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19992019
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Research Output 1999 2019

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Article
2019
2 Citations (Scopus)

Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer

Knudsen, E. S., Kumarasamy, V., Ruiz, A., Sivinski, J., Chung, S., Grant, A., Vail, P., Chauhan, S. S., Jie, T., Riall, T. S. & Witkiewicz, A., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Transcriptome
Cell Cycle
Adenocarcinoma
Cyclins
37 Citations (Scopus)

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

Autophagy
Chloroquine
Pancreatic Neoplasms
Fluxes
Adenocarcinoma
2 Citations (Scopus)

Coordinately targeting cell-cycle checkpoint functions in integrated models of pancreatic cancer

Chung, S., Vail, P., Witkiewicz, A. & Knudsen, E. S., Apr 1 2019, In : Clinical Cancer Research. 25, 7, p. 2290-2304 15 p.

Research output: Contribution to journalArticle

gemcitabine
Cell Cycle Checkpoints
Pancreatic Neoplasms
Adenocarcinoma
Preclinical Drug Evaluations

Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations

Grant, A. D., Vail, P., Padi, M., Witkiewicz, A. K. & Knudsen, E. S., Dec 1 2019, In : Scientific Reports. 9, 1, 12766.

Research output: Contribution to journalArticle

Open Access
Alleles
Genome
Mutation
Neoplasms
vif Genes
2018
15 Citations (Scopus)

Composite analysis of immunological and metabolic markers defines novel subtypes of triple negative breast cancer

Adams, T. A., Vail, P. J., Ruiz, A., Mollaee, M., McCue, P. A., Knudsen, E. S. & Witkiewicz, A. K., Feb 1 2018, In : Modern Pathology. 31, 2, p. 288-298 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Tumor-Infiltrating Lymphocytes
Neoplasms
Tumor Microenvironment
Survival
12 Citations (Scopus)

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A., Knudsen, E. S., Pecot, C. V., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 others, Der, C. J., Nov 12 2018, In : Cancer Cell. 34, 5, p. 807-822.e7

Research output: Contribution to journalArticle

Adenocarcinoma
Ubiquitin-Protein Ligases
Protein Stability
Proteasome Endopeptidase Complex
Growth
1 Citation (Scopus)

Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors

Mannakee, B. K., Balaji, U., Witkiewicz, A. K., Gutenkunst, R. N. & Knudsen, E. S., May 15 2018, In : Bioinformatics. 34, 10, p. 1713-1718 6 p.

Research output: Contribution to journalArticle

Heterografts
Mouse
Tumors
Tumor
Filtering
12 Citations (Scopus)

Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer

Witkiewicz, A. K., Chung, S., Brough, R., Vail, P., Franco, J., Lord, C. J. & Knudsen, E. S., Jan 30 2018, In : Cell Reports. 22, 5, p. 1185-1199 15 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Tumors
Chromosome Segregation
Neoplasms
Chromosomes
2017
17 Citations (Scopus)

Biological specificity of CDK4/6 inhibitors: Dose response relationship, in vivo signaling, and composite response signaturez

Knudsen, E. S., Hutcheson, J., Vail, P. & Witkiewicz, A. K., 2017, In : Oncotarget. 8, 27, p. 43678-43691 14 p.

Research output: Contribution to journalArticle

Cell Cycle
5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl)pyrimidin-2-yl)amine
Gene Expression
cdc Genes
Chloroquine
54 Citations (Scopus)

Kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer

Jansen, V. M., Bhola, N. E., Bauer, J. A., Formisano, L., Lee, K. M., Hutchinson, K. E., Witkiewicz, A. K., Moore, P. D., Estrada, M. V., Sánchez, V., Ericsson, P. G., Sanders, M. E., Pohlmann, P. R., Pishvaian, M. J., Riddle, D. A., Dugger, T. C., Wei, W., Knudsen, E. S. & Arteaga, C. L., May 1 2017, In : Cancer Research. 77, 9, p. 2488-2499 12 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase 4
RNA Interference
Protein Kinases
Breast Neoplasms
23 Citations (Scopus)

Pancreatic cancer cell lines as patient-derived avatars: Genetic characterisation and functional utility

Knudsen, E. S., Balaji, U., Mannakee, B., Vail, P., Eslinger, C., Moxom, C., Mansour, J. & Witkiewicz, A. K., Jan 10 2017, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Cell Line
Neoplasms
Heterografts
6 Citations (Scopus)

Sampling strategies to capture single-cell heterogeneity

Rajaram, S., Heinrich, L. E., Gordan, J. D., Avva, J., Bonness, K. M., Witkiewicz, A. K., Malter, J. S., Atreya, C. E., Warren, R. S., Wu, L. F. & Altschuler, S. J., Oct 1 2017, In : Nature Methods. 14, 10, p. 967-970 4 p.

Research output: Contribution to journalArticle

Sampling
Experiments
Research Personnel
Technology
Population
48 Citations (Scopus)

Stratification of pancreatic ductal adenocarcinoma: Combinatorial genetic, stromal, and immunologic markers

Knudsen, E. S., Vail, P., Balaji, U., Ngo, H., Botros, I. W., Makarov, V., Riaz, N., Balachandran, V., Leach, S., Thompson, D. M., Chan, T. A. & Witkiewicz, A. K., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4429-4440 12 p.

Research output: Contribution to journalArticle

Genetic Markers
Adenocarcinoma
Biomarkers
Immunosuppressive Agents
Hypoxis
2016
17 Citations (Scopus)

Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2-breast cancer

Knudsen, E. S. & Witkiewicz, A. K., 2016, In : Oncotarget. 7, 43, p. 69111-69123 13 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Genes
Cell Cycle
Therapeutics
Estrogens
54 Citations (Scopus)

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine

Knudsen, E. S., O'Reilly, E. M., Brody, J. R. & Witkiewicz, A. K., Jan 1 2016, In : Gastroenterology. 150, 1, p. 48-63 16 p.

Research output: Contribution to journalArticle

Precision Medicine
Adenocarcinoma
Therapeutics
Pancreatic Neoplasms
Sequence Analysis
29 Citations (Scopus)

Immunologic and metabolic features of pancreatic ductal adenocarcinoma define prognostic subtypes of disease

Hutcheson, J., Balaji, U., Porembka, M. R., Wachsmann, M. B., McCue, P. A., Knudsen, E. S. & Witkiewicz, A. K., Jul 15 2016, In : Clinical Cancer Research. 22, 14, p. 3606-3617 12 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Myeloid Cells
Immunosuppressive Agents
Immunosuppression
41 Citations (Scopus)

Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer

Witkiewicz, A. K., Balaji, U., Eslinger, C., McMillan, E., Conway, W., Posner, B., Mills, G. B., O'Reilly, E. M. & Knudsen, E. S., Aug 16 2016, In : Cell Reports. 16, 7, p. 2017-2031 15 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Tumors
Adenocarcinoma
Neoplasms
Drug Combinations
49 Citations (Scopus)

Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities

Franco, J., Balaji, U., Freinkman, E., Witkiewicz, A. K. & Knudsen, E. S., Feb 9 2016, In : Cell Reports. 14, 5, p. 979-990 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Metabolism
Enzyme inhibition
Adenocarcinoma
Cells
263 Citations (Scopus)

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Sousa, C. M., Biancur, D. E., Wang, X., Halbrook, C. J., Sherman, M. H., Zhang, L., Kremer, D., Hwang, R. F., Witkiewicz, A. K., Ying, H., Asara, J. M., Evans, R. M., Cantley, L. C., Lyssiotis, C. A. & Kimmelman, A. C., Aug 10 2016, In : Nature. 536, 7617, p. 479-483 5 p.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
Alanine
Adenocarcinoma
Tumor Microenvironment
Neoplasms
58 Citations (Scopus)

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

Briggs, KJ. J., Koivunen, P., Cao, S., Backus, KM. M., Olenchock, BA. A., Patel, H., Zhang, Q., Signoretti, S., Gerfen, GJ. J., Richardson, AL. L., Witkiewicz, AK. K., Cravatt, BF. F., Clardy, J. & Kaelin, WG. G., Jun 30 2016, In : Cell. 166, 1, p. 126-139 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Cysteine
Glutamic Acid
Breast Neoplasms
Prolyl Hydroxylases
9 Citations (Scopus)

Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells

Bendris, N., Stearns, C. J. S., Reis, C. R., Rodriguez-Canales, J., Liu, H., Witkiewicz, A. W. & Schmid, S. L., Jul 15 2016, In : Journal of Cell Science. 129, 14, p. 2804-2816 13 p.

Research output: Contribution to journalArticle

Sorting Nexins
Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Matrix Metalloproteinase 14
41 Citations (Scopus)

The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

Blanco, F. F., Jimbo, M., Wulfkuhle, J., Gallagher, I., Deng, J., Enyenihi, L., Meisner-Kober, N., Londin, E., Rigoutsos, I., Sawicki, J. A., Risbud, M. V., Witkiewicz, A. K., McCue, P. A., Jiang, W., Rui, H., Yeo, C. J., Petricoin, E., Winter, J. M. & Brody, J. R., May 1 2016, In : Oncogene. 35, 19, p. 2529-2541 13 p.

Research output: Contribution to journalArticle

ELAV Proteins
Proto-Oncogenes
Pancreatic Neoplasms
Carrier Proteins
Adenocarcinoma
15 Citations (Scopus)

Unique metabolic features of pancreatic cancer stroma: Relevance to the tumor compartment, prognosis, and invasive potential

Knudsen, E. S., Balaji, U., Freinkman, E., McCue, P. & Witkiewicz, A. K., 2016, In : Oncotarget. 7, 48, p. 78396-78411 16 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Neoplasms
Glutamine
Glucose
2015
229 Citations (Scopus)

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs

Londina, E., Lohera, P., Telonis, A. G., Quann, K., Clark, P., Jinga, Y., Hatzimichael, E., Kirino, Y., Honda, S., Lally, M., Ramratnam, B., Comstock, C. E. S., Knudsen, K. E., Gomella, L., Spaeth, G. L., Hark, L., Katz, L. J., Witkiewicz, A., Rostami, A., Jimenez, S. A. & 18 others, Hollingsworth, M. A., Yeh, J. J., Shaw, C. A., McKenzie, S. E., Bray, P., Nelson, P. T., Zupo, S., Van Roosbroeck, K., Keating, M. J., Calin, G. A., Yeo, C., Jimbo, M., Cozzitorto, J., Brody, J. R., Delgrosso, K., Mattick, J. S., Fortina, P. & Rigoutsos, I., Mar 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 10, p. E1106-E1115

Research output: Contribution to journalArticle

MicroRNAs
Primates
RNA Sequence Analysis
Invertebrates
RNA Interference
18 Citations (Scopus)

Fibulin-5 blocks microenvironmental ROS in pancreatic cancer

Wang, M., Topalovski, M., Toombs, J. E., Wright, C. M., Moore, Z. R., Boothman, D. A., Yanagisawa, H., Wang, H., Witkiewicz, A., Castrillon, D. H. & Brekken, R. A., Dec 1 2015, In : Cancer Research. 75, 23, p. 5058-5069 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Reactive Oxygen Species
Integrins
Adenocarcinoma
Neoplasms
8 Citations (Scopus)

MUC1 promoter-driven DTA as a targeted therapeutic strategy against pancreatic cancer

Tholey, R. M., Lal, S., Jimbo, M., Burkhart, R. A., Blanco, F. F., Cozzitorto, J. A., Eisenberg, J. D., Jiang, W., Iacobuzio-Donahue, C. A., Witkiewicz, A. K., Glbert, M., Yeo, C. J., Brody, J. R., Sawicki, J. A. & Winter, J. M., Mar 1 2015, In : Molecular Cancer Research. 13, 3, p. 439-448 10 p.

Research output: Contribution to journalArticle

Diphtheria Toxin
Pancreatic Neoplasms
Adenocarcinoma
Luciferases
Therapeutics
22 Citations (Scopus)

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer

Knudsen, E. S., Kathleen McClendon, A., Franco, J., Ertel, A., Fortina, P. & Witkiewicz, A. K., Jan 1 2015, In : Cell Cycle. 14, 1, p. 109-122 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Phenotype
Neoplasms
Breast
Epithelial Cells
27 Citations (Scopus)

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

Witkiewicz, A. K., Borja, N. A., Franco, J., Brody, J. R., Yeo, C. J., Mansour, J., Choti, M. A., McCue, P. & Knudsen, E. S., 2015, In : Oncotarget. 6, 18, p. 15788-15801 14 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Heterografts
Adenocarcinoma
Neoplasms
Cell Line
550 Citations (Scopus)

The history and future of targeting cyclin-dependent kinases in cancer therapy

Asghar, U., Witkiewicz, A. K., Turner, N. C. & Knudsen, E. S., Jan 1 2015, In : Nature Reviews Drug Discovery. 14, 2, p. 130-146 17 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
History
Neoplasms
Cell Cycle
Therapeutics
18 Citations (Scopus)

The RB tumor suppressor at the intersection of proliferation and immunity: Relevance to disease immune evasion and immunotherapy

Hutcheson, J., Witkiewicz, A. K. & Knudsen, E. S., Jan 1 2015, In : Cell Cycle. 14, 24, p. 3812-3819 8 p.

Research output: Contribution to journalArticle

Immune Evasion
Immunotherapy
Immunity
Neoplasms
Retinoblastoma
381 Citations (Scopus)

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Witkiewicz, A. K., McMillan, E. A., Balaji, U., Baek, G., Lin, W. C., Mansour, J., Mollaee, M., Wagner, K. U., Koduru, P., Yopp, A., Choti, M. A., Yeo, C. J., McCue, P., White, M. A. & Knudsen, E. S., Apr 10 2015, In : Nature Communications. 6, 7744.

Research output: Contribution to journalArticle

Exome
biological diversity
sequencing
mutations
Pancreatic Neoplasms
2014
238 Citations (Scopus)

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., Horton, J. D., Hammer, R. E., McKnight, S. L. & Tu, B. P., Dec 18 2014, In : Cell. 159, 7, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

Tumors
Acetates
Acetyl Coenzyme A
Neoplasms
Carbon
52 Citations (Scopus)

CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models

Witkiewicz, A. K., Cox, D. & Knudsen, E. S., 2014, In : Genes and Cancer. 5, 7-8, p. 261-272 12 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Therapeutics
Cyclin D1
Heterografts
Phosphotransferases
98 Citations (Scopus)

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

Franco, J., Witkiewicz, A. K. & Knudsen, E. S., 2014, In : Oncotarget. 5, 15, p. 6512-6525 14 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Cyclins
gemcitabine
Therapeutics
9 Citations (Scopus)

Contrast-enhanced sonography for detection of secondary lymph nodes in a melanoma tumor animal model

Liu, J. B., Merton, D. A., Berger, A. C., Forsberg, F., Witkiewicz, A., Zhao, H., Eisenbrey, J. R., Fox, T. B. & Goldberg, B. B., Jun 1 2014, In : Journal of Ultrasound in Medicine. 33, 6, p. 939-947 9 p.

Research output: Contribution to journalArticle

Melanoma
Ultrasonography
Lymph Node Excision
Animal Models
Lymph Nodes
26 Citations (Scopus)

dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: A dual-institutional follow-up with the RTOG 9704 trial

McAllister, F., Pineda, D. M., Jimbo, M., Lal, S., Burkhart, R. A., Moughan, J., Winter, K. A., Abdelmohsen, K., Gorospe, M., De Jesus Acosta, A., Lankapalli, R. H., Winter, J. M., Yeo, C. J., Witkiewicz, A. K., Iacobuzio-Donahue, C. A., Laheru, D. & Brody, J. R., 2014, In : Cancer Biology and Therapy. 15, 6, p. 688-698 11 p.

Research output: Contribution to journalArticle

Deoxycytidine Kinase
Radiation Oncology
Pancreatic Neoplasms
Fluorouracil
Radiotherapy
76 Citations (Scopus)

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

Baek, G. H., Tse, Y. F., Hu, Z., Cox, D., Buboltz, N., McCue, P., Yeo, C. J., White, M. A., DeBerardinis, R. J., Knudsen, E. S. & Witkiewicz, A. K., Dec 24 2014, In : Cell Reports. 9, 6, p. 2233-2249 17 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Metabolism
Tumors
Adenocarcinoma
Cell death
3 Citations (Scopus)

RB tumor suppressive function in response to xenobiotic hepatocarcinogens

Reed, C., Hutcheson, J., Mayhew, C. N., Witkiewicz, A. K. & Knudsen, E. S., 2014, In : American Journal of Pathology. 184, 6, p. 1853-1859 7 p.

Research output: Contribution to journalArticle

Retinoblastoma
Xenobiotics
Neoplasms
Hepatocellular Carcinoma
Peroxisome Proliferators
14 Citations (Scopus)

Retinoblastoma protein potentiates the innate immune response in hepatocytes: Significance for hepatocellular carcinoma

Hutcheson, J., Bourgo, R. J., Balaji, U., Ertel, A., Witkiewicz, A. K. & Knudsen, E. S., Oct 1 2014, In : Hepatology. 60, 4, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

Retinoblastoma Protein
Innate Immunity
Hepatocytes
Hepatocellular Carcinoma
Liver
59 Citations (Scopus)
Precision Medicine
Retinoblastoma
Breast Neoplasms
Neoplasms
Estrogen Receptors
8 Citations (Scopus)

Systematically defining single-gene determinants of response to neoadjuvant chemotherapy reveals specific biomarkers

Witkiewicz, A. K., Balaji, U. & Knudsen, E. S., Sep 15 2014, In : Clinical Cancer Research. 20, 18, p. 4837-4848 12 p.

Research output: Contribution to journalArticle

Biomarkers
Drug Therapy
Estrogen Receptors
Genes
Breast Neoplasms
20 Citations (Scopus)

The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer

Witkiewicz, A. K., Cox, D. W., Rivadeneira, D., Ertel, A. E., Fortina, P., Schwartz, G. F. & Knudsen, E. S., Jul 24 2014, In : Oncogene. 33, 30, p. 3980-3991 12 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Retinoblastoma
Breast Neoplasms
Neoplasms
Epithelial-Mesenchymal Transition
2013
36 Citations (Scopus)

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer

Lin, W. C., Rajbhandari, N., Liu, C., Sakamoto, K., Zhang, Q., Triplett, A. A., Batra, S. K., Opavsky, R., Felsher, D. W., DiMaio, D. J., Hollingsworth, M. A., Morris IV, J. P., Hebrok, M., Witkiewicz, A. K., Brody, J. R., Rui, H. & Wagner, K. U., Mar 15 2013, In : Cancer Research. 73, 6, p. 1821-1830 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Neoplasms
Maintenance
Oncogenes
23 Citations (Scopus)

EZH2 and ALDH1 expression in ductal carcinoma in situ: Complex association with recurrence and progression to invasive breast cancer

Knudsen, E. S., Dervishaj, O., Kleer, C. G., Pajak, T., Schwartz, G. F. & Witkiewicz, A. K., Jul 1 2013, In : Cell Cycle. 12, 13, p. 2042-2050 9 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Recurrence
Neoplastic Stem Cells
Mammography
141 Citations (Scopus)

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

Abel, E. V., Basile, K. J., Kugel, C. H., Witkiewicz, A. K., Le, K., Amaravadi, R. K., Karakousis, G. C., Xu, X., Xu, W., Schuchter, L. M., Lee, J. B., Ertel, A., Fortina, P. & Aplin, A. E., May 1 2013, In : Journal of Clinical Investigation. 123, 5, p. 2155-2168 14 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Melanoma
Up-Regulation
Tumor Burden
Heterografts
41 Citations (Scopus)

Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival

Burkhart, R. A., Peng, Y., Norris, Z. A., Tholey, R. M., Talbott, V. A., Liang, Q., Ai, Y., Miller, K., Lal, S., Cozzitorto, J. A., Witkiewicz, A. K., Yeo, C. J., Gehrmann, M., Napper, A., Winter, J. M., Sawicki, J. A., Zhuang, Z. & Brody, J. R., Aug 2013, In : Molecular Cancer Research. 11, 8, p. 901-911 11 p.

Research output: Contribution to journalArticle

Mitoxantrone
Ubiquitin
Pancreatic Neoplasms
gemcitabine
Cell Survival
12 Citations (Scopus)

Regulation of miR106b cluster through the RB pathway: Mechanismand functional targets

Thangavel, C., Boopathi, E., Ertel, A., Lim, M., Addya, S., Fortina, P., Witkiewicz, A. K. & Knudsen, E. S., Jan 1 2013, In : Cell Cycle. 12, 1, p. 98-111 14 p.

Research output: Contribution to journalArticle

MicroRNAs
cdc Genes
Neoplasms
Untranslated RNA
Gene Expression Profiling
8 Citations (Scopus)

Somatostatin receptor scintigraphy in patients with metastatic uveal melanoma

Valsecchi, M. E., Coronel, M., Intenzo, C. M., Kim, S. M., Witkiewicz, A. K. & Sato, T., Feb 2013, In : Melanoma Research. 23, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Somatostatin Receptors
Radionuclide Imaging
Octreotide
Staining and Labeling
Uveal melanoma
2012
3 Citations (Scopus)

A case of endometrial cancer in the context of a BRCA2 mutation and double heterozygosity for Lynch syndrome

Gong, P., Charles, S., Rosenblum, N., Wang, Z. & Witkiewicz, A. K., Aug 2012, In : Gynecologic Oncology Case Reports. 2, 3, p. 69-72 4 p.

Research output: Contribution to journalArticle

Hereditary Nonpolyposis Colorectal Neoplasms
Endometrial Neoplasms
Mutation
14 Citations (Scopus)

Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma

Mahipal, A., McDonald, M. J., Witkiewicz, A. & Carr, B. I., Mar 2012, In : Medical Oncology. 29, 1, p. 134-139 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Adenocarcinoma
Cell Membrane
Pancreatic Neoplasms
Survival