Simmons Comprehensive Cancer Center - Research Labs

Research output

Research output per year 1973 2004 2006 2007 2008 2009 2011 2014 2015 2016 2017 2018 2024

• 545 Article
• 52 Review article
• 18 Conference contribution
• 17 Comment/debate
• 18 More
  • 10 Chapter
  • 4 Short survey
  • 2 Editorial
  • 1 Book
  • 1 Conference article

Research output per year

Research output per year

Search results

• 2024

  Severely polarized extracellular acidity around tumour cells

  Feng, Q., Bennett, Z., Grichuk, A., Pantoja, R., Huang, T., Faubert, B., Huang, G., Chen, M., DeBerardinis, R. J., Sumer, B. D. & Gao, J., 2024, (Accepted/In press) In: Nature Biomedical Engineering.

  Research output: Contribution to journal › Article › peer-review

  • Acidity 100%
  • Tumors 74%
  • Cells 70%
  • Nanoprobes 65%
  • Chemical activation 32%

• STING licensing of type I dendritic cells potentiates antitumor immunity

  Wang, J., Li, S., Wang, M., Wang, X., Chen, S., Sun, Z., Ren, X., Huang, G., Sumer, B. D., Yan, N., Fu, Y. X. & Gao, J., Feb 2024, In: Science Immunology. 9, 92, eadj3945.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Licensure 100%
  • Interferons 84%
  • Dendritic Cells 82%
  • Immunity 75%
  • Genes 37%
• 2023

  Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function

  Prabhakar, A. T., James, C. D., Fontan, C. T., Otoa, R., Wang, X., Bristol, M. L., Yeager, C., Hill, R. D., Dubey, A., Wu, S. Y., Chiang, C. M. & Morgan, I. M., Oct 2023, In: Journal of virology. 97, 10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human papillomavirus 16 71%
  • chromatin 54%
  • Chromatin 54%
  • Plasmids 49%
  • plasmids 46%

• Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping

  Yang, H., Sui, P., Guo, Y., Chen, S., Maloof, M. E., Ge, G., Nihozeko, F., Delma, C. R., Zhu, G., Zhang, P., Ye, Z., Medina, E. A., Ayad, N. G., Mesa, R., Nimer, S. D., Chiang, C. M., Xu, M., Chen, Y. & Yang, F. C., Oct 9 2023, In: EMBO Reports. 24, 10, e57032.

  Research output: Contribution to journal › Article › peer-review

  • Cellular Senescence 100%
  • Histone 97%
  • Hematopoietic Stem Cells 90%
  • Histones 85%
  • H3K4Me3 42%
  1 Scopus citations

• Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden

  Zhu, M., Kim, J., Deng, Q., Ricciuti, B., Alessi, J. V., Eglenen-Polat, B., Bender, M. E., Huang, H. C., Kowash, R. R., Cuevas, I., Bennett, Z. T., Gao, J., Minna, J. D., Castrillon, D. H., Awad, M. M., Xu, L. & Akbay, E. A., Oct 9 2023, In: Cancer Cell. 41, 10, p. 1731-1748.e8

  Research output: Contribution to journal › Article › peer-review

  • Tumor Burden 100%
  • Lung Neoplasms 83%
  • Immunotherapy 46%
  • Neoplasms 33%
  • DNA-Directed DNA Polymerase 29%
  3 Scopus citations

• MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation

  Guan, Q., Chen, Z., Yu, F., Liu, L., Huang, Y., Wei, G., Chiang, C. M., Wong, J. & Li, J., Sep 2023, In: Science China Life Sciences. 66, 9, p. 2167-2184 18 p.

  Research output: Contribution to journal › Article › peer-review

  • sumoylation 100%
  • Peptide Elongation Factors 92%
  • Sumoylation 90%
  • complex formation 83%
  • mutant 70%
  2 Scopus citations

• The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association

  Cao, J., Shi, M., Zhu, L., Li, X., Li, A., Wu, S. Y., Chiang, C. M. & Zhang, Y., Oct 2023, In: Journal of virology. 97, 10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptors for Activated C Kinase 100%
  • Respiratory syncytial virus 97%
  • Respiratory Syncytial Viruses 76%
  • interferons 73%
  • Interferons 59%
• 2022

  Author Correction: Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus (Nature Communications, (2019), 10, 1, (2300), 10.1038/s41467-019-10246-5)

  Zhao, J., Lee, E. E., Kim, J., Yang, R., Chamseddin, B., Ni, C., Gusho, E., Xie, Y., Chiang, C. M., Buszczak, M., Zhan, X., Laimins, L. & Wang, R. C., Dec 2022, In: Nature communications. 13, 1, 2889.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • RNA(circular) 100%
  • document markup languages 98%
  • Circular RNAs 75%
  • Oncogene Proteins 61%
  • files 60%

• Conditional Human BRD4 Knock-In Transgenic Mouse Genotyping and Protein Isoform Detection

  Lewis, M. P., Wu, S. Y. & Chiang, C. M., Apr 5 2022, In: Bio-protocol. 12, 7, e4374.

  Research output: Contribution to journal › Article › peer-review

  • human BRD4 protein 100%
  • protein isoforms 57%
  • genotyping 40%
  • Transgenic Mice 38%
  • Protein Isoforms 34%
  1 Scopus citations

• Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site

  Liu, Z., Li, Y., Chen, H., Lai, H. T., Wang, P., Wu, S. Y., Wold, E. A., Leonard, P. G., Joseph, S., Hu, H., Chiang, C. M., Brasier, A. R., Tian, B. & Zhou, J., Feb 10 2022, In: Journal of Medicinal Chemistry. 65, 3, p. 2388-2408 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • X Ray Crystallography 100%
  • Antiinflammatory 69%
  • X-Ray Crystallography 60%
  • Binding Sites 56%
  • Anti-Inflammatory Agents 53%
  23 Scopus citations

• Dual-target inhibitors of bromodomain and extra-terminal proteins in cancer: A review from medicinal chemistry perspectives

  Feng, L., Wang, G., Chen, Y., He, G., Liu, B., Liu, J., Chiang, C. M. & Ouyang, L., Mar 2022, In: Medicinal Research Reviews. 42, 2, p. 710-743 34 p.

  Research output: Contribution to journal › Review article › peer-review

  • Pharmaceutical Chemistry 100%
  • Chemistry 42%
  • Protein 30%
  • Proteins 26%
  • Neoplasms 23%
  24 Scopus citations

• EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation

  Guo, G., Gong, K., Beckley, N., Zhang, Y., Yang, X., Chkheidze, R., Hatanpaa, K. J., Garzon-Muvdi, T., Koduru, P., Nayab, A., Jenks, J., Sathe, A. A., Liu, Y., Xing, C., Wu, S. Y., Chiang, C. M., Mukherjee, B., Burma, S., Wohlfeld, B., Patel, T., & 10 othersMickey, B., Abdullah, K., Youssef, M., Pan, E., Gerber, D. E., Tian, S., Sarkaria, J. N., McBrayer, S. K., Zhao, D. & Habib, A. A., Aug 2022, In: Nature cell biology. 24, 8, p. 1291-1305 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioblastoma 100%
  • ErbB Receptors 96%
  • Oncogenes 96%
  • Up-Regulation 73%
  • Ligands 71%
  12 Scopus citations

• Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy

  Jiang, X., Wang, J., Zheng, X., Liu, Z., Zhang, X., Li, Y., Wilhelm, J., Cao, J., Huang, G., Zhang, J., Sumer, B., Lea, J., Lu, Z., Gao, J. & Luo, M., May 27 2022, In: Journal for ImmunoTherapy of Cancer. 10, 5, e003960.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunotherapy 100%
  • T-Lymphocytes 70%
  • Neoplasms 33%
  • Subcutaneous Injections 27%
  • Myeloid Cells 26%
  22 Scopus citations

• Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity

  Feng, Q., Liu, Z., Yu, X., Huang, T., Chen, J., Wang, J., Wilhelm, J., Li, S., Song, J., Li, W., Sun, Z., Sumer, B. D., Li, B., Fu, Y. X. & Gao, J., Dec 2022, In: Nature communications. 13, 1, 4981.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • lactates 100%
  • immunity 80%
  • Lactate 69%
  • tumors 65%
  • Lactic Acid 61%
  86 Scopus citations

• Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition

  Udden, S. N., Wang, Q., Kumar, S., Malladi, V. S., Wu, S. Y., Wei, S., Posner, B. A., Geboers, S., Williams, N. S., Liu, Y., Sharma, J. K., Mani, R. S., Malladi, S., Parra, K., Hofstad, M., Raj, G. V., Larios, J. M., Jagsi, R., Wicha, M. S., Park, B. H., & 4 othersGupta, G. P., Chinnaiyan, A. M., Chiang, C. M. & Alluri, P. G., Sep 8 2022, In: JCI Insight. 7, 17, e151851.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • OTX015 100%
  • 5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl)pyrimidin-2-yl)amine 44%
  • Fulvestrant 32%
  • Breast Neoplasms 31%
  • Mutation 13%
  4 Scopus citations
• 2021

  Antigen folding improves loading efficiency and antitumor efficacy of PC7A nanoparticle vaccine

  Wilhelm, J., Quiñones-Pérez, M., Wang, J., Wang, X., Basava, V. S. & Gao, J., Jan 10 2021, In: Journal of Controlled Release. 329, p. 353-360 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Antitumor 100%
  • Nanoparticles 96%
  • Antigen 90%
  • Vaccines 81%
  • Peptides 69%
  13 Scopus citations

• A Standardized Framework for Fluorescence-Guided Margin Assessment for Head and Neck Cancer Using a Tumor Acidosis Sensitive Optical Imaging Agent

  Steinkamp, P. J., Voskuil, F. J., van der Vegt, B., Doff, J. J., Schepman, K. P., de Visscher, S. A. H. J., Kelder, W., Jayalakshmi, Y., Gao, J., Sumer, B. D., van Dam, G. M. & Witjes, M. J. H., Dec 2021, In: Molecular Imaging and Biology. 23, 6, p. 809-817 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Optical Imaging 100%
  • Acidosis 94%
  • Head and Neck Neoplasms 91%
  • Fluorescence 74%
  • Margins of Excision 54%
  7 Scopus citations

• Author Correction: Prolonged activation of innate immune pathways by a polyvalent STING agonist (Nature Biomedical Engineering, (2021), 5, 5, (455-466), 10.1038/s41551-020-00675-9)

  Li, S., Luo, M., Wang, Z., Feng, Q., Wilhelm, J., Wang, X., Li, W., Wang, J., Cholka, A., Fu, Y. X., Sumer, B. D., Yu, H. & Gao, J., May 2021, In: Nature Biomedical Engineering. 5, 5, p. 483 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Biomedical Engineering 100%
  • Biomedical engineering 93%
  • Open access 92%
  • Licensure 77%
  • Agonist 68%
  1 Scopus citations

• Blood-based biomarkers of human papillomavirus–associated cancers: A systematic review and meta-analysis

  Balachandra, S., Kusin, S. B., Lee, R., Blackwell, J. M., Tiro, J. A., Cowell, L. G., Chiang, C. M., Wu, S. Y., Varma, S., Rivera, E. L., Mayo, H. G., Ding, L., Sumer, B. D., Lea, J. S., Bagrodia, A., Farkas, L. M., Wang, R., Fakhry, C., Dahlstrom, K. R., Sturgis, E. M., & 1 othersDay, A. T., Mar 15 2021, In: Cancer. 127, 6, p. 850-864 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Meta-Analysis 100%
  • Systematic Reviews 98%
  • Biomarkers 87%
  • Human papillomavirus 16 60%
  • Odds Ratio 46%
  23 Scopus citations

• BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination

  Jung, H., Chen, J., Hu, X., Sun, H., Wu, S. Y., Chiang, C. M., Kemper, B., Chen, L. F. & Kemper, J. K., Jan 11 2021, In: JCI Insight. 6, 1, e141640.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cholestasis 100%
  • obeticholic acid 90%
  • Bile Acids and Salts 36%
  • Proteins 32%
  • Fibrosis 26%
  13 Scopus citations

• Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy

  Zhang, J., Tang, P., Zou, L., Zhang, J., Chen, J., Yang, C., He, G., Liu, B., Liu, J., Chiang, C. M., Wang, G., Ye, T. & Ouyang, L., Dec 23 2021, In: Journal of Medicinal Chemistry. 64, 24, p. 18025-18053 29 p.

  Research output: Contribution to journal › Article › peer-review

  • Casein Kinase II 100%
  • Triple Negative Breast Neoplasms 89%
  • Cell Death 79%
  • Autophagy 71%
  • Apoptosis 45%
  18 Scopus citations

• Expression of phosphorylated brd4 is markedly associated with the activation status of the pp2a pathway and shows astrong prognostic value in triple negative breast cancer patients

  Sanz-álvarez, M., Cristóbal, I., Luque, M., Santos, A., Zazo, S., Madoz-Gúrpide, J., Caramés, C., Chiang, C. M., García-Foncillas, J., Eroles, P., Albanell, J. & Rojo, F., Mar 2 2021, In: Cancers. 13, 6, p. 1-11 11 p., 1246.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • Proteins 30%
  • Phosphoric Monoester Hydrolases 14%
  • Protein Domains 13%
  • Progression-Free Survival 12%
  7 Scopus citations

• Factors Associated with Lymph Node Count in Mucosal Squamous Cell Carcinoma Neck Dissection

  Bhalli, H., Chen, S., Day, A., Tillman, B., Gordin, E., Truelson, J., Sher, D., Myers, L., Gao, J. & Sumer, B. D., Jul 2021, In: Laryngoscope. 131, 7, p. 1516-1521 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Neck Dissection 100%
  • Squamous Cell Carcinoma 70%
  • Lymph Nodes 60%
  • Squamous Cell Carcinoma of Head and Neck 47%
  • Malnutrition 26%
  4 Scopus citations

• Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome

  Kim, S. K., Liu, X., Park, J., Um, D., Kilaru, G., Chiang, C. M., Kang, M., Huber, K. M., Kang, K. & Kim, T. K., May 2021, In: Science Advances. 7, 21, eabf7346.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fragile X Syndrome 100%
  • Memory 56%
  • Proteins 28%
  • Psychological Inhibition 25%
  • p300-CBP-associated factor 24%
  8 Scopus citations

• Polyvalent design in the cGAS-STING pathway

  Bennett, Z. T., Li, S., Sumer, B. D. & Gao, J., Aug 2021, In: Seminars in Immunology. 56, 101580.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • cyclic guanosine monophosphate-adenosine monophosphate 100%
  • Cellular Senescence 24%
  • Polymers 19%
  • Immunotherapy 19%
  • Immunity 17%
  8 Scopus citations

• Prolonged activation of innate immune pathways by a polyvalent STING agonist

  Li, S., Luo, M., Wang, Z., Feng, Q., Wilhelm, J., Wang, X., Li, W., Wang, J., Cholka, A., Fu, Y. X., Sumer, B. D., Yu, H. & Gao, J., May 2021, In: Nature Biomedical Engineering. 5, 5, p. 455-466 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interferons 100%
  • Agonist 53%
  • Genes 53%
  • Antitumor 51%
  • Cyclic GMP 50%
  142 Scopus citations

• Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development

  Tang, P., Zhang, J., Liu, J., Chiang, C. M. & Ouyang, L., Mar 11 2021, In: Journal of Medicinal Chemistry. 64, 5, p. 2419-2435 17 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Drug Discovery 100%
  • Drug 51%
  • Protein 40%
  • Proteins 35%
  • Lysine Residue 21%
  71 Scopus citations

• Tumor-Targeted Inhibition of Monocarboxylate Transporter 1 Improves T-Cell Immunotherapy of Solid Tumors

  Huang, T., Feng, Q., Wang, Z., Li, W., Sun, Z., Wilhelm, J., Huang, G., Vo, T., Sumer, B. D. & Gao, J., Feb 17 2021, In: Advanced Healthcare Materials. 10, 4, 2000549.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T-cells 100%
  • Tumors 69%
  • Immunotherapy 59%
  • AZD3965 58%
  • T-Lymphocytes 41%
  51 Scopus citations
• 2020

  Detection of lymph node metastases by ultra-pH-sensitive polymeric nanoparticles

  Bennett, Z. T., Feng, Q., Bishop, J. A., Huang, G., Sumer, B. D. & Gao, J., 2020, In: Theranostics. 10, 7, p. 3340-3350 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nanoparticles 100%
  • Lymph Nodes 80%
  • Neoplasm Metastasis 69%
  • Indocyanine Green 57%
  • Fluorescence 39%
  18 Scopus citations

• EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer

  Gong, K., Guo, G., Panchani, N., Bender, M. E., Gerber, D. E., Minna, J. D., Fattah, F., Gao, B., Peyton, M., Kernstine, K., Mukherjee, B., Burma, S., Chiang, C. M., Zhang, S., Amod Sathe, A., Xing, C., Dao, K. H., Zhao, D., Akbay, E. A. & Habib, A. A., Apr 1 2020, In: Nature Cancer. 1, 4, p. 394-409 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Non-Small Cell Lung Carcinoma 100%
  • Antiviral Agents 95%
  • Lung Neoplasms 88%
  • Interferons 58%
  • Protein-Tyrosine Kinases 58%
  44 Scopus citations

• Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

  Dubois, V., Gheeraert, C., Vankrunkelsven, W., Dubois-Chevalier, J., Dehondt, H., Bobowski-Gerard, M., Vinod, M., Zummo, F. P., Güiza, F., Ploton, M., Dorchies, E., Pineau, L., Boulinguiez, A., Vallez, E., Woitrain, E., Baugé, E., Lalloyer, F., Duhem, C., Rabhi, N., van Kesteren, R. E., & 10 othersChiang, C. M., Lancel, S., Duez, H., Annicotte, J. S., Paumelle, R., Vanhorebeek, I., Van den Berghe, G., Staels, B., Lefebvre, P. & Eeckhoute, J., May 1 2020, In: Molecular Systems Biology. 16, 5, e9156.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Endoplasmic Reticulum 100%
  • Liver 78%
  • endoplasmic reticulum stress 75%
  • Endoplasmic Reticulum Stress 64%
  • Cofactor 53%
  20 Scopus citations

• Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery

  the SHINE study group, Dec 1 2020, In: Nature communications. 11, 1, 3257.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • acidosis 100%
  • Indocyanine Green 77%
  • surgery 60%
  • Acidosis 55%
  • Conjugated Polymer 54%
  93 Scopus citations

• Exploiting nanoscale cooperativity for precision medicine

  Wilhelm, J., Wang, Z., Sumer, B. D. & Gao, J., Jan 2020, In: Advanced Drug Delivery Reviews. 158, p. 63-72 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Precision Medicine 100%
  • Drug Liberation 90%
  • Nanomedicine 59%
  • Phase Transition 58%
  • Micelles 55%
  18 Scopus citations

• Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail

  Lu, L., Chen, Z., Lin, X., Tian, L., Su, Q., An, P., Li, W., Wu, Y., Du, J., Shan, H., Chiang, C. M. & Wang, H., Jan 1 2020, In: Cell Death and Differentiation. 27, 1, p. 255-268 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Proteins 57%
  • Snails 54%
  • Protein Stability 52%
  • Neoplasms 50%
  67 Scopus citations

• KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs

  Bacon, C. W., Challa, A., Hyder, U., Shukla, A., Borkar, A. N., Bayo, J., Liu, J., Wu, S. Y., Chiang, C. M., Kutateladze, T. G. & D'Orso, I., Jun 18 2020, In: Molecular cell. 78, 6, p. 1133-1151.e14

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Polymerase II 100%
  • Chromatin 75%
  • Transcription Factors 32%
  • Histones 20%
  • Homeostasis 15%
  22 Scopus citations

• N6-methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming

  Chen, Z., Wu, L., Zhou, J., Lin, X., Peng, Y., Ge, L., Chiang, C. M., Huang, H., Wang, H. & He, W., 2020, In: Theranostics. 10, 8, p. 3382-3396 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • N(6)-methyladenosine 100%
  • Up-Regulation 45%
  • Neoplasms 20%
  • Fatty Acids 15%
  • RNA Precursors 10%
  40 Scopus citations

• Nano-Immune-Engineering Approaches to Advance Cancer Immunotherapy: Lessons from Ultra-pH-Sensitive Nanoparticles

  Li, S., Bennett, Z. T., Sumer, B. D. & Gao, J., Nov 17 2020, In: Accounts of Chemical Research. 53, 11, p. 2546-2557 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nanoparticle 100%
  • Antitumor 92%
  • Antigen 42%
  • Dose 38%
  • Condensation 36%
  31 Scopus citations

• Opposing Functions of BRD4 Isoforms in Breast Cancer

  Wu, S. Y., Lee, C. F., Lai, H. T., Yu, C. T., Lee, J. E., Zuo, H., Tsai, S. Y., Tsai, M. J., Ge, K., Wan, Y. & Chiang, C. M., Jun 18 2020, In: Molecular cell. 78, 6, p. 1114-1132.e10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Isoforms 100%
  • Breast Neoplasms 79%
  • Proteins 45%
  • Cystatins 18%
  • Cathepsins 16%
  80 Scopus citations

• PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition

  Wang, L. T., Liu, K. Y., Jeng, W. Y., Chiang, C. M., Chai, C. Y., Chiou, S. S., Huang, M. S., Yokoyama, K. K., Wang, S. N., Huang, S. K. & Hsu, S. H., Feb 5 2020, In: EMBO Reports. 21, 2, e48795.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • p300-CBP-associated factor 100%
  • Homeobox Genes 73%
  • Acetylation 66%
  • Epithelial-Mesenchymal Transition 65%
  • Lysine 59%
  32 Scopus citations

• PET imaging of occult tumours by temporal integration of tumour-acidosis signals from pH-sensitive ⁶⁴Cu-labelled polymers

  Huang, G., Zhao, T., Wang, C., Nham, K., Xiong, Y., Gao, X., Wang, Y., Hao, G., Ge, W. P., Sun, X., Sumer, B. D. & Gao, J., Mar 1 2020, In: Nature Biomedical Engineering. 4, 3, p. 314-324 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Positron 100%
  • Acidosis 88%
  • Tumors 87%
  • Polymers 76%
  • Imaging techniques 65%
  41 Scopus citations

• Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window

  Wang, X., Wilhelm, J., Li, W., Li, S., Wang, Z., Huang, G., Wang, J., Tang, H., Khorsandi, S., Sun, Z., Evers, B. & Gao, J., Dec 2020, In: Nature communications. 11, 1, 5828.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • polycarbonate 100%
  • polycarbonates 78%
  • Nanoparticles 63%
  • Polymers 54%
  • nanoparticles 47%
  45 Scopus citations

• Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

  Li, J., Chen, Z., Chen, F., Xie, G., Ling, Y., Peng, Y., Lin, Y., Luo, N., Chiang, C. M. & Wang, H., 2020, In: Nucleic acids research. 48, 10, p. 5684-5694 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • AlkB Enzymes 100%
  • Demethylation 63%
  • Messenger RNA 30%
  • Proteins 19%
  • Cytochromes b5 15%
  131 Scopus citations

• Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer

  Tsai, L. H., Hsu, K. W., Chiang, C. M., Yang, H. J., Liu, Y. H., Yang, S. F., Peng, P. H., Cheng, W. C. & Wu, H. H., Dec 1 2020, In: Scientific reports. 10, 1, 17817.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-17 Receptors 100%
  • gemcitabine 69%
  • Mucins 67%
  • Pancreatic Neoplasms 58%
  • Down-Regulation 43%
  10 Scopus citations
• 2019

  Combinatorial therapy of zinc metallochaperones with mutant p53 reactivation and diminished copper binding

  Zaman, S., Yu, X., Bencivenga, A. F., Blanden, A. R., Liu, Y., Withers, T., Na, B., Blayney, A. J., Gilleran, J., Boothman, D. A., Loh, S. N., Kimball, S. D. & Carpizo, D. R., 2019, In: Molecular Cancer Therapeutics. 18, 8, p. 1355-1365 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metallochaperones 100%
  • Copper 54%
  • Zinc 51%
  • Radiation 35%
  • Drug Therapy 31%
  16 Scopus citations

• NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers

  Motea, E. A., Huang, X., Singh, N., Kilgore, J. A., Williams, N. S., Xie, X. J., Gerber, D. E., Beg, M. S., Bey, E. A. & Boothman, D. A., Apr 15 2019, In: Clinical Cancer Research. 25, 8, p. 2601-2609 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Non-Small Cell Lung Carcinoma 100%
  • NAD 68%
  • Neoplasms 36%
  • Adenosine Triphosphate 34%
  • Pharmacokinetics 33%
  28 Scopus citations

• Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy

  Luo, M., Liu, Z., Zhang, X., Han, C., Samandi, L. Z., Dong, C., Sumer, B. D., Lea, J., Fu, Y. X. & Gao, J., Apr 28 2019, In: Journal of Controlled Release. 300, p. 154-160 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ionizing Radiation 100%
  • Antitumor 75%
  • Interferons 75%
  • Transcriptional Activation 74%
  • Immunotherapy 72%
  59 Scopus citations

• Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

  Kim, J. J., Lee, S. Y., Gong, F., Battenhouse, A. M., Boutz, D. R., Bashyal, A., Refvik, S. T., Chiang, C. M., Xhemalce, B., Paull, T. T., Brodbelt, J. S., Marcotte, E. M. & Miller, K. M., Dec 1 2019, In: Genes and Development. 33, 23-24, p. 1751-1774 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • R-Loop Structures 100%
  • Homologous Recombination 70%
  • Genome 42%
  • 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione 30%
  • Proteins 22%
  77 Scopus citations

• Targeting NAD ⁺ Metabolism to Enhance Radiation Therapy Responses

  Lewis, J. E., Singh, N., Holmila, R. J., Sumer, B. D., Williams, N. S., Furdui, C. M., Kemp, M. L. & Boothman, D. A., Jan 2019, In: Seminars in Radiation Oncology. 29, 1, p. 6-15 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • NAD 100%
  • Radiotherapy 67%
  • Radiation Tolerance 16%
  • Ionizing Radiation 14%
  • Metabolic Networks and Pathways 13%
  18 Scopus citations

• Targeting the oncogene kras mutant pancreatic cancer by synergistic blocking of lysosomal acidification and rapid drug release

  Kong, C., Li, Y., Liu, Z., Ye, J., Wang, Z., Zhang, L., Kong, W., Liu, H., Liu, C., Pang, H., Hu, Z., Gao, J. & Qian, F., Apr 23 2019, In: ACS Nano. 13, 4, p. 4049-4063 15 p.

  Research output: Contribution to journal › Article › peer-review

  • oncogenes 100%
  • Micelles 84%
  • Acidification 83%
  • Triptolide 58%
  • drugs 56%
  73 Scopus citations

• Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis

  Penas, C., Maloof, M. E., Stathias, V., Long, J., Tan, S. K., Mier, J., Fang, Y., Valdes, C., Rodriguez-Blanco, J., Chiang, C. M., Robbins, D. J., Liebl, D. J., Lee, J. K., Hatten, M. E., Clarke, J. & Ayad, N. G., Dec 1 2019, In: Nature communications. 10, 1, 3028.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • Neurogenesis 63%
  • Cell Cycle 47%
  • Stem Cells 44%
  • cycles 40%
  23 Scopus citations