Physiology - Division W

Research Output 1999 2019

2019
2 Citations (Scopus)
Hedgehogs
Zinc Fingers
Transcription
Proteomics
Modulators

Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling

Han, Y., Wang, B., Cho, Y. S., Zhu, J., Wu, J., Chen, Y. & Jiang, J., Sep 9 2019, In : Developmental Cell. 50, 5, p. 610-626.e4

Research output: Contribution to journalArticle

Phosphorylation
Phosphotransferases
Hordeolum
Transcription Factors
Neuroglia
2017
3 Citations (Scopus)

Epigenetic regulation in medulloblastoma

Yi, J. & Wu, J., Jan 1 2017, (Accepted/In press) In : Molecular and Cellular Neuroscience.

Research output: Contribution to journalArticle

Medulloblastoma
Epigenomics
Chromatin
Brain Neoplasms
Neoplasms
10 Citations (Scopus)

Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system

Han, Y., Xiong, Y., Shi, X., Wu, J., Zhao, Y. & Jiang, J., Aug 1 2017, In : PLoS Biology. 15, 8, e2002063.

Research output: Contribution to journalArticle

karyopherins
Karyopherins
Nuclear Localization Signals
nuclear localization signals
Cell Nucleus Active Transport
2016
8 Citations (Scopus)
MEF2 Transcription Factors
Autistic Disorder
Synapses
Chromatin
Genes
8 Citations (Scopus)

SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development

Shi, X., Wang, Q., Gu, J., Xuan, Z. & Wu, J. I., Nov 3 2016, In : Oncogene. 35, 44, p. 5746-5758 13 p.

Research output: Contribution to journalArticle

Medulloblastoma
Hedgehogs
Epigenomics
Neoplasms
Gene Regulatory Networks
2015
3 Citations (Scopus)
Medulloblastoma
Protein-Tyrosine Kinases
Tyrosine
Neoplasms
src-Family Kinases
2 Citations (Scopus)

Camk2a-Cre-mediated conditional deletion of chromatin remodeler Brg1 causes perinatal hydrocephalus

Cao, M. & Wu, J. I., Jun 5 2015, In : Neuroscience Letters. 597, p. 71-76 6 p.

Research output: Contribution to journalArticle

Hydrocephalus
Chromatin
Autistic Disorder
Subcommissural Organ
Cerebral Aqueduct
7 Citations (Scopus)

Chromatin Remodeling Factor Brg1 Supports the Early Maintenance and Late Responsiveness of Nestin-Lineage Adult Neural Stem and Progenitor Cells

Petrik, D., Latchney, S. E., Masiulis, I., Yun, S., Zhang, Z., Wu, J. I. & Eisch, A. J., Dec 1 2015, In : Stem Cells. 33, 12, p. 3655-3665 11 p.

Research output: Contribution to journalArticle

Nestin
Adult Stem Cells
Chromatin Assembly and Disassembly
Neural Stem Cells
Neurogenesis
2 Citations (Scopus)

Generation of BAF53b-Cre transgenic mice with pan-neuronal Cre activities

Zhan, X., Cao, M., Yoo, A. S., Zhang, Z., Chen, L., Crabtree, G. R. & Wu, J. I., Jul 1 2015, In : Genesis. 53, 7, p. 440-448 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Neurons
Artificial Chromosomes
Genes
Chromatin Assembly and Disassembly
2014
42 Citations (Scopus)

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Li, Q., Wang, R., Wang, C., Ge, K. & Wu, J., 2014, In : Nature Communications. 5, 6425.

Research output: Contribution to journalArticle

Medulloblastoma
Methyltransferases
Growth and Development
Epigenomics
genes
2013
1 Citation (Scopus)

Characterization of synaptic dysfunction in an in vitro corticostriatal model system of Huntington's disease

Artamonov, D. N., Korzhova, V. V., Wu, J., Rybalchenko, P. D., Im, K., Krasnoborova, V. A., Vlasova, O. L. & Bezprozvanny, I. B., Jul 2013, In : Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 7, 3, p. 192-202 11 p.

Research output: Contribution to journalArticle

Huntington Disease
Neurons
Corpus Striatum
Spine
Optogenetics
1 Citation (Scopus)

Characterization of synaptic dysfunction in an In Vitro corticostriatal model system of Huntington's disease

Artamonov, D. N., Korzhova, V. V., Wu, J., Rybalchenko, P. D., Im, C., Krasnoborova, V. A., Vlasova, O. L. & Bezprozvanny, I. B., 2013, In : Biologicheskie Membrany. 30, 4, p. 276-288 13 p.

Research output: Contribution to journalArticle

Huntington Disease
Neurons
Corpus Striatum
Spine
Optogenetics
36 Citations (Scopus)

NF-κB forms a complex with the chromatin remodeler BRG1 to regulate schwann cell differentiation

Limpert, A. S., Bai, S., Narayan, M., Wu, J., Yoon, S. O., Carter, B. D. & Richard Lu, Q., Feb 6 2013, In : Journal of Neuroscience. 33, 6, p. 2388-2397 10 p.

Research output: Contribution to journalArticle

Schwann Cells
Myelin Sheath
Chromatin
Cell Differentiation
Chromatin Assembly and Disassembly
151 Citations (Scopus)

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation

Yu, Y., Chen, Y., Kim, B., Wang, H., Zhao, C., He, X., Liu, L., Liu, W., Wu, L. M. N., Mao, M., Chan, J. R., Wu, J. & Lu, Q. R., Jan 7 2013, In : Cell. 152, 1-2, p. 248-261 14 p.

Research output: Contribution to journalArticle

Oligodendroglia
Chromatin
Chromatin Assembly and Disassembly
Genes
Adenosine Triphosphate
108 Citations (Scopus)

The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network

Ninkovic, J., Steiner-Mezzadri, A., Jawerka, M., Akinci, U., Masserdotti, G., Petricca, S., Fischer, J., Von Holst, A., Beckers, J., Lie, C. D., Petrik, D., Miller, E., Tang, J., Wu, J., Lefebvre, V., Demmers, J., Eisch, A., Metzger, D., Crabtree, G., Irmler, M. & 2 others, Poot, R. & Götz, M., Oct 3 2013, In : Cell Stem Cell. 13, 4, p. 403-418 16 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Olfactory Bulb
Neurogenesis
Neuroglia
Down-Regulation
117 Citations (Scopus)

The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory

Vogel-Ciernia, A., Matheos, D. P., Barrett, R. M., Kramár, E. A., Azzawi, S., Chen, Y., Magnan, C. N., Zeller, M., Sylvain, A., Haettig, J., Jia, Y., Tran, A., Dang, R., Post, R. J., Chabrier, M., Babayan, A. H., Wu, J. I., Crabtree, G. R., Baldi, P., Baram, T. Z. & 2 others, Lynch, G. & Wood, M. A., May 2013, In : Nature Neuroscience. 16, 5, p. 552-561 10 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Chromatin
Neurons
Exome
Mutation
2012
61 Citations (Scopus)
Chromatin Assembly and Disassembly
Chromatin
Hydrolysis
Adenosine Triphosphate
Transcription
2011
44 Citations (Scopus)
Chromatin Assembly and Disassembly
Hedgehogs
Activator Appliances
Genes
Telencephalon
2010
14 Citations (Scopus)

STAR TREK: An introduction to STAR family proteins and review of quaking (QKI)

Artzt, K. & Wu, J. I., 2010, In : Advances in Experimental Medicine and Biology. 693, p. 1-24 24 p.

Research output: Contribution to journalArticle

RNA
Signal transduction
3' Untranslated Regions
Bioinformatics
Computational Biology
2009
326 Citations (Scopus)

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency

Ho, L., Ronan, J. L., Wu, J., Staahl, B. T., Chen, L., Kuo, A., Lessard, J., Nesvizhskii, A. I., Ranish, J. & Crabtree, G. R., Mar 31 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 13, p. 5181-5186 6 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Embryonic Stem Cells
Proteomics
Genes
Xenopus
228 Citations (Scopus)

Understanding the Words of Chromatin Regulation

Wu, J. I., Lessard, J. & Crabtree, G. R., Jan 23 2009, In : Cell. 136, 2, p. 200-206 7 p.

Research output: Contribution to journalArticle

Histone Code
Chromatin Assembly and Disassembly
Chromatin
Histones
2008
162 Citations (Scopus)

Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis

Stankunas, K., Hang, C. T., Tsun, Z. Y., Chen, H., Lee, N. V., Wu, J. I., Shang, C., Bayle, J. H., Shou, W., Iruela-Arispe, M. L. & Chang, C. P., Feb 12 2008, In : Developmental Cell. 14, 2, p. 298-311 14 p.

Research output: Contribution to journalArticle

Endocardium
Morphogenesis
Chromatin
Secreted Matrix Metalloproteinases
Chromatin Assembly and Disassembly
35 Citations (Scopus)

Heterotrimeric G Proteins Regulate a Noncanonical Function of Septate Junction Proteins to Maintain Cardiac Integrity in Drosophila

Yi, P., Johnson, A. N., Han, Z., Wu, J. & Olson, E. N., Nov 11 2008, In : Developmental Cell. 15, 5, p. 704-713 10 p.

Research output: Contribution to journalArticle

Heterotrimeric GTP-Binding Proteins
Drosophila
Gene Regulatory Networks
Cell adhesion
Cell Adhesion
2007
418 Citations (Scopus)

An Essential Switch in Subunit Composition of a Chromatin Remodeling Complex during Neural Development

Lessard, J., Wu, J. I., Ranish, J. A., Wan, M., Winslow, M. M., Staahl, B. T., Wu, H., Aebersold, R., Graef, I. A. & Crabtree, G. R., Jul 19 2007, In : Neuron. 55, 2, p. 201-215 15 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Neural Stem Cells
Stem Cells
Neuroglia
Proteomics

Erratum: Nuclear actin as choreographer of cell morphology and transcription (Science (1710))

Wu, J. I. & Crabtree, G. R., Sep 21 2007, In : Science. 317, 5845, p. 1682 1 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Nuclear actin as choreographer of cell morphology and transcription

Wu, J. I. & Crabtree, G. R., Jun 22 2007, In : Science. 316, 5832, p. 1710-1711 2 p.

Research output: Contribution to journalArticle

Cytoskeleton
Actins
Gene Expression
245 Citations (Scopus)

Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes

Wu, J. I., Lessard, J., Olave, I. A., Qiu, Z., Ghosh, A., Graef, I. A. & Crabtree, G. R., Oct 4 2007, In : Neuron. 56, 1, p. 94-108 15 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Actins
Neurons
Essential Genes
Genes
8 Citations (Scopus)

Targeted disruption of Mib2 causes exencephaly with a variable penetrance

Wu, J. I., Rajendra, R., Barsi, J. C., Durfee, L., Benito, E., Gao, G., Kuruvilla, M., Hrdličková, R., Liss, A. S. & Artzt, K., Nov 2007, In : Genesis. 45, 11, p. 722-727 6 p.

Research output: Contribution to journalArticle

Neural Tube Defects
Penetrance
Notch Receptors
Neural Tube
Ligases
2 Citations (Scopus)

tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury

Wu, J. I., Centilli, M. A., Vasquez, G., Young, S., Scolnick, J., Durfee, L. A., Spearow, J. L., Schwantz, S. D., Rennebeck, G. & Artzt, K., Oct 2007, In : Genetics. 177, 2, p. 1151-1161 11 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 17
Tail
Genes
Nucleic Acid Regulatory Sequences
2005
54 Citations (Scopus)

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling

Barsi, J. C., Rajendra, R., Wu, J. I. & Artzt, K., Oct 2005, In : Mechanisms of Development. 122, 10, p. 1106-1117 12 p.

Research output: Contribution to journalArticle

Notch1 Receptor
Ubiquitin-Protein Ligases
Neurogenesis
Ligases
Ubiquitin
2004
55 Citations (Scopus)
Serum Response Factor
Transcription Factors
Cell Movement
Mesoderm
Imaginal Discs
2002
24 Citations (Scopus)

A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication

Raghavendar Reddy, T., Suhasini, M., Xu, W., Yeh, L. Y., Yang, J. P., Wu, J., Artzt, K. & Wong-Staal, F., Feb 22 2002, In : Journal of Biological Chemistry. 277, 8, p. 5778-5784 7 p.

Research output: Contribution to journalArticle

Response Elements
HIV
Chloramphenicol O-Acetyltransferase
Proteins
Viruses
132 Citations (Scopus)

Function of quaking in myelination: Regulation of alternative splicing

Wu, J. I., Reed, R. B., Grabowski, P. J. & Artzt, K., Apr 2 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4233-4238 6 p.

Research output: Contribution to journalArticle

Alternative Splicing
Myelin-Associated Glycoprotein
RNA Precursors
Quaking Mice
Heterogeneous-Nuclear Ribonucleoprotein K
1999
74 Citations (Scopus)

Genomic organization and expression analysis of the mouse qkI locus

Kondo, T., Furuta, T., Mitsunaga, K., Ebersole, T. A., Shichiri, M., Wu, J., Artzt, K., Yamamura, K. I. & Abe, K., 1999, In : Mammalian Genome. 10, 7, p. 662-669 8 p.

Research output: Contribution to journalArticle

Exons
3' Untranslated Regions
Protein Isoforms
Transcription Initiation Site
Brain
95 Citations (Scopus)

The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm

Wu, J., Zhou, L., Tonissen, K., Tee, R. & Artzt, K., Oct 8 1999, In : Journal of Biological Chemistry. 274, 41, p. 29202-29210 9 p.

Research output: Contribution to journalArticle

Nuclear Localization Signals
Signal transduction
Cytoplasm
Signal Transduction
RNA
95 Citations (Scopus)

T-STAR/ETOILE: A novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis

Venables, J. P., Vernet, C., Chew, S. L., Elliott, D. J., Cowmeadow, R. B., Wu, J., Cooke, H. J., Artzt, K. & Eperon, I. C., 1999, In : Human Molecular Genetics. 8, 6, p. 959-969 11 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Spermatogenesis
Germ Cells
Testis
Heterogeneous-Nuclear Ribonucleoproteins