146-157 12 p.

Research output: Contribution to journalArticle

Signal Recognition Particle
Particle interactions
Quality Control
Quality control
RNA Stability
13 Citations (Scopus)

The bip molecular chaperone plays multiple roles during the biogenesis of torsina, an aaa atpase associated with the neurological disease early-onset torsion dystonia

Zacchi, L. F., Wu, H. C., Bell, S. L., Millen, L., Paton, A. W., Paton, J. C., Thomas, P. J., Zolkiewski, M. & Brodsky, J. L., 2014, In : Journal of Biological Chemistry. 289, 18, p. 12727-12747 21 p.

Research output: Contribution to journalArticle

Dystonia Musculorum Deformans
Glycosylation
Molecular Chaperones
Torsional stress
Solubility
2013
293 Citations (Scopus)

Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene

Sosnay, P. R., Siklosi, K. R., Van Goor, F., Kaniecki, K., Yu, H., Sharma, N., Ramalho, A. S., Amaral, M. D., Dorfman, R., Zielenski, J., Masica, D. L., Karchin, R., Millen, L., Thomas, P. J., Patrinos, G. P., Corey, M., Lewis, M. H., Rommens, J. M., Castellani, C., Penland, C. M. & 1 others, Cutting, G. R., Oct 2013, In : Nature Genetics. 45, 10, p. 1160-1167 8 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Regulator Genes
Cystic Fibrosis
Aptitude
Penetrance
78 Citations (Scopus)

Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions

Bozoky, Z., Krzeminski, M., Muhandiram, R., Birtley, J. R., Al-Zahrani, A., Thomas, P. J., Frizzell, R. A., Ford, R. C. & Forman-Kay, J. D., Nov 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 47

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Chloride Channels
Nucleic Acid Regulatory Sequences
Phosphorylation
Intrinsically Disordered Proteins
2012
12 Citations (Scopus)

Development of CFTR structure

Patrick, A. E. & Thomas, P. J., 2012, In : Frontiers in Pharmacology. 3 SEP, Article 162.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
ATP-Binding Cassette Transporters
Mutation
Inborn Genetic Diseases
Sequence Deletion
153 Citations (Scopus)

Requirements for efficient correction of Δf508 CFTR revealed by analyses of evolved sequences

Mendoza, J. L., Schmidt, A., Li, Q., Nuvaga, E., Barrett, T., Bridges, R. J., Feranchak, A. P., Brautigam, C. A. & Thomas, P. J., Jan 20 2012, In : Cell. 148, 1-2, p. 164-174 11 p.

Research output: Contribution to journalArticle

Sequence Analysis
Cystic Fibrosis Transmembrane Conductance Regulator
Defects
Mutation
Ceilings
10 Citations (Scopus)

TDP-43 identified from a genome wide RNAi screen for SOD1 regulators

Somalinga, B. R., Day, C. E., Wei, S., Roth, M. G. & Thomas, P. J., Apr 26 2012, In : PLoS One. 7, 4, e35818.

Research output: Contribution to journalArticle

RNA Interference
Superoxide Dismutase
superoxide dismutase
Genes
Genome
2011
11 Citations (Scopus)

Alteration of CFTR transmembrane span integration by disease-causing mutations

Patrick, A. E., Karamyshev, A. L., Millen, L. & Thomas, P. J., Dec 1 2011, In : Molecular Biology of the Cell. 22, 23, p. 4461-4471 11 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Endoplasmic Reticulum
Mutation
Proteins
Glycine
3 Citations (Scopus)

A screen to identify cellular modulators of soluble levels of an amyotrophic lateral sclerosis (ALS)-causing mutant SOD1

Somalinga, B. R., Miller, G. A., Malik, H. T., Wigley, W. C. & Thomas, P. J., Oct 2011, In : Journal of Biomolecular Screening. 16, 9, p. 974-985 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Solubility
Modulators
Assays
Genes
4 Citations (Scopus)

Biochemical and biophysical approaches to probe CFTR structure.

Schmidt, A., Mendoza, J. L. & Thomas, P. J., 2011, In : Methods in molecular biology (Clifton, N.J.). 741, p. 365-376 12 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Mutation
Genetic Suppression
Fluids and Secretions
Inborn Genetic Diseases
20 Citations (Scopus)

CFTR Folding Consortium: methods available for studies of CFTR folding and correction.

Peters, K. W., Okiyoneda, T., Balch, W. E., Braakman, I., Brodsky, J. L., Guggino, W. B., Penland, C. M., Pollard, H. B., Sorscher, E. J., Skach, W. R., Thomas, P. J., Lukacs, G. L. & Frizzell, R. A., 2011, In : Methods in molecular biology (Clifton, N.J.). 742, p. 335-353 19 p.

Research output: Contribution to journalArticle

Antibodies
Drug Discovery
Cystic Fibrosis
Proteins
Enzyme-Linked Immunosorbent Assay
2 Citations (Scopus)

Introduction to section IV: biophysical methods to approach CFTR structure.

Mendoza, J. L., Schmidt, A. & Thomas, P. J., 2011, In : Methods in molecular biology (Clifton, N.J.). 741, p. 321-327 7 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
X Ray Crystallography
Electron Microscopy
Membrane Proteins
Theoretical Models
62 Citations (Scopus)

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway

Yang, D., Li, Q., So, I., Huang, C. L., Ando, H., Mizutani, A., Seki, G., Mikoshiba, K., Thomas, P. J. & Muallem, S., Mar 1 2011, In : Journal of Clinical Investigation. 121, 3, p. 956-965 10 p.

Research output: Contribution to journalArticle

Phosphotransferases
Protein Phosphatase 1
Fluids and Secretions
Sodium-Bicarbonate Symporters
Inositol 1,4,5-Trisphosphate Receptors
2010
17 Citations (Scopus)

Abnormal neurites containing C-terminally truncated α-synuclein are present in Alzheimer's disease without conventional lewy body pathology

Lewis, K. A., Su, Y., Jou, O., Ritchie, C., Foong, C., Hynan, L. S., White, C. L., Thomas, P. J. & Hatanpaa, K. J., Dec 2010, In : American Journal of Pathology. 177, 6, p. 3037-3050 14 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Bodies
Neurites
Lewy Body Disease
Alzheimer Disease
16 Citations (Scopus)
Synucleins
Proteasome Endopeptidase Complex
Mutation
Parkinson Disease
Amyloid
31 Citations (Scopus)

A unique redox-sensing sensor II motif in torsina plays a critical role in nucleotide and partner binding

Zhu, L., Millen, L., Mendoza, J. L. & Thomas, P. J., Nov 26 2010, In : Journal of Biological Chemistry. 285, 48, p. 37271-37280 10 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Nucleotides
Dystonia
Sensors
Cysteine
1 Citation (Scopus)

Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease

Balch, W. E., Braakman, I., Brodsky, J., Frizzell, R., Guggino, W., Lukacs, G. L., Penland, C., Pollard, H., Skach, W., Sorscher, E. & Thomas, P., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 425-452 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cystic Fibrosis
66 Citations (Scopus)

NMR evidence for differential phosphorylation-dependent interactions in WT and DF508 CFTR

Kanelis, V., Hudson, R. P., Thibodeau, P. H., Thomas, P. J. & Forman-Kay, J. D., Jan 6 2010, In : EMBO Journal. 29, 1, p. 263-277 15 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Phosphorylation
Nuclear magnetic resonance
Nucleotides
Nucleic Acid Regulatory Sequences
176 Citations (Scopus)

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

Hutt, D. M., Herman, D., Rodrigues, A. P. C., Noel, S., Pilewski, J. M., Matteson, J., Hoch, B., Kellner, W., Kelly, J. W., Schmidt, A., Thomas, P. J., Matsumura, Y., Skach, W. R., Gentzsch, M., Riordan, J. R., Sorscher, E. J., Okiyoneda, T., Yates, J. R., Lukacs, G. L., Frizzell, R. A. & 3 others, Manning, G., Gottesfeld, J. M. & Balch, W. E., Jan 2010, In : Nature Chemical Biology. 6, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Histone Deacetylase Inhibitors
Histone Deacetylases
Cystic Fibrosis
Chloride Channels
65 Citations (Scopus)

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

Kalid, O., Mense, M., Fischman, S., Shitrit, A., Bihler, H., Ben-Zeev, E., Schutz, N., Pedemonte, N., Thomas, P. J., Bridges, R. J., Wetmore, D. R., Marantz, Y. & Senderowitz, H., Dec 2010, In : Journal of Computer-Aided Molecular Design. 24, 12, p. 971-991 21 p.

Research output: Contribution to journalArticle

Computer Simulation
Screening
screening
Nucleotides
Binding Sites
109 Citations (Scopus)

The cystic fibrosis-causing mutation ΔF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis

Thibodeau, P. H., Richardson, J. M., Wang, W., Millen, L., Watson, J., Mendoza, J. L., Du, K., Fischman, S., Senderowitz, H., Lukacs, G. L., Kirk, K. & Thomas, P. J., Nov 12 2010, In : Journal of Biological Chemistry. 285, 46, p. 35825-35835 11 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Genetic Suppression
Cystic Fibrosis
Mutation
Nucleotides
51 Citations (Scopus)

The primary folding defect and rescue of δf508 CFTR emerge during translation of the mutant domain

Hoelen, H., Kleizen, S., Schmidt, A., Richardson, J., Charitou, P., Thomas, P. J. & Braakman, I., 2010, In : PLoS One. 5, 11, e15458.

Research output: Contribution to journalArticle

cystic fibrosis
Cystic Fibrosis
translation (genetics)
Nucleotides
Genetic Suppression
2008
51 Citations (Scopus)

Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3

Dorwart, M. R., Shcheynikov, N., Baker, J. M. R., Forman-Kay, J. D., Muallem, S. & Thomas, P. J., Mar 28 2008, In : Journal of Biological Chemistry. 283, 13, p. 8711-8722 12 p.

Research output: Contribution to journalArticle

Sigma Factor
Sulfates
Chlorides
Mutation
Diarrhea

Regulatory Interaction between CFTR and the SLC26 Transporters

Shcheynikov, N., Ko, S. B. H., Zeng, W., Choi, J. Y., Dorwart, M. R., Thomas, P. J. & Muallem, S., Oct 7 2008, Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family. Wiley Blackwell, p. 177-186 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphorylation
Scaffolds
Stoichiometry
Chlorides
Protein Isoforms
61 Citations (Scopus)

Solubilizing Mutations Used to Crystallize One CFTR Domain Attenuate the Trafficking and Channel Defects Caused by the Major Cystic Fibrosis Mutation

Pissarra, L. S., Farinha, C. M., Xu, Z., Schmidt, A., Thibodeau, P. H., Cai, Z., Thomas, PJ., Sheppard, D. N. & Amaral, M. D., Jan 25 2008, In : Chemistry and Biology. 15, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Bearings (structural)
Crystal structure
Defects
Mutation
42 Citations (Scopus)

The torsin-family AAA+ protein OOC-5 contains a critical disulfide adjacent to sensor-II that couples redox state to nucleotide binding

Zhu, L., Wrabl, J. O., Hayashi, A. P., Rose, L. S. & Thomas, P. J., Aug 2008, In : Molecular Biology of the Cell. 19, 8, p. 3599-3612 14 p.

Research output: Contribution to journalArticle

Disulfides
Oxidation-Reduction
Nucleotides
Cysteine
Proteins
2007
37 Citations (Scopus)

Building an understanding of cystic fibrosis on the foundation of ABC transporter structures

Mendoza, J. L. & Thomas, P. J., Dec 2007, In : Journal of Bioenergetics and Biomembranes. 39, 5-6, p. 499-505 7 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
ATP-Binding Cassette Transporters
Cystic Fibrosis
Mutation
Digestive System
198 Citations (Scopus)

CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices

Baker, J. M. R., Hudson, R. P., Kanelis, V., Choy, W. Y., Thibodeau, P. H., Thomas, P. J. & Forman-Kay, J. D., Aug 2007, In : Nature Structural and Molecular Biology. 14, 8, p. 738-745 8 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Nucleic Acid Regulatory Sequences
Phosphorylation
Nucleotides
Hydrolysis
31 Citations (Scopus)

Hook2 contributes to aggresome formation

Szebenyi, G., Wigley, W. C., Hall, B., Didier, A., Yu, M., Thomas, P. & Krämer, H., May 31 2007, In : BMC Cell Biology. 8, 19.

Research output: Contribution to journalArticle

Microtubules
Organelles
Dyneins
Centrosome
Proteins
2006
127 Citations (Scopus)

ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome

Liu, C. W., Li, X., Thompson, D., Wooding, K., Chang, T. L., Tang, Z., Yu, H., Thomas, P. J. & DeMartino, G. N., Oct 6 2006, In : Molecular Cell. 24, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

Hydrolysis
Adenosine Triphosphate
Proteasome Endopeptidase Complex
Proteolysis
Proteins
131 Citations (Scopus)

Coupling modes and stoichiometry of Cl-/HCO3 - exchange by slc26a3 and slc26a6

Shcheynikov, N., Wang, Y., Park, M., Ko, S. B. H., Dorwart, M., Naruse, S., Thomas, P. J. & Muallem, S., May 2006, In : Journal of General Physiology. 127, 5, p. 511-524 14 p.

Research output: Contribution to journalArticle

Membrane Potentials
Oocytes
Xenopus laevis
Protein Isoforms
Kidney

Discussion

Muallem, S., Ashmore, J., Quinton, P. M., Alper, S. L., Gray, M. A., Turner, R. J., Thomas, P. J., Romero, M. F., Welsh, M. J., Mount, D. B., Knipper, M., Lee, M. G., Soleimani, M., Aronson, P. S. & Case, M., 2006, Novartis Foundation Symposium. Vol. 273. p. 68-73 6 p. (Novartis Foundation Symposium; vol. 273).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Muallem, S., Oliver, D., Ashmore, J., Alper, S. L., Turner, R. J., Welsh, M. J., Romero, M. F., Kere, J., Thomas, P. J., Quinton, P. M. & Knipper, M., 2006, Novartis Foundation Symposium. Vol. 273. p. 253-260 8 p. (Novartis Foundation Symposium; vol. 273).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Muallem, S., Case, M., Höglund, P., Quinton, P. M., Kere, J., Lee, M. G., Thomas, P. J., Mount, D. B., Seidler, U., Alper, S. L., Soleimani, M., Chan, H. C. & Welsh, M. J., 2006, Novartis Foundation Symposium. Vol. 273. p. 86-90 5 p. (Novartis Foundation Symposium; vol. 273).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Welsh, M. J., Muallem, S., Lee, M. G., Thomas, P. J., Alper, S. L., Gray, M. A., Soleimani, M., Argent, B. E., Ashmore, J., Case, M., Romero, M. F., Quinton, P. M. & Seidler, U., 2006, Novartis Foundation Symposium. Vol. 273. p. 186-192 7 p. (Novartis Foundation Symposium; vol. 273).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Welsh, M. J., Rossi, A., Lee, M. G., Markovich, D., Quinton, P. M., Thomas, P. J., Soleimani, M., Alper, S. L., Knipper, M., Romero, M. F., Aronson, P. S., Stewart, A. K., Muallem, S. & Mount, D. B., 2006, Novartis Foundation Symposium. Vol. 273. p. 206-212 7 p. (Novartis Foundation Symposium; vol. 273).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Welsh, M. J., Knipper, M., Muallem, S., Alper, S. L., Lee, M. G., Everett, L. A., Kere, J., Turner, R. J., Ashmore, J., Mount, D. B., Case, M., Oliver, D., Soleimani, M., Markovich, D., Thomas, P. J., Aronson, P. S., Quinton, P. M. & Chan, H. C., 2006, Novartis Foundation Symposium. Vol. 273. p. 30-41 12 p. (Novartis Foundation Symposium; vol. 273).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

45 Citations (Scopus)

Regulatory interaction between CFTR and the SLC26 transporters

Shcheynikov, N., Ko, S. B. H., Zeng, W., Joo, Y. C., Dorwart, M. R., Thomas, P. J. & Muallem, S., 2006, Novartis Foundation Symposium. Vol. 273. p. 177-186 10 p. (Novartis Foundation Symposium; vol. 273).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

PDZ Domains
Secretory Pathway
Cystic Fibrosis
Protein Isoforms
Epithelium
97 Citations (Scopus)

Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3 - secretion: Relevance to cystic fibrosis

Wang, Y., Soyombo, A. A., Shcheynikov, N., Zeng, W., Dorwart, M., Marino, C. R., Thomas, P. J. & Muallem, S., Nov 1 2006, In : EMBO Journal. 25, 21, p. 5049-5057 9 p.

Research output: Contribution to journalArticle

Fluids and Secretions
Pancreatic Ducts
Cystic Fibrosis
Ducts
Fluids
2005
42 Citations (Scopus)

Aggresome formation.

Corboy, M. J., Thomas, P. J. & Wigley, W. C., 2005, In : Methods in molecular biology (Clifton, N.J.). 301, p. 305-327 23 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Quality Control
Centrosome
Proteins
172 Citations (Scopus)

A precipitating role for truncated α-synuclein and the proteasome in α-synuclein aggregation: Implications for pathogenesis of parkinson disease

Liu, C. W., Giasson, B. I., Lewis, K. A., Lee, V. M., DeMartino, G. N. & Thomas, P. J., Jun 17 2005, In : Journal of Biological Chemistry. 280, 24, p. 22670-22678 9 p.

Research output: Contribution to journalArticle

Synucleins
Proteasome Endopeptidase Complex
Parkinson Disease
Agglomeration
Proteins