Pul & Vas Biology

Research Output

2011

27-Hydroxycholesterol: The first identified endogenous SERM

Umetani, M. & Shaul, P. W., Apr 2011, In : Trends in Endocrinology and Metabolism. 22, 4, p. 130-135 6 p.

Research output: Contribution to journalArticle

64 Scopus citations

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

Ramesh, S., Morrell, C. N., Tarango, C., Thomas, G. D., Yuhanna, I. S., Girardi, G., Herz, J., Urbanus, R. T., De Groot, P. G., Thorpe, P. E., Salmon, J. E., Shaul, P. W. & Mineo, C., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 120-131 12 p.

Research output: Contribution to journalArticle

99 Scopus citations

Coupling of Fcγ receptor i to Fcγ receptor IIB by src kinase mediates c-reactive protein impairment of endothelial function

Sundgren, N. C., Zhu, W., Yuhanna, I. S., Chambliss, K. L., Ahmed, M., Tanigaki, K., Umetani, M., Mineo, C. & Shaul, P. W., Oct 28 2011, In : Circulation Research. 109, 10, p. 1132-1140 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Inhaled nitric oxide and bronchopulmonary dysplasia

Steinhorn, R. H., Shaul, P. W., DeRegnier, R. A. O. & Kennedy, K. A., Jul 2011, In : Pediatrics. 128, 1

Research output: Contribution to journalArticle

6 Scopus citations
7 Scopus citations

Non-nuclear estrogen receptor signaling in the endothelium

Wu, Q., Chambliss, K., Umetani, M., Mineo, C. & Shaul, P. W., Apr 29 2011, In : Journal of Biological Chemistry. 286, 17, p. 14737-14743 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Patent ductus arteriosus ligation alters pulmonary gene expression in preterm baboons

Waleh, N., McCurnin, D. C., Yoder, B. A., Shaul, P. W. & Clyman, R. I., Mar 2011, In : Pediatric Research. 69, 3, p. 212-216 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

PON-dering differences in HDL function in coronary artery disease

Mineo, C. & Shaul, P. W., Jul 2011, In : Journal of Clinical Investigation. 121, 7, p. 2545-2548 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regulation of vegf-induced endothelial cell migration by mitochondrial reactive oxygen species

Wang, Y., Zang, Q. S., Liu, Z., Wu, Q., Maass, D., Dulan, G., Shaul, P. W., Melito, L., Frantz, D. E., Kilgore, J. A., Williams, N. S., Terada, L. S. & Nwariaku, F. E., Sep 2011, In : American Journal of Physiology - Cell Physiology. 301, 3

Research output: Contribution to journalArticle

102 Scopus citations

The effects of postnatal estrogen therapy on brain development in preterm baboons

Rees, S., Loeliger, M., Shields, A., Shaul, P. W., McCurnin, D., Yoder, B. & Inder, T., Feb 2011, In : American Journal of Obstetrics and Gynecology. 204, 2

Research output: Contribution to journalArticle

4 Scopus citations
2010

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

Chambliss, K. L., Wu, Q., Oltmann, S., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G. D., Mineo, C., Yuhanna, I. S., Kim, S. H., Madak-Erdogan, Z., Maggi, A., Dineen, S. P., Roland, C. L., Hui, D. Y., Brekken, R. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shaul, P. W., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

168 Scopus citations

Signaling by the high-affinity HDL receptor scavenger receptor B type i

Saddar, S., Mineo, C. & Shaul, P. W., Feb 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 2, p. 144-150 7 p.

Research output: Contribution to journalArticle

68 Scopus citations
2009

C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcγRIIB and SHIP-1

Tanigaki, K., Mineo, C., Yuhanna, I. S., Chambliss, K. L., Quon, M. J., Bonvini, E. & Shaul, P. W., Jun 5 2009, In : Circulation Research. 104, 11, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Developmental and neuropathological consequences of ductal ligation in the preterm baboon

Loeliger, M., Inder, T. E., Dalitz, P. A., Cain, S., Camm, E. J., Yoder, B., McCurnin, D., Shaul, P. W., Clyman, R. & Rees, S. M., Feb 2009, In : Pediatric Research. 65, 2, p. 209-214 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia

McCurnin, D. C., Pierce, R. A., Willis, B. C., Chang, L. Y., Yoder, B. A., Yuhanna, I. S., Ballard, P. L., Clyman, R. I., Waleh, N., Maniscalco, W., Crapo, J. D., Grubb, P. H. & Shaul, P. W., Mar 15 2009, In : American Journal of Respiratory and Critical Care Medicine. 179, 6, p. 492-500 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2008

27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator

DuSell, C. D., Umetani, M., Shaul, P. W., Mangelsdorf, D. J. & McDonnell, D. P., Jan 2008, In : Molecular Endocrinology. 22, 1, p. 65-77 13 p.

Research output: Contribution to journalArticle

156 Scopus citations

Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus

Chang, L. Y., McCurnin, D., Yoder, B., Shaul, P. W. & Clyman, R. I., Mar 2008, In : Pediatric Research. 63, 3, p. 299-302 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

G-CSF exerts dual effects on endothelial cells-Opposing actions of direct eNOS induction versus indirect CRP elevation

Park, K. W., Kwon, Y. W., Cho, H. J., Shin, J. I., Kim, Y. J., Lee, S. E., Youn, S. W., Lee, H. C., Kang, H. J., Shaul, P. W., Oh, B. H., Park, Y. B. & Kim, H. S., Nov 2008, In : Journal of Molecular and Cellular Cardiology. 45, 5, p. 670-678 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity

Zhu, W., Saddar, S., Seetharam, D., Chambliss, K. L., Longoria, C., Silver, D. L., Yuhanna, I. S., Shaul, P. W. & Mineo, C., Feb 2008, In : Circulation Research. 102, 4, p. 480-487 8 p.

Research output: Contribution to journalArticle

83 Scopus citations
2007

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Umetani, M., Domoto, H., Gormley, A. K., Yuhanna, I. S., Cummins, C. L., Javitt, N. B., Korach, K. S., Shaul, P. W. & Mangelsdorf, D. J., Oct 2007, In : Nature Medicine. 13, 10, p. 1185-1192 8 p.

Research output: Contribution to journalArticle

234 Scopus citations

Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: Altered caveolar localization and impaired response to shear

Joshi, M. S., Mineo, C., Shaul, P. W. & Bauer, J. A., Sep 2007, In : FASEB Journal. 21, 11, p. 2655-2663 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice

Vongpatanasin, W., Thomas, G. D., Schwartz, R., Cassis, L. A., Osborne-Lawrence, S., Hahner, L., Gibson, L. L., Black, S., Samols, D. & Shaul, P. W., Feb 2007, In : Circulation. 115, 8, p. 1020-1028 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice

Schwartz, R., Osborne-Lawrence, S., Hahner, L., Gibson, L. L., Gormley, A. K., Vongpatanasin, W., Zhu, W., Word, R. A., Seetharam, D., Black, S., Samols, D., Mineo, C. & Shaul, P. W., May 2007, In : Circulation Research. 100, 10, p. 1452-1459 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

Direct interactions with Gαi and Gβγ mediate nongenomic signaling by estrogen receptor α

Kumar, P., Wu, Q., Chambliss, K. L., Yuhanna, I. S., Mumby, S. M., Mineo, C., Tall, G. G. & Shaul, P. W., Jun 2007, In : Molecular Endocrinology. 21, 6, p. 1370-1380 11 p.

Research output: Contribution to journalArticle

102 Scopus citations
121 Scopus citations

Inhaled nitric oxide: Effects on cerebral growth and injury in a baboon model of premature delivery

Rees, S. M., Camm, E. J., Loeliger, M., Cain, S., Dieni, S., Mccurnin, D., Shaul, P. W., Yoder, B., Mclean, C. & Inder, T. E., May 2007, In : Pediatric Research. 61, 5 PART 1, p. 552-558 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells

Vyas-Read, S., Shaul, P. W., Yuhanna, I. S. & Willis, B. C., Jul 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 293, 1

Research output: Contribution to journalArticle

57 Scopus citations
46 Scopus citations

The cold, hard truth about pediatric research

Shaul, P. W., Apr 2007, In : Pediatric Research. 61, 4, p. 506-509 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2006

Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae

Mineo, C. & Shaul, P. W., Apr 1 2006, In : Cardiovascular Research. 70, 1, p. 31-41 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

Endothelial and antithrombotic actions of HDL

Mineo, C., Deguchi, H., Griffin, J. H. & Shaul, P. W., Jun 2006, In : Circulation Research. 98, 11, p. 1352-1364 13 p.

Research output: Contribution to journalArticle

440 Scopus citations

High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I

Seetharam, D., Mineo, C., Gormley, A. K., Gibson, L. L., Vongpatanasin, W., Chambliss, K. L., Hahner, L. D., Cummings, M. L., Kitchens, R. L., Marcel, Y. L., Rader, D. J. & Shaul, P. W., Jan 2006, In : Circulation Research. 98, 1, p. 63-72 10 p.

Research output: Contribution to journalArticle

212 Scopus citations

Surfactant composition and function in a primate model of infant chronic lung disease: Effects of inhaled nitric oxide

Ballard, P. L., Gonzales, L. W., Godinez, R. I., Godinez, M. H., Savani, R. C., Mccurnin, D. C., Gibson, L. L., Yoder, B. A., Kerecman, J. D., Grubb, P. H. & Shaul, P. W., Jan 2006, In : Pediatric Research. 59, 1, p. 157-162 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
2005

Caveolin-1 is not required for murine intestinal cholesterol transport

Valasek, M. A., Weng, J., Shaul, P. W., Anderson, R. G. W. & Repa, J. J., Jul 29 2005, In : Journal of Biological Chemistry. 280, 30, p. 28103-28109 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Chapter 6 Caveolae and Estrogen Receptor Signaling

Shaul, P. W. & Chambliss, K. L., 2005, In : Advances in Molecular and Cell Biology. 36, p. 109-123 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling

Assanasen, C., Mineo, C., Seetharam, D., Yuhanna, I. S., Marcel, Y. L., Connelly, M. A., Williams, D. L., De La Llera-Moya, M., Shaul, P. W. & Silver, D. L., Apr 2005, In : Journal of Clinical Investigation. 115, 4, p. 969-977 9 p.

Research output: Contribution to journalArticle

121 Scopus citations

Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: Role of ERα domains with known nuclear functions

Chambliss, K. L., Simon, L., Yuhanna, I. S., Mineo, C. & Shaul, P. W., Feb 2005, In : Molecular Endocrinology. 19, 2, p. 277-289 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

Effect of ductus ligation on cardiopulmonary function in premature baboons

McCurnin, D. C., Yoder, B. A., Coalson, J., Grubb, P., Kerecman, J., Kupferschmid, J., Breuer, C., Siler-Khodr, T., Shaul, P. W. & Clyman, R., Dec 15 2005, In : American Journal of Respiratory and Critical Care Medicine. 172, 12, p. 1569-1574 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

FcγRIIB mediates C-reactive protein inhibition of endothelial NO synthase

Mineo, C., Gormley, A. K., Yuhanna, I. S., Osborne-Lawrence, S., Gibson, L. L., Hahner, L., Shohet, R. V., Black, S., Salmon, J. E., Samols, D., Karp, D. R., Thomas, G. D. & Shaul, P. W., Nov 2005, In : Circulation Research. 97, 11, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

88 Scopus citations

Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease

McCurnin, D. C., Pierce, R. A., Ling, Y. C., Gibson, L. L., Osborne-Lawrence, S., Yoder, B. A., Kerecman, J. D., Albertine, K. H., Winter, V. T., Coalson, J. J., Crapo, J. D., Grubb, P. H. & Shaul, P. W., Mar 2005, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 288, 3 32-3

Research output: Contribution to journalArticle

163 Scopus citations

Molecular basis of estrogen-induced cyclooxygenase type 1 upregulation in endothelial cells

Gibson, L. L., Hahner, L., Osborne-Lawrence, S., German, Z., Wu, K. K., Chambliss, K. L. & Shaul, P. W., Mar 18 2005, In : Circulation Research. 96, 5, p. 518-525 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease

Munson, D. A., Grubb, P. H., Kerecman, J. D., McCurnin, D. C., Yoder, B. A., Hazen, S. L., Shaul, P. W. & Ischiropoulos, H., Dec 2005, In : American Journal of Respiratory Cell and Molecular Biology. 33, 6, p. 582-588 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2004

HDL action on the vascular wall: Is the answer NO?

Shaul, P. W. & Mineo, C., Feb 2004, In : Journal of Clinical Investigation. 113, 4, p. 509-513 5 p.

Research output: Contribution to journalArticle

43 Scopus citations
2003

Endothelial nitric oxide synthase, caveolae and the development of atherosclerosis

Shaul, P. W., Feb 15 2003, In : Journal of Physiology. 547, 1, p. 21-33 13 p.

Research output: Contribution to journalArticle

127 Scopus citations

HDL stimulation of endothelial nitric oxide synthase: A novel mechanism of HDL action

Mineo, C. & Shaul, P. W., Aug 2003, In : Trends in Cardiovascular Medicine. 13, 6, p. 226-231 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases

Mineo, C., Yuhanna, I. S., Quon, M. J. & Shaul, P. W., Mar 14 2003, In : Journal of Biological Chemistry. 278, 11, p. 9142-9149 8 p.

Research output: Contribution to journalArticle

306 Scopus citations

Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice

Mammen, P. P. A., Kanatous, S. B., Yuhanna, I. S., Shaul, P. W., Garry, M. G., Balaban, R. S. & Garry, D. J., Nov 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 285, 5 54-5

Research output: Contribution to journalArticle

27 Scopus citations

Physiology of Nitric Oxide in the Developing Lung

Kinsella, J. P. & Shaul, P. W., Dec 1 2003, Fetal and Neonatal Physiology: Third Edition. Saunders, Vol. 1-2. p. 733-743 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease

Afshar, S., Gibson, L. L., Yuhanna, I. S., Sherman, T. S., Kerecman, J. D., Grubb, P. H., Yoder, B. A., McCurnin, D. C. & Shaul, P. W., May 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 5 28-5

Research output: Contribution to journalArticle

84 Scopus citations

Vasomodulation by skeletal muscle-derived nitric oxide requires α-syntrophin-mediated sarcolemmal localization of neuronal nitric oxide synthase

Thomas, G. D., Shaul, P. W., Yuhanna, I. S., Froehner, S. C. & Adams, M. E., Mar 21 2003, In : Circulation Research. 92, 5, p. 554-560 7 p.

Research output: Contribution to journalArticle

105 Scopus citations