Pul & Vas Biology

Research Output 1984 2019

12 Citations (Scopus)

17β-Estradiol dysregulates innate immune responses to Pseudomonas aeruginosa respiratory infection and is modulated by estrogen receptor antagonism

Abid, S., Xie, S. K., Bose, M., Shaul, P. W., Terada, L. S., Brody, S. L., Thomas, P. J., Katzenellenbogen, J. A., Kim, S. H., Greenberg, D. E. & Jain, R., 2017, In : Infection and Immunity. 85, 10, e00422-17.

Research output: Contribution to journalArticle

Innate Immunity
Respiratory Tract Infections
Estrogen Receptors
Pseudomonas aeruginosa
Estradiol
64 Citations (Scopus)

27-Hydroxycholesterol: The first identified endogenous SERM

Umetani, M. & Shaul, P. W., Apr 2011, In : Trends in Endocrinology and Metabolism. 22, 4, p. 130-135 6 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Physiologic Calcification
Bone Neoplasms
Systems Biology
Sterols
9 Citations (Scopus)
Extramedullary Hematopoiesis
Hematopoietic Stem Cell Mobilization
Pregnancy
Hematopoietic Stem Cells
Estrogen Receptors
155 Citations (Scopus)

27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator

DuSell, C. D., Umetani, M., Shaul, P. W., Mangelsdorf, D. J. & McDonnell, D. P., Jan 2008, In : Molecular Endocrinology. 22, 1, p. 65-77 13 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Estrogen Receptors
Ligands
Breast Neoplasms
Co-Repressor Proteins
233 Citations (Scopus)

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Umetani, M., Domoto, H., Gormley, A. K., Yuhanna, I. S., Cummins, C. L., Javitt, N. B., Korach, K. S., Shaul, P. W. & Mangelsdorf, D. J., Oct 2007, In : Nature Medicine. 13, 10, p. 1185-1192 8 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Estrogens
Blood Vessels
Hypercholesterolemia
Gene encoding
156 Citations (Scopus)

27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth

Wu, Q., Ishikawa, T., Sirianni, R., Tang, H., McDonald, J. G., Yuhanna, I. S., Thompson, B., Girard, L., Mineo, C., Brekken, R. A., Umetani, M., Euhus, D. M., Xie, Y. & Shaul, P. W., 2013, In : Cell Reports. 5, 3, p. 637-645 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Tumors
Growth
MCF-7 Cells
385 Citations (Scopus)

Abnormal vascular function and hypertension in mice deficient in estrogen receptor β

Zhu, Y., Bian, Z., Lu, P., Karas, R. H., Bao, L., Cox, D., Hodgin, J., Shaul, P. W., Thorén, P., Smithies, O., Gustafsson, J. Å. & Mendelsohn, M. E., Jan 18 2002, In : Science. 295, 5554, p. 505-508 4 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Blood Vessels
Hypertension
Multiple Abnormalities
Vasoconstriction
77 Citations (Scopus)

Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms

Shaul, P. W., Wells, L. B. & Horning, K. M., 1993, In : Journal of Cardiovascular Pharmacology. 22, 6, p. 819-827 9 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Nitric Oxide
Calcimycin
Nitric Oxide Synthase
Acetylcholine

Acylation targets endothelial nitric oxide synthase (enos) to plasmalemmal caveolae

Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I. S., Ying, Y., Andersonand, R. G. W. & Michel, T., 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Caveolae
Acylation
acylation
Nitric Oxide Synthase Type III
Cell membranes
1 Citation (Scopus)

Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae

Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I., Ying, Y., Anderson, R. G. W. & Michel, T., 1996, In : Journal of Investigative Medicine. 44, 3

Research output: Contribution to journalArticle

Caveolae
Acylation
Nitric Oxide Synthase Type III
Cell membranes
Citrulline
595 Citations (Scopus)

Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae

Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I. S., Ying, Y., Anderson, R. G. W. & Michel, T., Mar 15 1996, In : Journal of Biological Chemistry. 271, 11, p. 6518-6522 5 p.

Research output: Contribution to journalArticle

Caveolae
Acylation
Nitric Oxide Synthase Type III
Cell membranes
Cell Membrane
658 Citations (Scopus)

A detergent-free method for purifying caveolae membrane from tissue culture cells

Smart, E. J., Ying, Y. S., Mineo, C. & Anderson, R. G. W., Oct 24 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 22, p. 10104-10108 5 p.

Research output: Contribution to journalArticle

Caveolae
Detergents
Cell Culture Techniques
Membranes
Octoxynol
30 Citations (Scopus)

Advances in the treatment of persistent pulmonary hypertension of the newborn

Roberts, J. D. & Shaul, P. W., 1993, In : Pediatric Clinics of North America. 40, 5, p. 983-1004 22 p.

Research output: Contribution to journalArticle

Persistent Fetal Circulation Syndrome
Meconium Aspiration Syndrome
Aspiration Pneumonia
Pneumothorax
Sepsis
4 Citations (Scopus)

Anemia blunts the thermogenic response to environmental cold stress in newborn piglets

Mayfield, S. R., Shaul, P. W., Oh, W. & Stonestreet, B. S., 1987, In : Pediatric Research. 21, 5, p. 482-486 5 p.

Research output: Contribution to journalArticle

Anemia
Oxygen Consumption
Hypothermia
Temperature
Thermogenesis
45 Citations (Scopus)

Angiotensin II vascular smooth-muscle receptors are not down-regulated in near-term pregnant sheep

Mackanjee, H. R., Shaul, P. W., Magness, R. R. & Rosenfeld, C. R., 1991, In : American Journal of Obstetrics and Gynecology. 165, 6 PART 1, p. 1641-1648 8 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Angiotensin II
Sheep
Uterine Artery
Mesenteric Arteries

A Novel Proangiogenic Function of Fsp27 in Endothelium: You Only Live Thrice?

Mineo, C., Jun 4 2019, In : Journal of the American Heart Association. 8, 11, e013042.

Research output: Contribution to journalEditorial

Open Access
Adiposity
Endothelium
Endothelial Cells
Obesity
8 Citations (Scopus)

Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice

Ulrich, V., Konaniah, E. S., Lee, W. R., Khadka, S., Shen, Y. M., Herz, J., Salmon, J. E., Hui, D. Y., Shaul, P. W. & Mineo, C., 2014, In : Journal of the American Heart Association. 3, 5, e001369.

Research output: Contribution to journalArticle

Neointima
Antiphospholipid Antibodies
Antiphospholipid Syndrome
Hypertrophy
Blood Vessels
8 Citations (Scopus)

Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium

Sacharidou, A., Chambliss, K. L., Ulrich, V., Salmon, J. E., Shen, Y. M., Herz, J., Hui, D. Y., Terada, L. S., Shaul, P. W. & Mineo, C., May 10 2018, In : Blood. 131, 19, p. 2097-2110 14 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Antiphospholipid Antibodies
Endothelium
Thrombosis
Chemical activation
97 Citations (Scopus)

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

Ramesh, S., Morrell, C. N., Tarango, C., Thomas, G. D., Yuhanna, I. S., Girardi, G., Herz, J., Urbanus, R. T., De Groot, P. G., Thorpe, P. E., Salmon, J. E., Shaul, P. W. & Mineo, C., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 120-131 12 p.

Research output: Contribution to journalArticle

Antiphospholipid Antibodies
Cell Adhesion
Glycoproteins
Thrombosis
Leukocytes
23 Citations (Scopus)

ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice

Ulrich, V., Gelber, S. E., Vukelic, M., Sacharidou, A., Herz, J., Urbanus, R. T., De Groot, P. G., Natale, D. R., Harihara, A., Redecha, P., Abrahams, V. M., Shaul, P. W., Salmon, J. E. & Mineo, C., Mar 1 2016, In : Arthritis and Rheumatology. 68, 3, p. 730-739 10 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Antiphospholipid Antibodies
Pregnancy Complications
Trophoblasts
Antiphospholipid Syndrome
33 Citations (Scopus)

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome

Lee, E. E., Ma, J., Sacharidou, A., Mi, W., Salato, V. K., Nguyen, N., Jiang, Y., Pascual, J. M., North, P. E., Shaul, P. W., Mettlen, M. & Wang, R. C., Nov 24 2014, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

Protein Kinase C
Phosphorylation
Glucose
Acetates
Glucose Transporter Type 1
28 Citations (Scopus)

A vacuolar-type proton ATPase mediates acidification of plasmalemmal vesicles during potocytosis

Mineo, C. & Anderson, R. G. W., May 1 1996, In : Experimental Cell Research. 224, 2, p. 237-242 6 p.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Protons
Proton Pumps
Caveolae
Folic Acid
24 Citations (Scopus)
Conjugated (USP) Estrogens
Type 2 Diabetes Mellitus
Obesity
Diet
Liver
14 Citations (Scopus)

Behavioral characteristics and early temperament of premature infants with intracranial hemorrhage

Anderson, L. T., Coll, C. G., Vohr, B. R., Emmons, L., Brann, B., Shaul, P. W., Mayfield, S. R. & Oh, W., 1989, In : Early Human Development. 18, 4, p. 273-283 11 p.

Research output: Contribution to journalArticle

Temperament
Intracranial Hemorrhages
Premature Infants
Arousal
Abnormal Reflexes
39 Citations (Scopus)

Behavioral responsiveness in preterm infants with intraventricular hemorrhage

Garcia-Coll, C. T., Emmons, L., Vohr, B. R., Monds Ward, A., Brann, B. S., Shaul, P. W., Mayfield, S. R. & Oh, W., 1988, In : Pediatrics. 81, 3, p. 412-418 7 p.

Research output: Contribution to journalArticle

Premature Infants
Hemorrhage
Temperament
Individuality
Touch
89 Citations (Scopus)

Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: Altered caveolar localization and impaired response to shear

Joshi, M. S., Mineo, C., Shaul, P. W. & Bauer, J. A., Sep 2007, In : FASEB Journal. 21, 11, p. 2655-2663 9 p.

Research output: Contribution to journalArticle

endothelium
Endothelium
shears
Viperidae
Membranes
32 Citations (Scopus)

Caffeine toxicity as a cause of acute psychosis in anorexia nervosa

Shaul, P. W., Farrell, M. K. & Maloney, M. J., 1984, In : The Journal of Pediatrics. 105, 3, p. 493-495 3 p.

Research output: Contribution to journalArticle

Substance-Induced Psychoses
Anorexia Nervosa
Caffeine
Psychotic Disorders
Differential Diagnosis
52 Citations (Scopus)

Caveolin-1 is not required for murine intestinal cholesterol transport

Valasek, M. A., Weng, J., Shaul, P. W., Anderson, R. G. W. & Repa, J. J., Jul 29 2005, In : Journal of Biological Chemistry. 280, 30, p. 28103-28109 7 p.

Research output: Contribution to journalArticle

Caveolin 1
Cholesterol
Knockout Mice
Annexins
Intestinal Mucosa
16 Citations (Scopus)

Cell growth modulates nitric oxide synthase expression in fetal pulmonary artery endothelial cells

Whitney, J. A., German, Z., Sherman, T. S., Yuhanna, I. S. & Shaul, P. W., Jan 2000, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 278, 1 22-1

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Pulmonary Artery
Endothelial Cells
Growth
Nitric Oxide
2 Citations (Scopus)

Chapter 6 Caveolae and Estrogen Receptor Signaling

Shaul, P. W. & Chambliss, K. L., 2005, In : Advances in Molecular and Cell Biology. 36, p. 109-123 15 p.

Research output: Contribution to journalArticle

Caveolae
Estrogen Receptors
Cell Membrane
Nitric Oxide Synthase
Estrogens
121 Citations (Scopus)

Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling

Assanasen, C., Mineo, C., Seetharam, D., Yuhanna, I. S., Marcel, Y. L., Connelly, M. A., Williams, D. L., De La Llera-Moya, M., Shaul, P. W. & Silver, D. L., Apr 2005, In : Journal of Clinical Investigation. 115, 4, p. 969-977 9 p.

Research output: Contribution to journalArticle

PDZ Domains
Scavenger Receptors
Cholesterol
Cyclodextrins
Unilamellar Liposomes
6 Citations (Scopus)

Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells

Morel, E., Ghezzal, S., Lucchi, G., Truntzer, C., Pais de Barros, J. P., Simon-Plas, F., Demignot, S., Mineo, C., Shaul, P. W., Leturque, A., Rousset, M. & Carrière, V., Feb 1 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 2, p. 199-211 13 p.

Research output: Contribution to journalArticle

CD36 Antigens
Epithelial Cells
Cholesterol
Lipids
Membranes
40 Citations (Scopus)

Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae

Mineo, C. & Shaul, P. W., Apr 1 2006, In : Cardiovascular Research. 70, 1, p. 31-41 11 p.

Research output: Contribution to journalArticle

Caveolae
Cardiovascular Diseases
Endothelial Cells
Nitric Oxide Synthase
Scavenger Receptors
76 Citations (Scopus)

Clustered folate receptors deliver 5-methyltetrahydrofolate to cytoplasm of MA104 cells

Smart, E. J., Mineo, C. & Anderson, R. G. W., Sep 1996, In : Journal of Cell Biology. 134, 5, p. 1169-1177 9 p.

Research output: Contribution to journalArticle

Caveolae
Folic Acid
Cytoplasm
Cell Fractionation
Filipin
54 Citations (Scopus)

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

Worthmann, A., John, C., Rühlemann, M. C., Baguhl, M., Heinsen, F. A., Schaltenberg, N., Heine, M., Schlein, C., Evangelakos, I., Mineo, C., Fischer, M., Dandri, M., Kremoser, C., Scheja, L., Franke, A., Shaul, P. W. & Heeren, J., Jul 1 2017, In : Nature Medicine. 23, 7, p. 839-849 11 p.

Research output: Contribution to journalArticle

Thermogenesis
Bile Acids and Salts
Cholesterol
Brown Adipose Tissue
Lipoproteins
15 Citations (Scopus)
Receptors, Adrenergic, beta
Adenylyl Cyclases
Pulmonary Artery
Aorta
Isoproterenol
8 Citations (Scopus)

Conventional estrogen receptors are found in the plasma membrane of vaginal epithelial cells of the rat

Singh, S., Shaul, P. W. & Gupta, P. D., 2002, In : Steroids. 67, 9, p. 757-764 8 p.

Research output: Contribution to journalArticle

Cell membranes
Estrogen Receptors
Rats
Signal transduction
Epithelial Cells
18 Citations (Scopus)

Coupling of Fcγ receptor i to Fcγ receptor IIB by src kinase mediates c-reactive protein impairment of endothelial function

Sundgren, N. C., Zhu, W., Yuhanna, I. S., Chambliss, K. L., Ahmed, M., Tanigaki, K., Umetani, M., Mineo, C. & Shaul, P. W., Oct 28 2011, In : Circulation Research. 109, 10, p. 1132-1140 9 p.

Research output: Contribution to journalArticle

Fc Receptors
C-Reactive Protein
Nitric Oxide Synthase Type III
Proteins
src Homology Domains
67 Citations (Scopus)

C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice

Vongpatanasin, W., Thomas, G. D., Schwartz, R., Cassis, L. A., Osborne-Lawrence, S., Hahner, L., Gibson, L. L., Black, S., Samols, D. & Shaul, P. W., Feb 2007, In : Circulation. 115, 8, p. 1020-1028 9 p.

Research output: Contribution to journalArticle

Angiotensins
C-Reactive Protein
Blood Vessels
Down-Regulation
Hypertension
30 Citations (Scopus)

C-reactive protein causes insulin resistance in mice through fcg receptor IIB-mediated inhibition of skeletal muscle glucose delivery

Tanigaki, K., Vongpatanasin, W., Barrera, J. A., Atochin, D. N., Huang, P. L., Bonvini, E., Shaul, P. W. & Mineo, C., Mar 2013, In : Diabetes. 62, 3, p. 721-731 11 p.

Research output: Contribution to journalArticle

C-Reactive Protein
Insulin Resistance
Skeletal Muscle
Glucose
Insulin
62 Citations (Scopus)

C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice

Schwartz, R., Osborne-Lawrence, S., Hahner, L., Gibson, L. L., Gormley, A. K., Vongpatanasin, W., Zhu, W., Word, R. A., Seetharam, D., Black, S., Samols, D., Mineo, C. & Shaul, P. W., May 2007, In : Circulation Research. 100, 10, p. 1452-1459 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
C-Reactive Protein
Down-Regulation
Endothelial Cells
Carotid Arteries
36 Citations (Scopus)

C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcγRIIB and SHIP-1

Tanigaki, K., Mineo, C., Yuhanna, I. S., Chambliss, K. L., Quon, M. J., Bonvini, E. & Shaul, P. W., Jun 5 2009, In : Circulation Research. 104, 11, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

Immunoreceptor Tyrosine-Based Inhibition Motif
Nitric Oxide Synthase Type III
C-Reactive Protein
Insulin
Nitric Oxide Synthase
11 Citations (Scopus)

Decreased amniotic fluid magnesium concentration in diabetic pregnancy

Mimouni, F., Miodovnik, M., Tsang, R. C., Callahan, J. & Shaul, P., 1987, In : Obstetrics and Gynecology. 69, 1, p. 12-14 3 p.

Research output: Contribution to journalArticle

Pregnancy in Diabetics
Amniotic Fluid
Magnesium
Magnesium Deficiency
Hypocalcemia
687 Citations (Scopus)

Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells

Venugopal, S. K., Devaraj, S., Yuhanna, I., Shaul, P. & Jialal, I., Sep 17 2002, In : Circulation. 106, 12, p. 1439-1441 3 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
C-Reactive Protein
Endothelial Cells
Atherosclerosis
Cyclic GMP
35 Citations (Scopus)

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

Madak-Erdogan, Z., Kim, S. H., Gong, P., Zhao, Y. C., Zhang, H., Chambliss, K. L., Carlson, K. E., Mayne, C. G., Shaul, P. W., Korach, K. S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., May 24 2016, In : Science Signaling. 9, 429, ra53.

Research output: Contribution to journalArticle

Blood Vessels
Estrogens
Tissue
Ligands
Estrogen Receptors
15 Citations (Scopus)

Developmental and neuropathological consequences of ductal ligation in the preterm baboon

Loeliger, M., Inder, T. E., Dalitz, P. A., Cain, S., Camm, E. J., Yoder, B., McCurnin, D., Shaul, P. W., Clyman, R. & Rees, S. M., Feb 2009, In : Pediatric Research. 65, 2, p. 209-214 6 p.

Research output: Contribution to journalArticle

Papio
Ligation
Patent Ductus Arteriosus
Brain
Newborn Infant
67 Citations (Scopus)

Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung

Shaul, P. W., Afshar, S., Gibson, L. L., Sherman, T. S., Kerecman, J. D., Grubb, P. H., Yoder, B. A. & McCurnin, D. C., Dec 1 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 283, 6 27-6

Research output: Contribution to journalArticle

Papio
Nitric Oxide Synthase
Nitric Oxide
Protein Isoforms
Lung
17 Citations (Scopus)
Epoprostenol
Vascular Smooth Muscle
Endothelium
Muscle
Cyclooxygenase 1
102 Citations (Scopus)

Direct interactions with Gαi and Gβγ mediate nongenomic signaling by estrogen receptor α

Kumar, P., Wu, Q., Chambliss, K. L., Yuhanna, I. S., Mumby, S. M., Mineo, C., Tall, G. G. & Shaul, P. W., Jun 2007, In : Molecular Endocrinology. 21, 6, p. 1370-1380 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
GTP-Binding Proteins
Estradiol
Mutagenesis
Estrogens
57 Citations (Scopus)

Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: Role of ERα domains with known nuclear functions

Chambliss, K. L., Simon, L., Yuhanna, I. S., Mineo, C. & Shaul, P. W., Feb 2005, In : Molecular Endocrinology. 19, 2, p. 277-289 13 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Estrogen Receptors
Estradiol
1-Phosphatidylinositol 4-Kinase
Phosphorylation