Pul & Vas Biology

Research Output 1984 2019

2002
385 Citations (Scopus)

Abnormal vascular function and hypertension in mice deficient in estrogen receptor β

Zhu, Y., Bian, Z., Lu, P., Karas, R. H., Bao, L., Cox, D., Hodgin, J., Shaul, P. W., Thorén, P., Smithies, O., Gustafsson, J. Å. & Mendelsohn, M. E., Jan 18 2002, In : Science. 295, 5554, p. 505-508 4 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Blood Vessels
Hypertension
Multiple Abnormalities
Vasoconstriction
8 Citations (Scopus)

Conventional estrogen receptors are found in the plasma membrane of vaginal epithelial cells of the rat

Singh, S., Shaul, P. W. & Gupta, P. D., 2002, In : Steroids. 67, 9, p. 757-764 8 p.

Research output: Contribution to journalArticle

Cell membranes
Estrogen Receptors
Rats
Signal transduction
Epithelial Cells
687 Citations (Scopus)

Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells

Venugopal, S. K., Devaraj, S., Yuhanna, I., Shaul, P. & Jialal, I., Sep 17 2002, In : Circulation. 106, 12, p. 1439-1441 3 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
C-Reactive Protein
Endothelial Cells
Atherosclerosis
Cyclic GMP
67 Citations (Scopus)

Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung

Shaul, P. W., Afshar, S., Gibson, L. L., Sherman, T. S., Kerecman, J. D., Grubb, P. H., Yoder, B. A. & McCurnin, D. C., Dec 1 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 283, 6 27-6

Research output: Contribution to journalArticle

Papio
Nitric Oxide Synthase
Nitric Oxide
Protein Isoforms
Lung
229 Citations (Scopus)

Erβ has nongenomic action in caveolae

Chambliss, K. L., Yuhanna, I. S., Anderson, R. G. W., Mendelsohn, M. E. & Shaul, P. W., 2002, In : Molecular Endocrinology. 16, 5, p. 938-946 9 p.

Research output: Contribution to journalArticle

Caveolae
Nitric Oxide Synthase Type III
Cell Membrane
Endothelial Cells
COS Cells
61 Citations (Scopus)

Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endothelium

Sherman, T. S., Chambliss, K. L., Gibson, L. L., Pace, M. C., Mendelsohn, M. E., Pfister, S. L. & Shaul, P. W., 2002, In : American Journal of Respiratory Cell and Molecular Biology. 26, 5, p. 610-616 7 p.

Research output: Contribution to journalArticle

Epoprostenol
Pulmonary Artery
Endothelium
Sheep
Estrogens
101 Citations (Scopus)

Estrogen causes dynamic alterations in endothelial estrogen receptor expression

Ihionkhan, C. E., Chambliss, K. L., Gibson, L. L., Hahner, L. D., Mendelsohn, M. E. & Shaul, P. W., Nov 1 2002, In : Circulation Research. 91, 9, p. 814-820 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Down-Regulation
Endothelial Cells
Vascular Endothelium
402 Citations (Scopus)

Estrogen modulation of endothelial nitric oxide synthase

Chambliss, K. L. & Shaul, P. W., Oct 2002, In : Endocrine Reviews. 23, 5, p. 665-686 22 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Nitric Oxide Synthase
Protein Isoforms
Estrogens
Caveolae
3 Citations (Scopus)
Caveolae
Signal transduction
Nitric Oxide Synthase Type III
COS Cells
Vascular Endothelium
83 Citations (Scopus)

Rapid activation of endothelial NO synthase by estrogen: Evidence for a steroid receptor fast-action complex (SRFC) in caveolae

Chambliss, K. L. & Shaul, P. W., 2002, In : Steroids. 67, 6, p. 413-419 7 p.

Research output: Contribution to journalArticle

Caveolae
Nitric Oxide Synthase Type III
Steroid Receptors
Cell membranes
Estrogen Receptors
444 Citations (Scopus)

Regulation of endothelial nitric oxide synthase: Location, location, location

Shaul, P. W., 2002, In : Annual Review of Physiology. 64, p. 749-774 26 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Caveolae
Nitric Oxide
Vascular Endothelium
G-Protein-Coupled Receptors
2001
15 Citations (Scopus)

Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation

Parker, T. A., Afshar, S., Kinsella, J. P., Grover, T. R., Gebb, S., Geraci, M., Shaul, P. W., Cryer, C. M. T. & Abman, S. H., 2001, In : American Journal of Physiology - Heart and Circulatory Physiology. 281, 3 50-3

Research output: Contribution to journalArticle

Pulmonary Circulation
Estrogen Receptors
Vascular Resistance
Sheep
Vasodilator Agents
570 Citations (Scopus)

High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase

Yuhanna, I. S., Zhu, Y., Cox, B. E., Hahner, L. D., Osborne-Lawrence, S., Lu, P., Marcel, Y. L., Anderson, R. G. W., Mendelsohn, M. E., Hobbs, H. H. & Shaul, P. W., 2001, In : Nature Medicine. 7, 7, p. 853-857 5 p.

Research output: Contribution to journalArticle

Scavenger Receptors
Nitric Oxide Synthase Type III
HDL Lipoproteins
Apolipoprotein A-I
Apolipoprotein A-II
7 Citations (Scopus)

Maternal vitamin A administration and the fetal ductus arteriosus

Shaul, P. W., 2001, In : Pediatric Research. 49, 6, p. 744-746 3 p.

Research output: Contribution to journalArticle

Maternal-Fetal Exchange
Ductus Arteriosus
Retinoic Acid Receptors
Patent Ductus Arteriosus
Vitamin A
240 Citations (Scopus)

Plasma Membrane Estrogen Receptors Are Coupled to Endothelial Nitric-oxide Synthase through Gαi

Wyckoff, M. H., Chambliss, K. L., Mineo, C., Yuhanna, I. S., Mendelsohn, M. E., Mumby, S. M. & Shaul, P. W., Jul 20 2001, In : Journal of Biological Chemistry. 276, 29, p. 27071-27076 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Cell membranes
Estrogen Receptors
Cell Membrane
Nitric Oxide Synthase
69 Citations (Scopus)

Potocytosis

Mineo, C. & Anderson, R. G. W., 2001, In : Histochemistry and Cell Biology. 116, 2, p. 109-118 10 p.

Research output: Contribution to journalArticle

Caveolae
membranes
Membranes
Cell membranes
cells
2000
16 Citations (Scopus)

Cell growth modulates nitric oxide synthase expression in fetal pulmonary artery endothelial cells

Whitney, J. A., German, Z., Sherman, T. S., Yuhanna, I. S. & Shaul, P. W., Jan 2000, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 278, 1 22-1

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Pulmonary Artery
Endothelial Cells
Growth
Nitric Oxide
334 Citations (Scopus)

Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae.

Chambliss, K. L., Yuhanna, I. S., Mineo, C., Liu, P., German, Z., Sherman, T. S., Mendelsohn, M. E., Anderson, R. G. & Shaul, P. W., Nov 24 2000, In : Circulation Research. 87, 11

Research output: Contribution to journalArticle

Caveolae
Estrogen Receptor alpha
Nitric Oxide Synthase Type III
Nitric Oxide Synthase
Cell Membrane
257 Citations (Scopus)

High density lipoprotein prevents oxidized low density lipoprotein- induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae

Uittenbogaard, A., Shaul, P. W., Yuhanna, I. S., Blair, A. & Smart, E. J., Apr 14 2000, In : Journal of Biological Chemistry. 275, 15, p. 11278-11283 6 p.

Research output: Contribution to journalArticle

Caveolae
Nitric Oxide Synthase Type III
HDL Lipoproteins
Chemical activation
Blocking Antibodies
39 Citations (Scopus)

Molecular basis of cell-specific endothelial nitric-oxide synthase expression in airway epithelium

German, Z., Chambliss, K. L., Pace, M. C., Arnet, U. A., Lowenstein, C. J. & Shaul, P. W., Mar 17 2000, In : Journal of Biological Chemistry. 275, 11, p. 8183-8189 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Nitric Oxide Synthase
Epithelium
Electrophoretic mobility
Electrophoretic Mobility Shift Assay
20 Citations (Scopus)

Novel role of estrogen receptors in vascular endothelium

Shaul, P. W., 2000, In : Seminars in Perinatology. 24, 1, p. 70-74 5 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Vascular Endothelium
Estrogen Receptors
Estrogens
Mitogen-Activated Protein Kinases
52 Citations (Scopus)
Uterine Artery
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type III
Nitric Oxide Synthase
Sheep
57 Citations (Scopus)

Specific association of estrogen receptor β with the cell cycle spindle assembly checkpoint protein, MAD2

Poelzl, G., Kasai, Y., Mochizuki, N., Shaul, P. W., Brown, M. & Mendelsohn, M. E., Mar 14 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 6, p. 2836-2839 4 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Mitosis
Estrogen Receptors
Cell Cycle
Proteins
146 Citations (Scopus)

Sustained endothelial nitric-oxide synthase activation requires capacitative Ca2+ entry

Lin, S., Fagan, K. A., Li, K. X., Shaul, P. W., Cooper, D. M. F. & Rodman, D. M., Jun 16 2000, In : Journal of Biological Chemistry. 275, 24, p. 17979-17985 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Chemical activation
Aequorin
Cell membranes
Cell Membrane
72 Citations (Scopus)

Synaptotagmin regulation of coated pit assembly

Von Poser, C., Zhang, J. Z., Mineo, C., Ding, W., Ying, Y., Südhof, T. C. & Anderson, R. G. W., Oct 6 2000, In : Journal of Biological Chemistry. 275, 40, p. 30916-30924 9 p.

Research output: Contribution to journalArticle

Synaptotagmins
Clathrin
Oligomerization
Endocytosis
Cysteine
1999
17 Citations (Scopus)
Epoprostenol
Vascular Smooth Muscle
Endothelium
Muscle
Cyclooxygenase 1
20 Citations (Scopus)

Establishment of an immortalized fetal intrapulmonary artery endothelial cell line

Pace, M. C., Chambliss, K. L., German, Z., Yuhanna, I. S., Mendelsohn, M. E. & Shaul, P. W., Jul 1999, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 1 21-1

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Endothelial Cells
Arteries
Cell Line
Estradiol
60 Citations (Scopus)

Estrogen acutely stimulates endothelial nitric oxide synthase in H441 human airway epithelial cells

Kirsch, E. A., Yuhanna, I. S., Chen, Z., German, Z., Sherman, T. S. & Shaul, P. W., 1999, In : American Journal of Respiratory Cell and Molecular Biology. 20, 4, p. 658-666 9 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Nitric Oxide Synthase
Estrogens
Epithelial Cells
Estrogen Receptors
735 Citations (Scopus)

Estrogen receptor mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

Chen, Z., Yuhanna, I. S., Galcheva-Gargova, Z., Karas, R. H., Mendelsohn, M. E. & Shaul, P. W., Feb 1999, In : Journal of Clinical Investigation. 103, 3, p. 401-406 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Estrogen Receptors
Estrogens
Mitogen-Activated Protein Kinases
Cardiovascular Physiological Phenomena
48 Citations (Scopus)
Alveolar Epithelial Cells
Exocytosis
Fluorescence
Cell Membrane
Coloring Agents
40 Citations (Scopus)

Glucocorticoids downregulate cyclooxygenase-1 gene expression and prostacyclin synthesis in fetal pulmonary artery endothelium

Jun, S. S., Chen, Z., Pace, M. C. & Shaul, P. W., Feb 5 1999, In : Circulation Research. 84, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Epoprostenol
Pulmonary Artery
Glucocorticoids
Endothelium
39 Citations (Scopus)

Nitric Oxide (NO) Upregulates NO Synthase Expression in Fetal Intrapulmonary Artery Endothelial Cells

Yuhanna, I. S., MacRitchie, A. N., Lantin-Hermoso, R. L., Wells, L. B. & Shaul, P. W., 1999, In : American Journal of Respiratory Cell and Molecular Biology. 21, 5, p. 629-636 8 p.

Research output: Contribution to journalArticle

Endothelial cells
Nitric Oxide Synthase
Nitric Oxide
Up-Regulation
Endothelial Cells
114 Citations (Scopus)

Nitric oxide synthase isoform expression in the developing lung epithelium

Sherman, T. S., Chen, Z., Yuhanna, I. S., Lau, K. S., Margraf, L. R. & Shaul, P. W., 1999, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 276, 2 20-2

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Protein Isoforms
Epithelium
Lung
Bronchioles
274 Citations (Scopus)

Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation

Blair, A., Shaul, P. W., Yuhanna, I. S., Conrad, P. A. & Smart, E. J., Nov 5 1999, In : Journal of Biological Chemistry. 274, 45, p. 32512-32519 8 p.

Research output: Contribution to journalArticle

Caveolae
Nitric Oxide Synthase Type III
Chemical activation
Caveolins
Cholesterol
137 Citations (Scopus)

Polarized distribution of endogenous Rac1 and RhoA at the cell surface

Michaely, P. A., Mineo, C., Ying, Y. S. & Anderson, R. G. W., Jul 23 1999, In : Journal of Biological Chemistry. 274, 30, p. 21430-21436 7 p.

Research output: Contribution to journalArticle

Caveolae
Platelet-Derived Growth Factor
Fibroblasts
Cell membranes
Membranes
62 Citations (Scopus)

Rapid activation of endothelial nitric oxide synthase by estrogen

Shaul, P. W., Jan 1999, In : Steroids. 64, 1-2, p. 28-34 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Estrogens
Chemical activation
Estrogen Receptors
Phosphotransferases
259 Citations (Scopus)

Regulated migration of epidermal growth factor receptor from caveolae

Mineo, C., Gill, G. N. & Anderson, R. G. W., Oct 22 1999, In : Journal of Biological Chemistry. 274, 43, p. 30636-30643 8 p.

Research output: Contribution to journalArticle

Caveolae
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Clathrin
src-Family Kinases
22 Citations (Scopus)

Regulation of vasodilator synthesis during lung development

Shaul, P. W., Apr 1 1999, In : Early Human Development. 54, 3, p. 271-294 24 p.

Research output: Contribution to journalArticle

Vasodilator Agents
Epoprostenol
Lung
Nitric Oxide
Pulmonary Hypertension
1998
120 Citations (Scopus)

Estrogen upregulates cyclooxygenase-1 gene expression in ovine fetal pulmonary artery endothelium

Jun, S. S., Chen, Z., Pace, M. C. & Shaul, P. W., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 176-183 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Pulmonary Artery
Endothelium
Sheep
Estrogens
50 Citations (Scopus)

Ontogeny of cyclooxygenase-1 and cyclooxygenase-2 gene expression in ovine lung

Brannon, T. S., MacRitchie, A. N., Jaramillo, M. A., Sherman, T. S., Yuhanna, I. S., Margraf, L. R. & Shaul, P. W., Jan 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 274, 1 18-1

Research output: Contribution to journalArticle

Cyclooxygenase 1
Cyclooxygenase 2
Sheep
Gene Expression
Lung
454 Citations (Scopus)

Role of plasmalemmal caveolae in signal transduction

Shaul, P. W. & Anderson, R. G. W., 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 275, 5 19-5

Research output: Contribution to journalArticle

Caveolae
Signal Transduction
Lipid-Linked Proteins
Caveolins
Transcytosis
152 Citations (Scopus)

Targeting of protein kinase Cα to caveolae

Mineo, C., Ying, Y. S., Chapline, C., Jaken, S. & Anderson, R. G. W., May 4 1998, In : Journal of Cell Biology. 141, 3, p. 601-610 10 p.

Research output: Contribution to journalArticle

Caveolae
Protein Kinase C
Membranes
Serum
Enzymes
1997
263 Citations (Scopus)

Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium

Lantin-Hermoso, R. L., Rosenfeld, C. R., Yuhanna, I. S., German, Z., Chen, Z. & Shaul, P. W., Jul 1997, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 273, 1 17-1

Research output: Contribution to journalArticle

Fetal Movement
Nitric Oxide Synthase
Pulmonary Artery
Endothelium
Estrogens
239 Citations (Scopus)

Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium

MacRitchie, A. N., Jun, S. S., Chen, Z., German, Z., Yuhanna, I. S., Sherman, T. S. & Shaul, P. W., 1997, In : Circulation Research. 81, 3, p. 355-362 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Nitric Oxide Synthase
Pulmonary Artery
Endothelium
Estrogens
592 Citations (Scopus)

Inhaled nitric oxide and persistent pulmonary hypertension of the newborn

Roberts, J. D., Fineman, J. R., Morin, F. C., Shaul, P. W., Rimar, S., Schreiber, M. D., Polin, R. A., Zwass, M. S., Zayek, M. M., Gross, I., Heymann, M. A., Zapol, W. M., Thusu, K. G., Zellers, T. M., Wylam, M. E. & Zaslavsky, A., Feb 27 1997, In : New England Journal of Medicine. 336, 9, p. 605-610 6 p.

Research output: Contribution to journalArticle

Persistent Fetal Circulation Syndrome
Nitric Oxide
Pulmonary Hypertension
Extracorporeal Membrane Oxygenation
Vascular Resistance
39 Citations (Scopus)

Ontogeny of nitric oxide in the pulmonary vasculature

Shaul, P. W., 1997, In : Seminars in Perinatology. 21, 5, p. 381-392 12 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Nitric Oxide
Lung
Up-Regulation
Enzymes
72 Citations (Scopus)

Physical association with Ras enhances activation of membrane-bound Raf (RafCAAX)

Mineo, C., Anderson, R. G. W. & White, M. A., Apr 18 1997, In : Journal of Biological Chemistry. 272, 16, p. 10345-10348 4 p.

Research output: Contribution to journalArticle

Chemical activation
Association reactions
Membranes
Caveolae
Cell membranes
136 Citations (Scopus)

Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension

Shaul, P. W., Yuhanna, I. S., German, Z., Chen, Z., Steinhorn, R. H. & Morin, F. C., May 1997, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 272, 5 16-5

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Pulmonary Hypertension
Gene Expression
Lung
Nitric Oxide
1996

Acylation targets endothelial nitric oxide synthase (enos) to plasmalemmal caveolae

Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I. S., Ying, Y., Andersonand, R. G. W. & Michel, T., 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Caveolae
Acylation
acylation
Nitric Oxide Synthase Type III
Cell membranes
1 Citation (Scopus)

Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae

Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I., Ying, Y., Anderson, R. G. W. & Michel, T., 1996, In : Journal of Investigative Medicine. 44, 3

Research output: Contribution to journalArticle

Caveolae
Acylation
Nitric Oxide Synthase Type III
Cell membranes
Citrulline