• 10528 Citations
  • 56 h-Index
19992020

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Article
2020

Chemotherapy impacts on the cellular response to CDK4/6 inhibition: distinct mechanisms of interaction and efficacy in models of pancreatic cancer

Kumarasamy, V., Ruiz, A., Nambiar, R., Witkiewicz, A. K. & Knudsen, E. S., Feb 27 2020, In : Oncogene. 39, 9, p. 1831-1845 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pan-cancer molecular analysis of the RB tumor suppressor pathway

Knudsen, E. S., Nambiar, R., Rosario, S. R., Smiraglia, D. J., Goodrich, D. W. & Witkiewicz, A. K., Dec 1 2020, In : Communications Biology. 3, 1, 158.

Research output: Contribution to journalArticle

Open Access
2019

Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer

Knudsen, E. S., Kumarasamy, V., Ruiz, A., Sivinski, J., Chung, S., Grant, A., Vail, P., Chauhan, S. S., Jie, T., Riall, T. S. & Witkiewicz, A. K., May 2 2019, In : Oncogene. 38, 18, p. 3355-3370 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

76 Scopus citations

Coordinately targeting cell-cycle checkpoint functions in integrated models of pancreatic cancer

Chung, S., Vail, P., Witkiewicz, A. K. & Knudsen, E. S., Apr 1 2019, In : Clinical Cancer Research. 25, 7, p. 2290-2304 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations

Grant, A. D., Vail, P., Padi, M., Witkiewicz, A. K. & Knudsen, E. S., Dec 1 2019, In : Scientific reports. 9, 1, 12766.

Research output: Contribution to journalArticle

Open Access

P27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

Guiley, K. Z., Stevenson, J. W., Lou, K., Barkovich, K. J., Kumarasamy, V., Wijeratne, T. U., Bunch, K. L., Tripathi, S., Knudsen, E. S., Witkiewicz, A. K., Shokat, K. M. & Rubin, S. M., Dec 13 2019, In : Science. 366, 6471, eaaw2106.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Composite analysis of immunological and metabolic markers defines novel subtypes of triple negative breast cancer

Adams, T. A., Vail, P. J., Ruiz, A., Mollaee, M., McCue, P. A., Knudsen, E. S. & Witkiewicz, A. K., Feb 1 2018, In : Modern Pathology. 31, 2, p. 288-298 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, Der, C. J., Nov 12 2018, In : Cancer Cell. 34, 5, p. 807-822.e7

Research output: Contribution to journalArticle

28 Scopus citations

Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors

Mannakee, B. K., Balaji, U., Witkiewicz, A. K., Gutenkunst, R. N. & Knudsen, E. S., May 15 2018, In : Bioinformatics. 34, 10, p. 1713-1718 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer

Witkiewicz, A. K., Chung, S., Brough, R., Vail, P., Franco, J., Lord, C. J. & Knudsen, E. S., Jan 30 2018, In : Cell Reports. 22, 5, p. 1185-1199 15 p.

Research output: Contribution to journalArticle

19 Scopus citations
2017

Biological specificity of CDK4/6 inhibitors: Dose response relationship, in vivo signaling, and composite response signaturez

Knudsen, E. S., Hutcheson, J., Vail, P. & Witkiewicz, A. K., 2017, In : Oncotarget. 8, 27, p. 43678-43691 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer

Jansen, V. M., Bhola, N. E., Bauer, J. A., Formisano, L., Lee, K. M., Hutchinson, K. E., Witkiewicz, A. K., Moore, P. D., Estrada, M. V., Sánchez, V., Ericsson, P. G., Sanders, M. E., Pohlmann, P. R., Pishvaian, M. J., Riddle, D. A., Dugger, T. C., Wei, W., Knudsen, E. S. & Arteaga, C. L., May 1 2017, In : Cancer research. 77, 9, p. 2488-2499 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Pancreatic cancer cell lines as patient-derived avatars: Genetic characterisation and functional utility

Knudsen, E. S., Balaji, U., Mannakee, B., Vail, P., Eslinger, C., Moxom, C., Mansour, J. & Witkiewicz, A. K., Jan 10 2017, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

28 Scopus citations

Sampling strategies to capture single-cell heterogeneity

Rajaram, S., Heinrich, L. E., Gordan, J. D., Avva, J., Bonness, K. M., Witkiewicz, A. K., Malter, J. S., Atreya, C. E., Warren, R. S., Wu, L. F. & Altschuler, S. J., Oct 1 2017, In : Nature methods. 14, 10, p. 967-970 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Stratification of pancreatic ductal adenocarcinoma: Combinatorial genetic, stromal, and immunologic markers

Knudsen, E. S., Vail, P., Balaji, U., Ngo, H., Botros, I. W., Makarov, V., Riaz, N., Balachandran, V., Leach, S., Thompson, D. M., Chan, T. A. & Witkiewicz, A. K., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4429-4440 12 p.

Research output: Contribution to journalArticle

58 Scopus citations
2016

Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2-breast cancer

Knudsen, E. S. & Witkiewicz, A. K., Jan 1 2016, In : Oncotarget. 7, 43, p. 69111-69123 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Immunologic and metabolic features of pancreatic ductal adenocarcinoma define prognostic subtypes of disease

Hutcheson, J., Balaji, U., Porembka, M. R., Wachsmann, M. B., McCue, P. A., Knudsen, E. S. & Witkiewicz, A. K., Jul 15 2016, In : Clinical Cancer Research. 22, 14, p. 3606-3617 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer

Witkiewicz, A. K., Balaji, U., Eslinger, C., McMillan, E., Conway, W., Posner, B., Mills, G. B., O'Reilly, E. M. & Knudsen, E. S., Aug 16 2016, In : Cell Reports. 16, 7, p. 2017-2031 15 p.

Research output: Contribution to journalArticle

49 Scopus citations

Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities

Franco, J., Balaji, U., Freinkman, E., Witkiewicz, A. K. & Knudsen, E. S., Feb 9 2016, In : Cell Reports. 14, 5, p. 979-990 12 p.

Research output: Contribution to journalArticle

68 Scopus citations

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Sousa, C. M., Biancur, D. E., Wang, X., Halbrook, C. J., Sherman, M. H., Zhang, L., Kremer, D., Hwang, R. F., Witkiewicz, A. K., Ying, H., Asara, J. M., Evans, R. M., Cantley, L. C., Lyssiotis, C. A. & Kimmelman, A. C., Aug 10 2016, In : Nature. 536, 7617, p. 479-483 5 p.

Research output: Contribution to journalArticle

315 Scopus citations

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

Briggs, KJ. J., Koivunen, P., Cao, S., Backus, KM. M., Olenchock, BA. A., Patel, H., Zhang, Q., Signoretti, S., Gerfen, GJ. J., Richardson, AL. L., Witkiewicz, AK. K., Cravatt, BF. F., Clardy, J. & Kaelin, WG. G., Jun 30 2016, In : Cell. 166, 1, p. 126-139 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells

Bendris, N., Stearns, C. J. S., Reis, C. R., Rodriguez-Canales, J., Liu, H., Witkiewicz, A. W. & Schmid, S. L., Jul 15 2016, In : Journal of cell science. 129, 14, p. 2804-2816 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

Blanco, F. F., Jimbo, M., Wulfkuhle, J., Gallagher, I., Deng, J., Enyenihi, L., Meisner-Kober, N., Londin, E., Rigoutsos, I., Sawicki, J. A., Risbud, M. V., Witkiewicz, A. K., McCue, P. A., Jiang, W., Rui, H., Yeo, C. J., Petricoin, E., Winter, J. M. & Brody, J. R., May 1 2016, In : Oncogene. 35, 19, p. 2529-2541 13 p.

Research output: Contribution to journalArticle

50 Scopus citations

Unique metabolic features of pancreatic cancer stroma: Relevance to the tumor compartment, prognosis, and invasive potential

Knudsen, E. S., Balaji, U., Freinkman, E., McCue, P. & Witkiewicz, A. K., 2016, In : Oncotarget. 7, 48, p. 78396-78411 16 p.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs

Londina, E., Lohera, P., Telonis, A. G., Quann, K., Clark, P., Jinga, Y., Hatzimichael, E., Kirino, Y., Honda, S., Lally, M., Ramratnam, B., Comstock, C. E. S., Knudsen, K. E., Gomella, L., Spaeth, G. L., Hark, L., Katz, L. J., Witkiewicz, A., Rostami, A., Jimenez, S. A. & 18 others, Hollingsworth, M. A., Yeh, J. J., Shaw, C. A., McKenzie, S. E., Bray, P., Nelson, P. T., Zupo, S., Van Roosbroeck, K., Keating, M. J., Calin, G. A., Yeo, C., Jimbo, M., Cozzitorto, J., Brody, J. R., Delgrosso, K., Mattick, J. S., Fortina, P. & Rigoutsos, I., Mar 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 10, p. E1106-E1115

Research output: Contribution to journalArticle

242 Scopus citations

Fibulin-5 blocks microenvironmental ROS in pancreatic cancer

Wang, M., Topalovski, M., Toombs, J. E., Wright, C. M., Moore, Z. R., Boothman, D. A., Yanagisawa, H., Wang, H., Witkiewicz, A., Castrillon, D. H. & Brekken, R. A., Dec 1 2015, In : Cancer Research. 75, 23, p. 5058-5069 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

MUC1 promoter-driven DTA as a targeted therapeutic strategy against pancreatic cancer

Tholey, R. M., Lal, S., Jimbo, M., Burkhart, R. A., Blanco, F. F., Cozzitorto, J. A., Eisenberg, J. D., Jiang, W., Iacobuzio-Donahue, C. A., Witkiewicz, A. K., Glbert, M., Yeo, C. J., Brody, J. R., Sawicki, J. A. & Winter, J. M., Mar 1 2015, In : Molecular Cancer Research. 13, 3, p. 439-448 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer

Knudsen, E. S., Kathleen McClendon, A., Franco, J., Ertel, A., Fortina, P. & Witkiewicz, A. K., Jan 1 2015, In : Cell Cycle. 14, 1, p. 109-122 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

Witkiewicz, A. K., Borja, N. A., Franco, J., Brody, J. R., Yeo, C. J., Mansour, J., Choti, M. A., McCue, P. & Knudsen, E. S., 2015, In : Oncotarget. 6, 18, p. 15788-15801 14 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

The RB tumor suppressor at the intersection of proliferation and immunity: Relevance to disease immune evasion and immunotherapy

Hutcheson, J., Witkiewicz, A. K. & Knudsen, E. S., Jan 1 2015, In : Cell Cycle. 14, 24, p. 3812-3819 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Witkiewicz, A. K., McMillan, E. A., Balaji, U., Baek, G., Lin, W. C., Mansour, J., Mollaee, M., Wagner, K. U., Koduru, P., Yopp, A., Choti, M. A., Yeo, C. J., McCue, P., White, M. A. & Knudsen, E. S., Apr 10 2015, In : Nature communications. 6, 6744.

Research output: Contribution to journalArticle

435 Scopus citations
2014

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., Horton, J. D., Hammer, R. E., McKnight, S. L. & Tu, B. P., Dec 18 2014, In : Cell. 159, 7, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

257 Scopus citations

CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models

Witkiewicz, A. K., Cox, D. & Knudsen, E. S., 2014, In : Genes and Cancer. 5, 7-8, p. 261-272 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

Franco, J., Witkiewicz, A. K. & Knudsen, E. S., 2014, In : Oncotarget. 5, 15, p. 6512-6525 14 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

Contrast-enhanced sonography for detection of secondary lymph nodes in a melanoma tumor animal model

Liu, J. B., Merton, D. A., Berger, A. C., Forsberg, F., Witkiewicz, A., Zhao, H., Eisenbrey, J. R., Fox, T. B. & Goldberg, B. B., Jun 1 2014, In : Journal of Ultrasound in Medicine. 33, 6, p. 939-947 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: A dual-institutional follow-up with the RTOG 9704 trial

McAllister, F., Pineda, D. M., Jimbo, M., Lal, S., Burkhart, R. A., Moughan, J., Winter, K. A., Abdelmohsen, K., Gorospe, M., De Jesus Acosta, A., Lankapalli, R. H., Winter, J. M., Yeo, C. J., Witkiewicz, A. K., Iacobuzio-Donahue, C. A., Laheru, D. & Brody, J. R., Jun 2014, In : Cancer Biology and Therapy. 15, 6, p. 688-698 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

Baek, G. H., Tse, Y. F., Hu, Z., Cox, D., Buboltz, N., McCue, P., Yeo, C. J., White, M. A., DeBerardinis, R. J., Knudsen, E. S. & Witkiewicz, A. K., Dec 24 2014, In : Cell Reports. 9, 6, p. 2233-2249 17 p.

Research output: Contribution to journalArticle

86 Scopus citations

RB tumor suppressive function in response to xenobiotic hepatocarcinogens

Reed, C., Hutcheson, J., Mayhew, C. N., Witkiewicz, A. K. & Knudsen, E. S., Jun 2014, In : American Journal of Pathology. 184, 6, p. 1853-1859 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Retinoblastoma protein potentiates the innate immune response in hepatocytes: Significance for hepatocellular carcinoma

Hutcheson, J., Bourgo, R. J., Balaji, U., Ertel, A., Witkiewicz, A. K. & Knudsen, E. S., Oct 1 2014, In : Hepatology. 60, 4, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Systematically defining single-gene determinants of response to neoadjuvant chemotherapy reveals specific biomarkers

Witkiewicz, A. K., Balaji, U. & Knudsen, E. S., Sep 15 2014, In : Clinical Cancer Research. 20, 18, p. 4837-4848 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer

Witkiewicz, A. K., Cox, D. W., Rivadeneira, D., Ertel, A. E., Fortina, P., Schwartz, G. F. & Knudsen, E. S., Jul 24 2014, In : Oncogene. 33, 30, p. 3980-3991 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer

Lin, W. C., Rajbhandari, N., Liu, C., Sakamoto, K., Zhang, Q., Triplett, A. A., Batra, S. K., Opavsky, R., Felsher, D. W., DiMaio, D. J., Hollingsworth, M. A., Morris IV, J. P., Hebrok, M., Witkiewicz, A. K., Brody, J. R., Rui, H. & Wagner, K. U., Mar 15 2013, In : Cancer research. 73, 6, p. 1821-1830 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

EZH2 and ALDH1 expression in ductal carcinoma in situ: Complex association with recurrence and progression to invasive breast cancer

Knudsen, E. S., Dervishaj, O., Kleer, C. G., Pajak, T., Schwartz, G. F. & Witkiewicz, A. K., Jul 1 2013, In : Cell Cycle. 12, 13, p. 2042-2050 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

Abel, E. V., Basile, K. J., Kugel, C. H., Witkiewicz, A. K., Le, K., Amaravadi, R. K., Karakousis, G. C., Xu, X., Xu, W., Schuchter, L. M., Lee, J. B., Ertel, A., Fortina, P. & Aplin, A. E., May 1 2013, In : Journal of Clinical Investigation. 123, 5, p. 2155-2168 14 p.

Research output: Contribution to journalArticle

152 Scopus citations

Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival

Burkhart, R. A., Peng, Y., Norris, Z. A., Tholey, R. M., Talbott, V. A., Liang, Q., Ai, Y., Miller, K., Lal, S., Cozzitorto, J. A., Witkiewicz, A. K., Yeo, C. J., Gehrmann, M., Napper, A., Winter, J. M., Sawicki, J. A., Zhuang, Z. & Brody, J. R., Aug 2013, In : Molecular Cancer Research. 11, 8, p. 901-911 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Regulation of miR106b cluster through the RB pathway: Mechanismand functional targets

Thangavel, C., Boopathi, E., Ertel, A., Lim, M., Addya, S., Fortina, P., Witkiewicz, A. K. & Knudsen, E. S., Jan 1 2013, In : Cell Cycle. 12, 1, p. 98-111 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Somatostatin receptor scintigraphy in patients with metastatic uveal melanoma

Valsecchi, M. E., Coronel, M., Intenzo, C. M., Kim, S. M., Witkiewicz, A. K. & Sato, T., Feb 1 2013, In : Melanoma research. 23, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

A case of endometrial cancer in the context of a BRCA2 mutation and double heterozygosity for Lynch syndrome

Gong, P., Charles, S., Rosenblum, N., Wang, Z. & Witkiewicz, A. K., Aug 2012, In : Gynecologic Oncology Reports. 2, 3, p. 69-72 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma

Mahipal, A., McDonald, M. J., Witkiewicz, A. & Carr, B. I., Mar 1 2012, In : Medical Oncology. 29, 1, p. 134-139 6 p.

Research output: Contribution to journalArticle

14 Scopus citations