Pul & Vas Biology

Research Output

Article

17β-Estradiol dysregulates innate immune responses to Pseudomonas aeruginosa respiratory infection and is modulated by estrogen receptor antagonism

Abid, S., Xie, S. K., Bose, M., Shaul, P. W., Terada, L. S., Brody, S. L., Thomas, P. J., Katzenellenbogen, J. A., Kim, S. H., Greenberg, D. E. & Jain, R., 2017, In : Infection and Immunity. 85, 10, e00422-17.

Research output: Contribution to journalArticle

12 Scopus citations

27-Hydroxycholesterol: The first identified endogenous SERM

Umetani, M. & Shaul, P. W., Apr 2011, In : Trends in Endocrinology and Metabolism. 22, 4, p. 130-135 6 p.

Research output: Contribution to journalArticle

64 Scopus citations
9 Scopus citations

27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator

DuSell, C. D., Umetani, M., Shaul, P. W., Mangelsdorf, D. J. & McDonnell, D. P., Jan 2008, In : Molecular Endocrinology. 22, 1, p. 65-77 13 p.

Research output: Contribution to journalArticle

156 Scopus citations

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Umetani, M., Domoto, H., Gormley, A. K., Yuhanna, I. S., Cummins, C. L., Javitt, N. B., Korach, K. S., Shaul, P. W. & Mangelsdorf, D. J., Oct 2007, In : Nature Medicine. 13, 10, p. 1185-1192 8 p.

Research output: Contribution to journalArticle

234 Scopus citations

27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth

Wu, Q., Ishikawa, T., Sirianni, R., Tang, H., McDonald, J. G., Yuhanna, I. S., Thompson, B., Girard, L., Mineo, C., Brekken, R. A., Umetani, M., Euhus, D. M., Xie, Y. & Shaul, P. W., 2013, In : Cell Reports. 5, 3, p. 637-645 9 p.

Research output: Contribution to journalArticle

161 Scopus citations

Abnormal vascular function and hypertension in mice deficient in estrogen receptor β

Zhu, Y., Bian, Z., Lu, P., Karas, R. H., Bao, L., Cox, D., Hodgin, J., Shaul, P. W., Thorén, P., Smithies, O., Gustafsson, J. Å. & Mendelsohn, M. E., Jan 18 2002, In : Science. 295, 5554, p. 505-508 4 p.

Research output: Contribution to journalArticle

388 Scopus citations

Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms

Shaul, P. W., Wells, L. B. & Horning, K. M., 1993, In : Journal of Cardiovascular Pharmacology. 22, 6, p. 819-827 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Acylation targets endothelial nitric oxide synthase (enos) to plasmalemmal caveolae

Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I. S., Ying, Y., Andersonand, R. G. W. & Michel, T., 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae

Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I., Ying, Y., Anderson, R. G. W. & Michel, T., 1996, In : Journal of Investigative Medicine. 44, 3

Research output: Contribution to journalArticle

1 Scopus citations

Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae

Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I. S., Ying, Y., Anderson, R. G. W. & Michel, T., Mar 15 1996, In : Journal of Biological Chemistry. 271, 11, p. 6518-6522 5 p.

Research output: Contribution to journalArticle

595 Scopus citations

A detergent-free method for purifying caveolae membrane from tissue culture cells

Smart, E. J., Ying, Y. S., Mineo, C. & Anderson, R. G. W., Oct 24 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 22, p. 10104-10108 5 p.

Research output: Contribution to journalArticle

658 Scopus citations

Advances in the treatment of persistent pulmonary hypertension of the newborn

Roberts, J. D. & Shaul, P. W., 1993, In : Pediatric Clinics of North America. 40, 5, p. 983-1004 22 p.

Research output: Contribution to journalArticle

30 Scopus citations

Anemia blunts the thermogenic response to environmental cold stress in newborn piglets

Mayfield, S. R., Shaul, P. W., Oh, W. & Stonestreet, B. S., 1987, In : Pediatric Research. 21, 5, p. 482-486 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Angiotensin II vascular smooth-muscle receptors are not down-regulated in near-term pregnant sheep

Mackanjee, H. R., Shaul, P. W., Magness, R. R. & Rosenfeld, C. R., 1991, In : American Journal of Obstetrics and Gynecology. 165, 6 PART 1, p. 1641-1648 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice

Ulrich, V., Konaniah, E. S., Lee, W. R., Khadka, S., Shen, Y. M., Herz, J., Salmon, J. E., Hui, D. Y., Shaul, P. W. & Mineo, C., 2014, In : Journal of the American Heart Association. 3, 5, e001369.

Research output: Contribution to journalArticle

8 Scopus citations

Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium

Sacharidou, A., Chambliss, K. L., Ulrich, V., Salmon, J. E., Shen, Y. M., Herz, J., Hui, D. Y., Terada, L. S., Shaul, P. W. & Mineo, C., May 10 2018, In : Blood. 131, 19, p. 2097-2110 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

Ramesh, S., Morrell, C. N., Tarango, C., Thomas, G. D., Yuhanna, I. S., Girardi, G., Herz, J., Urbanus, R. T., De Groot, P. G., Thorpe, P. E., Salmon, J. E., Shaul, P. W. & Mineo, C., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 120-131 12 p.

Research output: Contribution to journalArticle

99 Scopus citations

ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice

Ulrich, V., Gelber, S. E., Vukelic, M., Sacharidou, A., Herz, J., Urbanus, R. T., De Groot, P. G., Natale, D. R., Harihara, A., Redecha, P., Abrahams, V. M., Shaul, P. W., Salmon, J. E. & Mineo, C., Mar 1 2016, In : Arthritis and Rheumatology. 68, 3, p. 730-739 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome

Lee, E. E., Ma, J., Sacharidou, A., Mi, W., Salato, V. K., Nguyen, N., Jiang, Y., Pascual, J. M., North, P. E., Shaul, P. W., Mettlen, M. & Wang, R. C., Nov 24 2014, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

35 Scopus citations

A vacuolar-type proton ATPase mediates acidification of plasmalemmal vesicles during potocytosis

Mineo, C. & Anderson, R. G. W., May 1 1996, In : Experimental Cell Research. 224, 2, p. 237-242 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
24 Scopus citations

Behavioral characteristics and early temperament of premature infants with intracranial hemorrhage

Anderson, L. T., Coll, C. G., Vohr, B. R., Emmons, L., Brann, B., Shaul, P. W., Mayfield, S. R. & Oh, W., 1989, In : Early Human Development. 18, 4, p. 273-283 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Behavioral responsiveness in preterm infants with intraventricular hemorrhage

Garcia-Coll, C. T., Emmons, L., Vohr, B. R., Monds Ward, A., Brann, B. S., Shaul, P. W., Mayfield, S. R. & Oh, W., 1988, In : Pediatrics. 81, 3, p. 412-418 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: Altered caveolar localization and impaired response to shear

Joshi, M. S., Mineo, C., Shaul, P. W. & Bauer, J. A., Sep 2007, In : FASEB Journal. 21, 11, p. 2655-2663 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Caffeine toxicity as a cause of acute psychosis in anorexia nervosa

Shaul, P. W., Farrell, M. K. & Maloney, M. J., 1984, In : The Journal of Pediatrics. 105, 3, p. 493-495 3 p.

Research output: Contribution to journalArticle

32 Scopus citations

Caveolin-1 is not required for murine intestinal cholesterol transport

Valasek, M. A., Weng, J., Shaul, P. W., Anderson, R. G. W. & Repa, J. J., Jul 29 2005, In : Journal of Biological Chemistry. 280, 30, p. 28103-28109 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Cell growth modulates nitric oxide synthase expression in fetal pulmonary artery endothelial cells

Whitney, J. A., German, Z., Sherman, T. S., Yuhanna, I. S. & Shaul, P. W., Jan 2000, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 278, 1 22-1

Research output: Contribution to journalArticle

16 Scopus citations

Chapter 6 Caveolae and Estrogen Receptor Signaling

Shaul, P. W. & Chambliss, K. L., 2005, In : Advances in Molecular and Cell Biology. 36, p. 109-123 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling

Assanasen, C., Mineo, C., Seetharam, D., Yuhanna, I. S., Marcel, Y. L., Connelly, M. A., Williams, D. L., De La Llera-Moya, M., Shaul, P. W. & Silver, D. L., Apr 2005, In : Journal of Clinical Investigation. 115, 4, p. 969-977 9 p.

Research output: Contribution to journalArticle

121 Scopus citations

Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells

Morel, E., Ghezzal, S., Lucchi, G., Truntzer, C., Pais de Barros, J. P., Simon-Plas, F., Demignot, S., Mineo, C., Shaul, P. W., Leturque, A., Rousset, M. & Carrière, V., Feb 1 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 2, p. 199-211 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae

Mineo, C. & Shaul, P. W., Apr 1 2006, In : Cardiovascular Research. 70, 1, p. 31-41 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

Clustered folate receptors deliver 5-methyltetrahydrofolate to cytoplasm of MA104 cells

Smart, E. J., Mineo, C. & Anderson, R. G. W., Sep 1996, In : Journal of Cell Biology. 134, 5, p. 1169-1177 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

Worthmann, A., John, C., Rühlemann, M. C., Baguhl, M., Heinsen, F. A., Schaltenberg, N., Heine, M., Schlein, C., Evangelakos, I., Mineo, C., Fischer, M., Dandri, M., Kremoser, C., Scheja, L., Franke, A., Shaul, P. W. & Heeren, J., Jul 1 2017, In : Nature Medicine. 23, 7, p. 839-849 11 p.

Research output: Contribution to journalArticle

55 Scopus citations
15 Scopus citations

Conventional estrogen receptors are found in the plasma membrane of vaginal epithelial cells of the rat

Singh, S., Shaul, P. W. & Gupta, P. D., 2002, In : Steroids. 67, 9, p. 757-764 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Coupling of Fcγ receptor i to Fcγ receptor IIB by src kinase mediates c-reactive protein impairment of endothelial function

Sundgren, N. C., Zhu, W., Yuhanna, I. S., Chambliss, K. L., Ahmed, M., Tanigaki, K., Umetani, M., Mineo, C. & Shaul, P. W., Oct 28 2011, In : Circulation Research. 109, 10, p. 1132-1140 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice

Vongpatanasin, W., Thomas, G. D., Schwartz, R., Cassis, L. A., Osborne-Lawrence, S., Hahner, L., Gibson, L. L., Black, S., Samols, D. & Shaul, P. W., Feb 2007, In : Circulation. 115, 8, p. 1020-1028 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

C-reactive protein causes insulin resistance in mice through fcg receptor IIB-mediated inhibition of skeletal muscle glucose delivery

Tanigaki, K., Vongpatanasin, W., Barrera, J. A., Atochin, D. N., Huang, P. L., Bonvini, E., Shaul, P. W. & Mineo, C., Mar 2013, In : Diabetes. 62, 3, p. 721-731 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice

Schwartz, R., Osborne-Lawrence, S., Hahner, L., Gibson, L. L., Gormley, A. K., Vongpatanasin, W., Zhu, W., Word, R. A., Seetharam, D., Black, S., Samols, D., Mineo, C. & Shaul, P. W., May 2007, In : Circulation Research. 100, 10, p. 1452-1459 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcγRIIB and SHIP-1

Tanigaki, K., Mineo, C., Yuhanna, I. S., Chambliss, K. L., Quon, M. J., Bonvini, E. & Shaul, P. W., Jun 5 2009, In : Circulation Research. 104, 11, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Decreased amniotic fluid magnesium concentration in diabetic pregnancy

Mimouni, F., Miodovnik, M., Tsang, R. C., Callahan, J. & Shaul, P., 1987, In : Obstetrics and Gynecology. 69, 1, p. 12-14 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells

Venugopal, S. K., Devaraj, S., Yuhanna, I., Shaul, P. & Jialal, I., Sep 17 2002, In : Circulation. 106, 12, p. 1439-1441 3 p.

Research output: Contribution to journalArticle

687 Scopus citations

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

Madak-Erdogan, Z., Kim, S. H., Gong, P., Zhao, Y. C., Zhang, H., Chambliss, K. L., Carlson, K. E., Mayne, C. G., Shaul, P. W., Korach, K. S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., May 24 2016, In : Science Signaling. 9, 429, ra53.

Research output: Contribution to journalArticle

35 Scopus citations

Developmental and neuropathological consequences of ductal ligation in the preterm baboon

Loeliger, M., Inder, T. E., Dalitz, P. A., Cain, S., Camm, E. J., Yoder, B., McCurnin, D., Shaul, P. W., Clyman, R. & Rees, S. M., Feb 2009, In : Pediatric Research. 65, 2, p. 209-214 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung

Shaul, P. W., Afshar, S., Gibson, L. L., Sherman, T. S., Kerecman, J. D., Grubb, P. H., Yoder, B. A. & McCurnin, D. C., Dec 1 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 283, 6 27-6

Research output: Contribution to journalArticle

67 Scopus citations
17 Scopus citations

Direct interactions with Gαi and Gβγ mediate nongenomic signaling by estrogen receptor α

Kumar, P., Wu, Q., Chambliss, K. L., Yuhanna, I. S., Mumby, S. M., Mineo, C., Tall, G. G. & Shaul, P. W., Jun 2007, In : Molecular Endocrinology. 21, 6, p. 1370-1380 11 p.

Research output: Contribution to journalArticle

102 Scopus citations

Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: Role of ERα domains with known nuclear functions

Chambliss, K. L., Simon, L., Yuhanna, I. S., Mineo, C. & Shaul, P. W., Feb 2005, In : Molecular Endocrinology. 19, 2, p. 277-289 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus

Chang, L. Y., McCurnin, D., Yoder, B., Shaul, P. W. & Clyman, R. I., Mar 2008, In : Pediatric Research. 63, 3, p. 299-302 4 p.

Research output: Contribution to journalArticle

43 Scopus citations