Research Output 1973 2019

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2019

Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression

Kalainayakan, S. P., Ghosh, P., Dey, S., Fitzgerald, K. E., Sohoni, S., Konduri, P. C., Garrossian, M., Liu, L. & Zhang, L., Dec 1 2019, In : Scientific Reports. 9, 1, 1405.

Research output: Contribution to journalArticle

Open Access
Oxidative Phosphorylation
Heme
Respiration
Lung
Non-Small Cell Lung Carcinoma

Kinetics-Based Measurement of Hypoxia in Living Cells and Animals Using an Acetoxymethyl Ester Chemiluminescent Probe

Ryan, L. S., Gerberich, J., Cao, J., An, W., Jenkins, B. A., Mason, R. P. & Lippert, A. R., May 24 2019, In : ACS Sensors. 4, 5, p. 1391-1398 8 p.

Research output: Contribution to journalArticle

hypoxia
animals
Tumors
esters
Esters

Oxygen-sensitive MRI assessment of tumor response to hypoxic gas breathing challenge

Yang, D. M., Arai, T. J., Campbell, J. W., Gerberich, J. L., Zhou, H. & Mason, R. P., Jan 1 2019, In : NMR in biomedicine. e4101.

Research output: Contribution to journalArticle

Open Access
Magnetic resonance imaging
Tumors
Respiration
Gases
Oxygen
1 Citation (Scopus)

Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization

Niu, H., Strecker, T. E., Gerberich, J. L., Campbell, J. W., Saha, D., Mondal, D., Hamel, E., Chaplin, D. J., Mason, R. P., Trawick, M. L. & Pinney, K. G., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5594-5615 22 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Colchicine
Blood Vessels
Cytotoxins
Biological Products
3 Citations (Scopus)

The effect of flow on blood oxygen level dependent (R2*) MRI of orthotopic lung tumors

Zhou, H., Belzile, O., Zhang, Z., Wagner, J., Ahn, C., Richardson, J. A., Saha, D., Brekken, R. A. & Mason, R. P., Jan 1 2019, In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Oxygen
Lung
Neoplasms
Heterografts
Nude Rats
2018
8 Citations (Scopus)

A Chemiluminescent Probe for HNO Quantification and Real-Time Monitoring in Living Cells

An, W., Ryan, L. S., Reeves, A. G., Bruemmer, K. J., Mouhaffel, L., Gerberich, J. L., Winters, A., Mason, R. P. & Lippert, A. R., Jan 1 2018, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

phosphine
Reactive Nitrogen Species
Bioactivity
Cells
Tissue
6 Citations (Scopus)

Energy transfer chemiluminescence for ratiometric pH imaging

An, W., Mason, R. P. & Lippert, A. R., Jan 1 2018, In : Organic and Biomolecular Chemistry. 16, 22, p. 4176-4182 7 p.

Research output: Contribution to journalArticle

Chemiluminescence
Energy Transfer
chemiluminescence
Luminescence
Energy transfer
1 Citation (Scopus)

MR-CBCT image-guided system for radiotherapy of orthotopic rat prostate tumors

Chiu, T. D., Arai, T. J., Campbell, J., Jiang, S. B., Mason, R. P. & Stojadinovic, S., May 1 2018, In : PLoS One. 13, 5, e0198065.

Research output: Contribution to journalArticle

Image-Guided Radiotherapy
Cone-Beam Computed Tomography
Radiotherapy
prostatic neoplasms
radiotherapy
2 Citations (Scopus)

Noninvasive Anatomical and Functional Imaging of Orthotopic Glioblastoma Development and Therapy using Multispectral Optoacoustic Tomography

Balasundaram, G., Ding, L., Li, X., Attia, A. B. E., Dean-Ben, X. L., Ho, C. J. H., Chandrasekharan, P., Tay, H. C., Lim, H. Q., Ong, C. B., Mason, R. P., Razansky, D. & Olivo, M., Oct 1 2018, In : Translational Oncology. 11, 5, p. 1251-1258 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Tomography
Neoplasms
Brain
Therapeutics
4 Citations (Scopus)

Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents

Maguire, C. J., Chen, Z., Mocharla, V. P., Sriram, M., Strecker, T. E., Hamel, E., Zhou, H., Lopez, R., Wang, Y., Mason, R. P., Chaplin, D. J., Trawick, M. L. & Pinney, K. G., Jan 1 2018, In : MedChemComm. 9, 10, p. 1649-1662 14 p.

Research output: Contribution to journalArticle

Bearings (structural)
Antineoplastic Agents
Tumors
Tubulin Modulators
Prodrugs

Synthesis of fluorescent polythiophene dots

Liu, Z., Nahhas, A., Liu, L., Ada, E., Zhang, X. & Manohar, S. K., Jan 1 2018, In : Journal of Nanomaterials. 2018, 8987348.

Research output: Contribution to journalArticle

Polymers
hydrazine
Thiophenes
Hydrazine
Thiophene
2 Citations (Scopus)

Targeting phosphatidylserine with calcium-dependent protein-drug conjugates for the treatment of cancer

Li, R., Chiguru, S., Li, L., Kim, D., Velmurugan, R., Kim, D., Devanaboyina, S. C., Tian, H., Schroit, A., Mason, R. P., Ober, R. J. & Ward, E. S., Jan 1 2018, In : Molecular Cancer Therapeutics. 17, 1, p. 169-182 14 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Calcium
Pharmaceutical Preparations
Neoplasms
Proteins
9 Citations (Scopus)

The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells

Dey, S., Kumari, S., Kalainayakan, S. P., Campbell, J., Ghosh, P., Zhou, H., FitzGerald, K. E., Li, M., Mason, R. P., Zhang, L. & Liu, L., Jan 1 2018, In : Oncotarget. 9, 3, p. 4090-4101 12 p.

Research output: Contribution to journalArticle

Heme
Blood Vessels
Phosphates
Neoplasms
Proteins

Tomographic breathing detection: A method to noninvasively assess in situ respiratory dynamics

O'Kelly, D., Zhou, H. & Mason, R. P., May 1 2018, In : Journal of Biomedical Optics. 23, 5, 056011.

Research output: Contribution to journalArticle

breathing
Imaging techniques
Monitoring
Anesthetics
Photoacoustic effect
2017
24 Citations (Scopus)

Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors

Yan, Y., Zhou, K., Xiong, H., Miller, J. B., Motea, E. A., Boothman, D. A., Liu, L. & Siegwart, D. J., Feb 1 2017, In : Biomaterials. 118, p. 84-93 10 p.

Research output: Contribution to journalArticle

Polyesters
Aerosols
Gene expression
Nanoparticles
Small Interfering RNA
19 Citations (Scopus)

Interactions of Renal-Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects

Yu, M., Zhou, C., Liu, L., Zhang, S., Sun, S., Hankins, J. D., Sun, X. & Zheng, J., Apr 3 2017, In : Angewandte Chemie - International Edition. 56, 15, p. 4314-4319 6 p.

Research output: Contribution to journalArticle

Acidity
Gold
Tumors
Nanoparticles
Medical nanotechnology
8 Citations (Scopus)

Synthesis of a cell penetrating peptide modified superparamagnetic iron oxide and MRI detection of bladder cancer

Ding, C., Wu, K., Wang, W., Guan, Z., Wang, L., Wang, X., Wang, R., Liu, L. & Fan, J., 2017, In : Oncotarget. 8, 3, p. 4718-4729 12 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Urinary Bladder Neoplasms
Nanoparticles
Contrast Media
Urinary Bladder
21 Citations (Scopus)

TRF/miR-1280 suppresses stem cell-like cells and metastasis in colorectal cancer

Huang, B., Yang, H., Cheng, X., Wang, D., Fu, S., Shen, W., Zhang, Q., Zhang, L., Xue, Z., Li, Y., Da, Y., Yang, Q., Li, Z., Liu, L., Qiao, L., Kong, Y., Yao, Z., Zhao, P., Li, M. & Zhang, R., Jun 15 2017, In : Cancer Research. 77, 12, p. 3194-3206 13 p.

Research output: Contribution to journalArticle

Transfer RNA
Colorectal Neoplasms
Stem Cells
Neoplasm Metastasis
Neoplastic Stem Cells
8 Citations (Scopus)

Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multi-parametric magnetic resonance imaging

Zhou, H., Zhang, Z., Denney, R., Williams, J. S., Gerberich, J., Stojadinovic, S., Saha, D., Shelton, J. M. & Mason, R. P., 2017, In : Oncotarget. 8, 23, p. 37464-37477 14 p.

Research output: Contribution to journalArticle

Radiotherapy
Magnetic Resonance Imaging
Neoplasms
Oxygen
Blood Vessels
2016
2 Citations (Scopus)

A role for dynamic contrast-enhanced magnetic resonance imaging in predicting tumour radiation response

Hallac, R. R., Zhou, H., Pidikiti, R., Song, K., Solberg, T., Kodibagkar, V. D., Peschke, P. & Mason, R. P., May 3 2016, (Accepted/In press) In : British Journal of Cancer.

Research output: Contribution to journalArticle

Magnetic Resonance Imaging
Radiation
Neoplasms
Respiration
Air
17 Citations (Scopus)

Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors

Glowa, C., Karger, C. P., Brons, S., Zhao, D., Mason, R. P., Huber, P. E., Debus, J. & Peschke, P., Aug 10 2016, In : Cancer Letters. 378, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

Heavy Ion Radiotherapy
Prostate
Radiation
Photons
Ions
18 Citations (Scopus)

Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents

Devkota, L., Lin, C. M., Strecker, T. E., Wang, Y., Tidmore, J. K., Chen, Z., Guddneppanavar, R., Jelinek, C. J., Lopez, R., Liu, L., Hamel, E., Mason, R. P., Chaplin, D. J., Trawick, M. L. & Pinney, K. G., Mar 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 5, p. 938-956 19 p.

Research output: Contribution to journalArticle

Prodrugs
Leucyl Aminopeptidase
Blood Vessels
Cytotoxicity
Amino Acids
19 Citations (Scopus)

Developing oxygen-enhanced magnetic resonance imaging as a prognostic biomarker of radiation response

White, D. A., Zhang, Z., Li, L., Gerberich, J., Stojadinovic, S., Peschke, P. & Mason, R. P., Sep 28 2016, In : Cancer Letters. 380, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

Biomarkers
Magnetic Resonance Imaging
Radiation
Oxygen
Respiration
5 Citations (Scopus)

Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy

Zhang, Z., Wodzak, M., Belzile, O., Zhou, H., Sishc, B., Yan, H., Stojadinovic, S., Mason, R. P., Brekken, R. A., Chopra, R., Story, M. D., Timmerman, R. & Saha, D., Jun 1 2016, In : Radiation Research. 185, 6, p. 616-622 7 p.

Research output: Contribution to journalArticle

lungs
rats
radiation therapy
Radiotherapy
tumors
35 Citations (Scopus)

Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells

Yan, Y., Liu, L., Xiong, H., Miller, J. B., Zhou, K., Kos, P., Huffman, K. E., Elkassih, S., Norman, J. W., Carstens, R., Kim, J., Minna, J. D. & Siegwart, D. J., Sep 27 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 39, p. E5702-E5710

Research output: Contribution to journalArticle

Polyesters
Small Interfering RNA
Lung Neoplasms
Nanoparticles
Neoplasms
7 Citations (Scopus)

Inorganic phosphate-triggered release of anti-cancer arsenic trioxide from a self-delivery system: An in vitro and in vivo study

Chen, F. Y., Yi, J. W., Gu, Z. J., Tang, B. B., Li, J. Q., Li, L., Kulkarni, P., Liu, L., Mason, R. P. & Tang, Q., Mar 21 2016, In : Nanoscale. 8, 11, p. 6094-6100 7 p.

Research output: Contribution to journalArticle

Arsenic
Drug delivery
Tumors
Phosphates
Cells
7 Citations (Scopus)

Investigation of the strategies for targeting of the afterglow nanoparticles to tumor cells

Rashidi, L. H., Homayoni, H., Zou, X., Liu, L. & Chen, W., Mar 1 2016, In : Photodiagnosis and Photodynamic Therapy. 13, p. 244-254 11 p.

Research output: Contribution to journalArticle

Folic Acid
Nanoparticles
Neoplasms
Breast Neoplasms
Integrins
46 Citations (Scopus)

In Vivo Chemiluminescent Imaging Agents for Nitroreductase and Tissue Oxygenation

Cao, J., Campbell, J., Liu, L., Mason, R. P. & Lippert, A. R., May 3 2016, In : Analytical Chemistry. 88, 9, p. 4995-5002 8 p.

Research output: Contribution to journalArticle

Nitroreductases
Oxygenation
Tumors
Tissue
Oxygen
3 Citations (Scopus)

Latex carrier for improving protoporphyrin IX for photodynamic therapy

Bui, B., Liu, L. & Chen, W., Jun 1 2016, In : Photodiagnosis and Photodynamic Therapy. 14, p. 159-165 7 p.

Research output: Contribution to journalArticle

Latex
Photochemotherapy
Styrene
Singlet Oxygen
protoporphyrin IX
13 Citations (Scopus)

Synthesis and biological evaluation of benzocyclooctene-based and indene-based anticancer agents that function as inhibitors of tubulin polymerization

Herdman, C. A., Strecker, T. E., Tanpure, R. P., Chen, Z., Winters, A., Gerberich, J., Liu, L., Hamel, E., Mason, R. P., Chaplin, D. J., Trawick, M. L. & Pinney, K. G., 2016, In : MedChemComm. 7, 12, p. 2418-2427 10 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Antineoplastic Agents
Blood Vessels
Prodrugs
Salts
2 Citations (Scopus)

The evaluation of lanthanum trapped prussian blue as a phosphate binding agent with reduced bone uptake

Chen, F. Y., Gu, Z. J., Yi, J. W., Xu, X. Z., Kulkarni, P. & Tang, Q., 2016, In : New Journal of Chemistry. 40, 3, p. 2644-2648 5 p.

Research output: Contribution to journalArticle

Lanthanum
Bone
Phosphates
Binders
Liver
2 Citations (Scopus)

Tumor radio-sensitivity assessment by means of volume data and magnetic resonance indices measured on prostate tumor bearing rats

Belfatto, A., White, D. A., Mason, R. P., Zhang, Z., Stojadinovic, S., Baroni, G. & Cerveri, P., Mar 1 2016, In : Medical Physics. 43, 3, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

Radio
Prostate
Magnetic Resonance Spectroscopy
Radiotherapy
Oxygen
8 Citations (Scopus)

Wavelength shifting of chemiluminescence using quantum dots to enhance tissue light penetration

Mason, E. A., Lopez, R. & Mason, R. P., Apr 1 2016, In : Optical Materials Express. 6, 4, p. 1384-1392 9 p.

Research output: Contribution to journalArticle

Chemiluminescence
Semiconductor quantum dots
Tissue
Wavelength
Bioluminescence
2015
7 Citations (Scopus)

Acquisition, preprocessing, and reconstruction of ultralow dose volumetric CT scout for organ-based CT scan planning

Yin, Z., Yao, Y., Montillo, A., Wu, M., Edic, P. M., Kalra, M. & De Man, B., May 1 2015, In : Medical Physics. 42, 5, p. 2730-2739 10 p.

Research output: Contribution to journalArticle

Cone-Beam Computed Tomography
Cadaver
Noise
Thorax
Radiation
12 Citations (Scopus)

Assessment of tumor response to oxygen challenge using quantitative diffusion MRI in an animal model

Zhang, Z., Yuan, Q., Zhou, H., Zhao, D., Li, L., Gerberich, J. L. & Mason, R. P., Nov 1 2015, In : Journal of Magnetic Resonance Imaging. 42, 5, p. 1450-1457 8 p.

Research output: Contribution to journalArticle

Diffusion Magnetic Resonance Imaging
Animal Models
Oxygen
Neoplasms
Air
61 Citations (Scopus)

Chemiluminescent probes for imaging H2S in living animals

Cao, J., Lopez, R., Thacker, J. M., Moon, J. Y., Jiang, C., Morris, S. N. S., Bauer, J. H., Tao, P., Mason, R. P. & Lippert, A. R., Mar 1 2015, In : Chemical Science. 6, 3, p. 1979-1985 7 p.

Research output: Contribution to journalArticle

Animals
Imaging techniques
Hydrogen Sulfide
Light emission
CCD cameras
13 Citations (Scopus)

Click-chemistry strategy for labeling antibodies with copper-64 via a cross-bridged tetraazamacrocyclic chelator scaffold

Kumar, A., Hao, G., Liu, L., Ramezani, S., Hsieh, J. T., Öz, O. K. & Sun, X., Apr 15 2015, In : Bioconjugate Chemistry. 26, 4, p. 782-789 8 p.

Research output: Contribution to journalArticle

Click Chemistry
Chelating Agents
Antibodies
Scaffolds
Labeling
3 Citations (Scopus)

Commentary on photoacoustic tomography

Mason, R. P., Dec 1 2015, In : Journal of Nuclear Medicine. 56, 12, p. 1815-1816 2 p.

Research output: Contribution to journalArticle

Photoacoustic Techniques
Recombinant Fusion Proteins
Angiogenesis Inhibitors
Ovarian Neoplasms
Blood Vessels
36 Citations (Scopus)

Controlled release of therapeutics using interpenetrating polymeric networks

Aminabhavi, T. M., Nadagouda, M. N., More, U. A., Joshi, S. D., Kulkarni, V. H., Noolvi, M. N. & Kulkarni, P. V., Apr 1 2015, In : Expert Opinion on Drug Delivery. 12, 4, p. 669-688 20 p.

Research output: Contribution to journalArticle

Polymers
Anti-Asthmatic Agents
Drug Compounding
Hydrogels
Expert Testimony
19 Citations (Scopus)

Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs

Zhang, L., Zhang, Z., Mason, R. P., Sarkaria, J. N. & Zhao, D., May 12 2015, In : Scientific Reports. 5, 09874.

Research output: Contribution to journalArticle

temozolomide
Manganese
Glioma
Glioblastoma
Pharmaceutical Preparations
17 Citations (Scopus)
Optical Imaging
Heterografts
Brain Neoplasms
Blood Vessels
Neoplasms
26 Citations (Scopus)

Dynamic oxygen challenge evaluated by NMR T<inf>1</inf> and T<inf>2</inf>* - insights into tumor oxygenation

Zhao, D., Pacheco-Torres, J., Hallac, R. R., White, D., Peschke, P., Cerdán, S. & Mason, R. P., 2015, (Accepted/In press) In : NMR in Biomedicine.

Research output: Contribution to journalArticle

Oxygenation
Tumors
Nuclear magnetic resonance
Oxygen
Neoplasms
9 Citations (Scopus)

One-pot synthesis of functional poly(amino ester sulfide)s and utility in delivering pDNA and siRNA

Yan, Y., Xue, L., Miller, J. B., Zhou, K., Kos, P., Elkassih, S., Liu, L., Nagai, A., Xiong, H. & Siegwart, D. J., Jan 3 2015, In : Polymer (United Kingdom). 72, p. 271-280 10 p.

Research output: Contribution to journalArticle

Sulfides
Small Interfering RNA
Esters
Polymers
Gene therapy
12 Citations (Scopus)

Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization

Herdman, C. A., Devkota, L., Lin, C. M., Niu, H., Strecker, T. E., Lopez, R., Liu, L., George, C. S., Tanpure, R. P., Hamel, E., Chaplin, D. J., Mason, R. P., Trawick, M. L. & Pinney, K. G., Dec 15 2015, In : Bioorganic and Medicinal Chemistry. 23, 24, p. 7497-7520 24 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Cytotoxicity
Inhibitory Concentration 50
Blood Vessels
Bearings (structural)
13 Citations (Scopus)

The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts

Strecker, T. E., Odutola, S. O., Lopez, R., Cooper, M. S., Tidmore, J. K., Charlton-Sevcik, A. K., Li, L., MacDonough, M. T., Hadimani, M. B., Ghatak, A., Liu, L., Chaplin, D. J., Mason, R. P., Pinney, K. G. & Trawick, M. L., Dec 1 2015, In : Cancer Letters. 369, 1, p. 229-241 13 p.

Research output: Contribution to journalArticle

Human Umbilical Vein Endothelial Cells
Prodrugs
Heterografts
Blood Vessels
Endothelial Cells
2014
19 Citations (Scopus)

A noninvasive tumor oxygenation imaging strategy using magnetic resonance imaging of endogenous blood and tissue water

Zhang, Z., Hallac, R. R., Peschke, P. & Mason, R. P., Feb 2014, In : Magnetic Resonance in Medicine. 71, 2, p. 561-569 9 p.

Research output: Contribution to journalArticle

Magnetic Resonance Imaging
Blood Volume
Water
Oxygen
Neoplasms
61 Citations (Scopus)

Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response

Hallac, R. R., Zhou, H., Pidikiti, R., Song, K., Stojadinovic, S., Zhao, D., Solberg, T., Peschke, P. & Mason, R. P., 2014, In : Magnetic Resonance in Medicine. 71, 5, p. 1863-1873 11 p.

Research output: Contribution to journalArticle

Radiation
Neoplasms
Growth
Oxygen
Respiration
38 Citations (Scopus)

Development of intrinsically photoluminescent and photostable polylactones

Xie, Z., Zhang, Y., Liu, L., Weng, H., Mason, R. P., Tang, L., Nguyen, K. T., Hsieh, J. T. & Yang, J., Jul 9 2014, In : Advanced Materials. 26, 26, p. 4491-4496 6 p.

Research output: Contribution to journalArticle

Biodegradable polymers
Drug delivery
Nanoparticles
Imaging techniques
Degradation
5 Citations (Scopus)
Molecular imaging
Molecular Imaging
Indocyanine Green
Heterografts
Blood Vessels
20 Citations (Scopus)
Nitroimidazoles
Magnetic resonance imaging
Contrast Media
Tumors
Metals