Research output per year
Research output per year
- 1 - 50 out of 476 results
Search results
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2024
Leptin Reduction as a Required Component for Weight Loss
Zhao, S., Li, N., Xiong, W., Li, G., He, S., Zhang, Z., Zhu, Q., Jiang, N., Ikejiofor, C., Zhu, Y., Wang, M. Y., Han, X., Zhang, N., Solis-Herrera, C., Kusminski, C., An, Z., Elmquist, J. K. & Scherer, P. E., Feb 2024, In: Diabetes. 73, 2, p. 197-210 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis
Ursino, G., Ramadori, G., Höfler, A., Odouard, S., Teixeira, P. D. S., Visentin, F., Veyrat-Durebex, C., Lucibello, G., Firnkes, R., Ricci, S., Vianna, C. R., Jia, L., Dirlewanger, M., Klee, P., Elmquist, J. K., Roth, J., Vogl, T., Schwitzgebel, V. M., Jornayvaz, F. R., Boland, A., & 1 others, Dec 2022, In: Nature communications. 13, 1, 4107.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90
Alzheimer's Disease Genetics Consortium, Dec 2022, In: Scientific reports. 12, 1, 6117.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Mechanisms of Homeostatically Regulated Behaviors
Elmquist, J. K., Zigman, J. M. & Saper, C. B., Jan 1 2022, Neuroscience in the 21st Century: From Basic to Clinical: Third Edition. Springer International Publishing, p. 2415-2443 29 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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New insights into the genetic etiology of Alzheimer’s disease and related dementias
EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC & CHARGE, Apr 1 2022, In: Nature genetics. 54, 4, p. 412-436 25 p.Research output: Contribution to journal › Article › peer-review
Open Access520 Scopus citations -
Obesity: an evolutionary context
Speakman, J. R. & Elmquist, J. K., Aug 1 2022, In: Life Metabolism. 1, 1, p. 10-24 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access13 Scopus citations -
Response to Kunos et al. and Lotersztajn and Mallat
Wang, S., Zhu, Q., Liang, G., Franks, T., Boucher, M., Bence, K. K., Lu, M., Castorena, C. M., Zhao, S., Elmquist, J. K., Scherer, P. E. & Horton, J. D., Jan 4 2022, In: Journal of Clinical Investigation. 132, 1, e156247.Research output: Contribution to journal › Letter › peer-review
Open Access2 Scopus citations -
2021
Cannabinoid receptor 1 signaling in hepatocytes and stellate cells does not contribute to NAFLD
Wang, S., Zhu, Q., Liang, G., Franks, T., Boucher, M., Bence, K. K., Lu, M., Castorena, C. M., Zhao, S., Elmquist, J. K., Scherer, P. E. & Horton, J. D., Nov 15 2021, In: Journal of Clinical Investigation. 131, 22, e152242.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
CB1Rs in VMH neurons regulate glucose homeostasis but not body weight
Castorena, C. M., Caron, A., Michael, N. J., Ahmed, N. I., Arnold, A. G., Lee, J., Lee, C., Limboy, C., Tinajero, A. S., Granier, M., Wang, S., Horton, J. D., Holland, W. L., Lee, S., Liu, C., Fujikawa, T. & Elmquist, J. K., Jul 2021, In: American Journal of Physiology - Endocrinology and Metabolism. 321, 1, p. E146–E155Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Comparison of inflammatory markers as moderators of depression outcomes: A CO-MED study
Czysz, A., Mason, B. L., Li, Q., Chin-Fatt, C., Minhajuddin, A., Carmody, T. & Trivedi, M. H., Dec 1 2021, In: Journal of affective disorders. 295, p. 1066-1071 6 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions
Gupta, D., Patterson, A. M., Osborne-Lawrence, S., Bookout, A. L., Varshney, S., Shankar, K., Singh, O., Metzger, N. P., Richard, C. P., Wyler, S. C., Elmquist, J. K. & Zigman, J. M., Nov 2021, In: Molecular Metabolism. 53, 101258.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
The effectiveness of enhanced evidence-based care for depressive disorders: a meta-analysis of randomized controlled trials
Xiao, L., Qi, H., Zheng, W., Xiang, Y. T., Carmody, T. J., Mayes, T. L., Trivedi, M. H. & Wang, G., Dec 2021, In: Translational psychiatry. 11, 1, 531.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
TLR4 signaling selectively and directly promotes CGRP release from Vagal afferents in the mouse
Jia, L., Lee, S., Tierney, J. A., Elmquist, J. K., Burton, M. D. & Gautron, L., Jan 1 2021, In: eNeuro. 8, 1, p. 1-16 16 p., ENEURO.0254-20.2020.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2020
Combined Loss of Ghrelin Receptor and Cannabinoid CB1 Receptor in Mice Decreases Survival but does not Additively Reduce Body Weight or Eating
Mani, B. K., Castorena, C. M., Vianna, C. R., Lee, C. E., Metzger, N. P., Vijayaraghavan, P., Osborne-Lawrence, S., Elmquist, J. K. & Zigman, J. M., Nov 1 2020, In: Neuroscience. 447, p. 53-62 10 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Coordination of metabolism, arousal, and reward by orexin/hypocretin neurons
Michael, N. J. & Elmquist, J. K., Sep 1 2020, In: Journal of Clinical Investigation. 130, 9, p. 4540-4542 3 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Electrophysiological Properties of Genetically Identified Histaminergic Neurons
Michael, N. J., Zigman, J. M., Williams, K. W. & Elmquist, J. K., Sep 15 2020, In: Neuroscience. 444, p. 183-195 13 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
The Alzheimer’s Disease Genetics Consortium, Dec 1 2020, In: Nature communications. 11, 1, 667.Research output: Contribution to journal › Article › peer-review
Open Access218 Scopus citations -
Leptin: Less is more
Zhao, S., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., May 1 2020, In: Diabetes. 69, 5, p. 823-829 7 p.Research output: Contribution to journal › Article › peer-review
Open Access72 Scopus citations -
Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors
Michael, N. J., Caron, A., Lee, C. E., Castorena, C. M., Lee, S., Zigman, J. M., Williams, K. W. & Elmquist, J. K., May 2020, In: Molecular Metabolism. 35, 100956.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Partial leptin deficiency confers resistance to diet-induced obesity in mice
Zhao, S., Li, N., Zhu, Y., Straub, L., Zhang, Z., Wang, M. Y., Zhu, Q., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., Jul 2020, In: Molecular Metabolism. 37, 100995.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity
Shan, B., Shao, M., Zhang, Q., Hepler, C., Paschoal, V. A., Barnes, S. D., Vishvanath, L., An, Y. A., Jia, L., Malladi, V. S., Strand, D. W., Gupta, O. T., Elmquist, J. K., Oh, D. & Gupta, R. K., Nov 2020, In: Nature Metabolism. 2, 11, p. 1332-1349 18 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
2019
Anxiety and anhedonia in depression: Associations with neuroticism and cognitive control
Liao, A., Walker, N. R., Carmody, T. J., Cooper Cortes, C., Shaw, M. A., Grannemann, B. D., Adams, P., Bruder, G. E., McInnis, M. G., Webb, C. A., Dillon, D. G., Pizzagalli, D. A., Phillips, M. L., Kurian, B. T., Fava, M., Parsey, R. V., McGrath, P. J., Weissman, M. M. & Trivedi, M. H., Feb 15 2019, In: Journal of affective disorders. 245, p. 1070-1078 9 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)
Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Sep 1 2019, In: Nature genetics. 51, 9, p. 1423-1424 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access44 Scopus citations -
Erratum: Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction (Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction (2011) 14(4) (453–465), (S1550413111003391), (10.1016/j.cmet.2011.08.009))
Xu, Y., Nedungadi, T. P., Zhu, L., Sobhani, N., Irani, B. G., Davis, K. E., Zhang, X., Zou, F., Gent, L. M., Hahner, L. D., Khan, S. A., Elias, C. F., Elmquist, J. K. & Clegg, D. J., May 7 2019, In: Cell Metabolism. 29, 5, p. 1232 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access8 Scopus citations -
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In: Nature genetics. 51, 3, p. 414-430 17 p.Research output: Contribution to journal › Article › peer-review
Open Access1488 Scopus citations -
NURR1 activation in skeletal muscle controls systemic energy homeostasis
Amoasii, L., Sanchez-Ortiz, E., Fujikawa, T., Elmquist, J. K., Bassel-Duby, R. & Olson, E. N., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11299-11308 10 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver
Cappel, D. A., Deja, S., Duarte, J. A. G., Kucejova, B., Iñigo, M., Fletcher, J. A., Fu, X., Berglund, E. D., Liu, T., Elmquist, J. K., Hammer, S., Mishra, P., Browning, J. D. & Burgess, S. C., Jun 4 2019, In: Cell Metabolism. 29, 6, p. 1291-1305.e8Research output: Contribution to journal › Article › peer-review
Open Access116 Scopus citations -
The Concise Health Risk Tracking Self-Report (CHRT-SR) assessment of suicidality in depressed outpatients: A psychometric evaluation
De La Garza, N., Rush, A. J., Killian, M. O., Grannemann, B. D., Carmody, T. J. & Trivedi, M. H., Apr 2019, In: Depression and anxiety. 36, 4, p. 313-320 8 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2018
A complier average causal effect analysis of the Stimulant Reduction Intervention using dosed exercise study
Carmody, T., Greer, T. L., Walker, R., Rethorst, C. D. & Trivedi, M. H., Jun 2018, In: Contemporary Clinical Trials Communications. 10, p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
A psychometric evaluation of the Concise Health Risk Tracking Self-Report (CHRT-SR)- a measure of suicidality-in patients with stimulant use disorder
Sanchez, K., Killian, M. O., Mayes, T. L., Greer, T. L., Trombello, J. M., Lindblad, R., Grannemann, B. D., Carmody, T. J., Rush, A. J., Walker, R. & Trivedi, M. H., Jul 2018, In: Journal of Psychiatric Research. 102, p. 65-71 7 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Characterizing anxiety subtypes and the relationship to behavioral phenotyping in major depression: Results from the EMBARC study
Trombello, J. M., Pizzagalli, D. A., Weissman, M. M., Grannemann, B. D., Cooper, C. M., Greer, T. L., Malchow, A. L., Jha, M. K., Carmody, T. J., Kurian, B. T., Webb, C. A., Dillon, D. G., McGrath, P. J., Bruder, G., Fava, M., Parsey, R. V., McInnis, M. G., Adams, P. & Trivedi, M. H., Jul 2018, In: Journal of Psychiatric Research. 102, p. 207-215 9 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance
Mountjoy, K. G., Caron, A., Hubbard, K., Shome, A., Grey, A. C., Sun, B., Bould, S., Middleditch, M., Pontré, B., McGregor, A., Harris, P. W. R., Kowalczyk, R., Brimble, M. A., Botha, R., Tan, K. M. L., Piper, S. J., Buchanan, C., Lee, S., Coll, A. P. & Elmquist, J. K., Mar 2018, In: Molecular Metabolism. 9, p. 207-216 10 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
ARUK Consortium, GERAD/PERADES, CHARGE, ADGC, EADI, International Genomics of Alzheimer's Project (IGAP), ARUK Consortium & GERAD/PERADES, CHARGE, ADGC, EADI, Jan 1 2018, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 595-598 4 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Ghrelin mediates exercise endurance and the feeding response post-exercise
Mani, B. K., Castorena, C. M., Osborne-Lawrence, S., Vijayaraghavan, P., Metzger, N. P., Elmquist, J. K. & Zigman, J. M., Mar 2018, In: Molecular Metabolism. 9, p. 114-130 17 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease
Jia, L., Chang, X., Qian, S., Liu, C., Lord, C. C., Ahmed, N., Lee, C. E., Lee, S., Gautron, L., Mitchell, M. C., Horton, J. D., Scherer, P. E. & Elmquist, J. K., Aug 2018, In: Molecular Metabolism. 14, p. 121-129 9 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Leptin and brain-adipose crosstalks
Caron, A., Lee, S., Elmquist, J. K. & Gautron, L., Feb 16 2018, In: Nature Reviews Neuroscience. 19, 3, p. 153-165 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access170 Scopus citations -
POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels
Caron, A., Lemko, H. M. D., Castorena, C. M., Fujikawa, T., Lee, S., Lord, C. C., Ahmed, N., Lee, C. E., Holland, W. L., Liu, C. & Elmquist, J. K., Mar 12 2018, In: eLife. 7, e33710.Research output: Contribution to journal › Article › peer-review
Open Access73 Scopus citations -
Pretreatment rostral anterior cingulate cortex theta activity in relation to symptom improvement in depression: A randomized clinical trial
Pizzagalli, D. A., Webb, C. A., Dillon, D. G., Tenke, C. E., Kayser, J., Goer, F., Fava, M., McGrath, P., Weissman, M., Parsey, R., Adams, P., Trombello, J., Cooper, C., Deldin, P., Oquendo, M. A., McInnis, M. G., Carmody, T., Bruder, G. & Trivedi, M. H., Jun 2018, In: JAMA Psychiatry. 75, 6, p. 547-554 8 p.Research output: Contribution to journal › Article › peer-review
Open Access109 Scopus citations -
Psychometric properties of the concise health risk tracking (CHRT) in adolescents with suicidality
Mayes, T. L., Kennard, B. D., Killian, M., Carmody, T., Grannemann, B. D., Rush, A. J., Jha, M. K., Hughes, J., Emslie, G. J. & Trivedi, M. H., Aug 1 2018, In: Journal of affective disorders. 235, p. 45-51 7 p.Research output: Contribution to journal › Review article › peer-review
30 Scopus citations -
Psychometrics of the self-report concise associated symptoms tracking scale (CAST-SR): Results from the STRIDE (CTN-0037) study
Trombello, J. M., Killian, M. O., Liao, A., Sanchez, K., Greer, T. L., Walker, R., Grannemann, B., Rethorst, C. D., Carmody, T. & Trivedi, M. H., Mar 1 2018, In: Journal of Clinical Psychiatry. 79, 2, p. 41-47 7 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Risk of amphetamine use disorder and mortality among incident users of prescribed stimulant medications in the Veterans Administration
Westover, A. N., Nakonezny, P. A., Halm, E. A. & Adinoff, B., May 2018, In: Addiction. 113, 5, p. 857-867 11 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau
Alzheimer's Disease Genetics Consortium and the Alzheimer's Disease Neuroimaging Initiative, Aug 1 2018, In: JAMA neurology. 75, 8, p. 989-998 10 p.Research output: Contribution to journal › Article › peer-review
Open Access193 Scopus citations -
Sex-specific genetic predictors of Alzheimer’s disease biomarkers
Alzheimer’S Disease Neuroimaging Initiative (Adni) & The Alzheimer Disease Genetics Consortium (Adgc), Dec 1 2018, In: Acta Neuropathologica. 136, 6, p. 857-872 16 p.Research output: Contribution to journal › Article › peer-review
Open Access69 Scopus citations -
Test-retest reliability of cerebral blood flow in healthy individuals using arterial spin labeling: Findings from the EMBARC study
Almeida, J. R. C., Greenberg, T., Lu, H., Chase, H. W., Fournier, J., Cooper, C. M., Deckersbach, T., Adams, P., Carmody, T., Fava, M., Kurian, B., McGrath, P. J., McInnis, M. G., Oquendo, M. A., Parsey, R., Weissman, M., Trivedi, M. & Phillips, M. L., Jan 2018, In: Magnetic Resonance Imaging. 45, p. 26-33 8 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
The Promoting Activity in Cancer Survivors (PACES) trial: A multiphase optimization of strategy approach to increasing physical activity in breast cancer survivors
Rethorst, C. D., Hamann, H. A., Carmody, T. J., Sharp, K. J., Argenbright, K. E., Haley, B. B., Skinner, C. S. & Trivedi, M. H., Jul 18 2018, In: BMC Cancer. 18, 1, 744.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2017
Accurately identifying patients who are excellent candidates or unsuitable for a medication: A novel approach
South, C., Rush, A., Carmody, T. J., Jha, M. K. & Trivedi, M. H., Dec 15 2017, In: Neuropsychiatric Disease and Treatment. 13, p. 3001-3010 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
An adipo-biliary-uridine axis that regulates energy homeostasis
Deng, Y., Wang, Z., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., De Brabander, J. K., Elmquist, J. K., Horton, J. D., Hill, J. A., Klein, S. & Scherer, P. E., Mar 17 2017, In: Science. 355, 6330, eaaf5375.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
Brain nuclear receptors and body weight regulation
Xu, Y., O'Malley, B. W. & Elmquist, J. K., Apr 3 2017, In: Journal of Clinical Investigation. 127, 4, p. 1172-1180 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access19 Scopus citations -
Effect of sertraline on depressive symptoms in patients with chronic kidney disease without dialysis dependence: The CAST randomized clinical trial
Hedayati, S. S., Gregg, L. P., Carmody, T., Jain, N., Toups, M., Rush, A. J., Toto, R. D. & Trivedi, M. H., Nov 21 2017, In: JAMA - Journal of the American Medical Association. 318, 19, p. 1876-1890 15 p.Research output: Contribution to journal › Article › peer-review
Open Access88 Scopus citations -
Exercise is an effective treatment for positive valence symptoms in major depression
Toups, M., Carmody, T., Greer, T., Rethorst, C., Grannemann, B. & Trivedi, M. H., Feb 1 2017, In: Journal of affective disorders. 209, p. 188-194 7 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations