Research Output 1954 2020

2020

Signal transduction from small particles: Sulfur nanodots featuring mercury sensing, cell entry mechanism and in vitro tracking performance

Qiao, G., Liu, L., Hao, X., Zheng, J., Liu, W., Gao, J., Zhang, C. C. & Wang, Q., Feb 15 2020, In : Chemical Engineering Journal. 382, 122907.

Research output: Contribution to journalArticle

Signal transduction
Mercury
Sulfur
Semiconductor quantum dots
fluorescence
2019

2020 Herbert Tabor Early Career Investigator Awards: Call for nominations

Gierasch, L. M. & DeMartino, G. N., Jan 1 2019, In : Journal of Biological Chemistry. 294, 36, 1 p.

Research output: Contribution to journalEditorial

Open Access
Research Personnel
2 Citations (Scopus)

Acute Kidney Injury After Burn: A Cohort Study From the Parkland Burn Intensive Care Unit

Clark, A. T., Li, X., Kulangara, R., Huet, B. A., Huen, S., Madni, T. D., Imran, J. B., Phelan, H., Arnoldo, B. D., Moe, O. W., Wolf, S. E. & Neyra, J. A., Jan 1 2019, In : Journal of burn care & research : official publication of the American Burn Association. 40, 1, p. 72-78 7 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Intensive Care Units
Cohort Studies
Body Surface Area
Hospital Mortality
1 Citation (Scopus)

Aggregation-induced-emission (AIE) directed assembly of a novel responsive nanoprobe for dual targets sensing

Zhou, Z., Li, X., Zhang, Y., Zhang, C., Tang, Y., Gao, J., Ma, L. & Wang, Q., Jun 1 2019, In : Materials Science and Engineering C. 99, p. 1092-1098 7 p.

Research output: Contribution to journalArticle

Nanoprobes
sulfonates
Agglomeration
assembly
Sodium

Amyloid β perturbs elevated heme flux induced with neuronal development

Vidal, C., Daescu, K., Fitzgerald, K. E., Starokadomska, A., Bezprozvanny, I. & Zhang, L., Jan 1 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 27-37 11 p.

Research output: Contribution to journalArticle

Heme
Amyloid
Alzheimer Disease
Enzymes
Respiration
Permeability
Anti-Bacterial Agents
Membranes
Microbial Viability
Mycobacterium smegmatis

Analysis of Phosphatidylinositol Transfer at ER-PM Junctions in Receptor-Stimulated Live Cells

Chang, C. L. & Liou, J., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1949, p. 1-11 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Endoplasmic Reticulum
Cell Membrane
Phospholipid Transfer Proteins
Spatio-Temporal Analysis

Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease

Chernyuk, D., Zernov, N., Kabirova, M., Bezprozvanny, I. & Popugaeva, E., Jul 1 2019, In : Neuroscience. 410, p. 118-127 10 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Agaricales
Calcium
Neurons
Spine
2 Citations (Scopus)
Hedgehogs
Zinc Fingers
Transcription
Proteomics
Modulators

Author Correction: TMEM16F activation by Ca 2+ triggers plasma membrane expansion and directs PD-1 trafficking (Scientific Reports, (2019), 9, 1, (619), 10.1038/s41598-018-37056-x)

Bricogne, C., Fine, M., Pereira, P. M., Sung, J., Tijani, M., Wang, Y., Henriques, R., Collins, M. K. & Hilgemann, D. W., Dec 1 2019, In : Scientific Reports. 9, 1, 7705.

Research output: Contribution to journalComment/debate

Open Access
Cell Membrane

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Sep 1 2019, In : Nature genetics. 51, 9, p. 1423-1424 2 p.

Research output: Contribution to journalComment/debate

Open Access
Meta-Analysis
Immunity
Alzheimer Disease
Lipids
1 Citation (Scopus)

Biocompatible Nanoplatform Based on Mussel Adhesive Chemistry: Effective Assembly, Dual Mode Sensing, and Cellular Imaging Performance

Wu, N., Yu, A., Zhang, L., Liu, W., Gao, J., Zhang, C. & Zheng, Y., Jan 1 2019, In : Advanced Materials Interfaces. 1900732.

Research output: Contribution to journalArticle

Silver
Nanoparticles
Imaging techniques
Condensation reactions
T-cells
2 Citations (Scopus)

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

Jakkamsetti, V., Marin-Valencia, I., Ma, Q., Good, L. B., Terrill, T., Rajasekaran, K., Pichumani, K., Khemtong, C., Hooshyar, M. A., Sundarrajan, C., Patel, M. S., Bachoo, R., Malloy, C. R. & Pascual, J. M., Jan 1 2019, In : Science Translational Medicine. 11, 480, aan0457.

Research output: Contribution to journalArticle

Pyruvate Dehydrogenase Complex Deficiency Disease
Citric Acid Cycle
Brain
Glutamic Acid
Pyruvic Acid

Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations

Kim, S., Zeng, W., Bernard, S., Liao, J., Venkateshwaran, M., Ane, J. M. & Jiang, Y., Dec 1 2019, In : Nature communications. 10, 1, 3703.

Research output: Contribution to journalArticle

Open Access
regulators
Binding Sites
infectious diseases
Large-Conductance Calcium-Activated Potassium Channels
Symbiosis

Celebrating science’s next generation

Gierasch, L. M. & De Martino, G., Jan 1 2019, In : Journal of Biological Chemistry. 294, 9, p. 3323-3324 2 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Cell-Specific Loss of SNAP25 from Cortical Projection Neurons Allows Normal Development but Causes Subsequent Neurodegeneration

Hoerder-Suabedissen, A., Korrell, K. V., Hayashi, S., Jeans, A., Ramirez, D. M. O., Grant, E., Christian, H. C., Kavalali, E. T., Wilson, M. C. & Molnár, Z., May 1 2019, In : Cerebral cortex (New York, N.Y. : 1991). 29, 5, p. 2148-2159 12 p.

Research output: Contribution to journalArticle

Synaptosomal-Associated Protein 25
Synaptic Vesicles
Neurons
SNARE Proteins
Lipofuscin

CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D. H., Kim, J., Hyun Hwang, T. & Lum, L., Dec 1 2019, In : Nature communications. 10, 1, 4056.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
mutagenesis
deletion
Mutagenesis
insertion

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

Li, J., Shang, G., Chen, Y. J., Brautigam, C. A., Liou, J., Zhang, X. & Bai, X. C., Sep 2019, In : eLife. 8, e47650.

Research output: Contribution to journalArticle

Open Access
Chemical activation
Ligands
Glial Cell Line-Derived Neurotrophic Factor
Phosphorylation
Dimerization
2 Citations (Scopus)

Derivatives of piperazines as potential therapeutic agents for Alzheimer’s disease

Popugaeva, E., Chernyuk, D., Zhang, H., Postnikova, T. Y., Pats, K., Fedorova, E., Poroikov, V., Zaitsev, A. V. & Bezprozvanny, I., Apr 1 2019, In : Molecular Pharmacology. p. 337-348 12 p.

Research output: Contribution to journalArticle

Piperazines
Alzheimer Disease
Neuroprotective Agents
Spine
Therapeutics

Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development

Gui, X., Deng, M., Song, H., Chen, Y., Xie, J., Li, Z., He, L., Huang, F., Xu, Y., Anami, Y., Yu, H., Yu, C., Li, L., Yuan, Z., Xu, X., Wang, Q., Chai, Y., Huang, T., Shi, Y., Tsuchikama, K. & 6 others, Charlene Liao, X., Xia, N., Gao, G. F., Zhang, N., Zhang, C. C. & An, Z., Jan 1 2019, In : Cancer Immunology Research. 7, 8, p. 1244-1257 14 p.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Acute Myeloid Leukemia
Immunoglobulins
Leukocytes
T-Lymphocytes

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang Ph.D., D-W., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptors
Regulatory T-Lymphocytes
Colitis
Dendritic Cells
3 Citations (Scopus)
Reflex
Exercise
Type 2 Diabetes Mellitus
Arterial Pressure
Kidney

FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora

Liu, X., Chen, A., Caicedo-Casso, A., Cui, G., Du, M., He, Q., Lim, S., Kim, H. J., Hong, C. I. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 4352.

Research output: Contribution to journalArticle

Open Access
neurospora
circadian rhythms
Neurospora
Circadian Clocks
Circadian Rhythm
1 Citation (Scopus)

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L. G., Faubert, B., Vu, H. S., Jiang, L., Ko, B., Morales, N. M., Pei, J., Dias do Vale, G., Rakheja, D., Grishin, N. V., McDonald, J. G., Gotway, G. K. & 3 others, McNutt, M. C., Pascual, J. M. & DeBerardinis, R. J., Apr 30 2019, In : Cell Reports. 27, 5, p. 1376-1386.e6

Research output: Contribution to journalArticle

Open Access
Functional assessment
Inborn Errors Metabolism
Metabolomics
Genomics
Metabolism
38 Citations (Scopus)

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In : Nature genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journalArticle

Meta-Analysis
Immunity
Alzheimer Disease
Lipids
Serum Amyloid A Protein
3 Citations (Scopus)

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Peri-Okonny, P., Baskin, K. K., Iwamoto, G. A., Mitchell, J. H., Smith, S. A., Kim, H. K., Szweda, L. I., Bassel-Duby, R. S., Fujikawa, T., Castorena, C. M., Richardson, J. A., Shelton, J. M., Ayers, C., Berry, J. D., Malladi, V. S., Hu, M. C., Moe, O. W., Scherer, P. E. & Vongpatanasin, W., Mar 12 2019, In : Circulation. 139, 11, p. 1422-1434 13 p.

Research output: Contribution to journalArticle

Fatty Acids
Phosphates
Diet
Skeletal Muscle Fibers
Serum
1 Citation (Scopus)
Transient Receptor Potential Channels
Cations
Amphibian Proteins
Mutation
TRPV Cation Channels
Open Access
Diglycerides
Ouabain
Cardiac Myocytes
Hypertrophy
Feedback
4 Citations (Scopus)

Increased production and reduced urinary buffering of acid in uric acid stone formers is ameliorated by pioglitazone

Maalouf, N. M., Poindexter, J. R., Huet, B. A., Moe, O. W. & Sakhaee, K., May 1 2019, In : Kidney international. 95, 5, p. 1262-1268 7 p.

Research output: Contribution to journalArticle

pioglitazone
Uric Acid
Nephrolithiasis
Acids
Urine

Insulin potentiates the response to mechanical stimuli in small dorsal root ganglion neurons and thin fibre muscle afferents in vitro

Hotta, N., Katanosaka, K., Mizumura, K., Iwamoto, G. A., Ishizawa, R., Kim, H. K., Vongpatanasin, W., Mitchell, J. H., Smith, S. A. & Mizuno, M., Oct 1 2019, In : Journal of Physiology. 597, 20, p. 5049-5062 14 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Insulin
Neurons
Muscles
Sympathetic Nervous System
1 Citation (Scopus)

Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets

Rasmussen, T., Rasmussen, A., Yang, L., Kaul, C., Black, S., Galbiati, H., Conway, S. J., Miller, S., Blount, P. & Booth, I. R., Jan 1 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

Open Access
Lipid Bilayers
Lipids
Membranes
Cardiolipins
Membrane Lipids

In vitro monitoring of glutathione via a switched-on effect based on a lanthanide incorporated carbon nanostructure with biocompatibility

Wen, Q., Zeng, Z., Liu, W., Gao, J., Zhang, H. M., Zhang, C. C. & Zheng, Y., Nov 2019, In : Synthetic Metals. 257, 116183.

Research output: Contribution to journalArticle

Europium
Lanthanoid Series Elements
glutathione
biocompatibility
europium
Open Access
Acute Kidney Injury
Thoracic Surgery
Biomarkers
Kidney
Cardiopulmonary Bypass
3 Citations (Scopus)

Legal and ethical implications of defining an optimum means of achieving unconsciousness in assisted dying

Sinmyee, S., Pandit, V. J., Pascual, J. M., Dahan, A., Heidegger, T., Kreienbühl, G., Lubarsky, D. A. & Pandit, J. J., May 1 2019, In : Anaesthesia. 74, 5, p. 630-637 8 p.

Research output: Contribution to journalArticle

Open Access
Unconsciousness
Capital Punishment
Intraoperative Awareness
General Anesthetics
Helium

Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution

Chakraborty, T., Driscoll, M. K., Jeffery, E., Murphy, M. M., Roudot, P., Chang, B. J., Vora, S., Wong, W. M., Nielson, C. D., Zhang, H., Zhemkov, V., Hiremath, C., De La Cruz, E. D., Yi, Y., Bezprozvanny, I., Zhao, H., Tomer, R., Heintzmann, R., Meeks, J. P., Marciano, D. K. & 4 others, Morrison, S. J., Danuser, G., Dean, K. M. & Fiolka, R., Nov 1 2019, In : Nature methods. 16, 11, p. 1109-1113 5 p.

Research output: Contribution to journalArticle

Microscopy
Microscopic examination
Tissue
Light
Immersion

Light stimulation parameters determine neuron dynamic characteristics

Erofeev, A., Gerasimov, E., Lavrova, A., Bolshakova, A., Postnikov, E., Bezprozvanny, I. & Vlasova, O. L., Sep 1 2019, In : Applied Sciences (Switzerland). 9, 18, 3673.

Research output: Contribution to journalArticle

Open Access
neurons
stimulation
dynamic characteristics
Neurons
Halorhodopsins

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang Ph.D., D-W., Fang, B., Russell, J., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 others, Moresco, E. Y. & Beutler, B., Jan 1 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

Lymphopoiesis
Catenins
Wnt2 Protein
Ethylnitrosourea
Wnt Signaling Pathway

Low serum magnesium is associated with faster decline in kidney function: The Dallas Heart Study experience

Ferrè, S., Li, X., Huet, B. A., Maalouf, N. M., Sakhaee, K., Toto, R. D., Moe, O. W. & Neyra, J. A., Jan 1 2019, In : Journal of Investigative Medicine.

Research output: Contribution to journalArticle

Magnesium
Glomerular Filtration Rate
Medical problems
Kidney
Serum

Mechanism of action of the new ethanolamine derivative bis{2-[(2E)-4-hydroxy-4-oxobut-2-enoyloxy]-N,N-diethylethanaminium}butanedioate

Sysoev, Y. I., Popugaeva, E. A., Chernyuk, D. P., Titovich, I. A., Zagladkina, E. V., Bolotova, V. C., Bezprozvanny, I. & Okovityi, S. V., Jan 1 2019, In : Eksperimental'naya i Klinicheskaya Farmakologiya. 82, 4, p. 3-10 8 p.

Research output: Contribution to journalArticle

Ethanolamine
Dendritic Spines
Calcium
Derivatives
Cytidine Diphosphate Choline
2 Citations (Scopus)

Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche

Hao, X., Gu, H., Chen, C., Huang, D., Zhao, Y., Xie, L., Zou, Y., Shu, H. S., Zhang, Y., He, X., Lai, X., Zhang, X., Zhou, B. O., Zhang, C., Chen, G. Q., Yu, Z., Yang, Y. & Zheng, J., Apr 2 2019, In : Cell Metabolism. 29, 4, p. 950-965.e6

Research output: Contribution to journalArticle

Cell Division
Leukemia
Glycolysis
Acute Myeloid Leukemia
Stem Cells

Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2

Egorova, P. A. & Bezprozvanny, I., Jan 1 2019, (Accepted/In press) In : Neurotherapeutics.

Research output: Contribution to journalReview article

Spinocerebellar Ataxias
Therapeutics
Inborn Genetic Diseases
Palliative Care

Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

Ryskamp, D. A., Zhemkov, V. & Bezprozvanny, I., Sep 19 2019, In : Frontiers in Neuroscience. 13, 1012.

Research output: Contribution to journalArticle

Open Access
Agaricales
Spine
sigma-1 receptor
Clustered Regularly Interspaced Short Palindromic Repeats
Presenilin-1

Myristoylation-Dependent Palmitoylation of the Receptor Tyrosine Kinase Adaptor FRS2α

Barylko, B., Chen, Y. J., Hennen, J., Angert, I., Chen, Y., Mueller, J. D., Sun, H. Q., Taylor, C. A., Liou, J., Yin, H. & Albanesi, J. P., Jun 25 2019, In : Biochemistry. 58, 25, p. 2809-2813 5 p.

Research output: Contribution to journalArticle

Lipoylation
Receptor Protein-Tyrosine Kinases
Fibroblast Growth Factor Receptors
Substrates
Tyrosine
2 Citations (Scopus)

Net Acid Excretion and Urinary Organic Anions in Idiopathic Uric Acid Nephrolithiasis

Bobulescu, I. A., Park, S. K., Xu, L. H. R., Blanco, F., Poindexter, J., Huet, B. A., Davidson, T. L., Sakhaee, K., Maalouf, N. M. & Moe, O. W., Mar 7 2019, In : Clinical journal of the American Society of Nephrology : CJASN. 14, 3, p. 411-420 10 p.

Research output: Contribution to journalArticle

Nephrolithiasis
Uric Acid
Anions
Acids
Urine

Neuronal sigma-1 receptors: Signaling functions and protective roles in neurodegenerative diseases

Ryskamp, D. A., Korban, S., Zhemkov, V., Kraskovskaya, N. & Bezprozvanny, I., Jan 1 2019, In : Frontiers in Neuroscience. 13, AUG, 862.

Research output: Contribution to journalReview article

Open Access
Neurodegenerative Diseases
Endoplasmic Reticulum
Mitochondrial Membranes
Ion Channels
sigma-1 receptor

On the existence of endocytosis driven by membrane phase separations

Hilgemann, D. W., Lin, M. J., Fine, M. & Deisl, C., Jan 1 2019, In : Biochimica et Biophysica Acta - Biomembranes.

Research output: Contribution to journalReview article

Open Access
Endocytosis
Phase separation
Membranes
Dynamins
Clathrin
Cholesterol
Cyclodextrins
Small Intestine
Sterol O-Acyltransferase
Glycosphingolipids

Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling

Han, Y., Wang, B., Cho, Y. S., Zhu, J., Wu, J., Chen, Y. & Jiang, J., Sep 9 2019, In : Developmental Cell. 50, 5, p. 610-626.e4

Research output: Contribution to journalArticle

Phosphorylation
Phosphotransferases
Hordeolum
Transcription Factors
Neuroglia
4 Citations (Scopus)

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor

Ryskamp, D., Wu, L., Wu, J., Kim, D., Rammes, G., Geva, M., Hayden, M. & Bezprozvanny, I., Apr 1 2019, In : Neurobiology of Disease. 124, p. 489-504 16 p.

Research output: Contribution to journalArticle

Agaricales
Alzheimer Disease
Spine
Presenilin-1
Calcium

Publisher Correction: Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations (Nature Communications, (2019), 10, 1, (3703), 10.1038/s41467-019-11698-5)

Kim, S., Zeng, W., Bernard, S., Liao, J., Venkateshwaran, M., Ane, J. M. & Jiang, Y., Dec 1 2019, In : Nature communications. 10, 1, 4607.

Research output: Contribution to journalComment/debate

Open Access
Typesetting
communication
document markup languages
HTML
rings