Pul & Vas Biology

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2020

Identification of scavenger receptor B1 as the airway microfold cell receptor for mycobacterium tuberculosis

Khan, H. S., Nair, V. R., Ruhl, C. R., Alvarez-Arguedas, S., Rendiz, J. L. G., Franco, L. H., Huang, L., Shaul, P. W., Kim, J., Xie, Y., Mitchell, R. B. & Shiloh, M. U., Mar 2020, In : eLife. 9, e52551.

Research output: Contribution to journalArticle

Open Access

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

Cardoso, A. C., Lam, N. T., Savla, J. J., Nakada, Y., Pereira, A. H. M., Elnwasany, A., Menendez-Montes, I., Ensley, E. L., Bezan Petric, U., Sharma, G., Sherry, A. D., Malloy, C. R., Khemtong, C., Kinter, M. T., Tan, W. L. W., Anene-Nzelu, C. G., Foo, R. S. Y., Nguyen, N. U. N., Li, S., Ahmed, M. S. & 14 others, Elhelaly, W. M., Abdisalaam, S., Asaithamby, A., Xing, C., Kanchwala, M., Vale, G., Eckert, K. M., Mitsche, M. A., McDonald, J. G., Hill, J. A., Huang, L., Shaul, P. W., Szweda, L. I. & Sadek, H. A., Feb 1 2020, In : Nature Metabolism. 2, 2, p. 167-178 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Multiscale and morphological analysis of microvascular patterns depicted in contrast-enhanced ultrasound images

Oezdemir, I., Peng, J., Ghosh, D., Sirsi, S., Sirsi, S., Mineo, C., Shaul, P. W. & Hoyt, K., May 1 2020, In : Journal of Medical Imaging. 7, 3, 034001.

Research output: Contribution to journalArticle

2019

Identifying genes with tri-modal association with survival and tumor grade in cancer patients

Zhang, M., Wang, T., Sirianni, R., Shaul, P. W. & Xie, Y., Jan 8 2019, In : BMC Bioinformatics. 20, 1, 13.

Research output: Contribution to journalArticle

7 Scopus citations

Supplementation with the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link between Obesity and Hypertension

Peng, J., Vongpatanasin, W., Sacharidou, A., Kifer, D., Yuhanna, I. S., Banerjee, S., Tanigaki, K., Polasek, O., Chu, H., Sundgren, N. C., Rohatgi, A., Chambliss, K. L., Lauc, G., Mineo, C. & Shaul, P. W., Dec 10 2019, In : Circulation. 140, 24, p. 2005-2018 14 p.

Research output: Contribution to journalArticle

2018

Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium

Sacharidou, A., Chambliss, K. L., Ulrich, V., Salmon, J. E., Shen, Y. M., Herz, J., Hui, D. Y., Terada, L. S., Shaul, P. W. & Mineo, C., May 10 2018, In : Blood. 131, 19, p. 2097-2110 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells

Morel, E., Ghezzal, S., Lucchi, G., Truntzer, C., Pais de Barros, J. P., Simon-Plas, F., Demignot, S., Mineo, C., Shaul, P. W., Leturque, A., Rousset, M. & Carrière, V., Feb 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 2, p. 199-211 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Enhanced Liver Regeneration after Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability

Peng, J., Yu, J., Xu, H., Kang, C., Shaul, P. W., Guan, Y., Zhang, X. & Su, W., Jun 1 2018, In : Cellular Physiology and Biochemistry. 47, 2, p. 784-799 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance

Tanigaki, K., Sacharidou, A., Peng, J., Chambliss, K. L., Yuhanna, I. S., Ghosh, D., Ahmed, M., Szalai, A. J., Vongpatanasin, W., Mattrey, R. F., Chen, Q., Azadi, P., Lingvay, I., Botto, M., Holland, W. L., Kohler, J. J., Sirsi, S. R., Hoyt, K., Shaul, P. W. & Mineo, C., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 309-322 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice

Selvaraj, U. M., Zuurbier, K. R., Whoolery, C. W., Plautz, E. J., Chambliss, K. L., Kong, X., Zhang, S., Kim, S. H., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C., Shaul, P. W. & Stowe, A. M., Nov 1 2018, In : Endocrinology. 159, 11, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Sirtuin1 protects against systemic sclerosis–related pulmonary fibrosis by decreasing proinflammatory and profibrotic processes

Chu, H., Jiang, S., Liu, Q., Ma, Y., Zhu, X., Liang, M., Shi, X., Ding, W., Zhou, X., Zou, H., Qian, F., Shaul, P. W., Jin, L. & Wang, J., Jan 1 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 1, p. 28-39 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2017

17β-Estradiol dysregulates innate immune responses to Pseudomonas aeruginosa respiratory infection and is modulated by estrogen receptor antagonism

Abid, S., Xie, S. K., Bose, M., Shaul, P. W., Terada, L. S., Brody, S. L., Thomas, P. J., Katzenellenbogen, J. A., Kim, S. H., Greenberg, D. E. & Jain, R., Jan 1 2017, In : Infection and immunity. 85, 10, e00422-17.

Research output: Contribution to journalArticle

15 Scopus citations
10 Scopus citations

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

Worthmann, A., John, C., Rühlemann, M. C., Baguhl, M., Heinsen, F. A., Schaltenberg, N., Heine, M., Schlein, C., Evangelakos, I., Mineo, C., Fischer, M., Dandri, M., Kremoser, C., Scheja, L., Franke, A., Shaul, P. W. & Heeren, J., Jul 1 2017, In : Nature Medicine. 23, 7, p. 839-849 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

New Insights in the Pathophysiology of Antiphospholipid Syndrome

Sacharidou, A., Shaul, P. W. & Mineo, C., 2017, (Accepted/In press) In : Seminars in Thrombosis and Hemostasis.

Research output: Contribution to journalArticle

8 Scopus citations

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice

Menazza, S., Sun, J., Appachi, S., Chambliss, K. L., Kim, S. H., Aponte, A., Khan, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Shaul, P. W. & Murphy, E., Jun 1 2017, In : Journal of Molecular and Cellular Cardiology. 107, p. 41-51 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
19 Scopus citations
2016

ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice

Ulrich, V., Gelber, S. E., Vukelic, M., Sacharidou, A., Herz, J., Urbanus, R. T., De Groot, P. G., Natale, D. R., Harihara, A., Redecha, P., Abrahams, V. M., Shaul, P. W., Salmon, J. E. & Mineo, C., Mar 1 2016, In : Arthritis and Rheumatology. 68, 3, p. 730-739 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

Madak-Erdogan, Z., Kim, S. H., Gong, P., Zhao, Y. C., Zhang, H., Chambliss, K. L., Carlson, K. E., Mayne, C. G., Shaul, P. W., Korach, K. S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., May 24 2016, In : Science signaling. 9, 429, ra53.

Research output: Contribution to journalArticle

39 Scopus citations

Endothelial fcg receptor IIB activation blunts insulin delivery to skeletal muscle to cause insulin resistance in mice

Tanigaki, K., Chambliss, K. L., Yuhanna, I. S., Sacharidou, A., Ahmed, M., Atochin, D. N., Huang, P. L., Shaul, P. W. & Mineo, C., Jul 1 2016, In : Diabetes. 65, 7, p. 1996-2005 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of a monoclonal antibody that attenuates antiphospholipid syndrome-related pregnancy complications and thrombosis

Mineo, C., Lanier, L., Jung, E., Sengupta, S., Ulrich, V., Sacharidou, A., Tarango, C., Osunbunmi, O., Shen, Y. M., Salmon, J. E., Brekken, R. A., Huang, X., Thorpe, P. E. & Shaul, P. W., Jul 2016, In : PloS one. 11, 7, e0158757.

Research output: Contribution to journalArticle

11 Scopus citations

Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation

Ding, Y., Huang, L., Xian, X., Yuhanna, I. S., Wasser, C. R., Frotscher, M., Mineo, C., Shaul, P. W. & Herz, J., Mar 15 2016, In : Science Signaling. 9, 419, RA29.

Research output: Contribution to journalArticle

17 Scopus citations

Nonnuclear estrogen receptor activation improves hepatic steatosis in female mice

Chambliss, K. L., Barrera, J., Umetani, M., Umetani, J., Kim, S. H., Madak-Erdogan, Z., Huang, L., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C. & Shaul, P. W., 2016, In : Endocrinology. 157, 10, p. 3731-3741 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth

Koo, Y., Barry, D. M., Xu, K., Tanigaki, K., Davis, G. E., Mineo, C. & Cleaver, O., Apr 1 2016, In : Angiogenesis. 19, 2, p. 173-190 18 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

IgG receptor FcγRIIB plays a key role in obesity-induced hypertension

Sundgren, N. C., Vongpatanasin, W., Boggan, B. M. D., Tanigaki, K., Yuhanna, I. S., Chambliss, K. L., Mineo, C. & Shaul, P. W., Feb 21 2015, In : Hypertension. 65, 2, p. 456-462 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice

Huang, L., Fan, B., Ma, A., Shaul, P. W. & Zhu, H., May 1 2015, In : Journal of Lipid Research. 56, 5, p. 986-997 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle

Lee, W. R., Sacharidou, A., Behling-Kelly, E., Oltmann, S. C., Zhu, W., Ahmed, M., Gerard, R. D., Hui, D. Y., Abe, J. I., Shaul, P. W. & Mineo, C., Apr 17 2015, In : PloS one. 10, 4, e0124494.

Research output: Contribution to journalArticle

5 Scopus citations

Role of the endothelium in the metabolic syndrome: IIB or Not IIB

Shaul, P. W., Jan 2015, In : American Journal of the Medical Sciences. 349, 1, p. 3-5 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

The authors reply

Rohatgi, A. K., de Lemos, J. A. & Shaul, P. W., May 7 2015, In : New England Journal of Medicine. 372, 19, p. 1871-1872 2 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice

Ulrich, V., Konaniah, E. S., Lee, W. R., Khadka, S., Shen, Y. M., Herz, J., Salmon, J. E., Hui, D. Y., Shaul, P. W. & Mineo, C., 2014, In : Journal of the American Heart Association. 3, 5, e001369.

Research output: Contribution to journalArticle

11 Scopus citations

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome

Lee, E. E., Ma, J., Sacharidou, A., Mi, W., Salato, V. K., Nguyen, N., Jiang, Y., Pascual, J. M., North, P. E., Shaul, P. W., Mettlen, M. & Wang, R. C., Nov 24 2014, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

41 Scopus citations
24 Scopus citations

Genetic variants of ApoE and ApoER2 differentially modulate endothelial function

Ulrich, V., Konaniah, E. S., Herz, J., Gerard, R. D., Jung, E., Yuhanna, I. S., Ahmed, M., Hui, D. Y., Mineo, C. & Shaul, P. W., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13493-13498 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

HDL cholesterol efflux capacity and incident cardiovascular events

Rohatgi, A. K., Khera, A., Berry, J. D., Givens, E. G., Ayers, C. R., Wedin, K. E., Neeland, I. J., Yuhanna, I. S., Rader, D. R., de Lemos, J. A. & Shaul, P. W., Dec 18 2014, In : New England Journal of Medicine. 371, 25, p. 2383-2393 11 p.

Research output: Contribution to journalArticle

683 Scopus citations

Mutation of the palmitoylation site of estrogen receptor a in vivo reveals tissue-specific roles for membrane versus nuclear actions

Adlanmerini, M., Solinhac, R., Abot, A., Fabre, A., Raymond-Letron, I., Guihot, A. L., Boudou, F., Sautier, L., Vessieres, E., Kim, S. H., Liere, P., Fontaine, C., Krust, A., Chambon, P., Katzenellenbogen, J. A., Gourdy, P., Shaul, P. W., Henrion, D., Arnal, J. F. & Lenfant, F., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 2, p. E283-E290

Research output: Contribution to journalArticle

136 Scopus citations

The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha

Umetani, M., Ghosh, P., Ishikawa, T., Umetani, J., Ahmed, M., Mineo, C. & Shaul, P. W., Jul 1 2014, In : Cell Metabolism. 20, 1, p. 172-182 11 p.

Research output: Contribution to journalArticle

93 Scopus citations
2013

27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth

Wu, Q., Ishikawa, T., Sirianni, R., Tang, H., McDonald, J. G., Yuhanna, I. S., Thompson, B., Girard, L., Mineo, C., Brekken, R. A., Umetani, M., Euhus, D. M., Xie, Y. & Shaul, P. W., Nov 8 2013, In : Cell Reports. 5, 3, p. 637-645 9 p.

Research output: Contribution to journalArticle

173 Scopus citations

C-reactive protein causes insulin resistance in mice through fcg receptor IIB-mediated inhibition of skeletal muscle glucose delivery

Tanigaki, K., Vongpatanasin, W., Barrera, J. A., Atochin, D. N., Huang, P. L., Bonvini, E., Shaul, P. W. & Mineo, C., Mar 2013, In : Diabetes. 62, 3, p. 721-731 11 p.

Research output: Contribution to journalArticle

32 Scopus citations
18 Scopus citations

LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity

Ishikawa, T., Yuhanna, I. S., Umetani, J., Lee, W. R., Korach, K. S., Shaul, P. W. & Umetani, M., Aug 1 2013, In : Journal of Clinical Investigation. 123, 8, p. 3488-3497 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass

Bartell, S. M., Han, L., Kim, H. N., Kim, S. H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Chambliss, K. L., Shaul, P. W., Roberson, P. K., Weinstein, R. S., Jilka, R. L., Almeida, M. & Manolagas, S. C., Apr 1 2013, In : Molecular Endocrinology. 27, 4, p. 649-656 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Point mutations in the ERα Gαi binding domain segregate nonnuclear from nuclear receptor function

Wu, Q., Chambliss, K., Lee, W. R., Yuhanna, I. S., Mineo, C. & Shaul, P. W., 2013, In : Molecular Endocrinology. 27, 1, p. 2-11 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Scavenger receptor class B type I is a plasma membrane cholesterol sensor.

Saddar, S., Carriere, V., Lee, W. R., Tanigaki, K., Yuhanna, I. S., Parathath, S., Morel, E., Warrier, M., Sawyer, J. K., Gerard, R. D., Temel, R. E., Brown, J. M., Connelly, M., Mineo, C. & Shaul, P. W., Jan 4 2013, In : Unknown Journal. 112, 1, p. 140-151 12 p.

Research output: Contribution to journalArticle

46 Scopus citations
2011

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

Ramesh, S., Morrell, C. N., Tarango, C., Thomas, G. D., Yuhanna, I. S., Girardi, G., Herz, J., Urbanus, R. T., De Groot, P. G., Thorpe, P. E., Salmon, J. E., Shaul, P. W. & Mineo, C., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 120-131 12 p.

Research output: Contribution to journalArticle

104 Scopus citations

Coupling of Fcγ receptor i to Fcγ receptor IIB by src kinase mediates c-reactive protein impairment of endothelial function

Sundgren, N. C., Zhu, W., Yuhanna, I. S., Chambliss, K. L., Ahmed, M., Tanigaki, K., Umetani, M., Mineo, C. & Shaul, P. W., Oct 28 2011, In : Circulation research. 109, 10, p. 1132-1140 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Patent ductus arteriosus ligation alters pulmonary gene expression in preterm baboons

Waleh, N., McCurnin, D. C., Yoder, B. A., Shaul, P. W. & Clyman, R. I., Mar 1 2011, In : Pediatric Research. 69, 3, p. 212-216 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regulation of vegf-induced endothelial cell migration by mitochondrial reactive oxygen species

Wang, Y., Zang, Q. S., Liu, Z., Wu, Q., Maass, D., Dulan, G., Shaul, P. W., Melito, L., Frantz, D. E., Kilgore, J. A., Williams, N. S., Terada, L. S. & Nwariaku, F. E., Sep 1 2011, In : American Journal of Physiology - Cell Physiology. 301, 3, p. C695-C704

Research output: Contribution to journalArticle

109 Scopus citations

The effects of postnatal estrogen therapy on brain development in preterm baboons

Rees, S., Loeliger, M., Shields, A., Shaul, P. W., McCurnin, D., Yoder, B. & Inder, T., Feb 2011, In : American journal of obstetrics and gynecology. 204, 2, p. 177.e8-177.e14

Research output: Contribution to journalArticle

4 Scopus citations
2010

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

Chambliss, K. L., Wu, Q., Oltmann, S., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G. D., Mineo, C., Yuhanna, I. S., Kim, S. H., Madak-Erdogan, Z., Maggi, A., Dineen, S. P., Roland, C. L., Hui, D. Y., Brekken, R. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shaul, P. W., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

176 Scopus citations