Research Output

2020

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia

Winn, B. A., Devkota, L., Kuch, B., Macdonough, M. T., Strecker, T. E., Wang, Y., Shi, Z., Gerberich, J. L., Mondal, D., Ramirez, A. J., Hamel, E., Chaplin, D. J., Davis, P., Mason, R. P., Trawick, M. L. & Pinney, K. G., Apr 24 2020, In : Journal of Natural Products. 83, 4, p. 937-954 18 p.

Research output: Contribution to journalArticle

2019

A Chemiluminescent Probe for HNO Quantification and Real-Time Monitoring in Living Cells

An, W., Ryan, L. S., Reeves, A. G., Bruemmer, K. J., Mouhaffel, L., Gerberich, J. L., Winters, A., Mason, R. P. & Lippert, A. R., Jan 28 2019, In : Angewandte Chemie - International Edition. 58, 5, p. 1361-1365 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression

Kalainayakan, S. P., Ghosh, P., Dey, S., Fitzgerald, K. E., Sohoni, S., Konduri, P. C., Garrossian, M., Liu, L. & Zhang, L., Dec 1 2019, In : Scientific Reports. 9, 1, 1405.

Research output: Contribution to journalArticle

Open Access

Deep learning convolutional neural networks for the estimation of liver fibrosis severity from ultrasound texture

Treacher, A., Beauchamp, D., Quadri, B., Fetzer, D., Vij, A., Yokoo, T. & Montillo, A., Jan 1 2019, Medical Imaging 2019: Computer-Aided Diagnosis. Mori, K. & Hahn, H. K. (eds.). SPIE, 109503E. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10950).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kinetics-Based Measurement of Hypoxia in Living Cells and Animals Using an Acetoxymethyl Ester Chemiluminescent Probe

Ryan, L. S., Gerberich, J., Cao, J., An, W., Jenkins, B. A., Mason, R. P. & Lippert, A. R., May 24 2019, In : ACS Sensors. 4, 5, p. 1391-1398 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Multiple deep learning architectures achieve superior performance diagnosing autism spectrum disorder using features previously extracted from structural and functional mri

Mellema, C., Treacher, A., Nguyen, K. & Montillo, A., Apr 2019, ISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging. IEEE Computer Society, p. 1891-1895 5 p. 8759193. (Proceedings - International Symposium on Biomedical Imaging; vol. 2019-April).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Oxygen-sensitive MRI assessment of tumor response to hypoxic gas breathing challenge

Yang, D. M., Arai, T. J., Campbell, J. W., Gerberich, J. L., Zhou, H. & Mason, R. P., Jul 2019, In : NMR in biomedicine. 32, 7, e4101.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization

Niu, H., Strecker, T. E., Gerberich, J. L., Campbell, J. W., Saha, D., Mondal, D., Hamel, E., Chaplin, D. J., Mason, R. P., Trawick, M. L. & Pinney, K. G., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5594-5615 22 p.

Research output: Contribution to journalArticle

3 Scopus citations

The effect of flow on blood oxygen level dependent (R2*) MRI of orthotopic lung tumors

Zhou, H., Belzile, O., Zhang, Z., Wagner, J., Ahn, C., Richardson, J. A., Saha, D., Brekken, R. A. & Mason, R. P., Jan 1 2019, In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

3 Scopus citations

Translating preclinical MRI methods to clinical oncology

Hormuth, D. A., Sorace, A. G., Virostko, J., Abramson, R. G., Bhujwalla, Z. M., Enriquez-Navas, P., Gillies, R., Hazle, J. D., Mason, R. P., Quarles, C. C., Weis, J. A., Whisenant, J. G., Xu, J. & Yankeelov, T. E., Jan 1 2019, In : Journal of Magnetic Resonance Imaging.

Research output: Contribution to journalReview article

2 Scopus citations
2018

Determining the optimal number of MEG trials: A machine learning and speech decoding perspective

Dash, D., Ferrari, P., Malik, S., Montillo, A., Maldjian, J. A. & Wang, J., Jan 1 2018, Brain Informatics - International Conference, BI 2018, Proceedings. Yang, Y., Yamamoto, V., Wang, S., Jones, E., Su, J., Mitchell, T. & Iasemidis, L. (eds.). Springer Verlag, p. 163-172 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11309 LNAI).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Energy transfer chemiluminescence for ratiometric pH imaging

An, W., Mason, R. P. & Lippert, A. R., Jan 1 2018, In : Organic and Biomolecular Chemistry. 16, 22, p. 4176-4182 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

MR-CBCT image-guided system for radiotherapy of orthotopic rat prostate tumors

Chiu, T. D., Arai, T. J., Campbell, J., Jiang, S. B., Mason, R. P. & Stojadinovic, S., May 1 2018, In : PLoS One. 13, 5, e0198065.

Research output: Contribution to journalArticle

2 Scopus citations

Noninvasive Anatomical and Functional Imaging of Orthotopic Glioblastoma Development and Therapy using Multispectral Optoacoustic Tomography

Balasundaram, G., Ding, L., Li, X., Attia, A. B. E., Dean-Ben, X. L., Ho, C. J. H., Chandrasekharan, P., Tay, H. C., Lim, H. Q., Ong, C. B., Mason, R. P., Razansky, D. & Olivo, M., Oct 1 2018, In : Translational Oncology. 11, 5, p. 1251-1258 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Oxygenation imaging by nuclear magnetic resonance methods

Zhou, H., Arias-Ramos, N., López-Larrubia, P., Mason, R. P., Cerdán, S. & Pacheco-Torres, J., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1718. p. 297-313 17 p. (Methods in Molecular Biology; vol. 1718).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Quantifying the association between white matter integrity changes and subconcussive head impact exposure from a single season of youth and high school football using 3D convolutional neural networks

Saghafi, B., Murugesan, G., Davenport, E., Wagner, B., Urban, J., Kelley, M., Jones, D., Powers, A., Whitlow, C., Stitzel, J., Maldjian, J. A. & Montillo, A., Jan 1 2018, Medical Imaging 2018: Computer-Aided Diagnosis. SPIE, Vol. 10575. 105750E

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Single season changes in resting state network power and the connectivity between regions distinguish head impact exposure level in high school and youth football players

Murugesan, G., Saghafi, B., Davenport, E., Wagner, B., Urban, J., Kelley, M., Jones, D., Powers, A., Whitlow, C., Stitzel, J., Maldjian, J. A. & Montillo, A., Jan 1 2018, Medical Imaging 2018: Computer-Aided Diagnosis. SPIE, Vol. 10575. 105750F

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents

Maguire, C. J., Chen, Z., Mocharla, V. P., Sriram, M., Strecker, T. E., Hamel, E., Zhou, H., Lopez, R., Wang, Y., Mason, R. P., Chaplin, D. J., Trawick, M. L. & Pinney, K. G., Jan 1 2018, In : MedChemComm. 9, 10, p. 1649-1662 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis of fluorescent polythiophene dots

Liu, Z., Nahhas, A., Liu, L., Ada, E., Zhang, X. & Manohar, S. K., Jan 1 2018, In : Journal of Nanomaterials. 2018, 8987348.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting phosphatidylserine with calcium-dependent protein-drug conjugates for the treatment of cancer

Li, R., Chiguru, S., Li, L., Kim, D., Velmurugan, R., Kim, D., Devanaboyina, S. C., Tian, H., Schroit, A., Mason, R. P., Ober, R. J. & Ward, E. S., Jan 1 2018, In : Molecular Cancer Therapeutics. 17, 1, p. 169-182 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells

Dey, S., Kumari, S., Kalainayakan, S. P., Campbell, J., Ghosh, P., Zhou, H., FitzGerald, K. E., Li, M., Mason, R. P., Zhang, L. & Liu, L., Jan 1 2018, In : Oncotarget. 9, 3, p. 4090-4101 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Tomographic breathing detection: A method to noninvasively assess in situ respiratory dynamics

O'Kelly, D., Zhou, H. & Mason, R. P., May 1 2018, In : Journal of Biomedical Optics. 23, 5, 056011.

Research output: Contribution to journalArticle

2017

Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors

Yan, Y., Zhou, K., Xiong, H., Miller, J. B., Motea, E. A., Boothman, D. A., Liu, L. & Siegwart, D. J., Feb 1 2017, In : Biomaterials. 118, p. 84-93 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Applications of Resting State Functional MR Imaging to Traumatic Brain Injury

O'Neill, T., Davenport, E. M., Murugesan, G., Montillo, A. & Maldjian, J. A., Nov 1 2017, In : Neuroimaging Clinics of North America. 27, 4, p. 685-696 12 p.

Research output: Contribution to journalReview article

4 Scopus citations

Automatic 1D convolutional neural network-based detection of artifacts in MEG acquired without electrooculography or electrocardiography

Garg, P., Davenport, E., Murugesan, G., Wagner, B., Whitlow, C., Maldjian, J. A. & Montillo, A., Jul 14 2017, 2017 International Workshop on Pattern Recognition in Neuroimaging, PRNI 2017. Institute of Electrical and Electronics Engineers Inc., 7981506

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Automatic identification of successful memory encoding in stereo-EEG of refractory, mesial temporal lobe epilepsy

Famili, A., Krishnan, G., Davenport, E., Germi, J., Wagner, B., Lega, B. & Montillo, A., Jun 15 2017, 2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017. IEEE Computer Society, p. 587-590 4 p. 7950589

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Changes in resting state MRI networks from a single season of football distinguishes controls, low, and high head impact exposure

Murugesan, G., Famili, A., Davenport, E., Wagner, B., Urban, J., Kelley, M., Jones, D., Whitlow, C., Stitzel, J., Maldjian, J. A. & Montillo, A., Jun 15 2017, 2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017. IEEE Computer Society, p. 464-467 4 p. 7950561

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Interactions of Renal-Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects

Yu, M., Zhou, C., Liu, L., Zhang, S., Sun, S., Hankins, J. D., Sun, X. & Zheng, J., Apr 3 2017, In : Angewandte Chemie - International Edition. 56, 15, p. 4314-4319 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Oxygen breathing challenge- The simplest theranostic

Mason, R. P., 2017, In : Theranostics. 7, 16, p. 3873-3875 3 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Preface MCV 2016

Müller, H., Kelm, B. M., Cai, W., Langs, G., Menze, B., Metaxas, D., Montillo, A. & Zhang, S., Jan 1 2017, In : Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 10081 LNCS

Research output: Contribution to journalEditorial

Quantifying the impact of type 2 diabetes on brain perfusion using deep neural networks

Saghafi, B., Garg, P., Wagner, B. C., Smith, S. C., Xu, J., Madhuranthakam, A. J., Jung, Y., Divers, J., Freedman, B. I., Maldjian, J. A. & Montillo, A., 2017, Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support - 3rd International Workshop, DLMIA 2017 and 7th International Workshop, ML-CDS 2017 Held in Conjunction with MICCAI 2017, Proceedings. Springer Verlag, Vol. 10553 LNCS. p. 151-159 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10553 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Synthesis of a cell penetrating peptide modified superparamagnetic iron oxide and MRI detection of bladder cancer

Ding, C., Wu, K., Wang, W., Guan, Z., Wang, L., Wang, X., Wang, R., Liu, L. & Fan, J., Jan 1 2017, In : Oncotarget. 8, 3, p. 4718-4729 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

TRF/miR-1280 suppresses stem cell-like cells and metastasis in colorectal cancer

Huang, B., Yang, H., Cheng, X., Wang, D., Fu, S., Shen, W., Zhang, Q., Zhang, L., Xue, Z., Li, Y., Da, Y., Yang, Q., Li, Z., Liu, L., Qiao, L., Kong, Y., Yao, Z., Zhao, P., Li, M. & Zhang, R., Jun 15 2017, In : Cancer Research. 77, 12, p. 3194-3206 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multi-parametric magnetic resonance imaging

Zhou, H., Zhang, Z., Denney, R., Williams, J. S., Gerberich, J., Stojadinovic, S., Saha, D., Shelton, J. M. & Mason, R. P., Jan 1 2017, In : Oncotarget. 8, 23, p. 37464-37477 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ultrasound-stimulated drug delivery using therapeutic reconstituted high-density lipoprotein nanoparticles

Xiong, F., Nirupama, S., Sirsi, S. R., Lacko, A. & Hoyt, K., Jan 1 2017, In : Nanotheranostics. 1, 4, p. 440-449 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Using convolutional neural networks to automatically detect eye-blink artifacts in magnetoencephalography without resorting to electrooculography

Garg, P., Davenport, E., Murugesan, G., Wagner, B., Whitlow, C., Maldjian, J. A. & Montillo, A., Jan 1 2017, Medical Image Computing and Computer Assisted Intervention − MICCAI 2017 - 20th International Conference, Proceedings. Springer Verlag, Vol. 10435 LNCS. p. 374-381 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10435 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations
2016

A role for dynamic contrast-enhanced magnetic resonance imaging in predicting tumour radiation response

Hallac, R. R., Zhou, H., Pidikiti, R., Song, K., Solberg, T., Kodibagkar, V. D., Peschke, P. & Mason, R. P., May 3 2016, (Accepted/In press) In : British Journal of Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors

Glowa, C., Karger, C. P., Brons, S., Zhao, D., Mason, R. P., Huber, P. E., Debus, J. & Peschke, P., Aug 10 2016, In : Cancer Letters. 378, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents

Devkota, L., Lin, C. M., Strecker, T. E., Wang, Y., Tidmore, J. K., Chen, Z., Guddneppanavar, R., Jelinek, C. J., Lopez, R., Liu, L., Hamel, E., Mason, R. P., Chaplin, D. J., Trawick, M. L. & Pinney, K. G., Mar 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 5, p. 938-956 19 p.

Research output: Contribution to journalArticle

22 Scopus citations

Developing oxygen-enhanced magnetic resonance imaging as a prognostic biomarker of radiation response

White, D. A., Zhang, Z., Li, L., Gerberich, J., Stojadinovic, S., Peschke, P. & Mason, R. P., Sep 28 2016, In : Cancer Letters. 380, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy

Zhang, Z., Wodzak, M., Belzile, O., Zhou, H., Sishc, B., Yan, H., Stojadinovic, S., Mason, R. P., Brekken, R. A., Chopra, R., Story, M. D., Timmerman, R. & Saha, D., Jun 1 2016, In : Radiation Research. 185, 6, p. 616-622 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells

Yan, Y., Liu, L., Xiong, H., Miller, J. B., Zhou, K., Kos, P., Huffman, K. E., Elkassih, S., Norman, J. W., Carstens, R., Kim, J., Minna, J. D. & Siegwart, D. J., Sep 27 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 39, p. E5702-E5710

Research output: Contribution to journalArticle

38 Scopus citations

Inorganic phosphate-triggered release of anti-cancer arsenic trioxide from a self-delivery system: An in vitro and in vivo study

Chen, F. Y., Yi, J. W., Gu, Z. J., Tang, B. B., Li, J. Q., Li, L., Kulkarni, P., Liu, L., Mason, R. P. & Tang, Q., Mar 21 2016, In : Nanoscale. 8, 11, p. 6094-6100 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Investigation of the strategies for targeting of the afterglow nanoparticles to tumor cells

Rashidi, L. H., Homayoni, H., Zou, X., Liu, L. & Chen, W., Mar 1 2016, In : Photodiagnosis and Photodynamic Therapy. 13, p. 244-254 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

In Vivo Chemiluminescent Imaging Agents for Nitroreductase and Tissue Oxygenation

Cao, J., Campbell, J., Liu, L., Mason, R. P. & Lippert, A. R., May 3 2016, In : Analytical Chemistry. 88, 9, p. 4995-5002 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Latex carrier for improving protoporphyrin IX for photodynamic therapy

Bui, B., Liu, L. & Chen, W., Jun 1 2016, In : Photodiagnosis and Photodynamic Therapy. 14, p. 159-165 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Overview of the 2015 workshop on medical computer vision — Algorithms for big data (MCV 2015)

Müller, H., Menze, B., Langs, G., Montillo, A., Kelm, M., Zhang, S., Cai, W. & Metaxas, D., Jan 1 2016, Medical Computer Vision: Algorithms for Big Data - International Workshop, MCV 2015 and Held in Conjunction with MICCAI 2015, Revised Selected Papers. Springer Verlag, Vol. 9601 LNCS. p. 3-9 7 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 9601 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Preface

Menze, B., Langs, G., Müller, H., Montillo, A., Kelm, M., Zhang, S., Cai, W. & Metaxas, D., Jan 1 2016, In : Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 9601 LNCS

Research output: Contribution to journalEditorial

Synthesis and biological evaluation of benzocyclooctene-based and indene-based anticancer agents that function as inhibitors of tubulin polymerization

Herdman, C. A., Strecker, T. E., Tanpure, R. P., Chen, Z., Winters, A., Gerberich, J., Liu, L., Hamel, E., Mason, R. P., Chaplin, D. J., Trawick, M. L. & Pinney, K. G., 2016, In : MedChemComm. 7, 12, p. 2418-2427 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

The evaluation of lanthanum trapped prussian blue as a phosphate binding agent with reduced bone uptake

Chen, F. Y., Gu, Z. J., Yi, J. W., Xu, X. Z., Kulkarni, P. & Tang, Q., 2016, In : New Journal of Chemistry. 40, 3, p. 2644-2648 5 p.

Research output: Contribution to journalArticle

2 Scopus citations